Gallicagram est un nouvel outil de lexicométrie, fondé notamment sur les archives océrisées de la Bibliothèque nationale de France et sur celles du journal Le Monde ; il dénombre dans le corpus choisi et pour une période donnée les occurrences d’un mot ou d’un syntagme, et offre différents modes de visualisation des données obtenues. Ce logiciel mérite à plusieurs titres d’être investi par les chercheurs : outre le volume des données qu’il exploite, suffisant pour fonder des analyses lexicométriques depuis le (...) XVIIe siècle jusqu’à nos jours, Gallicagram a sur son concurrent immédiat, Ngram Viewer, l’avantage d’une transparence très supérieure et d’une structure plus constante au cours du temps. L’article présente Gallibase, son extension qui lui applique les outils de la statistique textuelle – en particulier les analyses factorielles et arborées. Il illustre son potentiel et insiste sur l’intérêt spécifique des corpus de presse, qui permettent des études sur périodes courtes. (shrink)

Taking regular walks when living with Parkinson’s disease has beneficial effects on movement and quality of life. Yet, patients usually show reduced physical activity compared to healthy older adults. Using auditory stimulation such as music can facilitate walking but patients vary significantly in their response. An individualized approach adapting musical tempo to patients’ gait cadence, and capitalizing on these individual differences, is likely to provide a rewarding experience, increasing motivation for walk-in PD. We aim to evaluate the observance, safety, tolerance, (...) usability, and enjoyment of a new smartphone application. It was coupled with wearable sensors and delivered individualized musical stimulation for gait auto-rehabilitation at home. Forty-five patients with PD underwent a 1-month, outdoor, uncontrolled gait rehabilitation program, using the BeatWalk application. The music tempo was being aligned in real-time to patients’ gait cadence in a way that could foster an increase up to +10% of their spontaneous cadence. Open-label evaluation was based on BeatWalk use measures, questionnaires, and a six-minute walk test. Patients used the application 78.8% of the prescribed duration and enjoyed it throughout the program. The application was considered “easy to use” by 75% of the patients. Pain, fatigue, and falls did not increase. Fear of falling decreased and quality of life improved. After the program, patients improved their gait parameters in the six-minute walk test without musical stimulation. BeatWalk is an easy to use, safe, and enjoyable musical application for individualized gait rehabilitation in PD. It increases “walk for exercise” duration thanks to high observance.Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02647242. (shrink)

Laughter and yawning can both occur spontaneously and are highly contagious forms of social behavior. When occurring contagiously, laughter and yawning are usually confounded with a social situation and it is difficult to determine to which degree the social situation or stimulus itself contribute to its contagion. While contagious yawning can be reliably elicited in lab when no other individuals are present, such studies are more sparse for laughter. Moreover, laughter and yawning are multimodal stimuli with both an auditory and (...) a visual component: laughter is primarily characterized as a stereotyped vocalization whereas yawning is a predominantly visual signal and it is not known to which degree the visual and auditory modalities affect the contagion of laughter and yawning. We investigated how these two sensory modalities contribute to the contagion of laughter and yawning under controlled laboratory conditions in the absence of a social situation that might confound their contagion. Subjects were presented with naturally produced laughter and yawning in three sensory modalities, and we recorded their reaction to these stimuli. Contagious responses differed for laughter and yawning: overall, laughter elicited more contagious responses than yawning, albeit mostly smiling rather than overt laughter. While the audio-visual condition elicited most contagious responses overall, laughter was more contagious in the auditory modality, and yawning was more contagious in the visual modality. Furthermore, laughter became decreasingly contagious over time, while yawning remained steadily contagious. We discuss these results based on the ontogenetic and phylogenetic trajectories of laughter and yawning. (shrink)

L'article explore la notion wébérienne de «domination rationnelle» comme outil pour analyser les rapports entre les efforts de gestion des populations indigènes par l'État colonial, et le développement d'une forme spécifique de rationalité scientifique, prenant pour objet ces populations: les savoirs anthropologiques. En s'appuyant sur le cas de l'Afrique coloniale française, on s'efforce de montrer comment les dimensions d'instrumentation (avec la production d'instruments d'identification et de compréhension) et de légitimation sont essentielles dans l'émergence de savoirs sur les sociétés et les (...) cultures indigènes, d'abord au sein des appareils administratifs, mais aussi dans les institutions savantes métropolitaines. L'appui au développement de la science de l'homme se fait dans le cadre de projets de « rationalisation » de la colonisation qui rapprochent des savants et des réformateurs liés à l 'École coloniale, voulant redéfinir la profession d'administrateur colonial comme «spécialiste des indigènes». (shrink)

Les recompositions familiales touchent l’ensemble des liens familiaux et des liens intergénérationnels. Or, si l’on observe, tant sur le plan juridique que dans les pratiques des familles conjugales, une acception plus complexe et plus riche de la parentalité, les grands-parents restent souvent méconnus. Comment construisent-ils leurs rapports à leurs « beaux-petits-enfants »? Nous avons examiné la littérature et interrogé des « belles-grands-mères » pour tenter d’y voir plus clair. Quelles représentations le champ social offre-t-il des beaux-grands-parents? Et quelles sont concrètement (...) les conditions et les étapes qui rendent possible une identité « beau-grand-parentale »? (shrink)

Si la philosophie du droit a une très longue histoire, le bouleversement des conditions techniques, économiques, sociales et politiques nous impose aujourd'hui de renouveler en profondeur le traitement des questions qu'elle pose traditionnellement ainsi que les réponses qui y sont données. La définition de la justice, le partage des biens et des charges de la vie en société, les rôles respectifs de l'État, du marché et de la société civile, la mission des juges et l'application des lois, ou encore le (...) contenu et l'importance des droits de l'homme, doivent être réexaminés dans une perspective instruite par l'éclairage historique, mais résolument tournée vers les problèmes du présent et les choix qui engagent l'avenir. C'est dans une telle optique qu'a été conçu cet ouvrage. (shrink)

During the course of evolution, variations of a protein sequence is an ongoing phenomenon however limited by the need to maintain its structural and functional integrity. Deciphering the evolutionary path of a protein is thus of fundamental interest. With the development of new methods to visualize high dimension spaces and the improvement of phylogenetic analysis tools, it is possible to study the evolutionary trajectories of proteins in the sequence space. Using the data-driven high-dimensional scaling method, we show that it is (...) possible to predict and represent potential evolutionary trajectories by representing phylogenetic trees into a 3D projection of the sequence space. With the case of the aminodeoxychorismate synthase, an enzyme involved in folate synthesis, we show that this representation raises interesting questions about the complexity of the evolution of a given biological function, in particular concerning its capacity to explore the sequence space. (shrink)

Humanitarian organisations often work alongside those responsible for serious wrongdoing. In these circumstances, accusations of moral complicity are sometimes levelled at decision makers. These accusations can carry a strong if unfocused moral charge and are frequently the source of significant moral unease. In this paper, we explore the meaning and usefulness of complicity and its relation to moral accountability. We also examine the impact of concerns about complicity on the motivation of humanitarian staff and the risk that complicity may lead (...) to a retreat into moral narcissism. Moral narcissism is the possibility that where humanitarian actors inadvertently become implicated in wrongdoing, they may focus more on their image as self-consciously good actors than on the interests of potential beneficiaries. Moral narcissism can be triggered where accusations of complicity are made and can slew decision making. We look at three interventions by Médecins Sans Frontières that gave rise to questions of complicity. We question its decision-guiding usefulness. Drawing on recent thought, we suggest that complicity can helpfully draw attention to the presence of moral conflict and to the way International Non-Governmental Organisations can be drawn into unintentional wrongdoing. We acknowledge the moral challenge that complicity presents to humanitarian staff but argue that complicity does not help INGOs make tough decisions in morally compromising situations as to whether they should continue with an intervention or pull out. (shrink)

Deep learning and other black-box models are becoming more and more popular today. Despite their high performance, they may not be accepted ethically or legally because of their lack of explainability. This paper presents the increasing number of legal requirements on machine learning model interpretability and explainability in the context of private and public decision making. It then explains how those legal requirements can be implemented into machine-learning models and concludes with a call for more inter-disciplinary research on explainability.

During the past few years, the IRBIT domain has emerged as an important add‐on of S‐adenosyl‐L‐homocystein hydrolase (AHCY), thereby creating the new family of AHCY‐like proteins. In this review, we discuss the currently available data on this new family of proteins. We describe the IRBIT domain as a unique part of these proteins and give an overview of its regulation via (de)phosphorylation and proteolysis. The second part of this review is focused on the potential functions of the AHCY‐like proteins. We (...) propose that the IRBIT domain serves as an anchor for targeting AHCY‐like proteins towards cytoplasmic targets. This leads to regulation of (i) intracellular Ca2+ via the inositol 1,4,5‐trisphosphate receptor (IP3R), (ii) intracellular pH via the Na+/HCO3− cotransporters (NBCs); whereas inactivation of the IRBIT domain induces (iii) nuclear translocation and regulation of AHCY activity. Dysfunction of AHCY‐like proteins will disturb these three important functions, with various biological implications. BioEssays 30:642–652, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Although "intrasexual selection" has been accepted as the mechanism by which males evolve elaborate secondary sexual traits which are used in aggressive contests, the importance of "intersexual selection" as a mechanism by which males have acquired exaggerated traits to display to females during courtship was less readily accepted. In spite of this scepticism, several genetic models have supported the latter idea, and many empirical studies showed that females were generally more discriminating in mate choice than males, because of differences in (...) relative investment between sexes. Nowadays, this idea is reinforced by various concepts (parental investment, potential reproductive rate, environmental potential for polygamy...) which stress that the strength of sexual selection is related to many interdependent factors, such as mating systems, resource distribution (food, habitat, mate), life history and other ecological characteristics. The case of Salmonids is presented here to show how novel information on sexual selection has contributed to the understanding of the plasticity of breeding patterns in the context of evolutionary biology. (shrink)

In human groups performing oscillatory tasks, it has been observed that the frequency of participants' oscillations reduces when compared to that acquired in solo. This experimental observation is not captured by the standard Kuramoto oscillators, often employed to model human synchronization. In this work, we aim at capturing this observed phenomenon by proposing three alternative modifications of the standard Kuramoto model that are based on three different biologically-relevant hypotheses underlying group synchronization. The three models are tuned, validated and compared against (...) experiments on a group synchronization task, which is a multi-agent extension of the so-called mirror game. (shrink)

La présente étude rassemble les passages de l’Ab Vrbe condita de Tite-Live où un terme lié au rire est associé à un discours ou à une parole rapportée, afin de les confronter aux vues exprimées par Cicéron et Quintilien sur le rire en contexte rhétorique. Si tous les passages étudiés s’insèrent très bien dans la conception rhétorique du rire, l’historien latin s’appuie sur celle-ci pour offrir une répartition originale entre usages acceptables et formes abusives du rire qui participe à la (...) construction des portraits personnages et de l’œuvre. (shrink)

La réception de la théologie politique de Johann Baptist Metz est un fait d’interprétation. Cette contribution présente tout d’abord la périodisation, apparue dans les années 1980, de l’oeuvre de Metz en trois phases: la période de la théologie transcendantale; la première phase de la théologie politique ainsi que sa deuxième phase. Décrire deux phases de la théologie politique délimitées par la formulation de la thèse centrale de l’oeuvre de Metz, selon laquelle la foi est mémoire de la souffrance de l’humanité, (...) permet de mettre en lumière la signification et les enjeux de la théologie politique. La deuxième partie de l’article s’intéresse à un aspect encore sujet à discussions de la réception de l’oeuvre de Metz: en réponse au refus postmoderne des grands récits, Metz et ses disciples présentent la théologie politique comme une théologie négative. Cependant, une telle réponse peut-elle être séparée d’autres affirmations déterminantes pour la théologie politique, en particulier celle selon laquelle le temps a une fin? (shrink)

Le pragmatisme semble etre devenu la chose du monde la mieux partagee. A la fois revolution philosophique et rehabilitation du sens commun, il est en tout cas difficile aujourd'hui de se declarer anti-pragmatiste sans apparaitre vouloir defendre une forme depassee de ratiocination scolastique. Cet etat de fait necessite qu'une reponse claire soit apportee a la question Qu'est-ce que le pragmatisme?. La these qui se trouve defendue dans cet ouvrage est que le coeur, a la fois historique et conceptuel, du pragmatisme (...) consiste dans une theorie de la rationalite epistemique dont suit une theorie de la verite et, plus particulierement, de son role dans la croyance et l'enquete. Le commentaire du texte de Peirce permet d'aborder la question de la nature du faillibilisme et de la maniere dont l'enquete scientifique doit etre regulee. (shrink)

I outline and criticise the received interpretation of the controversy between Clifford and James over the ethics of belief. I defend Clifford’s view by arguing that his maxim ‘that it is wrong, always, everywhere, and for anyone, to believe anything upon insufficient evidence’ should be understood as stating that any belief that results from the corruption of one’s judgement by one’s desires is wrong. I indicate what follows about religious beliefs in particular.