BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

Graphical AbstractIs a two-fold approach — preliminary studies based on small samples followed by a large-sample study to check reproducibility — in the search for biomarkers really prudent?

This book aims to provide scientists and engineers, and those interested in scientific issues, with a concise account of how the nature of scientific knowledge evolved from antiquity to a seemingly final form in the Twentieth Century that now strongly limits the knowledge that people would like to gain in the Twenty-first Century. Some might think that such issues are only of interest to specialists in epistemology (the theory of knowledge); however, today's major scientific and engineering problems--in biology, medicine, environmental (...) science, etc.--involve enormous complexity, and it is precisely this complexity that runs up against the limits of what is scientifically knowable. To understand the issue, one must appreciate the radical break with antiquity that occurred with the birth of modern science in the Seventeenth Century, the problems of knowledge and truth engendered by modern science, and the evolution of scientific thinking through the Twentieth Century. While originally aimed at practicing scientists and engineers, it is my hope that this book can provide a generally educated person with a basic understanding of how our perspective on scientific knowledge has evolved over the centuries to escape pre-Galilean commonsense thinking. Such an appreciation is not only beneficial for one's general education, but is important for non-scientists who must teach young students or make policy decisions in government or business. (shrink)

OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during (...) standardized laboratory tasks than children who were homozygous for the short alleles. Children homozygous for the short alleles were also rated as significantly shyer, by maternal report, than those with at least one copy of the long allele of the 5-HTTLPR gene. CONCLUSIONS: This study extends the literature linking the short alleles of the serotonin transporter promoter region polymorphism to fear and anxiety-related traits in early childhood and adulthood, and is one of very few studies to examine the molecular genetics of preschoolers' temperament using multiple measures of traits in a normative sample. (shrink)

To accept ‘pragmatic encroachment’ is to take the view that whether you are in a position to know is in part a function of practical stakes. This position strikes many as not just unorthodox but extremely implausible. According to Jeremy Fantl and Matthew McGrath (F&M), however, the best account of the prima facie oddity of certain utterances incorporates just such a pragmatist maneuver. In reaching this conclusion, F&M begin with Trent Dougherty and Patrick Rysiew’s (D&R’s) theory as the best (...) on offer (2009a: 63/2009b: 20), but go on to raise objections to D&R’s recent account of the relevant oddity in purely pragmatic (i.e., extra-semantic) terms and to develop it in directions quite inimical to the general outlook established in D&R 2009 and D&R forthcoming. In this brief note, we reply to F&M’s objections and show that their development in the direction of interest-relativism is ill-founded: the relevant phenomena provide no grounds for budging on the issue of pragmatic encroachment. In addition, in the course of meeting F&M’s objections, an original account of certain Moore-paradoxical sentences is given, and the issue of how probable a proposition needs to be to be known is addressed. The result is a quite general defense of a commonsense, evidence-based approach to the relevant phenomena (quite apart from a defense of D&R). (shrink)

Dougherty, R., Critical points in an algebra of elementary embeddings, Annals of Pure and Applied Logic 65 211-241.Given two elementary embeddings from the collection of sets of rank less than λ to itself, one can combine them to obtain another such embedding in two ways: by composition, and by applying one to the other. Hence, a single such nontrivial embedding j generates an algebra of embeddings via these two operations, which satisfies certain laws . Laver has shown, among other (...) things, that this algebra is free on one generator with respect to these laws.The set of critical points of members of this algebra is the subject of this paper. This set contains the critical point κ0 of j, as well as all of the other ordinals κn in the critical sequence of j ). But the set includes many other ordinals as well. The main result of this paper is that the number of critical points below κn grows so quickly with n that it dominates any primitive recursive function. In fact, it grows faster than the Ackermann function, and even faster than a slow iterate of the Ackermann function. Further results show that, even just below κ4, one can find so many critical points that the number is only expressible using fast-growing hierarchies of iterated functions. (shrink)

A famous result of Hausdorff states that a sphere with countably many points removed can be partitioned into three pieces A, B, C such that A is congruent to B, B is congruent to C, and A is congruent to B ∪ C; this result was the precursor of the Banach–Tarski paradox. Later, R. Robinson characterized the systems of congruences like this which could be realized by partitions of the sphere with rotations witnessing the congruences. The pieces involved were nonmeasurable. (...) In the present paper, we consider the problem of which systems of congruences can be satisfied using open subsets of the sphere ; of course, these open sets cannot form a partition of the sphere, but they can be required to cover "most of" the sphere in the sense that their union is dense. Various versions of the problem arise, depending on whether one uses all isometries of the sphere or restricts oneself to a free group of rotations, or whether one omits the requirement that the open sets have dense union, and so on. While some cases of these problems are solved by simple geometrical dissections, others involve complicated iterative constructions and/or results from the theory of free groups. Many interesting questions remain open. (shrink)

Hausdorff's paradoxical decomposition of a sphere with countably many points removed actually produced a partition of this set into three pieces A,B,C such that A is congruent to B, B is congruent to C, and A is congruent to B ∪ C. While refining the Banach–Tarski paradox, R. Robinson characterized the systems of congruences like this which could be realized by partitions of the sphere with rotations witnessing the congruences: the only nontrivial restriction is that the system should not require (...) any set to be congruent to its complement. Later, J. F. Adams showed that this restriction can be removed if one allows arbitrary isometries of the sphere to witness the congruences. The purpose of this paper is to characterize those systems of congruences which can be satisfied by partitions of the sphere or related spaces into sets with the property of Baire. A paper of Dougherty and Foreman gives a proof that the Banach–Tarski paradox can be achieved using such sets, and gives versions of this result using open sets and related results about partitions of spaces into congruent sets. The same method is used here; it turns out that only one additional restriction on a system of congruences is needed to make it solvable using subsets of the sphere with the property of Baire with free rotations witnessing the congruences. Actually, the result applies to any complete metric space acted on in a sufficiently free way by a free group of homeomorphisms. We also characterize the systems solvable on the sphere using sets with the property of Baire but allowing all isometries. (shrink)

This paper attempts a reexamination of classical natural law theory and argues that such theory is properly understood as a meta-ethic rather than as a body of norms. As a meta-ethic, it speaks to topics such as ethical reasoning, the movement from descriptive to normative assertions, the use of science in ethics, the extra-legal grounds for judicial decision, judicial activism and the societal basis of law.

One must be grateful to Anthony O. Simon for collecting and editing these essays by his distinguished father. Any one of them would be worth the purchase of the book. In an essay entitled “The Philosopher's Calling,” Simon declares, “Generally speaking, the human mind is not at its best in philosophy.” That said, as if to refute his dictum, Simon goes on to show his readers what a mind respectful of a tradition that dates to Plato and Aristotle can say (...) about the human condition. Successive chapters, among others, are entitled “The Concept of Work,” “Nature and the Process of Mathematicalion,” “On Order in Analogical Sets,” and “An Essay on Sensation.”. (shrink)

Book Reviews STEPHEN R. L. CLARK, Religious Studies, FirstView Article.

Tom Dougherty (2013) argues that the following moral principles are inconsistent: (α) it is impermissible to benefit many people slightly rather than save someone’s life, and (β) it is permissible to risk someone’s life slightly to benefit them slightly. This inconsistency has highly counterintuitive consequences for non-consequentialist moral theories. However, Dougherty’s argument, the “Repetition Argument,” relies on a premise that ignores a morally important distinction between acting with statistical knowledge and acting with individualized knowledge. According to this premise, (...) if it is permissible to make it near certain that a distribution obtains, then it is permissible to bring about that distribution. I will argue that this premise proves too much for the Repetition Argument, and so we should reject it. Finally, to further motivate my own objection, I show that a recent objection to the Repetition Argument by James R. Kirkpatrick (2018) does not resolve the inconsistency. (shrink)

The standard view of honesty is a subjectivist one, according to which honesty concerns the facts merely “as the agent sees them”. Against this view, the present paper argues for a non-subjectivist view of honesty. It argues, in particular, that ideal honesty requires not merely expressing what one believes to be true but, moreover, expressing what is true. In that case, though one can be honest to an extent while merely expressing what one believes to be true, one cannot be (...) ideally honest without expressing the truth. (shrink)

This is a time of change in American healthcare. Market forces are restructuring local delivery systems around competing managed care networks. Many leading proposals for healthcare reform intend a reshaping of the national healthcare marketplace itself. Periods of change create an opportunity to reassess traditional values and practices. Such reassessments can be used to help insure that current innovations and proposed reforms preserve and strengthen the best in the traditions of medicine. A legitimate focus of concern in the medical and (...) medical ethics community has been the effect of these delivery system changes on the physician-patient relationship. For example, will the future American healthcare system support and encourage compassion by physicians? Suppose it does not. Would something of significant moral value have been lost? More pointedly, would a system that undervalued or frustrated physician compassion be incompatible with the moral obligations of physicians? In order to address these questions, we examine the meaning of compassion and the role it should play in the physician-patient relationship. We argue that compassion is a duty of all physicians. Because this is so, we believe that changes in the healthcare system must be judged, in part, by how well they protect and encourage compassionate conduct by physicians. (shrink)

This paper argues for the validity of inferences that take the form of: A is more X than B; therefore A and B are both X. After considering representative counterexamples, it is claimed that these inferences are valid if and only if the comparative terms in the inference are taken from no more than one comparative set, where a comparative set is understood to be comprised of a positive, comparative, and superlative, represented as {X, more X than, most X}. In (...) all instances where arguments appearing to be of this form are invalid, it is the case that the argument has fallaciously taken terms from more than one comparative set. The fallacy of appealing to more than one comparative set in an inference involving comparative terms is shown to be analogous to the fallacy of equivocation in argumentation. The paper concludes by suggesting a conflation of logical issues with grammatical issues is the core difficulty leading some to consider inferences in the form of A is more X than B; therefore A and B are X to be invalid. (shrink)

In this article, we explore how deep brain stimulation (DBS) devices designed to “close the loop”—to automatically adjust stimulation levels based on computational algorithms—may risk taking the individual agent “out of the loop” of control in areas where (at least apparent) conscious control is a hallmark of our agency. This is of particular concern in the area of psychiatric disorders, where closed-loop DBS is attracting increasing attention as a therapy. Using a relational model of identity and agency, we consider whether (...) DBS designed for psychiatric regulation may require special attention to agency. To do this, we draw on philosophical work on relational identity and agency, connecting it with reports from people using first-generation DBS devices for depression and obsessive-compulsive disorder. We suggest a way to extend a notion of relational agency to encompass neural devices. (shrink)