Despite optimistic reports about the results of amputation for advanced vascular disease, the patient’s assessment of advantages and disadvantages is seldom acknowledged. A detailed social study of 67 amputees has revealed considerable disparity between the patient’s views and those of the medical staff. About a third of the patients are forced to retire from active work by the amputation; about three-quarters report a serious decline in their social activities; only about half are really independent with prostheses in the long term; (...) a quarter report severe and intractable symptoms related to their amputation stumps; only about a quarter feel that the amputation was definitely beneficial; and only about one in five feel that the medical staff have provided adequate support during their hospital stay. Amputees face physical and financial disability, isolation, and discomfort. Every effort must be made to explain the implications of amputation honestly and realistically and to ensure continuing patient assessment and support. (shrink)

Issues of balancing data accessibility with ethical considerations and governance of a genomics research biobank, Generation Scotland, are explored within the evolving policy landscape of the past ten years. During this time data sharing and open data access have become increasingly important topics in biomedical research. Decisions around data access are influenced by local arrangements for governance and practices such as linkage to health records, and the global through policies for biobanking and the sharing of data with large-scale biomedical research (...) data resources and consortia. We use a literature review of policy relevant documents which apply to the conduct of biobanks in two areas: support for open access and the protection of data subjects and researchers managing a bioresource. We present examples of decision making within a biobank based upon observations of the Generation Scotland Access Committee. We reflect upon how the drive towards open access raises ethical dilemmas for established biorepositories containing data and samples from human subjects. Despite much discussion in science policy literature about standardisation, the contextual aspects of biobanking are often overlooked. Using our engagement with GS we demonstrate the importance of local arrangements in the creation of a responsive ethical approach to biorepository governance. We argue that governance decisions regarding access to the biobank are intertwined with considerations about maintenance and viability at the local level. We show that in addition to the focus upon ever more universal and standardised practices, the local expertise gained in the management of such repositories must be supported. A commitment to open access in genomics research has found almost universal backing in science and health policy circles, but repositories of data and samples from human subjects may have to operate under managed access, to protect privacy, align with participant consent and ensure that the resource can be managed in a sustainable way. Data access committees need to be reflexive and flexible, to cope with changing technology and opportunities and threats from the wider data sharing environment. To understand these interactions also involves nurturing what is particular about the biobank in its local context. (shrink)

Volume 19, Issue 12, December 2019, Page 60-62.

Much of the developing world, including Kenya, is rapidly urbanizing. Rising food and fuel prices in recent years have put the food security of the urban poor in a precarious position. In cities worldwide, urban agriculture helps some poor people gain access to food, but urban agriculture is less common in densely populated slums that lack space. In the Kibera slums of Nairobi, Kenya, households have recently begun a new form of urban agriculture called sack gardening in which vegetables such (...) as kale and Swiss chard are planted into large sacks filled with topsoil. This paper examines relationships among sack gardening, social capital, and food security in Kibera. We used a mixed methods approach, combining qualitative interviews with a household survey, as well as focus group discussions with both farmers and non-farmers. We present evidence that sack gardening increases social capital, especially for those households that undertake sack gardening in groups. We also find that sack gardening in the Kibera slums has a positive impact on household food security by improving household dietary diversity and by reducing the need to resort to painful coping mechanisms that are used during food shortages. (shrink)

Wright’s “adaptive landscape” has been influential in evolutionary thinking but controversial, especially because the landscape that organisms encounter is altered by the evolutionary process itsel...

Evidence that placebo acupuncture is an effective treatment for chronic pain presents a puzzle: how do placebo needles appearing to patients to penetrate the body, but instead sitting on the skin’s surface in the manner of a tactile stimulus, evoke a healing response? Previous accounts of ritual touch healing in which patients often described enhanced touch sensations suggest an embodied healing mechanism. In this qualitative study, we asked a subset of patients in a singleblind randomized trial in irritable bowel syndrome (...) to describe their treatment experiences while undergoing placebo treament. Analysis focused on patients’ unprompted descriptions of any enhanced touch sensations and any significance patients assigned to the sensations. We found in 5/6 cases, patients associated sensations including “warmth” and “tingling” with treatment efficacy. The conclusion offers a “neurophenomenological” account of the placebo effect by considering dynamic effects of attentional filtering on early sensory cortices, possibly underlying the phenomenology of placebo acupuncture. (shrink)

Previous research has successfully used feature integration theory to operationalise the predictions of Perceptual Load Theory, while simultaneously testing the predictions of both models. Building on this work, we test the extent to which these models hold up in a 3D world. In two experiments, participants responded to a target stimulus within an array of shapes whose apparent depth was manipulated using a combination of monoscopic and stereoscopic cues. The search task was designed to test the predictions of feature integration (...) theory, as the target was identified by a single feature or a conjunction of features and embedded in search arrays of varying size, and perceptual load theory, as the task included congruent and incongruent distractors presented alongside search tasks imposing high or low perceptual load. Findings from both experiments upheld the predictions of feature integration theory, regardless of 2D/3D condition. Longer search times in conditions with a combination of monoscopic and stereoscopic depth cues suggests that binding features into three-dimensional objects requires greater attentional effort. This additional effort should have implications for perceptual load theory, yet our findings did not uphold its predictions; the effect of incongruent distractors did not differ between conjunction search trials and feature search trials. Individual differences in susceptibility to the effects of perceptual load were evident and likely explain the absence of load effects. Overall, our findings suggest that feature integration theory may be useful for predicting attentional performance in a 3D world. (shrink)

The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

An increasing number of European research projects return, or plan to return, individual genomic research results (IRR) to participants. While data access is a data subject’s right under the General Data Protection Regulation (GDPR), and many legal and ethical guidelines allow or require participants to receive personal data generated in research, the practice of returning results is not straightforward and raises several practical and ethical issues. Existing guidelines focusing on return of IRR are mostly project-specific, only discuss which results to (...) return, or were developed outside Europe. To address this gap, we analysed existing normative documents identified online using inductive content analysis. We used this analysis to develop a checklist of steps to assist European researchers considering whether to return IRR to participants. We then sought feedback on the checklist from an interdisciplinary panel of European experts (clinicians, clinical researchers, population-based researchers, biobank managers, ethicists, lawyers and policy makers) to refine the checklist. The checklist outlines seven major components researchers should consider when determining whether, and how, to return results to adult research participants: 1) Decide which results to return; 2) Develop a plan for return of results; 3) Obtain participant informed consent; 4) Collect and analyse data; 5) Confirm results; 6) Disclose research results; 7) Follow-up and monitor. Our checklist provides a clear outline of the steps European researchers can follow to develop ethical and sustainable result return pathways within their own research projects. Further legal analysis is required to ensure this checklist complies with relevant domestic laws. (shrink)

Balancing Change and Tradition in Global Education Reform is an invaluable resource for policymakers, faculty, students, and anyone interested in how decisions made about the education system ultimately affect the quality of education, educational access, and social justice.

Karl Popper fut un réaliste scientifique malgré lui. Au mépris de ses propres restrictions concernant les formes de raisonnement scientifique acceptables et la portée de l’évidence empirique, il insista sur une conception fortement réaliste des buts et des accomplissements de la science. Dans cet article, je construis une défense générale du réalisme scientifique, m’appuyant, au il des développements, sur celles des positions popperiennes qui font progresser l’argument, et critiquant celles qui l’entravent. Bien que la ligne argumentative d’ensemble soit mienne, je (...) montre, par des attributions directes, que Popper partage mes conclusions réalistes, et pourquoi il les partage. (shrink)

Karl Popper fut un réaliste scientifique malgré lui. Au mépris de ses propres restrictions concernant les formes de raisonnement scientifique acceptables et la portée de l’évidence empirique, il insista sur une conception fortement réaliste des buts et des accomplissements de la science. Dans cet article, je construis une défense générale du réalisme scientifique, m’appuyant, au il des développements, sur celles des positions popperiennes qui font progresser l’argument, et critiquant celles qui l’entravent. Bien que la ligne argumentative d’ensemble soit mienne, je (...) montre, par des attributions directes, que Popper partage mes conclusions réalistes, et pourquoi il les partage. (shrink)

Jarrett has demonstrated that "strong locality," one of the conditions used by Bell to derive his well known inequality, is equivalent to the conjunction of two other conditions which he calls "hidden locality" and "completeness." He has also demonstrated that if it is possible to control the hidden states of the measured system, then violations of hidden locality can be used to transmit information superluminally; and that this is not so with respect to violations of completeness. This he has (...) taken to mean that it is not possible to use violations of completeness to do so under any circumstances. In this essay, it is argued that such violations can be used to do so, if one other condition is satisfied. (shrink)

Bell (1964) demonstrated that if two restrictions are imposed on the hypothetical hidden variables supposed to underlie quantum mechanical states, then it is possible to derive an inequality that is violated by certain predictions of QM (Quantum Mechanics); the predictions concern pairs of systems whose states are strongly correlated. The two restrictions are denoted herein as SL (Strong Locality) and HA (Hidden Autonomy)1, and the inequality as BI (the Bell Inequality). Since SL and HA together entail BI, and QM violates (...) BI, it follows that any HVT (Hidden-Variables Theory) for QM must violate either SL or HA.It is well known that a condition known as PA (Perfect Anti-correlation) was also used by Bell to derive the inequality. PA says that parallel experiments (experiments with parallel spin-analyzer orientations) never yield the same results. (shrink)

The neo-Kohlbergian approach to moral reasoning development maintains that intermediate concepts lie between bedrock moral schemas and professional codes of ethics and deal with issues of confidentiality, competence, informed consent, allocation of resources and professional autonomy (Rest et. al, 1999b Rest, J., Narvaez, D., Bebeau, M., & Thoma, S. J. (1999b). Postconventional moral thinking: A neo-Kohlbergian approach. Lawrence Erlbaum Associates.[Crossref], [Google Scholar]). Intermediate concepts provide concrete guides for behavior, they contrast general moral schemas that are concerned with issues of fairness, (...) justice and equality. This paper outlines the development and testing of a prototype Intermediate Concept Measure for teachers (TICM). Results indicate that the TICM has respectable psychometric properties and assesses a construct in the moral domain. (shrink)

The magnetic dipole moment of the Kerr–Newman metric, defined by mass \, electrical charge \ and angular momentum \, is \, corresponding, for all values of \, to a gyromagnetic ratio \, which is also the value of the intrinsic gyromagnetic ratio of the electron, as first noted by Carter. Here, we argue that this result can be understood in terms of the particle-wave complementarity principle. For \ can only be defined at asymptotic spatial infinity, where the metric appears (...) to describe a spinning point particle, and therefore setting \, \, we necessarily have a model of the electron. From the Dirac equation we can construct a covariantly conserved four-current \ that is the source of the electromagnetic field generated by the charge \. The result \ then follows from the minimal gauge principle \ which is implicit in the formulation of the spinorial wave equation, and which can also be justified from the line action for a spin-1/2 point particle interacting with an external electromagnetic field, due to Berezin and Marinov. By contrast, analysis of the gyrogravito-magnetic effect, investigated classically by Wald and quantum mechanically by Adler et al., yields the result \ in all non-relativistic cases, which can be explained from the principle of equivalence. The results are in accord with the correspondence principle. (shrink)

This paper involves one crucial assumption; namely, that the statistical predictions of quantum mechanics for Bell's variant of the EPR experiment will continue to be verified as detector efficiencies are improved and the need for coincidence counters is eliminated. This assumption entails that any hidden-variables theory for quantum mechanics must violate Bell's inequality--the inequality derived in Bell (1964). It is shown here that four locality conditions are involved in the derivation of Bell's inequality; and that a violation of any of (...) the four locality conditions will either entail the existence of superluminal influences or the existence of superluminal signals (superluminal influences that can be used to transmit information), if conspiratorial theories can be ruled out. The attempts so far to rule out conspiratorial theories are all found to be rather dubious, but there are other considerations developed here that rule them out convincingly. Finally, it is demonstrated that violations of each of the four locality conditions can be used to transmit information superluminally, if certain auxiliary conditions are satisfied. This is of particular interest because one of these conditions corresponds to a condition dubbed "completeness" by Jon Jarrett. Jarrett and others have suggested that violations of completeness cannot be used to send information superluminally. Demonstrating otherwise is, perhaps, the most significant result obtained in this paper. (shrink)

It is widely accepted that the violation of Bell inequalities excludes local theories of the quantum realm. This paper presents a stronger Bell argument which even forbids certain non-local theories. The conclusion of the stronger Bell argument presented here provably is the strongest possible consequence from the violation of Bell inequalities on a qualitative probabilistic level. Since among the excluded non-local theories are those whose only non-local probabilistic connection is a dependence between the space-like separated measurement outcomes of EPR/B experiments, (...) outcome dependence cannot be the crucial dependence for explaining a violation of Bell inequalities. Rather, the remaining non-local theories, which can violate Bell inequalities, are characterized by the fact that at least one of the measurement outcomes in some sense probabilistically depends both on its local as well as on its distant measurement setting. While this is not to say that what is usually called parameter dependence has to hold, some kind of dependence on the distant parameter cannot be avoided. Against the received view, established by Jarrett and Shimony, that on a probabilistic level quantum non-locality amounts to outcome dependence, this result confirms and makes precise Maudlin's claim that some kind of parameter dependence is required. (shrink)

Scholars who have attempted to explain Iris Murdoch’s moral realism have done so in widely divergent ways, some characterizing her as a classical moral realist, others as a pragmatic moral realist, and still others as a “reflexive realist.”See, e.g., respectively, Fergus Kerr, “Back to Plato with Iris Murdoch,” in Immortal Longings: Versions of Transcending Humanity (London: Society for Promoting Christian Knowledge, 1997), 68–88; Sami Pihlstrom, Pragmatic Moral Realism: A Transcendental Defence (Amsterdam: Rodopi, 2005); and Maria Antonaccio, Picturing the Human: (...) The Moral Thought of Iris Murdoch (Oxford: Oxford University Press, 2000). For the purpose of this article, I follow Maria Antonaccio’s characterization of these realisms. See pages 3–4. None of these attempts, however, capture adequately Murdoch’s distinctive position. In an effort to improve upon these accounts, this article argues that a proper characterization of Murdoch’s view must regard her as developing a version of m. (shrink)

In this short text, a distinguished philosopher turns his attention to one of the oldest and most fundamental philosophical problems of all: How it is that we are able to sort and classify different things as being of the same natural class? Professor Armstrong carefully sets out six major theories—ancient, modern, and contemporary—and assesses the strengths and weaknesses of each. Recognizing that there are no final victories or defeats in metaphysics, Armstrong nonetheless defends a traditional account of universals as the (...) most satisfactory theory we have.This study is written for advanced students, but as Armstrong goes considerably beyond his earlier work on this topic, it will interest professional scholars as well. Carefully plotted and clearly written, Universals is both a paradigm of exposition and a case study on the value of careful analysis of fundamental issues in philosophy. (shrink)

Calls for the expansion of ethics education in the business and accounting curricula have resulted in a variety of interventions including additional material on ethical cases, the code of conduct, and the development of new courses devoted to ethical development [Lampe, J.: 1996]. The issue of whether ethics should be taught has been addressed by many authors [see for example: Hanson, K. O.: 1987; Huss, H. F. and D. M. Patterson: 1993; Jones, T. M.: 1988–1989; Kerr, D. S. and (...) L. M. Smith : 1995; Loeb, S. E.: 1988; McDonald, G. M. and G. D. Donleavy: 1995]. The question addressed in this paper is not whether ethics should be taught but whether accounting students can reason more ethically after an intervention based on a discrete and dedicated course on accounting ethics. The findings in this paper indicate that a discrete intervention emphasising dilemma discussion has a positive and significant effect on students’ moral reasoning and development. The data collected from interviews suggest that the salient influences on moral judgement development include: learning theories of ethics particularly Kohlberg’s theory of cognitive moral reasoning and development; peer learning; and moral discourse. The implications from the findings in this study suggest that moral reasoning is responsive to particular types of ethics intervention and educators should carefully plan their attempts to foster moral judgement development. (shrink)

Part I Introduction -/- Passion at a Distance (Don Howard) -/- Part II Philosophy, Methodology and History -/- Balancing Necessity and Fallibilism: Charles Sanders Peirce on the Status of Mathematics and its Intersection with the Inquiry into Nature (Ronald Anderson) -/- Newton’s Methodology (William Harper) -/- Whitehead’s Philosophy and Quantum Mechanics (QM): A Tribute to Abner Shimony (Shimon Malin) -/- Bohr and the Photon (John Stachel) -/- Part III Bell’s Theorem and Nonlocality A. Theory -/- Extending the Concept of an (...) “Element of Reality” to Work with Inefficient Detectors (Daniel M. Greenberger) -/- A General Proof of Nonlocality without Inequalities for Bipartite States (GianCarlo Ghirardi and Luca Marinatto) -/- On the Separability of Physical Systems (Jon P. Jarrett) -/- Bell Inequalities: Many Questions, a Few Answers (Nicolas Gisin) -/- B. Experiment -/- Do Experimental Violations of Bell Inequalities Require a Nonlocal Interpretation of Quantum Mechanics? II: Analysis a la Bell (Edward S. Fry, Xinmei Qu, and Marlan O. Scully) -/- The Physics of 2 = 1 + 1 (Yanhua Shih) -/- Part IV Probability, Uncertainty, and Stochastic Modifications of Quantum Mechanics -/- Interpretations of Probability in Quantum Mechanics: A Case of “Experimental Metaphysics” (Geoffrey Hellman) -/- “No Information Without Disturbance”: Quantum Limitations of Measurement (Paul Busch) -/- How Stands Collapse II (Philip Pearle) -/- Is There a Relation Between the Breakdown of the Superposition Principle and an Indeterminacy in the Structure of the Einsteinian Space-Time? (Andor Frenkel) -/- Indistinguishability or Stochastic Dependence? (D. Costantini and U. Garibaldi) -/- Part V Relativity -/- Plane Geometry in Spacetime (N. David Mermin) -/- The Transient nows (Steven F. Savitt) -/- Quantum in Gravity? (Michael Horne) -/- A Proposed Test of the Local Causality of Spacetime (Adrian Kent) -/- Quantum Gravity Computers: On the Theory of Computation with Indefinite Causal Structure (Lucien Hardy) -/- “Definability,” “Conventionality,” and Simultaneity in Einstein–Minkowski Space-Time (Howard Stein) -/- Part VI Concluding Words -/- Bistro Banter: A Dialogue with Abner Shimony and Lee Smolin -/- Unfinished Work: A Bequest (Abner Shimony) -/- Bibliography of Abner Shimony. (shrink)