The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

This is a facing-Page translation of a two-Page fragment of kant's on inner sense, Similar to the ""reflexionen"" collected in volumes 14-19 of the academy edition of kant's complete works. It is especially important because of its subject matter: inner sense plays a key role in kant's epistemology, But is discussed separately only in the "anthropology". The fragment has a number of points in common with a number of similar "reflexionen" on the refutation of idealism, But also differs from these (...) in important ways. Three articles dealing with the fragment's history and significance are published along with it. (shrink)

Jeff Hoke has created a history of the human imagination with visual cues and clues and wonderment about and around everything you ever thought and everything..

Allied health professionals play an integral role in providing safe, affordable care to communities in need. Laws that define the permissible scope of practice for these professionals may take full advantage of these providers and may unnecessarily restrict safe and effective care. Nurse practitioners in many states may provide care independent of a physician; research reveals that this care is safe, affordable and accessible. Yet hurdles exist that prevent communities from securing the full benefit of NPs in independent practice. The (...) scope of independent practice for allied dental providers varies greatly across the country, often including stringent supervision requirements. Emerging approaches to allowing allied dental providers to practice independently in certain settings or with dentist supervision via telemedicine and creating the intermediate provider, the dental therapist, may increase access to safe, affordable dental care. Research on the impact of laws that allow broader independent practice by NPs to ferret out the hurdles to full implementation of the spirit of such laws is needed. That research could support expanded independent scope for allied dental providers and other allied health care providers. (shrink)

Can parents who choose not to vaccinate their children be held legally liable for any harm that results? The state of laboratory and epidemiological understanding of a disease such as measles makes it likely that a persuasive causal link can be established between a decision to not vaccinate, a failure to take appropriate precautions to isolate a non-vaccinated child who may have been exposed to measles from highly vulnerable persons, and a death. This paper argues that, even if a parent (...) chooses to not vaccinate a child under a state law permitting exemptions, that decision does not create complete protection against liability for the adverse consequences of that choice. (shrink)

Consider this hypothetical scenario involving a choice not to vaccinate a child. Ms. S has a niece who is autistic. The girl's parents are suspicious that there is some relationship between her autism and her Measles Mumps and Rubella vaccination. They have shared their concerns with Ms. S. She then declines to have her own daughter, Jinny S., vaccinated with the MMR vaccine. To bypass the state's mandatory vaccination requirement, Ms. S claims a state-legislated philosophical exemption, whereby she simply attests (...) to the fact that she is opposed to vaccinating her daughter due to a conscientiously held belief. At the age of four, Jinny goes on a trip by airplane to Germany with her mother. After returning to the United States, she attends daycare despite having some mild cold symptoms. Subsequently, she develops a classic measles rash, at which point her mother brings her to a pediatrician and keeps her home from daycare. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Logik-Vorlesung: Unveröffentlichte Nachschriften I (Logik Bauch), and Logik-Vorlesung: Unveröffentlichte Nachschriften II (Logik Hechsel, Warschauer Logik)Hoke RobinsonTillmann Pinder, editor. Logik-Vorlesung: Unveröffentlichte Nachschriften I (Logik Bauch), and Logik-Vorlesung: Unveröffentlichte Nachschriften II (Logik Hechsel, Warschauer Logik), vols. 8 and 9 of the series Kant-Forschungen, general editors Reinhard Brandt and Werner Stark. Hamburg: Felix Meiner Verlag, 1998. Vol. 8, pp. lxx + 268; vol. 9, pp. vii + 718. NP.Between 1755, (...) when he received the venia legendi, and 1796, when he ended his teaching activity, Kant taught logic some 30 times. In accordance with the requirements of the Prussian ministry of culture, his course lectures were built around a recognized text, G. F. Meier's 1752 Auszug aus der Vernunftlehre. Kant did not merely present Meier's views, however, but commented on and criticized these as he thought appropriate; his own copy of Meier was full of marginal notes and interleaved with notes on separate bits of paper. When in 1799 he entrusted G. B. Jäsche with this material for the compiling of a logic text, the thought was presumably of a Kantian logic organized around Meier's framework.Since logic plays such a prominent role in the Critical philosophy, one would expect the Jäsche logic to be viewed as an important tool for the interpretation of the Critical philosophy. But dissatisfaction with it was evident right from its original publication in 1800, and later scholars were even more negative (in 1913 Erich Adickes referred to it [End Page 603] as "the contrivance [Machwerk]... that Jäsche published under the name of Kant's logic," Erich Adickes, quoted in Ak. XXIV.960). And in fact, as Pinder's careful and detailed introduction points out, the nature and origin of the Jäsche logic presented a serious problem for Wilhelm Dilthey's organization of the now-standard Akademie-Ausgabe (Kants gesammelte Schriften, herausgegeben von der königlich preussischen [now: deutschen] Akademie der Wissenschaften. Berlin: de Gruyter, 1902- Cited as "Ak.").Dilthey conceived of four divisions of the Akademie-Ausgabe: Kant's published writings, his correspondence, his literary remains ("handschriftlicher Nachlass") and his lectures ("Vorlesungen"). Where, exactly, did the Jäsche logic belong? Kant had himself compiled a similar text from his lecture notes on anthropology, and this text was published in the first division (in volume VII). But did the Jäsche logic count as Kant's work? It was indeed authorized by Kant and based on Kant's own lecture notes; but these notes themselves were to be published in the Nachlass division. Furthermore, as it turned out, Jäsche had also employed manuscripts compiled from the lectures themselves, and these were to be published in the Vorlesungen division. This would not include his own transcription, as Erdmann had conjectured. It turns out Jäsche never heard Kant lecture on logic—he was never in Königsberg when they were being held! (xxvi, n. 29). The resulting controversies delayed the publication of the Jäsche logic in vol. IX from 1908 until 1923, after the 1914 publication in the Nachlass division of the notes on which it was based.Dilthey's projected Vorlesungen division itself was called into question by Benno Erdmann, Dilthey's successor as Akademie-Ausgabe general editor. Erdmann recognized the questionable nature of the Jäsche logic and the other compilations, but considered Dilthey's aim for a "critically secured" edition of the lecture manuscripts as "hopeless." Still, interest in the manuscripts resulted in their piecemeal publication independently of the Akademie-Ausgabe, and when the Nachlass division's publication had been completed in 1955, the Vorlesungen division was resurrected. Vol. XXIV (in two parts) appeared in 1966; it contained the logics Blomberg, Philippi, Pölitz, Busolt, Dohna-Wundlacken and the Vienna logic, the short logic Herder, and fragments of the lost logics Hintz and Hoffmann. The Pinder volumes reviewed here contain the logics Bauch, Hechsel, and the Warsaw logic.What exactly are the manuscripts in question? If Kant had been concerned merely to explicate Meier, his students could perhaps have been content with their marginal notes in the text and a few further ones for elucidation. But... (shrink)

Kant holds that the a human subject's free causation, as well as the deliberations and decision preceeding it, are literally timeless. This paper tries to defend this doctrine of timeless agency by first distinguishing three senses of "cause", then showing the relationship between cause and time-determination in the theoretical philosophy, and finally relating the timelessness of free agency to the status of the representations of perception. The result is that whereas agency has no time in isolation, it may borrow enough (...) time for its purposes from the theoretical realm. Kant meint, daß die freie Verursachung durch ein menschliches Subjekt, genauso wie die Überlegungen und die Entscheidung, die ihr vorausgehen, buchstäblich zeitlos sind. Der Beitrag versucht, diese Lehre von einem zeitlosen Handeln zu verteidigen. Zunächst wird zwischen drei verschiedenen Bedeutungen von "Ursache" unterschieden. Dann wird die Beziehung zwischen Ursache und Zeitbestimmung in der theoretischen Philosophie dargestellt. Schließlich wird die Zeitlosigkeit freien Handelns mit dem Status der Gegenstände der Wahrnehmung in eine Beziehung gesetzt. Das Ergebnis ist, daß das Handeln, während es für sich selbst betrachtet keine Zeit hat, für seine Zwecke doch genügend Zeit aus der theoretischen Sphäre entlehnen kann. (shrink)

Most commentators (especially guyer and allison) assume kant's position on inner sense to follow the lockean model, With inner sense preceding outer sense. In a previous paper I argued that outer sense was primary. Here, On the basis of the newly discovered leningrad fragment and other texts, I argue that the establishment of temporal order requires outer-Sense priority, But in its use, Inner sense can be prior. I close with some remarks on embodiment.

For most commentators, Kant holds a basically lockean view of the order of knowledge acquisition: sensory affection produces inner-Sense representations from which outer objects are subsequently inferred; in particular, Outer time order is derived from inner time order in the second analogy. But kant actually holds that outer sense is prior to inner sense. This latter view is defended by distinguishing two senses of inner sense: inner sense in itself and inner sense as appearance. The first, If there is one, (...) Is prior to outer sense; but the second, The one kant meant, Is posterior. (shrink)

Presents for the first time in English, this 1967 text which came to be known as the 'bible' of a new movement in German philosophy of language, the 'Erlanger School.' This school of linguistic philosophy's treatment of language is rooted in the tradition of transcendentalism, and bases its system on Kant and his Continental successors. For the Erlanger School, 'language is not just a fact we discover...but a human cultural accomplishment whose construction reason can and should be controlled.' An influential (...) work which will be a valuable resource for students of philosophy, particularly philosophy of language and transcendentalism. (shrink)

Among the many components of legal preparedness for public health emergencies is the assurance that the public health workforce and its private sector partners are competent to use the law to facilitate the performance of essential public health services and functions. This is a significant challenge. Multiple categories of emergencies, stemming from natural disasters to emerging infectious diseases, confront public health practitioners. Interpreting, assessing, and applying legal principles during emergencies are complicated by the changing legal environment and differences in governmental (...) organization of emergency management functions. While law and legal competencies are essential to routine public health practices, once government declares a state of public health emergency or disaster, the legal landscape changes. Typical legal responses to protect the public's health may no longer be the norm. Public health practitioners, legal counsel, health care partners, and others need to be able to assess changing laws and policies and apply them in real-time. (shrink)

Among the many components of legal preparedness for public health emergencies is the assurance that the public health workforce and its private sector partners are competent to use the law to facilitate the performance of essential public health services and functions. This is a significant challenge. Multiple categories of emergencies, stemming from natural disasters to emerging infectious diseases, confront public health practitioners. Interpreting, assessing, and applying legal principles during emergencies are complicated by the changing legal environment and differences in governmental (...) organization of emergency management functions. While law and legal competencies are essential to routine public health practices, once government declares a state of public health emergency or disaster, the legal landscape changes. Typical legal responses to protect the public's health may no longer be the norm. Public health practitioners, legal counsel, health care partners, and others need to be able to assess changing laws and policies and apply them in real-time. (shrink)

Background:Collaboration between physicians and nurses is key to improving patient care. We know very little about collaboration and interdisciplinary practice in African healthcare settings.Research question/aim:The purpose of this study was to explore the ethical challenges of interdisciplinary collaboration in clinical practice and education in Botswana Participants and research context: This qualitative descriptive study was conducted with 39 participants (20 physicians and 19 nurses) who participated in semi-structured interviews at public hospitals purposely selected to represent the three levels of hospitals in (...) Botswana (referral, district, and primary).Ethical considerations:Following Institutional Review Board Approval at the University of Pennsylvania and the Ministry of Health in Botswana, participants’ written informed consent was obtained.Findings:Respondents’ ages ranged from 23 to 60 years, and their duration of work experience ranged from 0.5 to 32 years. Major qualitative themes that emerged from the data centered on the nature of the work environment, values regarding nurse–doctor collaboration, the nature of such collaboration, resources available for supporting collaboration and the smooth flow of work, and participants’ views about how their work experiences could be improved.Discussion:Participants expressed concerns that their work environment compromised their ability to provide high-quality and safe care to their patients. The physician staffing structure was described as consisting of a few specialists at the top, a vacuum in the middle that should be occupied by senior doctors, and junior doctors at the bottom—and not a sufficient number of nursing staff.Conclusion:Collaboration between physicians and nurses is critical to optimizing patients’ health outcomes. This is true not only in the United States but also in developing countries, such as Botswana, where health care professionals reported that their ethical challenges arose from resource shortages, differing professional attitudes, and a stressful work environment. (shrink)

On one common reading, Kant's epistemology involves an "all-Or-Nothing" principle: the mind achieves either objective knowledge or nothing at all. But then we cannot account for dreams. L w beck maintains that the categories also function in non-Veridical contexts (including dreams), But do not serve to distinguish these from veridical contexts. I argue that the categories determine coherence both within and among different contexts of experience, And hence determine which are veridical.