This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1982.

The Alzheimer field is in desperate need for an effective treatment. After decades of research, the available drugs treat only symptoms, and even their effectiveness is disputed. Because brain changes precede the clinical symptoms by years to decades, disease-modifying treatments should probably be started early, when the first symptoms occur—or even before. But how to determine who to treat? In this issue, Erik Gustavsson c.s. approach this question by addressing the benefits, harms and ethical issues encountered when using different modes (...) of screening for ‘preclinical’ or early symptomatic Alzheimer disease.1 Their overall conclusion is clear—screening for high risk of developing AD dementia to select those who are eligible for treatment is ethically problematic, unless extremely effective treatment becomes available. An additional major challenge is that diagnostic test accuracy is generally poor, with a particularly high risk of false-positive results, that is, biological evidence of Alzheimer pathology in persons who will never develop dementia. The risk of overmedicalisation is serious, and the potential harms of screening for AD should not be ignored, as Le Couteur c.s. previously argued.2 In short, there is no evidence base for any form of screening for AD whether in a preclinical stage (an …. (shrink)

Explores the theories of democratic individualism articulated in the works of the American transcendentalist writer Ralph Waldo Emerson, pragmatic philosophers William James and John Dewey, and African-American novelist and essayist Ralph Ellison.

The Concept of a Phenomenon ANTHONY QUINTON In British philosophy 'phenomenon' usually means 'sensory appearance'. Yet until Wittgenstein and Ryle standard..

A revision of the author's thesis, Stuttgart, 1972.

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 110 Heft: 2 Seiten: 233-623.

Antike Noëtik und moderne Subjektivität / Helmut Kuhn -- Die platonische Idee des Guten und das sokratische Paradox bei Kierkegaard / Wilhelm Anz -- Der Herakliteer in Platons Theätet / Uvo Hölscher -- Antike und moderne Ethik / Ernst Tugendhat.

It is a trite fact that changes do occur, yet is it logically contradictory to deny that they do? If Zeno and McTaggart were right, then there is no logical contradiction in such a denial, although this is incompatible with the way in which we normally think of the world. Supporters of the 'block view' of the universe believe that there is a sense in which all events may be said to be contemporaneous, like episodes in a book, so that (...) there is no `objective' past or future.The aim of this book is not to demolish belief in the existence of objective change, but to elucidate the conditions under which it makes sense to suppose that changes occur. The book pays particular attention to the existence of selves as one such condition, and concludes that the naturalistic account of change is defective and leaves the sceptic victorious. (shrink)

G. Vespignani hat mit diesem Buch über den Hippodrom von Konstantinopel eine reich dokumentierte Studie vorgelegt, die sich vor allem mit der ideologischen und politischen Bedeutung des Bauwerks beschäftigt.

In the hope of future treatments to prevent or slow down the disease, there is a strong movement towards an ever-earlier detection of Alzheimer's disease. In conjunction with scientific developments, this has prompted a reconceptualization of AD, as a slowly progressive pathological process with a long asymptomatic phase. New concepts such as "preclinical" and "prodromal" AD have been introduced, raising a number of conceptual and ethical questions. We evaluate whether these new concepts are theoretically defensible, in light of theories of (...) health and disease, and whether they should be understood as disease or as an at-risk state. We introduce a pragmatic view on disease concepts and argue that an evaluation of the reconceptualization of AD should also take its aims and effects into account, and assess their ethical acceptability. The reconceptualization of AD is useful to coordinate research into preventive strategies, and may potentially benefit future patients. However, in the short term, early detection and labelling of "preclinical AD" can potentially harm people. Since there is no treatment available and the predictive value is unclear, it may only create a group of "patients in waiting" who may suffer from anxiety, uncertainty and stigmatization, but will never actually develop dementia. We conclude that only if the promise of preventive medication materializes, will the reconceptualization of AD turn out unequivocally to be for the better. Otherwise, the reconceptualization may do more harm than good. (shrink)