Stanford Encyclopedia article surveying the life and work of D.C. Williams, notably in defending realism in metaphysics in the mid-twentieth century and in justifying induction by the logic of statistical inference.

Persistence theories of causation – such as transference theory, conserved-quantity theory, and Douglas Ehring's theory – attempt to analyzecausation in terms of some persisting entityconnecting cause and effect. While mostpersistence accounts are intended as empiricaltheories, this article develops a persistenceanalysis of the concept of causation. The basic idea is that the central concept ofdirect causation can be analyzed in terms ofproperty acquisition. The analysis cohereswith our ordinary causal judgments andprovides a straightforward explanation of thedirection of causation. It also explains (...) whybackwards causation is conceptually problematic. (shrink)

Robust technology infrastructure is needed to enable learning health care systems to improve quality, access, and cost. Such infrastructure relies on the trust and confidence of individuals to share their health data for healthcare and research. Few studies have addressed consumers’ views on electronic data sharing and fewer still have explored the dual purposes of healthcare and research together. The objective of the study is to explore factors that affect consumers’ willingness to share electronic health information for healthcare and research. (...) This study involved a random-digit dial telephone survey of 800 adult Californians conducted in English and Spanish. Logistic regression was performed using backward selection to test for significant associations of each explanatory variable with the outcome variable. The odds of consent for electronic data sharing for healthcare decreased as Likert scale ratings for EHR impact on privacy worsened, odds ratio = 0.74, 95% CI [0.60, 0.90]; security, OR = 0.80, 95% CI [0.66, 0.98]; and quality, OR = 0.59, 95% CI [0.46–0.75]. The odds of consent for sharing for research was greater for those who think EHR will improve research quality, OR = 11.26, 95% CI [4.13, 30.73]; those who value research benefit over privacy OR = 2.72, 95% CI [1.55, 4.78]; and those who value control over research benefit OR = 0.49, 95% CI [0.26, 0.94]. Consumers’ choices about electronically sharing health information are affected by their attitudes toward EHRs as well as beliefs about research benefit and individual control. Design of person-centered interventions utilizing electronically collected health information, and policies regarding data sharing should address these values of importance to people. Understanding of these perspectives is critical for leveraging health data to support learning health care systems. (shrink)

Objective: There are benefits and risks of giving patients more granular control of their personal health information in electronic health record (EHR) systems. When designing EHR systems and policies, informaticists and system developers must balance these benefits and risks. Ethical considerations should be an explicit part of this balancing. Our objective was to develop a structured ethics framework to accomplish this. -/- Methods: We reviewed existing literature on the ethical and policy issues, developed an ethics framework called a “Points to (...) Consider” (P2C) document, and convened a national expert panel to review and critique the P2C. -/- Results: We developed the P2C to aid informaticists designing an advanced query tool for an electronic health record (EHR) system in Indianapolis. The P2C consists of six questions (“Points”) that frame important ethical issues, apply accepted principles of bioethics and Fair Information Practices, comment on how questions might be answered, and address implications for patient care. -/- Discussion: The P2C is intended to clarify whatis at stake when designers try to accommodate potentially competing ethical commitments and logistical realities. The P2C was developed to guide informaticists who were designing a query tool in an existing EHR that would permit patient granular control. While consideration of ethical issues is coming to the forefront of medical informatics design and development practices, more reflection is needed to facilitate optimal collaboration between designers and ethicists. This report contributes to that discussion. (shrink)

The translational research community, in general, and the Clinical and Translational Science Awards (CTSA) community, in particular, share the vision of repurposing EHRs for research that will improve the quality of clinical practice. Many members of these communities are also aware that electronic health records (EHRs) suffer limitations of data becoming poorly structured, biased, and unusable out of original context. This creates obstacles to the continuity of care, utility, quality improvement, and translational research. Analogous limitations to sharing objective data in (...) other areas of the natural sciences have been successfully overcome by developing and using common ontologies. This White Paper presents the authors’ rationale for the use of ontologies with computable semantics for the improvement of clinical data quality and EHR usability formulated for researchers with a stake in clinical and translational science and who are advocates for the use of information technology in medicine but at the same time are concerned by current major shortfalls. This White Paper outlines pitfalls, opportunities, and solutions and recommends increased investment in research and development of ontologies with computable semantics for a new generation of EHRs. (shrink)

Properties and objects are everywhere, but remain a philosophical mystery. Douglas Ehring argues that the idea of tropes--properties and relations understood as particulars--provides the best foundation for a metaphysical account of properties and objects. He develops and defends a new theory of trope nominalism.

Ehring shows the inadequacy of received theories of causation, and, introducing conceptual devices of his own, provides a wholly new account of causation as the persistence over time of individual properties, or "tropes.".

One of Hume's most well-known works and a masterpiece of philosophy, A Treatise of Human Nature is indubitably worth taking the time to read.

In this paper, I try to make a bundle theory of objects consistentwith a temporal parts theory of object persistence. To that end,I propose that such bundles are made up of tropes includingthe co-instantiation relation.

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

This thesis addresses the problem of causal asymmetry. This problem may be characterized as follows: what is the relation R such that if an event c causes an event e c bears relation R to e but e does not bear relation R to e. The traditional Humean account of causal asymmetry is that "R" may be replaced by "temporally prior." Difficulties with this account based on consideration of cases of simultaneous causation and backward causation have given rise to non-Humean (...) accounts of causal asymmetry. This dissertation analyzes some of these difficulties along with various non-Humean approaches. I offer a new theory of causal asymmetry which does not depend upon the temporal priority of causes to their effects and which differs from any of the other theories available. ;In chapter one the problem of causal asymmetry is clarified. This problem is distinguished from related issues. At the same time, I articulate the various philosophical considerations which bear on the scope and importance of this problem. I also state what I take to be the conditions an adequate account of causal asymmetry must satisfy. In the second chapter I discuss the classical Humean analysis of causal priority in terms of temporal priority. It is argued that arguments which have been put forward to show that backwards causation is logically impossible are unconvincing and that there are cases of simultaneous causation. In the third chapter the manipulability theory of causation is treated. Various formulations of this theory, from the most anthropomorphic to the least anthropomorphic are treated as they bear on the problem of causal asymmetry. Manipulability theory is found to be inadequate. ;In chapter four counterfactual theories of causation are considered. A number of counterexamples to these theories are presented and developed. In chapter five, two views which are grouped under "regularity theory" are analyzed and criticized: those of Bromberger and Berofsky. Mackie's earlier and later accounts of causal asymmetry along with Sanford's view are discussed in chapter six. In chapter seven, Erik Brown's recent view is considered alongside "transference theory." In the final chapter I develop a new theory of causal priority which utilizes the "circumstantial" character of the causal relation in accounting for causal asymmetry. (shrink)

A well-known ``overdetermination''argument aims to show that the possibility of mental causes of physical events in a causally closed physical world and the possibility of causally relevant mental properties are both problematic. In the first part of this paper, I extend an identity reply that has been given to the first problem to a property-instance account of causal relata. In the second, I argue that mental types are composed of physical types and, as a consequence, both mental and physical types (...) may be causally relevant with respect to the same physical effect, contrary to the overdetermination argument. In further sections, I argue that mental types have causal powers, consider some objections and reject an alternative version of part-whole physicalism. Throughout I assume that causal relata are tropes and property types are classes of tropes. (shrink)

Lexical Semantics is about the meaning of words. Although obviously a central concern of linguistics, the semantic behaviour of words has been unduly neglected in the current literature, which has tended to emphasize sentential semantics and its relation to formal systems of logic. In this textbook D. A. Cruse establishes in a principled and disciplined way the descriptive and generalizable facts about lexical relations that any formal theory of semantics will have to encompass. Among the topics covered in depth are (...) idiomaticity, lexical ambiguity, synonymy, hierarchical relations such as hyponymy and meronymy, and various types of oppositeness. Syntagmatic relations are also treated in some detail. The discussions are richly illustrated by examples drawn almost entirely from English. Although a familiarity with traditional grammar is assumed, readers with no technical linguistic background will find the exposition always accessible. All readers with an interest in semantics will find in this original text not only essential background but a stimulating new perspective on the field. (shrink)

A record of the words and teachings of Confucius, _The Analects_ is considered the most reliable expression of Confucian thought. However, the original meaning of Confucius's teachings have been filtered and interpreted by the commentaries of Confucianists of later ages, particularly the Neo-Confucianists of the Song dynasty, not altogether without distortion.In this monumental translation by Professor D. C. Lau, an attempt has been made to interpret the sayings as they stand. The corpus of the sayings is taken as an organic (...) whole and the final test of the interpretation rests on the internal consistency it exhibits. In other words, _The Analects_ is read in the light of _The Analects._This results in a truer understanding of Confucius' thought than the traditional interpretation and paves the way for a re-assessment of its importance in the history of Chinese thought and its relevance to the present day world.This volume also contains an introduction to the life and teachings of Confucius, and three appendices on the events in the life of Confucius, on his disciples, and on the composition of _The Analects._. (shrink)

Parfit has argued for the revolutionary thesis that personal identity does not matter in ordinary survival, only the R-relation does. “Reconciliationists,” such as Lewis, have tried to stop this revolution, arguing that both personal identity and the R-relation matter. The disagreement has been between those who hold that only the R-relation matters and those who hold that, in addition, personal identity matters. But there is a third option. I argue that Parfit is right that personal identity does not matter but (...) he is wrong that the R-relation matters, and the reconciliationists are wrong to think both matter since neither does. (shrink)

'Natural class' trope nominalism makes a trope's being of a certain sort--its nature--a matter of its membership in a certain natural class of actual tropes. It has been objected that on this theory had even a single member of the class of red tropes not existed, for example, then the type 'being red' would not have been instantiated and nothing would have been red. I argue that natural class trope nominalism can avoid this implication by way of counterpart theory as (...) applied to properties. (shrink)

Memory theories of personal identity are subject to the difficulty that distinct simultaneous person stages may both stand in the memory relation to an earlier person stage. Apparently, Such theories entail that these two duplicate person stages are stages of the same person, A claim argued to be "obviously false". In this paper, I argue that the characteristics of these duplication cases usually cited to support this claim do not provide adequate evidence to make it cogent.

"By combining recent advances in the physical sciences with some of the novel ideas, techniques, and data of modern biology, this book attempts to achieve a new and different kind of evolutionary synthesis. I found it to be challenging, fascinating, infuriating, and provocative, but certainly not dull."--James H, Brown, University of New Mexico "This book is unquestionably mandatory reading not only for every living biologist but for generations of biologists to come."--Jack P. Hailman, Animal Behaviour , review of the first (...) edition "An important contribution to modern evolutionary thinking. It fortifies the place of Evolutionary Theory among the other well-established natural laws."--R.Gessink, TAXON. (shrink)

Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated Hh (...) from the cell surface, and that another known upstream signaling modulator called Scube2 chaperones the dual‐lipidated morphogen to Ptc. By mechanistically and biochemically aligning this concept with established in vivo and recent in vitro findings, this reflection identifies remaining questions in lipidated Hh transport and evaluates additional mechanisms of Disp‐ and Scube2‐regulated release of a second bioactive Hh fraction that has one or both lipids removed. (shrink)

Johansson, in “Parfit on Fission,” rejects Parfit’s thesis that fission demonstrates that identity does not matter in survival based on the following assumption (call the person who fissions, “Mr. Fissiony” and the fission products, “Lefty” and “Righty”): It is determinately true that Mr. Fissiony is identical to Lefty or that he is identical to Righty, but it is indeterminate whether Mr. Fissiony is identical to Lefty and it is indeterminate whether Mr. Fissiony is identical to Righty. Johansson argues that there (...) are identity-based answers to the following questions that apply in fission case: (Future Time) Concerning any future time, what matters in my relation to it? (Future Person) Concerning any future individual, what matters in my relation to him? The identity-based answers are these: (Future Time Answer) That I am identical with someone at that time. (Future Person Answer) That it is not false that I and that future individual are identical and that this relation of it not being false that we are identical is not close to not obtaining. I argue that the combination of these answers is inconsistent with the implication that if person C1 at t1 stands in the mattering relation to person C2 at t2, then C1 gets what matters with respect to t2 and that the degree to which the relation specified in Future Person Answer holds between Mr. Fissiony and Lefty in the fission case does not match up to the degree to which Mr. Fissiony gets what matters with respect to Lefty. (shrink)

A standard objection to the thesis that all causation is simultaneous causation is that this claim rules out temporally extended causal chains. Defenders of universal simultaneous causation have suggested two replies: deny the supposed incompatibility between simultaneous causation and causal chains or deny the existence of causal chains. In this paper, I argue that neither type of defense of universal causation against this objection is plausible.

One of Parfit’s arguments for the thesis that identity never matters involves generalizing from “divergence” cases in which identity arguably does not matter. The primary divergence case for Parfit is fission. According to Parfit’s assessment, it is not true that the fissioner gets what matters with respect to either fissionee by way of being identical to each fissionee but does so by way of the M-relation, psychological continuity with its normal cause, the persistence of enough of the brain. The same (...) is true in all other divergence cases by Parfit’s accounting. Parfit generalizes. From (E) Whenever M and identity diverged, it would be M that mattered, not identity. Parfit infers (F) Whenever M and identity diverge and even when these relations coincide, it is M that matters, not identity. In this paper, I challenge the inference from (E) to (F). (shrink)

The Non-Reductionist holds that personal identity is a matter in whole or in part of “further facts,” facts over and above those about psychological and physical continuity and connectedness. If Non-Reductionism is true, then it is possible for there to be “nonsymmetrical fission cases” in which there is nonsymmetry with respect to further facts such that the fissioner is identical with one of the fission products but not the other, even though there is symmetry along each branch with respect to (...) non-further facts. If it is also true that the fissioner gets what matters with respect to the fission product to which the fissioner is not identical in those cases, it is possible for identity and what matters to come apart. If the Non-Reductionist is to hold fast to the importance of identity, she must demonstrate that the fissioner does not get what matters in survival with respect to the fission product to which he is not identical in cases of nonsymmetrical fission. One way to get this result would be to demonstrate that Non-Reductionism in and of itself has the implication that the fissioner does not get what matters with respect to the fission product to which he is not identical in the nonsymmetrical fission case. Parfit offers an argument that is meant to show that the Non-Reductionism qua Non-Reductionism has just this result. I outline Parfit’s argument and suggest that it does not work. (shrink)

This paper is an original attempt to understand the foundations of economic reasoning. It endeavors to rigorously define the relationship between subjective interpretations and objective valuations of such interpretations in the context of theoretical economics. This analysis is substantially expanded through a dynamic approach, where the truth of a valuation results in an updated interpretation or changes in the agent's subjective belief regarding the effectiveness of the selected action as well as the objective reality of the effectiveness of all other (...) possible actions (i.e. consequence realization). Complications arise when the economic agent is presented with a set of actions that render ambiguous preference, or when the effectiveness of an action cannot be perceived upon its selection, thereby necessitating a different theory of choice and consequence realization. (shrink)

In this paper, I consider an objection to ``natural class''trope nominalism, the view that a trope's nature isdetermined by its membership in a natural class of tropes.The objection is that natural class trope nominalismis inconsistent with causes' being efficacious invirtue of having tropes of a certain type. I arguethat if natural class trope nominalism is combinedwith property counterpart theory, then this objectioncan be rebutted.