We explore a notion of pseudofinite dimension, introduced by Hrushovski and Wagner, on an infinite ultraproduct of finite structures. Certain conditions on pseudofinite dimension are identified that guarantee simplicity or supersimplicity of the underlying theory, and that a drop in pseudofinite dimension is equivalent to forking. Under a suitable assumption, a measure-theoretic condition is shown to be equivalent to local stability. Many examples are explored, including vector spaces over finite fields viewed as 2-sorted finite structures, and homocyclic groups. Connections are (...) made to products of sets in finite groups, in particular to word maps, and a generalization of Tao's Algebraic Regularity Lemma is noted. (shrink)

Given a theoryTextending that of dense linear orders without endpoints, in a language ℒ ⊇ {<}, we are interested in extensionsT′ ofTin languages extending ℒ by unary relation symbols that are each interpreted in models ofT′ as sets that are both dense and codense in the underlying sets of the models.There is a canonically “wild” example, namelyT= Th andT′ = Th. Recall thatTis o-minimal, and so every open set definable in any model ofThas only finitely many definably connected components. But (...) it is well known that 〈ℝ, <, +, · ℚ 〉 defines every real Borel set, in particular, every open subset of any finite cartesian power of ℝ and every subset of any finite cartesian power of ℚ. To put this another way, the definable open sets in models ofTare essentially as simple as possible, whileT′ has a model where the definable open sets are as complicated as possible, as is the structure induced on the new predicate.In contrast to the preceding example, if ℝalgis the set of real algebraic numbers andT′ Th, then no model ofT′ defines any open set that is not definable in the underlying model ofT. (shrink)

O-minimal structures have long been thought to occupy the base of a hierarchy of ordered structures, in analogy with the role that strongly minimal structures play with respect to stable theories. This is the first in an anticipated series of papers whose aim is the development of model theory for ordered structures of rank greater than one. A class of ordered structures to which a notion of finite rank can be assigned, the decomposable structures, is introduced here. These include all (...) ordered structures definable in o-minimal structures. The principal result in this paper, Theorem 5.1, asserts roughly that a decomposable structure [Formula: see text] can be partitioned into finitely many definable subsets such that on each set the restriction of < is a "twisted lexicographic" order. As a consequence, for all n and linear orders ≺ definable on a subset X ⊆ Mn in an o-minimal structure [Formula: see text], there is a definable partition of X such that the restriction of ≺ to each set in the partition is "lexicographic". (shrink)

We study o-minimal expansions of Archimedean totally ordered groups. We first prove that any such expansion must be elementarily embeddable via a unique (provided some nonzero element is 0-definable) elementary embedding into a unique o-minimal expansion of the additive ordered group of real numbers R. We then show that a definable function in an o-minimal expansion of R enjoys good differentiability properties and use this to prove that an Archimedean real closed field is definable in any nonsemilinear expansion of R. (...) Combining these results, we obtain several restrictions on possible o-minimal expansions of arbitrary Archimedean ordered groups and in particular of the rational ordered group. (shrink)

We show, for various classes of totally ordered structures, including o‐minimal and weakly o‐minimal structures, that every definable partial order on a subset of extends definably in to a total order. This extends the result proved in for and o‐minimal.

For a countable complete o-minimal theory T, we introduce the notion of a sequentially complete model of T. We show that a model M of T is sequentially complete if and only if $\mathscr{M} \prec \mathscr{N}$ for some Dedekind complete model N. We also prove that if T has a Dedekind complete model of power greater than 2 ℵ 0 , then T has Dedekind complete models of arbitrarily large powers. Lastly, we show that a dyadic theory--namely, a theory relative (...) to which every formula is equivalent to a Boolean combination of formulas in two variables--that has some Dedekind complete model has Dedekind complete models in arbitrarily large powers. (shrink)

It is shown that if is an o-minimal structure such that is a dense total order and ≾ is a parameter-definable partial order on M, then ≾ has an extension to a definable total order.

Review by: Michael Benedikt The Bulletin of Symbolic Logic, Volume 19, Issue 1, Page 112-115, March 2013.

Larmore aims to recover three forms of moral complexity that have often been neglected by moral and political philosophers. First, he argues that virtue is not simply the conscientious adherence to principle. Rather, the exercise of virtue apply. He argues - and this is the second pattern of complexity - that recognizing the value of constitutive ties with shared forms of life does not undermine the liberal ideal of political neutrality toward differing ideals of the good life. Finally Larmore agrues (...) for what he calls the heterogeneity of morality. Moral thinking need not be exclusively deontological or consequentialist, and we should recognize that the ultimate sources of moral value are diverse. The arguments presented here do not attack the possibility of moral theory. But in addressing some of the central issues of moral and political thinking today thay attempt to restore to that thinking greater flexibility and a necessary sensitivity to our common experience. (shrink)

What is political philosophy’s relation to moral philosophy? Does it simply form part of moral philosophy, focusing on the proper application of certain moral truths to political reality? Or must it instead form a more autonomous discipline, drawing its bearings from the specifically political problem of determining the bounds of legitimate coercion? In this essay I work out an answer to these questions by examining both some of the classical views on the nature of political philosophy and, more particularly, some (...) recently published writings by Bernard Williams and G.A. Cohen. (shrink)

Aristotle initiated the systematic investigation of perception, the emotions, memory, desire, and action. David Charles argues that Aristotle's account of these phenomena is a philosophically live alternative to conventional modern thinking about the mind: it offers a way to dissolve, rather than solve, the mind-body problem we have inherited.

Reprint, in paper covers, of the Columbia U. Press edition of 1990. Annotation copyright by Book News, Inc., Portland, OR.

Interaction between Peter Singer and Christian ethics, to the extent that it has happened at all, has been unproductive and often antagonistic. Singer sees himself as leading a 'Copernican Revolution' against a sanctity of life ethic, while many Christians associate his work with a 'culture of death'. Charles Camosy shows that this polarized understanding of the two positions is a mistake. While their conclusions about abortion and euthanasia may differ, there is surprising overlap in Christian and Singerite arguments, and (...) disagreements are interesting and fruitful. Furthermore, it turns out that Christians and Singerites can even make common cause, for instance in matters such as global poverty and the dignity of non-human animals. Peter Singer and Christian ethics are far closer than almost anyone has imagined, and this book is valuable to those who are interested in fresh thinking about the relationship between religious and secular ethics. (shrink)

Although for the last 50 years, ethicists dealing with human experimentation have focused primarily on the need to protect individual research subjects and vulnerable groups, biomedical research, especially in genetics, now requires the establishment of standards for the protection of communities. We have developed such a strategy, based on five steps. (i) Identification of community characteristics relevant to the biomedical research setting, (ii) delineation of a typology of different types of communities using these characteristics, (iii) determination of the range of (...) possible community protections, (iv) creation of connections between particular protections and one or more community characteristics necessary for its implementation, and (v) synthesis of community characteristics and possible protections to define protections appropriate for each type of community. Depending on the particular community, consent and consultation, consultation alone, or no added protections may be required for research. (shrink)

Abstract:Therapeutic misconception (TM)—when clinical research participants fail to adequately grasp the difference between participating in a clinical trial and receiving ordinary clinical care—has long been recognized as a significant problem in consent to clinical trials. We suggest that TM does not primarily reflect inadequate disclosure or participants’ incompetence. Instead, TM arises from divergent primary cognitive frames. The researchers’ frame places the clinical trial in the context of scientific designs for assessing intervention efficacy. In contrast, most participants have a cognitive frame (...) that is personal and focused primarily on their medical problems. To illustrate this, we draw on interview material from both clinical researchers and participants in clinical trials. We suggest that reducing TM requires encouraging subjects to adjust their frame, not just add information to their existing frame. What is necessary is ascientific reframingof participation in a clinical trial. (shrink)

The issue of the protection of communities in clinical research first arose 10 years ago in studies conducted in technologically developing countries by scientists from technologically developed nations. The question was, which ethical standards ought to apply, those of the Western investigators or local standards?

Liberalism is a distinctively modern political conception. Only in modern times do we find, as the object of both systematic reflection and widespread allegiance and institutionalization, the idea that the principles of political association, being coercive, should be justifiable to all whom they are to bind. And so only here do we find the idea that these principles should rest, so far as possible, on a core, minimal morality which reasonable people can share, given their expectably divergent religious convictions and (...) conceptions of the meaning of life. No longer does it seem evident—as it did, let us say, before the seventeenth century—that the aim of political association must be to bring man into harmony with God's purposes or to serve some comprehensive vision of the good life. The causes of this transformation are various, and not all of them lie at the level of moral principle. But a change in moral consciousness has certainly been one of the factors involved. As Hegel observed, modern culture is inherently a reflective one: notions of principle are essential to our self-understanding and thus to the stability of the social forms in which we participate. Modern culture has no room for a dichotomy between “in principle” and “in practice.” It is worth determining, then, what new moral conceptions have been responsible for the emergence of modern liberalism. Not only will we thereby better understand how we have become who we are, we will also have a surer grasp of the principles that sustain our political life. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Place and the "Spatial Turn" in Geography and in HistoryCharles W. J. WithersI. IntroductionA few years ago, British Telecom ran a newspaper advertisement in the British press about the benefits—and consequences—of advances in communications technology. Featuring a remote settlement in the north-west Highlands of Scotland, and with the clear implication that such "out-of-the-way places" were now connected to the wider world (as if they had not been before), the (...) advert proclaimed "Geography is History." What the advert signalled to as the "end" of geography in the sense of the social gradients associated with space and distance is what is known, variously, as "time-space convergence" and "time-space distanciation."1 The terms embrace not just the "collapse" of geographical space given technical advances (in travel time and in communications—consequences of what Castells calls "the information age" and "the network society"2), but also the idea that the modern world has become [End Page 637] more homogenized. One place is now much the same as another. Further, given the likelihood of such technical and cultural changes continuing into the future, geographical distinctiveness, evident in the particularity of place, would be a thing of the past: geography would indeed be history. There is, of course, much evidence to the contrary: that, in the face of "globalisation," questions of locality, sense of place and of identity in place matter now more than ever. Even, then, as Francis Fukuyama cautioned against the "death" of liberal democratic politics as The End of History,3 geography—that is, geography understood as questions to do with place, and questions to do with where you are in the world as part of questions about how you are and who you are in the world—has had considerably heightened significance and for some places and people more than others.4These notions of place—as a particular location, and the character or sense of place—are only part of the meanings associated with place in geographical and in historical work. Like space, its regular epistemic dancing partner in geographical ubiquity and metaphysical imprecision, place is a widespread yet complex term. What follows is historiographical in focus and, of necessity, partial in range. I offer a historiographical survey of the term place, principally but not alone within recent work in geography. In more detail, and with reference to one of the strong senses in which place is used, namely that of locale, "the local," or localness, I trace here the connections between place, space, and the idea of the local as evident in recent work in history and in geography, especially within the history and the geography of science. Particular attention is paid in this context to the distinctive features of what we may think of as the "spatial turn" in the history of science by looking at the idea of place and space in recent work in Enlightenment studies. My argument is three-fold. Notions of place and space, much debated by geographers, have been as central a concern for intellectual historians and historians of science as for philosophers and others, but they have been differently expressed. There is, I shall argue, value in looking at these different views in order to understand that whilst place is a commonplace term it is not agreed upon: working with imprecision has been both opportunity and restriction. In relation to work within the history of science and in Enlightenment studies, consideration of the so-called "spatial turn," of place [End Page 638] as social practice and of placing as a process in accounting for the uneven movement of ideas over space and time may help provide some precision and strengthen connections between geography and history.II. Place (In Geography): A Partial HistoriographyPlace is one of the most fundamental concepts in human geography. It is also one of the most problematic.5 Place, or small-scale regional space, features as a subdivision within the Classical tripartite division of cosmography (the earth in relation to other planetary bodies), geography (the earth as a whole) and chorography (parts of the earth or regional geography). So, too, does the distinction between chorography and chronology as... (shrink)

The Belmont Report’s distinction between research and the practice of accepted therapy has led various authors to suggest that these purportedly distinct activities should be governed by different ethical principles. We consider some of the ethical consequences of attempts to separate the two and conclude that separation fails along ontological, ethical, and epistemological dimensions. Clinical practice and clinical research, as with yin and yang, can be thought of as complementary forces interacting to form a dynamic system in which the whole (...) exceeds the sum of its parts. Just as effective clinical practice cannot exist without clinical research, meaningful clinical research requires the context of clinical practice. We defend this thesis by triangulation, that is, by outlining how multiple investigators have reached this conclusion on the basis of varied theoretical and applied approaches. More confidence can be placed in a result if different methods/viewpoints have led to that result. (shrink)

As genetic research increasingly focuses on communities, there have been calls for extending research protections to them. We critically examine guidelines developed to protect aboriginal communities and consider their applicability to other communities. These guidelines are based on a model of researcher-community partnership and span the phases of a research project, from protocol development to publication. The complete list of 23 protections may apply to those few non-aboriginal communities, such as the Amish, that are highly cohesive. Although some protections may (...) be applicable to less-cohesive communities, such as Ashkenazi Jews, analysis suggests substantial problems in extending these guidelines in toto beyond the aboriginal communities for which they were developed. (shrink)

I distinguish between ‘substantival’ and ‘functional’ forms of vitalism in the eighteenth century. Substantival vitalism presupposes the existence of a (substantive) vital force which either plays a causal role in the natural world as studied scientifically, or remains an immaterial, extra-causal entity. Functional vitalism tends to operate ‘post facto’, from the existence of living bodies to the search for explanatory models that will account for their uniquely ‘vital’ properties better than fully mechanistic models can. I discuss representative figures of the (...) Montpellier school (Bordeu, Ménuret, Fouquet) as functional rather than substantival vitalists, and suggest an additional point regarding the reprisal of vitalism(s) in the 20th century, from Driesch to Canguilhem: that in addition to the substantival and functional varieties, we encounter a third species of vitalism, which I term ‘attitudinal’, as it argues for vitalism as a kind of attitude. (shrink)

This book presents and analyzes the most important arguments in the history of Western philosophy's skeptical tradition. It demonstrates that, although powerful, these arguments are quite limited and fail to prove their core assertion that knowledge is beyond our reach. Argues that skepticism is mistaken and that knowledge is possible Dissects the problems of realism and the philosophical doubts about the accuracy of the senses Explores the ancient argument against a criterion of knowledge, Descartes' skeptical arguments, and skeptical arguments applied (...) to inductive inference and self-knowledge Uses Moore's proof of an external world and the reliabilist conception of knowledge to illustrate that the traditional skeptical arguments fail to meet their mark. (shrink)

Intended for the first course in logic, The Power of Logic (POL) is written with the conviction that logic is the most important course that college students take. POL preserves the balance between informal and formal logic. Layman;s direct and accessible writing style, along with his plentiful examples, imaginative exercises, and POL;s accompanying Logic Tutor make this the best text for logic classes today.day.

Implicit bias results from living in a society structured by race. Tamar Gendler has drawn attention to several epistemic costs of implicit bias and concludes that paying some costs is unavoidable. In this paper, we reconstruct Gendler’s argument and argue that the epistemic costs she highlights can be avoided. Though epistemic agents encode discriminatory information from the environment, not all encoded information is activated. Agents can construct local epistemic environments that do not activate biasing representations, effectively avoiding the consequences of (...) activation. We conclude that changing our local environments provides a way to avoid paying implicit bias’s epistemic costs. (shrink)

In hospital rooms across the country, doctors, nurses, patients, and their families grapple with questions of life and death. Recently, they have been joined at the bedside by a new group of professional experts, bioethicists, whose presence raises a host of urgent questions. How has bioethics evolved into a legitimate specialty? When is such expertise necessary? How do bioethicists make their decisions? And whose interests do they serve? Renowned sociologist Charles L. Bosk has been observing medical care for thirty-five (...) years. In What Would You Do? he brings his extensive experience to bear on these questions while reflecting on the ethical dilemmas that his own ethnographic research among surgeons and genetic counselors has provoked. Bosk considers whether the consent given to ethnographers by their subjects can ever be fully voluntary and informed. He questions whether promises of confidentiality and anonymity can or should be made. And he wonders if social scientists overestimate the benefits of their work while downplaying the risks. Vital for practitioners of both the newly prominent field of bioethics and the long-established craft of ethnography, What Would You Do? will also engross anyone concerned with how our society addresses difficult health care issues. (shrink)