The fifteen essays which comprise this book are unified by an unmistakable philosophical voice, and addressed to an interlocking set of concepts: cause, law, event, action, feeling, freedom, and intention. Collectively they trace the loops and bights of the Welt-Knotte, where the physical and the psychological orders tie. But the book is more than a collection of bright inter-referential papers by a clever man, and its existence is justified by something greater than the value of having them bound conveniently together. (...) For it can be read as a kind of journal metaphysique, with advances and reversals, where early theses can be retained only by dialectical modification, and intuitions retained at the cost of sacrificing intuitions, and a kind of relentless will-to-system can be perceived coming to self-consciousness through the medium of invited papers to the routine conferences and symposia of academic philosophical life. What we have in the end is thinking, rather than specimens of thought. (shrink)

Two decades of research on euthanasia in the Netherlands have resulted into clear insights in the frequency and characteristics of euthanasia and other medical end-of-life decisions in the Netherlands. These empirical studies have contributed to the quality of the public debate, and to the regulating and public control of euthanasia and physician-assisted suicide. No slippery slope seems to have occurred. Physicians seem to adhere to the criteria for due care in the large majority of cases. Further, it has been shown (...) that the majority of physicians think that the euthanasia Act has improved their legal certainty and contributes to the carefulness of life-terminating acts. In 2005, eighty percent of the euthanasia cases were reported to the review committees. Thus, the transparency envisaged by the Act still does not extend to all cases. Unreported cases almost all involve the use of opioids, and are not considered to be euthanasia by physicians. More education and debate is needed to disentangle in these situations which acts should be regarded as euthanasia and which should not. Medical end-of-life decision-making is a crucial part of end-of-life care. It should therefore be given continuous attention in health care policy and medical training. Systematic periodic research is crucial for enhancing our understanding of end-of-life care in modern medicine, in which the pursuit of a good quality of dying is nowadays widely recognized as an important goal, in addition to the traditional goals such as curing diseases and prolonging life. (shrink)

The article offers a study of the theological method of Henry Dodwell, the most distinguished British savant of the late Stuart period and a leading figure in the Non-Juring movement. The study takes the form of arguments for the extension of the contemporary dispute between the Ancients and Moderns, in its historiographical dimension, into the field of divinity; for substantial modification of the claims made in discussions of the dispute about the inherent conflict between the Renaissance's desire for revivification of (...) the past and its historical scholarship; and for reconsideration of the relationship between 17th century critical scholarship and the Enlightenment. (shrink)

Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a polygenic risk score. We discuss four areas in which the use of polygenic risk scores in psychiatric research and clinical contexts could have ethical (...) implications. First, there is concern that clinical use of polygenic risk scores may exacerbate existing health inequities. Second, research findings regarding polygenic risk could be misinterpreted in stigmatising or discriminatory ways. Third, there are concerns associated with testing minors as well as eugenics concerns elicited by prenatal polygenic risk testing. Fourth, potential challenges that could arise with the feedback and interpretation of high polygenic risk for a psychiatric disorder would require consideration. While there would be extensive overlap with the challenges of feeding back genetic findings in general, the potential clinical use of polygenic risk scoring warrants discussion in its own right, given the recency of this possibility. To this end, we discuss how lay interpretations of risk and genetic information could intersect. Consideration of these factors would be necessary for ensuring effective and constructive communication and interpretation of polygenic risk information which, in turn, could have implications for the uptake of any therapeutic recommendations. Recent advances in polygenic risk scoring have major implications for its clinical potential, however, care should be taken to ensure that communication of polygenic risk does not feed into problematic assumptions regarding mental disorders or support reductive interpretations. (shrink)

The origination of novel structures has long been an intriguing topic for biologists. Over the past few decades it has served as a central theme in evolutionary developmental biology. Yet, definitions of evolutionary innovation and novelty are frequently debated and there remains disagreement about what kinds of causal factors best explain the origin of qualitatively new variation in the history of life. Here we examine aspects of these debates, survey three empirical case studies, and reflect on directions for future inquiry (...) that will advance research into the developmental evolution of novel structures. (shrink)

Acknowledging the considerable degree of identity which developed between Episcopalianism and the Jacobite movement in Scotland, this study investigates the character of Episcopalian thought at the end of the seventeenth and in the first decade of the eighteenth century, making particular use of the writings of Bishop John Sage (1652–1711) and Principal Alexander Monro (d. 1698). It comments on the origins of that thought, with reference to both locally and temporally specific circumstances and the intellectual traditions of the seventeenth century, (...) notably an increasing emphasis on historical method and the cultivation of neo-Stoicism. In commenting on the content of this thought, it centrally seeks to explain the relationship of the dominant theological theme of the writings examined to the intellectual, social and political threats to theocratic order offered by the period in general and the revolution of 1688–1689 in particular. It argues that it is chiefly in this way that Episcopalian Jacobite thought can be placed in the context of Enlightenment/counter-enlightenment debate. (shrink)

O artigo oferece uma breve exposição da biografia e do contexto histórico do filósofo neoplatônico Damáscio (c. 458 - c. 538) para, na sequência, apresentar a tradução de um dos seus poemas líricos do período final de sua vida. O procedimento adotado justifica-se pelo caráter lutuoso e decididamente pessoal dos versos, nos quais Damáscio lamenta consigo próprio as perdas sofridas no decorrer de sua longa e fascinante vida. Como veremos, tais perdas estão, em verdade, diretamente ligadas ao colapso do mundo (...) antigo e ao derradeiro golpe proferido por Justiniano contra a filosofia helênica pagã. (shrink)

The Hutchinsonian movement exercised considerable influence on thought about various topics of importance in England's Enlightenment/Counter-Enlightenment debates. Its epistemological stance, derived from a group of Irish writers of the early eighteenth century, places the movement at the centre of these debates and does much to explain its attraction to contemporaries. The article emphasises the persistence of Hutchinsonian thought and the continuing importance of its epistemological underpinnings into the early nineteenth century, drawing attention particularly to the writings of Bishop William Van (...) Mildert. (shrink)

Summary This article discusses and evaluates the historiographical work of a leading Oxford convert and Ultramontane, Thomas Allies (1813?1903). An evaluation of Allies by the criteria of the Ultramontane scholarship he endeavoured to practise allows the article to offer an illustration of the difficulty in establishing and maintaining an autonomous Catholic scholarship during the nineteenth century's secularising development of academic activity. It also allows substantial description of the patterns of nineteenth-century Catholic historical thought, noting the strength of its commitment to (...) providentialism and, in particular, its apocalyptic character. An examination of the influences brought to bear on the subject's thought during the formative period of his development as an historian, through his own study and his close friendship with John Henry Newman, indicates the reasons for Allies's ultimate failure either to create a clear and stimulating product of the Ultramontane historical vision or to achieve an academic or popular reputation as an historian. The article argues that an unresolved conflict, between Allies's inclination towards a providentialist historiography consistent with his commitment to a Catholic counter-culture and his willingness to accept, under Newman's guidance, contemporary secular historiographical norms, offers substantial explanation of this failure. (shrink)

Two decades of research on euthanasia in the Netherlands have resulted into clear insights in the frequency and characteristics of euthanasia and other medical end-of-life decisions in the Netherlands. These empirical studies have contributed to the quality of the public debate, and to the regulating and public control of euthanasia and physician-assisted suicide. No slippery slope seems to have occurred. Physicians seem to adhere to the criteria for due care in the large majority of cases. Further, it has been shown (...) that the majority of physicians think that the euthanasia Act has improved their legal certainty and contributes to the carefulness of life-terminating acts. In 2005, eighty percent of the euthanasia cases were reported to the review committees. Thus, the transparency envisaged by the Act still does not extend to all cases. Unreported cases almost all involve the use of opioids, and are not considered to be euthanasia by physicians. More education and debate is needed to disentangle in these situations which acts should be regarded as euthanasia and which should not. Medical end-of-life decision-making is a crucial part of end-of-life care. It should therefore be given continuous attention in health care policy and medical training. Systematic periodic research is crucial for enhancing our understanding of end-of-life care in modern medicine, in which the pursuit of a good quality of dying is nowadays widely recognized as an important goal, in addition to the traditional goals such as curing diseases and prolonging life. (shrink)

The article considers the fundamental motivations and associated theological thought of those involved in the Non-Juring schism in the Church of England in the period after the Revolution of 1688. It indicates and exemplifies how that thought is to be related to wider intellectual conflicts of the period, considered as constituting an early phase of Enlightenment/Counter-Enlightenment debate. The works of the leading Non-Juror theologian, Henry Dodwell, and in particular his writings on the destiny of the soul, serve as an area (...) of focus. Extensive reference is also made to the equally prominent Non-Juror, Charles Leslie. (shrink)

Recent research has relied on trolley-type sacrificial moral dilemmas to study utilitarian versus nonutili- tarian modes of moral decision-making. This research has generated important insights into people’s attitudes toward instrumental harm—that is, the sacrifice of an individual to save a greater number. But this approach also has serious limitations. Most notably, it ignores the positive, altruistic core of utilitarianism, which is characterized by impartial concern for the well-being of everyone, whether near or far. Here, we develop, refine, and validate a (...) new scale—the Oxford Utilitarianism Scale—to dissociate individual differences in the ‘negative’ (permissive attitude toward instrumental harm) and ‘positive’ (impartial concern for the greater good) dimensions of utilitarian thinking as manifested in the general population. We show that these are two independent dimensions of proto-utilitarian tendencies in the lay population, each exhibiting a distinct psychological profile. Empathic concern, identification with the whole of humanity, and concern for future generations were positively associated with impartial beneficence but negatively associated with instrumental harm; and although instrumental harm was associated with subclinical psychopathy, impartial beneficence was associated with higher religiosity. Importantly, although these two dimensions were independent in the lay population, they were closely associated in a sample of moral philosophers. Acknowledging this dissociation between the instrumental harm and impartial beneficence components of utilitarian thinking in ordinary people can clarify existing debates about the nature of moral psychology and its relation to moral philosophy as well as generate fruitful avenues for further research. (shrink)

This article argues that blacks should reject integration on self-protective and solidarity grounds. It distinguishes two aspects of black devaluation: a ‘stigmatization’ aspect that has to do with the fact that blacks are subject to various forms of discrimination, and an aesthetic aspect (‘phenotypic devaluation’) that concerns the aesthetic devaluation of characteristically black phenotypic traits. It identifies four self-worth harms that integration may inflict, and suggests that these may outweigh the benefits of integration. Further, it argues that, while the integrating (...) process may reduce stigmatization, there is less reason to think that it can do the same for phenotypic devaluation. (shrink)