In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

The mid-thirteenth-century theorist and rhetorician Brunetto Latini proposed a vigorous republican account of the art of government and the nature of community in his encyclopedic treatise, Li Livres dou Tresor. The interpretation of Latini's republicanism has been heavily based on its literary sensibilities, its attachment to rhetoric, and its praise for classical civic virtues. But Latini deserves to be classified as a republican insofar as he founds social and political order upon commercial principles-the production and exchange of material goods for (...) profit-and consequent economic defense of republican government. Hence, the example of Latini challenges one of the principal remaining barriers that supposedly separates medieval defenses of republicanism from Renaissance versions. The essay contends that Latini holds that self-governing institutions depend upon and are especially well suited to sustain a society whose conception of the common good includes the creation and exchange of those material necessities required for physical welfare and comfort. (shrink)

The mid-thirteenth-century theorist and rhetorician Brunetto Latini proposed a vigorous republican account of the art of government and the nature of community in his encyclopedic treatise, Li Livres dou Tresor. The interpretation of Latini's republicanism has been heavily based on its literary sensibilities, its attachment to rhetoric, and its praise for classical civic virtues. But Latini deserves to be classified as a republican insofar as he founds social and political order upon commercial principles—the production and exchange of material goods for (...) profit—and consequent economic defense of republican government. Hence, the example of Latini challenges one of the principal remaining barriers that supposedly separates medieval defenses of republicanism from Renaissance versions. The essay contends that Latini holds that self-governing institutions depend upon and are especially well suited to sustain a society whose conception of the common good includes the creation and exchange of those material necessities required for physical welfare and comfort. (shrink)

Obra estructurada en cinco ponencias: la primera acerca de aspectos básicos para el posterior desarrollo de las relaciones ciencia-trascendencia; la segunda sobre la difícil consideración acerca del tiempo; la tercera sobre el papel que desempeña la neurocienca; la cuarta sobre las relaciones de la trascendencia ética con lo científico, y la quinta sobre el sentido de la religión y del cristianismo desde el punto de vista de la ciencia.

The relationship between corporate social responsibility and corporate financial performance has long been a central and contentious debate in the literature. However, prior empirical studies provide indefinite conclusions. The purpose of this study is to review systematically and quantify the CSR–CFP link in a meta-analytic framework. Based on 119 effect sizes from 42 studies, this study estimates that the overall effect size of the CSR–CFP relationship is positive and significant, thus endorsing the argument that CSR does enhance financial performance. Furthermore, (...) this work sheds light on the causal relationship between CSR and CFP. Subsequent financial performance is associated with prior social responsibility, while the reverse direction is not supported. This finding supports the instrumental stakeholder theory. As predicted, the meta-analysis results indicate that the measurement strategies of the two key constructs of CSR and CFP explain some variations of the CSR–CFP relationship. Last, this study examines the moderating effect of the environmental context on the CSR–CFP link. This work proposes that CSR in the developed world, with a relatively mature institutional system and efficient market mechanism, will be more visible than CSR in the developing world. The results show that the CSR–CFP relationship is stronger for firms from advanced economies than for firms from developing economies. (shrink)

This research proposes an explanation for the conflicting extant evidence about whether family ownership of a business promotes proactive environmental strategy (PES). Based on insights drawn from strategic reference point theory, organizational identity theory, and the socioemotional wealth preservation perspective, we propose that family ownership has a moderated–mediated relationship with PES, with commitment as a moderator and long-term orientation as a mediator. A test using 454 China private firms with different levels of family ownership supports the hypotheses. This shows that (...) PES as a strategy related to business ethics does not happen without commitment and long-term orientation. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

We model a black hole spacetime as a causal set and count, with a certain definition, the number of causal links crossing the horizon in proximity to a spacelike or null hypersurface Σ. We find that this number is proportional to the horizon's area on Σ, thus supporting the interpretation of the links as the “horizon atoms” that account for its entropy. The cases studied include not only equilibrium black holes but ones far from equilibrium.

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...) previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

Based on the conservation of resource theory, this manuscript explores the impact mechanism of the challenge and hindrance stressors on innovation performance, introduces emotional atmosphere as a mediation variable, and on this basis, it examines the moderating role of organizational climate on emotional atmosphere and innovation performance. A two-wave survey of 263 subordinates and 29 supervisors who come from multisource field offered support for our model. Results showed that challenge stressors have a positive effect on innovation performance, positive emotional atmosphere (...) mediates the relationship between challenge stressors and innovation performance; hindrance stressors have a negative effect on innovation performance, and negative emotional atmosphere mediates the relationship between hindrance stressors and innovation performance. Organizational climate strengthens the positive relationship between positive emotional atmosphere and innovation performance and weakens the negative relationship between negative emotional atmosphere and innovation performance. This study enriches the existing literature by identifying the impact of stressors on employee innovation performance and has certain practical significance for optimizing the management of enterprises and improving employee innovation performance. (shrink)

Xukai Dou befasst sich in dieser Arbeit mit der Frage nach der Wesung des Menschen in Martin Heideggers Nietzsche-Interpretationen und seinsgeschichtlichem Denken. Diese Frage spielt nicht nur in der ganzen Philosophie Heideggers, sondern auch in der ganzen abendländischen Philosophie eine entscheidende Rolle, weil sie Heideggers Versuch der Verwindung der abendländischen Metaphysik als des Nihilismus und des metaphysischen Wesens des Menschen sowie die seinsgeschichtliche Besinnung auf die Wesung des Menschen in der Geviert-Welt nachvollziehbar macht. Damit können nicht nur Nietzsches Metaphysik des (...) ewig wiederkehrenden Willens zur Macht und der Gedanke des Übermenschen, sondern auch das Technikdenken, das Denken der Geviert-Welt und das Sprachdenken beim späten Heidegger verstanden und die ursprüngliche, eigentliche Wesung des Menschen erkannt werden - als des Sterblichen und sein dichterisches Wohnen in der Geviert-Welt."--Page 4 of cover. (shrink)

Recent studies have found abnormal levels of brain-derived neurotrophic factor in a variety of central nervous system diseases. This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status (...) of BDNF is also provided. (shrink)

This paper represents an introduction to whole approach of mathematics education and takes an example for wholeness principle by area. It is also an introduction to whole approach of education.

With the rapid development of emerging technologies such as electric vehicles and high-speed railways, the insulated gate bipolar transistor is becoming increasingly important as the core of the power electronic devices. Therefore, it is imperative to maintain the stability and reliability of IGBT under different circumstances. By predicting the junction temperature of IGBT, the operating condition and aging degree can be roughly evaluated. However, the current predicting approaches such as optical, physical, and electrical methods have various shortcomings. Hence, the backpropagation (...) neural network can be applied to avoid the difficulties encountered by conventional approaches. In this article, an advanced prediction model is proposed to obtain accurate IGBT junction temperature. This method can be divided into three phases, BP neural network estimation, interpolation, and Kalman filter prediction. First, the validities of the BP neural network and Kalman filter are verified, respectively. Then, the performances of them are compared, and the superiority of the Kalman filter is proved. In the future, the application of neural networks or deep learning in power electronics will create more possibilities. (shrink)

Patients with bipolar disorder may experience family dysfunction, which might result in worse psychosocial functioning through environmental and psychological factors. Research investigating the mediating role of social support, resilience and suicidal ideation on family and psychosocial functioning in BD is rare. The study aims to explore the predicting and mediating effects of social support, resilience and suicidal ideation on family and psychosocial functioning in BD patients. Two hundred forty-six patients with BD and sixty-nine healthy controls were recruited. The Family Assessment (...) Device, Functioning Assessment Short Test, Social Support Rating Scale, Connor-Davidson Resilience Scale and Beck Scale for Suicide Ideation were used to assess family functioning, psychosocial functioning, social support, resilience and suicidal ideation, respectively. Bipolar patients exhibited worse family and psychosocial functioning than healthy controls. Family functioning, social support, resilience and suicidal ideation significantly predict psychosocial functioning in the bipolar group. Social support, resilience and suicidal ideation indirectly mediate the effect of family functioning on psychosocial functioning in bipolar patients. Cross-sectional design and mixed sample including acute and remitted stages. Treatments for patients with bipolar disorder should be combined with family strategies that are formulated to improve psychosocial functioning. An emphasis should be placed on enhancing social support and resilience while paying attention to suicidal ideation. (shrink)

A generalized Bayesian inference nets model is proposed to aid researchers to construct Bayesian inference nets for various applications. The benefit of such a model is well demonstrated by applying GBINM in constructing a hierarchical Bayesian fuzzy inference nets to diagnose five important types of cardiovascular diseases. The patients' medical records with doctors' confirmed diagnostic results obtained from two hospitals in China are used to design and verify HBFIN. Bayesian theorem is used to calculate the propagation of probability and address (...) the uncertainties involved in each sequential stage of inference nets to deduce the disease. The validity and effectiveness of proposed approach is witnessed clearly from testing results obtained. (shrink)

With the existing research available on negative and malevolent creativity, this paper proposes a more narrowly defined concept: the bi-directional relationship between negative and malevolent creative thinking, which is intended to clarify the way forward for research in the area of negative and malevolent creativity. This paper uses qualitative research to identify and correlate an individual's concept of negative and malevolent creativity and uses a Inductive reasoning methodology to outline a preliminary theory. Following this, the preliminary theory was returned to (...) the primary sources for validation, continuous optimization, and presentation. To better demonstrate the bidirectional linkage mechanism of thinking between the two types, this paper constructed a model to describe the relationships between the variables. This study concludes that negative creative thinking is a kind of native thinking based on personal interests that are developed to emphasize the benefits of an individual's interests, while malevolent creative thinking is a kind of native thinking based on the value-added of personal interests and is deliberately harmful. Both types of thinking share a value orientation, environmental stimulation, and subjective motivation. However, they differ in terms of value goals, ways of thinking, and the scale of the subject. It is concluded from the intrinsic thinking logic of individual thinking as well as the temporal dimension of the individual creative process that value-added and intentions to exploit others are factors that drive the transformation of negative creative thinking into malevolent creative thinking, and personal intention is a vital factor for establishing a linkage between negative and malevolent creative thinking. (shrink)

Dance creation involves complex psychological activities. Although previous studies have conducted extensive investigations on the psychological aspects of choreographers’ creations, little is known regarding the psychological barrier of choreographers in terms of creativity. The study aims to explore the psychological barrier of innovation in dance choreography, which is a kind of situation between mental illness and mental problems. The research shows that improvisational dance is a free dance with the human body as a material carrier, and it is a dance (...) form that the dancer’s thinking is transformed into dance action to express their inner thoughts. The improvement of the potential creative thinking of dance creators through the improvisational dance movement and structure are explored. Meanwhile, the theoretical ideas of psychologists have been applied to the cultivation and improvement of improvisational dance creativity, which has made full certification and supplement. Moreover, through psychological experiments, it is proved that improvisational dance is an important way to release and develop creativity. Based on the theory of psychology, feasible suggestions are given to improve students’ creative ability in the process of improvisational dance teaching. (shrink)

“法律行為”是民法理論中的一個基本概念，是民法基本原則以及民法體系得以建立的基石。本書追溯了這一概念的歷史發展與社會理論基礎，剖析了法律行為傳統概念中以意思表示為核心的缺陷與困境，提出以規範性為核心取 代意思表示重新構建民法體系，才能符合理論與司法實踐的需要。法律行為國內少有研究，以專著形式的探究更是付之闕如，本書填補了近年來的理論空白。.

Academic performance occupies an important role in adolescent development. It reflects adolescents’ cognitive ability and also shapes their academic and career paths. Students who are satisfied with their school performance tend to show higher self-esteem, confidence, and motivation. Previous research has suggested that students’ problem behaviors, such as Internet Addiction, and academic values, including intrinsic and utility values, could predict satisfaction with academic performance. However, the influence of IA and academic values has not been thoroughly explored in Chinese contexts where (...) the pressure for academic success is heavy. This study examined the relationships between IA, academic values, and satisfaction with academic performance using two waves of data collected from secondary school students in four cities in mainland China. The matched sample included a total of 2,648 Grade 7 or 8 students. Participants completed the same questionnaire containing validated measures at both waves with a 1-year interval. In line with the hypotheses, multiple regression analyses showed that Wave 1 IA was a significant negative predictor of Wave 2 intrinsic value, utility value, and satisfaction with academic performance and their changes. Results of mediation analyses revealed that only intrinsic value, but not utility value, positively predicted satisfaction with academic performance. Structural equation modeling analyses also showed similar findings. Two observations are concluded from the present findings: IA impaired students’ intrinsic value, utility value, and perceived satisfaction with academic performance; two aspects of academic values demonstrated different influences on satisfaction with academic performance. These findings provide implications for the promotion of academic satisfaction experienced by students and the prevention of negative effects of IA. (shrink)

With the increasing volume of web services in the cloud environment, Collaborative Filtering- based service recommendation has become one of the most effective techniques to alleviate the heavy burden on the service selection decisions of a target user. However, the service recommendation bases, that is, historical service usage data, are often distributed in different cloud platforms. Two challenges are present in such a cross-cloud service recommendation scenario. First, a cloud platform is often not willing to share its data to other (...) cloud platforms due to privacy concerns, which decreases the feasibility of cross-cloud service recommendation severely. Second, the historical service usage data recorded in each cloud platform may update over time, which reduces the recommendation scalability significantly. In view of these two challenges, a novel privacy-preserving and scalable service recommendation approach based on SimHash, named SerRecSimHash, is proposed in this paper. Finally, through a set of experiments deployed on a real distributed service quality dataset WS-DREAM, we validate the feasibility of our proposal in terms of recommendation accuracy and efficiency while guaranteeing privacy-preservation. (shrink)

In response to the severe lack of leadership assessment tools in the Chinese context, the Service Leadership Behavior Scale was developed based on the Service Leadership Model proposed by Po Chung, the co-founder of DHL International. Utilizing responses from 4,486 Hong Kong undergraduates, this paper reports the findings of a validation study on the Short-Form Service Leadership Behavior Scale (SLB-SF-65). Previous findings based on exploratory factor analysis revealed a six-factor 48-item solution (SLB-SF-48). With the removal of ten items, confirmatory factor (...) analysis showed that the final 38-item scale (SLB-SF-38) possessed excellent psychometric properties and factorial stability based on multigroup invariance analyses. The SLB-SF-38 also exhibited excellent reliability and convergent validity. Overall speaking, the present study underscored the utility of the SLB-SF-38 as an objective assessment instrument of service leadership behavior in the education, research and personnel training contexts. (shrink)

Law abidance is very important for effective leaders. Without law abidance, abuse of power and corruption would easily happen, which would eventually erode organizational health. To promote law abidance leadership in university students in Hong Kong, we developed a law abidance leadership program with 3 h of face-to-face lecture and 7 h of self-study of materials disturbed to students. To understand students’ perception of the 3-h lecture, we conducted a post-lecture evaluation study using a 26-item measure. Results showed that the (...) scale possessed good reliability and validity. Confirmatory factor analyses showed that the assessment tool has three internally consistent and factorial invariant dimensions: program attributes, appreciation of law abidance, and teacher attributes. Regarding students’ perception of the program, students were generally satisfied with the lecture attributes, including design, content, lecture atmosphere, teaching quality, and benefits to students. In particular, students agreed that the lecture helped them understand the importance and value of law abidance and national security; over 95% of the students indicated that they would try their best to serve as law-abiding citizens and socially responsible leaders. Multiple regression analyses showed that program attributes, appreciation of law abidance, and teacher attributes predicted overall satisfaction with the lecture. Qualitative comments of the student echoed the quantitative findings, with most of the comments being positive in nature. The present study replicated the findings reported previously. Local and international contextual factors relevant to the interpretations of the findings are highlighted. (shrink)

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.