Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated Hh (...) from the cell surface, and that another known upstream signaling modulator called Scube2 chaperones the dual‐lipidated morphogen to Ptc. By mechanistically and biochemically aligning this concept with established in vivo and recent in vitro findings, this reflection identifies remaining questions in lipidated Hh transport and evaluates additional mechanisms of Disp‐ and Scube2‐regulated release of a second bioactive Hh fraction that has one or both lipids removed. (shrink)

This chapter contains sections titled: “I started when there was no such thing as traditional” “Simple is Good”:10 An Affirmation of Authenticity Notes.

This publication is an appreciation of the natural philosophy and epistemology of the philosopher Grete (Henry-)Hermann. A student of the mathematician Emmy Noether and the philosopher Leonard Nelson, she was one of the early interpreters of quantum mechanics. Werner Heisenberg memorialized her in his book "The Part and the Whole". For the first time, her writings on natural philosophy and epistemology are collected in one volume. An extensive introduction by various authors introduces the work of Grete Henry-Hermann. This edition is (...) supplemented by excerpts from correspondence on natural philosophical and epistemological topics, including correspondence with Carl Friedrich von Weizsäcker, Werner Heisenberg, and Gustav Heckmann. Contents ● Grete Henry-Hermann's contribution to the interpretation of quantum mechanics ● Grete Henry-Hermann's work on the relationship between modern physics and transcendental philosophy ● Grete Hermann's dissertation: The Question of the Finitely Many Steps in the Theory of Polynomial Ideals (1925) ● Discussions on the question of free will and the significance of behavioral research for the critique of reason ● Excerpts from correspondence from 1925 to 1982. (shrink)

Throughout the 2016 US presidential election, pundits repeatedly described Donald Trump as a performance artist and his campaign as performance art. Meanwhile, his alt-right supporters were mounting performance art shows, debating the meaning of Marina Abramović’s work, and developing their own theories of political performance. For experts in performance theory, such punditry and provocation is like the image in a funhouse mirror. It’s hard to make sense of such bizarre, distorted images—let alone to recognize ourselves in them. This article insists (...) that, nonetheless, we should try. Trump and his movement pose special challenges to American political culture—and also to academic performance theory. His rise has revealed the limitations of a politics (and performance theory) based on norms and their transgression. It has also given the lie to politicians’ false belief that they (and only they) are not performing their politics. The challenge now—for academics, activists, citizens, and journalists alike—is to articulate how performance works, how it provides models of cultural power. (shrink)

Name der Zeitschrift: Das Mittelalter Jahrgang: 22 Heft: 1 Seiten: 75-92.

This book is a groundbreaking history of balance, exploring how a new model of equilibrium emerged during the medieval period.

The doctrine of double effect, together with other moral principles that appeal to the intentions of moral agents, has come under attack from many directions in recent years, as have a variety of rationales that have been given in favor of it. In this paper, our aim is to develop, defend, and provide a new theoretical rationale for a secular version of the doctrine. Following Quinn (1989), we distinguish between Harmful Direct Agency and Harmful Indirect Agency. We propose the following (...) version of the doctrine: that in cases in which harm must come to some in order to achieve a good (and is the least costly of possible harms necessary), the agent foresees the harm, and all other things are equal, a stronger case is needed to justify Harmful Direct Agency than to justify Harmful Indirect Agency. We distinguish between two Kantian rationales that might be given for the doctrine, a “dependent right” rationale, defended by Quinn, and an “independent right” rationale, which we defend. We argue that the doctrine and the “independent right” rationale for it are not vulnerable to counterexamples or counterproposals, and conclude by drawing implications for the larger debate over whether agents' intentions are in any way relevant to permissibility and obligation. (shrink)

This paper starts by investigating Ackermann's interpretation of finite set theory in the natural numbers. We give a formal version of this interpretation from Peano arithmetic (PA) to Zermelo-Fraenkel set theory with the infinity axiom negated (ZF−inf) and provide an inverse interpretation going the other way. In particular, we emphasize the precise axiomatization of our set theory that is required and point out the necessity of the axiom of transitive containment or (equivalently) the axiom scheme of ∈-induction. This clarifies the (...) nature of the equivalence of PA and ZF−inf and corrects some errors in the literature. We also survey the restrictions of the Ackermann interpretation and its inverse to subsystems of PA and ZF−inf, where full induction, replacement, or separation is not assumed. The paper concludes with a discussion on the problems one faces when the totality of exponentiation fails, or when the existence of unordered pairs or power sets is not guaranteed. (shrink)

Sociology and Animals : Beginnings -- Animals and Biology as Destiny -- Animals, Social Inequalities and Oppression -- Animals, Crime and Abuse -- Town and Country : Animals, Space and Place -- Consumption of the Animal -- Animals, Leisure and Culture -- Animal Experiments and Animal Rights -- Conclusion: Sociology for Other Animals.

Critical Qualitative Health Research seeks to deepen understandings of the philosophies, politics and practices shaping contemporary qualitative health related research. This accessible, lively, controversial introduction draws on current empirical examples and critical discussion to show how qualitative research undertaken in neoliberal healthcare contexts emerges and the complex issues qualitative researchers confront. This book provides readers with a critical, interrogative discussion of the histories and the legacies of qualitative research, as well as of the more recent calls for renewed criticality in (...) research to respond to global health concerns. Contributions further showcase a range of contemporary work engaging with these issues and the complex encounters with philosophies, politics and practices this involves; from seeking explicit engagements with posthuman ideas or detailed explorations of deeply engaged humanist approaches, to critical discussions of the politics and practices of emerging novel, digital and creative methods. This book offers postgraduate researchers, health researchers and students alike opportunities to engage more deeply with the emergent, complex and messy terrain of qualitative health related research. (shrink)

Disillusioned with college, Everett takes a position teaching philosophy to kids at an innovative summer enrichment academy on an island off the New England coast. The academy is run by fellow student Juniper’s Aunt Laura, and at Laura’s recommendation, Everett uses as his curriculum an exploration of the concept of happiness as described by ten of history’s most significant philosophers. This idea is sparked by a collection of readings saved by Laura’s grandmother, a teacher who originally owned the mansion in (...) which the academy is housed. But along with those readings is a set of clues that lead to a rare historic work by an ancient Greek philosopher—a codex—that is hidden in the mansion. So Everett sets to work preparing the readings for his students while simultaneously solving the clues with Juniper to find the codex. -/- What Everett doesn’t know, however, is that he and Juniper are not the only ones on the hunt for the codex, and the stakes are high. The book is extremely valuable, and there are plenty of people who would like to get their hands on the money it would bring at auction, including the people who are funding Laura’s academy. The question of rightful ownership and the mystery of the codex’s location deepen as Everett and Juniper solve the riddles to find the keys that will open whatever safe contains the ancient text. And all the while, Everett finds himself falling for Juniper. -/- He’s also working through the collection of philosophical readings about happiness, taking each one in turn and presenting it in clear, concise, modern English to his students, who are eager to discover how to lead a happy life. Everett is equally eager to make the same discovery, and he carefully considers each philosopher’s thinking on the matter, applying the concepts to his own life in an effort to understand them in the context of a young person in the real world struggling to figure out what he wants to do with his future. -/- As Everett gains clarity on what he wants out of life, however, the mystery of the codex takes a dark turn, and everything he thought he knew is turned upside down. Who will end up with the codex? What will happen to the academy? And will Everett be able to take everything that he has learned—both the good and the bad—to build a life for himself that will bring him the most happiness? -/- There is an accompanying guidebook for this novel. (shrink)

Ludwig Wittgenstein was a brilliant, intense, complex man, and this novel, a work of historical fiction but based on fact, explores his early thinking, which led him to publish one of the most important works of logic ever written. The story is told by David Pinsent, a student in mathematics who meets Wittgenstein at Trinity College in Cambridge, England, just before World War I. Despite Wittgenstein’s odd mannerisms and difficult personality, David is attracted to him, recognizing his genius immediately and (...) forming a friendship that is as volatile as it is rewarding. Wittgenstein, under the tutelage of the eminent mathematician and philosopher Bernard Russell, has developed a picture theory of meaning to explain human language through the lens of logic, and he is tormented by the idea that he will die before he is able to put it into book form and present it to the world. -/- Both David and Ludwig are welcomed into the elite intellectual circles at Cambridge, which consist of some of the most notable philosophers, mathematicians, and logicians of the day, including not just Russell but also men like John Maynard Keynes and G.E. Moore, as well as the famous Bloomsbury Set. However, David is troubled by the mysteries that surround Wittgenstein. Ludwig, he learns, has developed an innovative propeller that can be used on a flying bomber, and David finds himself caught up in international intrigue as both England and Germany vie for the design to give them an advantage in the impending war. -/- But David and Ludwig have become both emotionally and physically intimate, and as war looms, David is forced to confront the role that their forbidden relationship plays in the escalating risks to Wittgenstein’s safety. Their story is one of tragedy and inspiration, and it aptly illustrates the deeply human core of philosophical ideas. This novel illuminates and clarifies the complex philosophical, linguistic, and mathematical issues that engaged some of the best thinkers of the early twentieth century. -/- There is an accompanying guidebook for this novel. (shrink)

This pioneering study is one of the first English-language books to address Jewish theology from a postmodern perspective, probing the question of how it has the potential to survive the postmodern onslaught that some see as heralding the collapse of religion. Basing her arguments on both philosophical and theological scholarship, the author shows how postmodernism might actually be a resource for rejuvenating religion. Her response to the conception of theology and postmodernism as competing systems of thought is based on a (...) close critical study of Rav Shagar (Shimon Gershon Rosenberg) and Tamar Ross. She analyzes their writings through the lens of the most radical continental postmodern philosophers and cultural critics in order to offer a compelling theology compatible with their world-view. Whether the reader considers postmodernism to be inherently problematic or merely inconsequential, this study demonstrates why reconsidering these preconceptions is one of the most pressing issues in contemporary Jewish thought. (shrink)

This book develops and defends a new understanding of Kant's account of perceptual representation, showing that it underlies the main doctrines of the Critique of Pure Reason. Intuitions consist of formal unifications by the schematized categories that projectively represent both time and external objects and enable synthetic a priori knowledge.

Gloria is a typical twenty-one-year-old living in post-World War II America, spending her time making fashionable clothing for herself and going out with her boyfriend, when her brother Stanley goes missing. While on her way to speak with his friends at the Delta Psi fraternity house at Princeton University, she discovers the body of one of his fellow students. The young man has been murdered, and Gloria’s worry for her brother deepens into a terrible fear for his safety. -/- Stanley (...) is a member of the Dreamcatcher Committee, which eminent philosopher John Dewey has tasked with locating the next greatest philosopher—the thinker who can solve the problem of how to establish both peace and justice in society. That person will receive a dreamcatcher from Dewey that has been handed down through several generations of notable philosophers. The only problem is that, not only is Stanley missing, but the dreamcatcher seems to be as well. -/- So Gloria and the committee members embark on a search for both her brother and the dreamcatcher, following a trail of clues laid out by Stanley himself. Their search leads them to explore the philosophical theories of an array of thinkers and writers who all had different ideas about how to achieve a society that is both peaceful and just. But the person who has the most profound and influential theory is not who they think, and the answer provides them with the whereabouts of both the dreamcatcher and Stanley in a fascinating twist that none of them could have foreseen. -/- This novel is part of an innovative philosophy curriculum that uses engaging stories to introduce students to important philosophical concepts. In this story, a teen named Gloria discovers that her brother has gone missing. When another student from his university is found murdered, Gloria and the members of a committee tasked with identifying the next great philosopher find themselves following a trail of clues in the search for answers. Along the way, they explore several philosophical theories for establishing a just, peaceful society. But the person who has the most profound theory is not who they think, leading them to the answers they’re seeking in a twist that none of them could have foreseen. -/- . (shrink)

Excerpt from The Semitic Religions: Hebrew, Jewish, Christian, Moslem John croall, Esq., of Southfield, being deeply interested in the defence and maintenance of the doctrines of the Christian Religion, and desirous of increasing the religious literature of Scotland, instituted a Lectureship. The Lectures shall be delivered biennially in Edinburgh, Shall be not less than six in number, and shall be devoted to a consideration of the Evidences of Natural and Revealed Religion and the Doctrines of the Christian Religion. About the (...) Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Recently, there has been a debate focusing on the question of whether groups can literally have beliefs. For the purposes of epistemology, however, the key question is whether groups can have knowledge. More specifi cally, the question is whether “group views” can have the key epistemic features of belief, viz., aiming at truth and being epistemically rational. I argue that, while groups may not have beliefs in the full sense of the word, group views can have these key epistemic features (...) of belief. However, I argue that on Margaret Gilbert's infl uential “plural subject” account of group belief, group views are unlikely to be epistemically rational. (shrink)

In this paper I take up a critical position in regard to the theme of debility around which this collection is framed. I argue that theorisations of ‘debility’ do little to progress theory and policy in regard to disability and share many of the problems inherent to the social model. I also suggest that the theorisation of debility is rooted in and reinforces ablebodied privilege. I begin with a critical analysis of the social model of disability and explore the dualisms (...) by which it either negates the body altogether or can only conceive the disabled body in negative terms. I then go on to explore how Puar's work on debility continues this negation of the disabled body. From this position I use the work of Inahara to excavate the foundations of ablebodied privilege. In Inahara's work gender is the analytic starting point, but for me white privilege is a much more effective mechanism through which to understand the impact and reproduction of ablebodied privilege— what McRuer refers to as ‘compulsory ablebodiedness'—which I argue underpins Puar's work. I conclude with some reflections upon how a critical analysis of ablebodied privilege might function and I reiterate its importance for a critical theory that goes beyond the mere repetition of binary structures of ablebodiedness and disability. (shrink)

In this fascinating study, the author analyzes the conceptual roots of molecular biology and the social matrix in which it was developed.

The second edition of Aboriginal and Torres Strait Islander Education: An Introduction for the Teaching Profession prepares students for the unique environment they will face when teaching Aboriginal and Torres Strait Islander students at early childhood, primary and secondary levels. This book enables future teachers to understand Aboriginal and Torres Strait Islander education within a social, cultural and historical context and uses compelling stories and practical strategies to empower both student and teacher. Updated with the Australian Curriculum in mind, this (...) is a unique textbook written by highly regarded Aboriginal and Torres Strait Islander academics. Each chapter opens with a powerful anecdote from the author, connecting the classroom to real-world issues. This updated edition has also been expanded to include information on fostering the unique talents of Aboriginal and Torres Strait Islander children and young people and allows the reader to reflect on classroom practices throughout. (shrink)

Objectives—To assess perceptions of the informed consent process in patients undergoing urgent abdominal surgery.Design—A prospective observational study was carried out using structured questionnaire-based interviews. Patients who had undergone urgent abdominal surgery were interviewed in the postoperative period to ascertain their perceptions of the informed consent process. Replies were compared to responses obtained from a control group undergoing elective surgery, to identify factors common to the surgical process and those specific to urgent surgery. Patients' perceptions of received information were also compared (...) to the information perceived to have been provided by the consent obtainers. Setting—Gastrointestinal surgical service of a university teaching hospital.Patients—Seventy-four consecutive patients undergoing urgent abdominal surgery and 80 control patients undergoing elective surgery. Main measurements—Principal outcome measures were patients' perceptions of factors interfering with the ability to give informed consent, assessment of the quality of informed consent and the degree of discussion of the expected outcomes. Results—Forty-nine of the seventy-four (66%) patients undergoing urgent surgery perceived that pain did not affect their ability to give informed consent. Twenty-seven reported an adverse effect of analgesia on the ability to give informed consent. Only 22% of patients undergoing urgent surgery perceived that there had been any discussion of potential side effects and complications of surgery. Conclusion–The majority of patients in this series with acute intra-abdominal surgical conditions perceive that they retain the ability to give informed consent for surgery. There is a need for improved discussion of therapeutic options and likely outcomes. (shrink)

RATIONALE: The concept of evidence-based medicine is important in providing efficient health care. The process uses research findings as the basis for clinical decision making. Evidence-based practice helps optimize current health care and enables the practitioners to be suitably accountable for the interventions they provide. Little work has been undertaken to examine how allied health professionals change their clinical practice in light of the latest evidence. The use of opinion leaders to disseminate new evidence around the management of low back (...) pain into practice has been proposed. AIMS: The aim of this study was to investigate if physiotherapists' clinical management of patients with low back pain would change following an evidence-based education package, which utilized local opinion leaders and delivered the best evidence. METHOD: Thirty musculoskeletal physiotherapists from a Community Trust in North Staffordshire were cluster randomized by location of work, to two groups. The intervention group received an evidence-based programme on the management of low back pain, including advice regarding increasing activity levels and return to normal activity and challenging patients' fears and beliefs about their pain. The control group received a standard in-service training package on the management of common knee pathologies. The physiotherapists' clinical management of patients with low back pain was measured prior to training and 6 months post training. Outcome measures were based on physiotherapists completing 'discharge summary' questionnaires, which included information relating to the use and importance of therapies for treating their low back pain patients. RESULTS: There were few significant differences in treatment options between the intervention and control groups post training. Whilst there was some indication that physiotherapists were already utilizing aspects of psychosocial management for patients with low back pain, there was little change in what physiotherapists perceived to be important to patient recovery and actual clinical practice following the intervention. CONCLUSIONS: Psychosocial factors have been identified as an important factor in the recovery of patients with low back pain. This project incorporated the latest evidence on the management of low back pain and utilized the theory of opinion leaders to disseminate this evidence into clinical practice. Whilst there were some limitations in the overall size of the study, the results help to give an insight into the challenges faced by the health care system and researchers alike to ensure quality evidence is actually utilized by practitioners for the benefits of patient care. (shrink)

This paper argues that current iterations of lesbian, gay, bisexual, transgender and intersex rights are limited by an overreliance on particular representations of sexuality, in which homosexuality is defined negatively through a binary of homosexual/heterosexual. The limits of these representations are explored in order to unpick the possibility of engaging in a form of sexuality politics that is grounded in difference rather than in sameness or opposition. The paper seeks to respond to Braidotti’s call for an “affirmative politics” that is (...) open to forms of creative, future-oriented action and that might serve to answer some of the more common criticisms of current LGBTI rights activism. (shrink)

The Logic of Happiness guidebook explores the logic concepts introduced in the novel and includes excerpts of original works by some of the most significant philosophers in human history: the Buddha, Lao Tzu, Plato, Aristotle, Epicurus, Marcus Aurelius, Thomas Aquinas, David Hume, John Stuart Mill, and Charles Darwin. The readings will introduce students to an array of theories about how to achieve happiness while also teaching them to use classical logic techniques to discern whether or not those theories are sound (...) enough to be applicable in modern daily life. The guidebook also contains discussion questions that will get students thinking critically and deeply about different aspects of the philosophical theories, giving them practice examining, analyzing, and evaluating the strength of various arguments. -/- This guidebook can be used by instructors, but it is meant to be a companion book to the novel that enables students to understand the theories and beliefs of a diverse group of individuals who explored the problem of how to find happiness in a complicated world filled with complicated people. Students who work through it will find themselves more thoughtful and discerning—and more prepared to work toward establishing for themselves a life that will bring them their own happiness. (shrink)

This book is an exploration of Žižek's theory of freedom. By examining key passages in Žižek's work the aim is to provide a functional, serviceable philosophy of power and ideology and show how this philosophy of power relates to freedom. Although some, like Noam Chomsky, have criticized Žižek's work as having no guiding principles, it is suggested that this misses the fact that Žižek's philosophy utilizes a dialectical methodology that often appears contradictory. Though a highly astute reader with a background (...) in the philosophical texts he frequently cites (the German Idealists, Freud, and modern philosophers), it becomes clear that there is a uniquely Zizekian philosophy that mobilizes a radical hermeneutics of freedom. (shrink)

Discusses songs by the troubadours, trouvères, and Guillaume de Machaut, performed live and on the page, in the context of antique, late antique, and medieval thought and poetic practice and in the light of later opera. Topics include cosmology, education, astronomy, breath, beasts, monsters, hybridity, imagination, life, and death.

Personal narratives have become one of the most potent vehicles for advancing human rights claims across the world. Human Rights and Narrated Lives explores what happens when autobiographical narratives are produced, received, and circulated in the field of human rights. It asks how personal narratives emerge in local settings how international rights discourse enables and constrains individual and collective subjectivities in narration how personal narratives circulate and take on new meanings in new contexts and how and under what conditions they (...) feed into, affect, and are affected by the reorganization of politics in post-cold war, postcolonial, globalizing human rights contexts. (shrink)