Liquid‐liquid phase separation (LLPS) has recently emerged as a possible mechanism that enables ubiquitin‐binding shuttle proteins to facilitate the degradation of ubiquitinated substrates via distinct protein quality control (PQC) pathways. Shuttle protein LLPS is modulated by multivalent interactions among their various domains as well as heterotypic interactions with polyubiquitin chains. Here, the properties of three different shuttle proteins (hHR23B, p62, and UBQLN2) are closely examined, unifying principles for the molecular determinants of their LLPS are identified, and how LLPS is connected (...) to their functions is discussed. Evidence supporting LLPS of other shuttle proteins is also found. In this review, it is proposed that shuttle protein LLPS leads to spatiotemporal regulation of PQC activities by mediating the recruitment of PQC machinery (including proteasomes or autophagic components) to biomolecular condensates, assembly/disassembly of condensates, selective enrichment of client proteins, and extraction of ubiquitinated proteins from condensates in cells. (shrink)

Membranous organelles allow sub‐compartmentalization of biological processes. However, additional subcellular structures create dynamic reaction spaces without the need for membranes. Such membrane‐less organelles (MLOs) are physiologically relevant and impact development, gene expression regulation, and cellular stress responses. The phenomenon resulting in the formation of MLOs is called liquid–liquid phase separation (LLPS), and is primarily governed by the interactions of multi‐domain proteins or proteins harboring intrinsically disordered regions as well as RNA‐binding domains. Although the presence of RNAs affects the formation and (...) dissolution of MLOs, it remains unclear how the properties of RNAs exactly contribute to these effects. Here, the authors review this emerging field, and explore how particular RNA properties can affect LLPS and the behavior of MLOs. It is suggested that post‐transcriptional RNA modification systems could be contributors for dynamically modulating the assembly and dissolution of MLOs. (shrink)

We consider the reduct to the module language of certain theories of fields with a non surjective endomorphism. We show in some cases the existence of a model companion. We apply our results for axiomatizing the reduct to the theory of modules of non principal ultraproducts of separably closed fields of fixed but non zero imperfection degree.

In Dellunde et al. 997–1015), we determined the complete theory Te of modules of separably closed fields of characteristic p and imperfection degree e, eω{∞}. Here, for 0≠eω, we describe the closed set of the Ziegler spectrum corresponding to Te. Further, we establish a correspondence between certain submodules and n-types and we investigate several notions of dimensions and their relationships with the Lascar rank. Finally, we show that Te has uniform p.p. elimination of imaginaries and deduce uniform weak elimination (...) of imaginaries. (shrink)

We characterize strict Mittag-Leffler modules in terms of free realizations of positive primitive formulas, and rings over which projectives are trivial in terms of various notions of separability of strict Mittag-Leffler modules. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

We consider the decision problem for modules over a group ring ℤ[G], where G is a cyclic group of prime order. We show that it reduces to the same problem for a class of certain abelian structures, and we obtain some partial decidability results for this class.

Traditionally, research on affordances and emotions follows two separate routes. For the first time, this article explicitly links the two phenomena by investigating whether, in a discrimination task, the motivational states induced by emotional images can modulate affordances-related motor response elicited by dangerous and neutral graspable objects. The results show faster RTs: for both neutral and dangerous objects with neutral images; for dangerous objects with pleasant images; for neutral objects with unpleasant images. Overall, these data support a significant effect of (...) emotions on affordances. The article also proposes a brain neural network underlying emotions and affordance interplay. (shrink)

This paper puts forward a general framework for thought about human information processing. It is intended to avoid some of the problems of pipeline or stage models of function. At the same time it avoids the snare of supposing a welter of indefinitely many separate processes. The approach is not particularly original, but rather represents the common elements or presuppositions in a number of modern theories. These presuppositions are not usually explicit, however, and making them so reduces the danger of (...) slipping back into earlier modes of thought.The key point is to distinguish between persisting representations and the processes that translate one representation into another. Various classes or groups of persisting representations can be distinguished by the experimental treatments that interfere with them. In particular, there now seem to be several kinds of short-term or temporary storage, different from each other as well as from longterm memory; the translating processes also have several different modes or kinds. A particularly important aspect of the current position is that a model of this general type no longer requires some external agent to direct and control long sequences of behaviour. (shrink)

We extend the analysis of the decision problem for modules over a group ring ℤ[G] to the case when G is a cyclic group of squarefree order. We show that separated ℤ[G]-modules have a decidable theory, and we discuss the model theoretic role of these modules within the class of all ℤ[G]-modules. The paper includes a short analysis of the decision problem for the theories of modules over ℤ[ζm], where m is a positive integer and (...) ζm is a primitive mth root of 1. (shrink)

The target article argues for the modularity of language interpretive processes without the usual criterion that a module be informationally encapsulated. It is the encapsulation criterion, however, that gives modularity most of its testability. Without the criterion of encapsulation, testing whether relatively automatic comprehension processes use their own unique resource is a very tricky matter.

Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...) [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAA receptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control. (shrink)

Voluntary stream segregation was investigated in cochlear implant users and normal-hearing listeners using a segregation-promoting objective approach which evaluated the role of spectral and amplitude-modulation rate separations on stream segregation and its build-up. Sequences of 9 or 3 pairs of A and B narrowband noise bursts were presented which differed in either center frequency of the noise band, the AM-rate, or both. In some sequences, the last B burst was delayed by 35 ms from their otherwise-steady temporal position. In the (...) other sequences, the last B bursts were temporally advanced from 0 to 10 ms. A single interval yes/no procedure was utilized to measure participants’ sensitivity in identifying delayed vs. no-delay sequences. A higher d′ value showed the higher ability to segregate the A and B subsequences. For NH listeners, performance improved with each spectral separation. However, for CI users, performance was only significantly better for the condition with the largest spectral separation. Additionally, performance was significantly poorer for the largest AM-rate separation than for the condition with no AM-rate separation for both groups. The significant effect of sequence duration in both groups indicated that listeners made more improvement with lengthening the duration of stimulus sequences, supporting the build-up effect. The results of this study suggest that CI users are less able than NH listeners to segregate NBN bursts into different auditory streams when they are moderately separated in the spectral domain. Contrary to our hypothesis, our results indicate that AM-rate separation may interfere with the segregation of streams of NBN. Additionally, our results add evidence to the literature that CI users build up stream segregation at a rate comparable to NH listeners, when the inter-stream spectral separations are adequately large. (shrink)

The heterogeneity of transcranial direct current stimulation protocols and clinical profiles may explain variable results in modulating excitability in the motor cortex after stroke. However, the cortical electrical effects induced by different tDCS protocols remain unclear. Here, we aimed to compare rhythm changes in electroencephalography induced by three tDCS position protocols and the association between tDCS effects and clinical factors in stroke. Nineteen patients with chronic ischemic stroke underwent four experimental sessions with three tDCS protocols [anodal, cathodal, and bilateral ] (...) and a sham protocol, according to a single-blind randomized crossover design. Resting-state EEG was acquired before and after each protocol. First, a paired-sample t-test was used to examine the difference in spectral power between pre- and post-stimulation. Then, linear and quadratic regression models were used separately to describe the association between the clinical factors of stroke and changes in spectral power which was significantly different between pre- and post-tDCS. Finally, repeated measures analysis of variance with lesion hemisphere, stimulation protocol, and the location was performed to investigate the effects of tDCS over time. The induced effect of tDCS was mainly reflected in the alpha rhythms. The alpha power was increased by atDCS, especially low-alpha, in localized areas of the central and distant areas of the frontal and parietal lobes. Bi-tDCS also affected alpha power but in a smaller area that mainly focused on high-alpha rhythms. However, ctDCS and sham had no significant effects on any EEG rhythm. The clinical factors of time since stroke and motor impairment level were related to the change in high-alpha induced by atDCS and bi-tDCS following quadratic regression models. The above-mentioned modulation effect lasted for 20 min without attenuation. In conclusion, our findings provide evidence that the alpha rhythm of EEG is modulated differently by different tDCS protocols and that high alpha is affected by clinical characteristics such as post-stroke time and motor deficits, which is of great significance for understanding the modulation effect of different tDCS protocols on stroke and the guidance of protocols to promote motor recovery following stroke. (shrink)

Transcranial direct current stimulation (tDCS) has been recognized as a promising tool for investigating the causal relationship between specific brain areas of interest and behavior. However, the reproducibility of previous tDCS studies is often questioned because of failures in replication. This study focused on the effects of tDCS on one cognitive domain: beauty perception. To date, the modulation of beauty perception by tDCS has been shown in two studies:Cattaneo et al. (2014)andNakamura and Kawabata (2015). Here, we aimed at replicating their (...) studies and investigating the effects of tDCS on beauty perception using the following parameters: (1) cathodal stimulation over the medial prefrontal cortex (mPFC) (Nakamura and Kawabata, 2015); (2) anodal stimulation over the left dorsolateral prefrontal cortex (lDLPFC) (Cattaneo et al., 2014). We also performed a more focal stimulation targeting the orbitofrontal cortex (OFC) to determine the optimal stimulation site for modulating beauty perception (3). Participants rated the subjectively-perceived beauty of the images before and after the tDCS administration. We divided images into four clusters according to the obtained scores in our preliminary study and examined changes in beauty ratings in each image cluster separately to exclude factors, such as stimuli attributions that may reduce tDCS effects. The results showed no strong effects of tDCS with the same parameters as in previous studies on beauty rating scores in any image cluster. Likewise, anodal stimulation over the OFC did not result in a change in rating scores. In contrast to previous studies, the current study did not corroborate the effects of tDCS on beauty perception. Our findings provide evidence regarding the recent reproducibility issue of tDCS effects and suggest the possible inflation of its effects on cognitive domains. (shrink)

A variety of studies show that parental absence early in life leads to deleterious effects on the developing CNS. This is thought to be largely because evolutionary-dependent stimuli are necessary for the appropriate postnatal development of the young brain, an effect sometimes termed the “experience-expectant brain,” with parents providing the necessary input for normative synaptic connections to develop and appropriate neuronal survival to occur. Principal among CNS systems affected by parental input are the monoamine systems. In the present study,N= 434 (...) rhesus monkeys (233 males, 201 females) were reared in one of two conditions: as mother-reared controls (MR;n= 269) or without adults with 24-h access to same-aged peers (PR;n= 165). When subjects were six-months-old, they underwent a separation paradigm involving 4, sequential, four-day social separations from their mothers or peers, with each separation followed by three-day reunions with their mothers or their peers. Prior to the separation paradigm, baseline cisternal CSF samples were obtained, as well as at the end of each the four social separations, and after final separation, during a recovery period. CSF was assayed for concentrations of monoamine metabolites and a blood sample was genotyped for the serotonin transporter (5-HTT) genotype. Replicating earlier landmark findings, PR subjects with thesallele exhibited lower baseline concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), when compared to PR subjects homozygous for theLallele. MR subjects were undifferentiated by genotype. PR subjects exhibited lower CSF 5-HIAA concentrations during baseline, but higher CSF 5-HIAA during social separations, when compared to MR subjects. There were rearing effects for the dopamine metabolite homovanillic acid (HVA) and for the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), with PR subjects showing higher HVA and lower MHPG when compared to MR subjects. These findings indicate that there are long-term deficits in the response of monoamines following early maternal absence. The results of this study confirm and extend earlier findings that early parental absence has deleterious consequences for the development of the monoamine systems, and that these consequences are modulated by the 5-HTT genotype. (shrink)

Films, compared with emotional static pictures, represent true-to-life dynamic stimuli that are both ecological and effective in inducing an emotional response given the involvement of multimodal stimulation (i.e., visual and auditory systems). We hypothesized that a direct comparison between the two methods would have shown greater efficacy of movies, compared to standardized slides, in eliciting emotions at both subjective and neurophysiological levels. To this end, we compared these two methods of emotional stimulation in a group of 40 young adults (20 (...) females). Electroencephalographic (EEG) Alpha rhythm (8–12 Hz) was recorded from 64 scalp sites while participants watched (in counterbalanced order across participants) two separate blocks of 45 slides and 45 clips. Each block included three groups of 15 validated stimuli classified as Erotic, Neutral and Fear content. Greater self-perceived arousal was found after the presentation of Fear and Erotic video clips compared with the same slide categories. sLORETA analysis showed a different lateralization pattern: slides induced decreased Alpha power (greater activation) in the left secondary visual area (Brodmann Area, BA, 18) to Erotic and Fear compared with the Neutral stimuli. Instead, video clips elicited reduced Alpha in the homologous right secondary visual area (BA 18) again to both Erotic and Fear contents compared with Neutral ones. Comparison of emotional stimuli showed smaller Alpha power to Erotic than to Fear stimuli in the left precuneus/posterior cingulate cortex (BA 7/31) for the slide condition, and in the left superior parietal lobule (BA 7) for the clip condition. This result matched the parallel analysis of the overlapped Mu rhythm (corresponding to the upper Alpha band) and can be interpreted as Mu/Alpha EEG suppression elicited by greater motor action tendency to Erotic (approach motivation) compared to Fear (withdrawal motivation) stimuli. Correlation analysis found lower Alpha in the left middle temporal gyrus (BA 21) associated with greater pleasantness to Erotic slides (r38= –0.62,p= 0.009), whereas lower Alpha in the right supramarginal/angular gyrus (BA 40/39) was associated with greater pleasantness to Neutral clips (r38= –0.69,p= 0.012). Results point to stronger emotion elicitation of movies vs. slides, but also to a specific involvement of the two hemispheres during emotional processing of slides vs. video clips, with a shift from the left to the right associative visual areas. (shrink)

In line with recent efforts to empirically study the folk concept of weakness of will, we examine two issues in this paper: (1) How is weakness of will attribution [WWA] influenced by an agent’s violations of best judgment and/or resolution, and by the moral valence of the agent’s action? (2) Do any of these influences depend on the cognitive dispositions of the judging individual? We implemented a factorial 2x2x2 between–subjects design with judgment violation, resolution violation, and action valence as independent (...) variables, and measured participants’ cognitive dispositions using Frederick’s Cognitive Reflection Test [CRT]. We conclude that intuitive and reflective individuals have two different concepts of weakness of will. The study supports this claim by showing that: a) the WWA of intuitive subjects is influenced by the action’s (and probably also the commitment’s) moral valence, while the WWA of reflective subjects is not; b) judgment violation plays a small role in the WWA of intuitive subjects, while reflective subjects treat resolution violation as the only relevant trait. Data were collected among students at two different universities. All subjects (N=710) answered the CRT. A three-way ANOVA was first conducted on the whole sample and then on the intuitive and reflective groups separately. This study suggests that differences in cognitive dispositions can significantly impact the folk understanding of philosophical concepts, and thus suggests that analysis of folk concepts should take cognitive dispositions into account. (shrink)

We study the infinitely definable subgroups of the additive group in a separably closed field of finite positive imperfection degree. We give some constructions of families of such subgroups which confirm the diversity and the richness of this class of groups. We show in particular that there exists a locally modular minimal subgroup such that the division ring of its quasi-endomorphisms is not a fraction field of the ring of its definable endomorphisms, and that in contrast there exist 20 pairwise (...) orthogonal locally modular minimal subgroups whose induced structure is exactly that of an-vector space. We also show that there exist infinitely many pairwise orthogonal subgroups of infinite U-rank. Furthermore, these constructions are carried out in the additive group considered as a module over its ring of definable endomorphisms. (shrink)

Lee and Schwarz made considerable theoretical advances in the psychology of cleansing by proposing that cleaning actions might serve as separation procedures between two psychological entities. Here, we propose that the effectiveness of the separation process may be modulated by the available amount of executive resources, and that separation may operate as a load-dependent resetting procedure.

The combined use of molecular and structural biology techniques has proved very efficient in elucidating structure‐function relationships in aminoacyl‐tRNA synthetases. Our present understanding of this family of enzymes is based on two main unifying principles: (i) division into two different classes, corresponding to two different modes of ATP binding and attachment of the activated amino acid to the last nucleotide of tRNA (either 2′OH or 3′OH of the ribose) by two different catalytic mechanisms and two structural domains with completely different (...) folding, and (ii) the modular organization into separate and additional domains that we are just beginning to understand. Sequence analysis complements very nicely existing structural, biochemical and genetic results and makes them more general, leading to verifiable predictions. (shrink)

The population of most non-dominant ethnic groups in the USA is growing dramatically. Faculty members are challenged to develop curricula that adequately prepare our future nurses. An increased focus on clinical ethics has resulted from the use of sophisticated technology, changes in health care financing, an increasing elderly population and the shift of care from inpatient to outpatient settings. Nurses frequently face situations demanding resolution of ethical dilemmas involving cultural differences. Nursing curricula must include content on both ethics and cultural (...) sensitivity. Active student participation is an important element providing a foundation for ethical practice. A proposed educational format was introduced with graduating baccalaureate students. In a pilot study, curricular content on cultural sensitivity and ethical practice was taught in separate modules. Students were then asked to identify and problem solve an ethical dilemma involving patients and professional caregivers from vastly different cultures. Course faculty members provided discussion questions to guide the students' thinking. (shrink)

The paper makes three points about the role of double dissociation in cognitive neuropsychology. First, arguments from double dissociation to separate modules work by inference to the best, not the only possible, explanation. Second, in the development of computational cognitive neuropsychology, the contribution of connectionist cognitive science has been to broaden the range of potential explanations of double dissociation. As a result, the competition between explanations, and the characteristic features of the assessment of theories against the criteria of probability (...) and explanatory value, are more visible. Third, cognitive neuropsychology is a division of cognitive psychology but the practice of cognitive neuropsychology proceeds on assumptions that go beyond the subject matter of cognitive psychology. Given such assumptions, neuroscientific findings about lesion location may enhance the value of double dissociation in shifting the balance of support between cognitive theories. (shrink)

This article explores the relationship between pragmatics and the other components of grammar. Specifically, it aims to determine whether pragmatics is a distinct module of grammar coming into play at some point in the derivation process to connect the sentence with the context. The conclusion is that, based on the phenomena considered in this work, pragmatics rather than being a separate module, is distributed in the various components. It is shown in fact that the context immediately intervenes at the representative (...) level to yield the correct syntax to be fed to the sensorimotor system on one side, and to the conceptual one on the other. The empirical focus of the article is on a specific type of questions in Italian, namely surprise and surprise-disapproval questions, because they are most sensitive to pragmatic factors. The syntactic, prosodic, and gestural components of these constructions will be examined, highlighting their most important characteristics. (shrink)

Postulating a variety of mutually isolated thought domains for prelinguistic creatures is both unparsimonious and implausible, requiring unexplained parallel evolution of each separate module. Furthermore, the proposal that domain-general concepts are not accessible without prior exposure to phonetically realized human language utterances cannot be implemented by any concept-acquisition mechanism.

Vision is so closely identified with visual phenomenology that we sometimes forget that the visual system does more than deliver our experience of the world. Vision also plays a critical role in the control of our movements, from picking up our coffee cups to playing tennis. But the visual control of movement has, until recently, been relatively neglected. Indeed, traditional accounts of vision, while acknowledging the role of vision in motor control, have simply regarded such control as part of a (...) larger function—that of constructing an internal model of the external world. Even though such accounts might postulate separate ‘modules’ for the processing of different visual features, such as motion, colour, texture, and form, in most of these accounts there is an implicit assumption that, in the end, vision delivers a single representation of the external world—a kind of simulacrum of the real thing that serves as the perceptual foundation for all visually driven thought and action. (shrink)

Vision is so closely identified with visual phenomenology that we sometimes forget that the visual system does more than deliver our experience of the world. Vision also plays a critical role in the control of our movements, from picking up our coffee cups to playing tennis. But the visual control of movement has, until recently, been relatively neglected. Indeed, traditional accounts of vision, while acknowledging the role of vision in motor control, have simply regarded such control as part of a (...) larger function – that of constructing an internal model of the external world. Even though such accounts might postulate separate ‘modules’ for the processing of different visual features, such as motion, colour, texture, and form, in most of these accounts there is an implicit assumption that, in the end, vision delivers a single representation of the external world – a kind of simulacrum of the real thing that serves as the perceptual foundation for all visually driven thought and action. (shrink)

This paper suggests that it is largely a want of notional distinctions which fosters the “explanatory gap” that has beset the study of consciousness since T. Nagel’s revival of the topic. Modifying Ned Block’s controversial claim that we should countenance a “phenomenal-consciousness” which exists in its own right, we argue that there is a way to recuperate the intuitions he appeals to without engaging in an onerous reification of the facet in question. By renewing with the full type/token/tone trichotomy developed (...) by C. S. Peirce, we think the distinctness Block calls attention to can be seen as stemming not from any separate module lurking within the mind, but rather from our ability to prescind qualities from occurrences. (shrink)

The processing of time intervals in the sub- to supra-second range by the brain is critical for the interaction of primates with their surroundings in activities, such as foraging and hunting. For an accurate processing of time intervals by the brain, representation of physical time within neuronal circuits is necessary. I propose that time dimension of the physical surrounding is represented in the brain by different types of neuronal oscillators, generating spikes or spike bursts at regular intervals. The proposed oscillators (...) include the pacemaker neurons, tonic inputs, and synchronized excitation and inhibition of inter-connected neurons. Oscillators, which are built inside various circuits of brain, help to form modular clocks, processing time intervals or other temporal characteristics specific to functions of a circuit. Relative or absolute duration is represented within neuronal oscillators by “neural temporal unit,” defined as the interval between regularly occurring spikes or spike bursts. Oscillator output is processed to produce changes in activities of neurons, named frequency modulator neuron, wired within a separate module, represented by the rate of change in frequency, and frequency of activities, proposed to encode time intervals. Inbuilt oscillators are calibrated by (a) feedback processes, (b) input of time intervals resulting from rhythmic external sensory stimulation, and (c) synchronous effects of feedback processes and evoked sensory activity. A single active clock is proposed per circuit, which is calibrated by one or more mechanisms. Multiple calibration mechanisms, inbuilt oscillators, and the presence of modular connections prevent a complete loss of interval timing functions of the brain. (shrink)

Background Ensuring morally competent nurses depends on many factors, such as environmental, social, political, and cultural. However, several inadequacies in nursing education have been documented, and no common framework has been established for how nursing ethics should be taught in undergraduate education. Research questions What are the different approaches across nursing programmes established in teaching ethics? What are the main similarities and differences across programmes facilitating a common understanding in developing a curriculum capable of preparing a morally competent nurse? Research (...) design International comparative education study in five steps: (1) formulating the initial question; (2) defining the units of comparison; (3) determining the variables of comparison; (4) describing the findings; (5) interpreting the findings. The comparative variables were identified, extracted, and populated in a piloted grid. Participants Six universities were purposefully selected by the Promoting a Morally Competent Nurse project partners for their nursing education curricula as delivered in 2022–2023. Ethical considerations No ethical approval was required, given no human participants and public data regarding nursing curricula. Findings Variability emerged in the terminologies used in naming the courses, the numbers of credits and hours devoted to teaching ethics, when the courses are delivered (since the initial semesters of nursing education or concentrated in the final years), and their main modes of delivery (a single or separate module or integrated across the curriculum). Contents have some similarities, whereas the teaching methods varied and included (or not) explicit connections with clinical practice. Attendance is mandatory in all courses. The assessment methods used varied from knowledge-based to more competence-based approaches involving multidimensional strategies. Conclusions This comparative study explored similarities and differences across nursing programmes in six different European countries. The reviewed ethics curricula lack significant clarity, and they offer important areas to consider for future development. Issues emerged regarding terminologies, learning workloads, when to deliver, how to deliver, the main contents, and the teaching and assessment methods that merit further discussion. (shrink)

A visual analogue, two-route model of somatosensory processing is advanced in this commentary. Touch for perception is seen as separate from, although interconnected with, touch for action. Separate modules are additionally proposed for internal (body) and external (object-related) somatosensation. Here we ask whether dissociation (divide) guarantees better efficiency (impera) in terms of the heuristic model within the somatosensory modality and across modalities.

In this article we review the discussion over the thesis that language serves as an integrator of contents coming from different cognitive modules. After presenting the theoretical considerations, we examine two strands of empirical research that tested the hypothesis — spatial cognition and mathematical cognition. The idea shared by both of them is that each is composed of two separate modules processing information of a specific kind. For spatial thinking these are geometric information about the location of the (...) object and the information about the object’s properties such as color or size. For mathematical thinking, they are the absolute representation of small numbers and the approximate representation of numerosities. Language is said to integrate the two kinds of information within each of these domains, which the reviewed data demonstrates. In the final part of the paper, we offer some comments on the theoretical side of the discussion. (shrink)

This book argues against the traditional understanding of the semantics/pragmatics divide and puts forward a radical alternative. Through half a dozen case studies, it shows that what an utterance says cannot be neatly separated from what the speaker means. In particular, the speaker's meaning endows words with senses that are tailored to the situation of utterance and depart from the conventional meanings carried by the words in isolation. This phenomenon of ‘pragmatic modulation’ must be taken into account in theorizing about (...) semantic content, for it interacts with the grammar-driven process of semantic composition. Because of that interaction, the book argues, the content of a sentence always depends upon the context in which it is used. This claim defines Contextualism, a view which has attracted considerable attention in recent years, and of which the author of this book is one of the main proponents. (shrink)

The ontological abyss that separates real objects from sensual objects is one of the central principles of Object-Oriented Ontology (OOO), which has its most explicit and profuse modulation in Timothy Morton’s notion of rift. This article argues that, despite succeeding in explaining the radical difference that inhabits every object, Morton’s rift fails to explain the object’s unification, rendering the overall theory inconsistent. An alternative approach that accounts simultaneously for disjunction and conjunction between essences and appearances can be found in Eugenio (...) Trías’s philosophy of the limit, a term widely ignored in OOO despite its deeply non-relational conception of the reality of things. The article further argues that the reinterpretation of Trías’s twofold liminal approach in light of OOO successfully addresses the inconsistencies found in Morton’s rift, paving the way for a theory of limits within Harman’s ontological framework. (shrink)

Predicting the defect-prone modules when the previous defect labels of modules are limited is a challenging problem encountered in the software industry. Supervised classification approaches cannot build high-performance prediction models with few defect data, leading to the need for new methods, techniques, and tools. One solution is to combine labeled data points with unlabeled data points during learning phase. Semi-supervised classification methods use not only labeled data points but also unlabeled ones to improve the generalization capability. In this (...) study, we evaluated four semi-supervised classification methods for semi-supervised defect prediction. Low-density separation, support vector machine, expectation-maximization, and class mass normalization methods have been investigated on NASA data sets, which are CM1, KC1, KC2, and PC1. Experimental results showed that SVM and LDS algorithms outperform CMN and EM-SEMI algorithms. In addition, LDS algorithm performs much better than SVM when the data set is large. In this study, the LDS-based prediction approach is suggested for software defect prediction when there are limited fault data. (shrink)

In the late 1980s, there were many who heralded the emergence of connectionism as a new paradigm – one which would eventually displace the classically symbolic methods then dominant in AI and Cognitive Science. At present, there remain influential connectionists who continue to defend connectionism as a more realistic paradigm for modeling cognition, at all levels of abstraction, than the classical methods of AI. Not infrequently, one encounters arguments along these lines: given what we know about neurophysiology, it is just (...) not plausible to suppose that our brains are digital computers. Thus, they could not support a classical architecture. I argue here for a middle ground between connectionism and classicism. I assume, for argument's sake, that some form(s) of connectionism can provide reasonably approximate models – at least for lower-level cognitive processes. Given this assumption, I argue on theoretical and empirical grounds that most human mental skills must reside in separate connectionist modules or sub-networks. Ultimately, it is argued that the basic tenets of connectionism, in conjunction with the fact that humans often employ novel combinations of skill modules in rule following and problem solving, lead to the plausible conclusion that, in certain domains, high level cognition requires some form of classical architecture. During the course of argument, it emerges that only an architecture with classical structure could support the novel patterns of information flow and interaction that would exist among the relevant set of modules. Such a classical architecture might very well reside in the abstract levels of a hybrid system whose lower-level modules are purely connectionist. (shrink)

High-level perception--”the process of making sense of complex data at an abstract, conceptual level--”is fundamental to human cognition. Through high-level perception, chaotic environmen- tal stimuli are organized into the mental representations that are used throughout cognitive pro- cessing. Much work in traditional artificial intelligence has ignored the process of high-level perception, by starting with hand-coded representations. In this paper, we argue that this dis- missal of perceptual processes leads to distorted models of human cognition. We examine some existing artificial-intelligence models--”notably (...) BACON, a model of scientific discovery, and the Structure-Mapping Engine, a model of analogical thought--”and argue that these are flawed pre- cisely because they downplay the role of high-level perception. Further, we argue that perceptu- al processes cannot be separated from other cognitive processes even in principle, and therefore that traditional artificial-intelligence models cannot be defended by supposing the existence of a --œrepresentation module--� that supplies representations ready-made. Finally, we describe a model of high-level perception and analogical thought in which perceptual processing is integrated with analogical mapping, leading to the flexible build-up of representations appropriate to a given context. (shrink)

In this paper, I argue that that polysemy is a two-sided phenomenon. It can be reduced neither to pragmatic modulation nor to ambiguity, for it is a mixture of both. The senses of a polysemous expression result from pragmatic modulation but they are stored in memory, as the senses of an ambiguous expression are. The difference with straightforward ambiguity is that the modulation relations between the senses are transparent to the language users: the senses are felt as related – they (...) form a family of senses. In other words, whereas two homonymous expressions are different expressions, with the same phonological realization but distinct meanings, a polyseme is a single expression, i.e. a semantic as well as a phonological unit. It has one meaning, which should not be confused with the separate senses which it contributes in context. Different ways of thinking of that unitary meaning will be discussed, and consequences drawn for the debate between more or less radical versions of Contextualism. (shrink)

The species-specific organizational property of speech is a continual mouth open-close alternation, the two phases of which are subject to continual articulatory modulation. The cycle constitutes the syllable, and the open and closed phases are segments framescontent displays that are prominent in many nonhuman primates. The new role of Broca's area and its surround in human vocal communication may have derived from its evolutionary history as the main cortical center for the control of ingestive processes. The frame and content components (...) of speech may have subsequently evolved separate realizations within two general purpose primate motor control systems: (1) a motivation-related medial system, including anterior cingulate cortex and the supplementary motor area, for self-generated behavior, formerly responsible for ancestral vocalization control and now also responsible for frames, and (2) a lateral system, including Broca's area and surround, and Wernicke's area, specialized for response to external input (and therefore the emergent vocal learning capacity) and more responsible for content. (shrink)

This paper reviews the fate of the central ideas behind the complementary learning systems (CLS) framework as originally articulated in McClelland, McNaughton, and O’Reilly (1995). This framework explains why the brain requires two differentially specialized learning and memory systems, and it nicely specifies their central properties (i.e., the hippocampus as a sparse, pattern-separated system for rapidly learning episodic memories, and the neocortex as a distributed, overlapping system for gradually integrating across episodes to extract latent semantic structure). We review the application (...) of the CLS framework to a range of important topics, including the following: the basic neural processes of hippocampal memory encoding and recall, conjunctive encoding, human recognition memory, consolidation of initial hippocampal learning in cortex, dynamic modulation of encoding versus recall, and the synergistic interactions between hippocampus and neocortex. Overall, the CLS framework remains a vital theoretical force in the field, with the empirical data over the past 15 years generally confirming its key principles. (shrink)

We challenge Gallagher’s distinction between the sense of ownership (SO) and the sense of agency (SA) as two separable modalities of experience of the minimal self and argue that a careful investigation of the examples provided to promote this distinction in fact reveals that SO and SA are intimately related and modulate each other. We propose a way to differentiate between the various notions of SO and SA that are currently used interchangeably in the debate, and suggest a more (...) gradual reading of the two that allows for various blends of SO and SA. Such an approach not only provides us with a richer phenomenology but also with a more parsimonious view of the minimal self. (shrink)

A distributed neural network model called SPEC for processing sentences with recursive relative clauses is described. The model is based on separating the tasks of segmenting the input word sequence into clauses, forming the case‐role representations, and keeping track of the recursive embeddings into different modules. The system needs to be trained only with the basic sentence constructs, and it generalizes not only to new instances of familiar relative clause structures but to novel structures as well. SPEC exhibits plausible (...) memory degradation as the depth of the center embeddings increases, its memory is primed by earlier constituents, and its performance is aided by semantic constraints between the constituents. The ability to process structure is largely due to a central executive network that monitors and controls the execution of the entire system. This way, in contrast to earlier subsymbolic systems, parsing is modeled as a controlled high‐level process rather than one based on automatic reflex responses. (shrink)

Perceptual processes, in particular modular processes, have long been understood as being mandatory. But exactly what mandatoriness amounts to is left to intuition. This paper identifies a crucial ambiguity in the notion of mandatoriness. Discussions of mandatory processes have run together notions of automaticity and ballisticity. Teasing apart these notions creates an important tool for the modularist's toolbox. Different putatively modular processes appear to differ in their kinds of mandatoriness. Separating out the automatic from the ballistic can help the modularist (...) diagnose and explain away some putative counterexamples to multimodal and central modules, thereby helping us to better evaluate the evidentiary status of modularity theory. (shrink)

The recent upsurge in “brain-training and perceptual-cognitive-training", proposing to improve isolated processes such as brain function, visual perception and decision-making, has created significant interest in elite sports practitioners, seeking to create an ‘edge’ for athletes. The claims of these related 'performance-enhancing industries' can be considered together as part of a process training approach proposing enhanced cognitive and perceptual skills and brain capacity, to support performance in everyday life activities, including sport. For example, the 'process-training industry' promotes the idea that playing (...) games not only makes you a better player, but also smarter, more alert, and a faster learner. In this position paper we critically evaluate the effectiveness of both types of process-training programmes in generalizing transfer to sport performance. These issues are addressed in three stages. First, we evaluate empirical evidence in support of perceptual-cognitive process training, and its application to enhancing sport performance. Second, we critically review putative modularised mechanisms underpinning this kind of training, addressing limitations and subsequent problems. Specifically, we consider merits of this highly specific form of training, which focuses on training of isolated processes such as cognitive processes (attention, memory, thinking) and visual perception processes, separately from performance behaviors and actions. We conclude that these approaches may, at best, may provide some 'general transfer' of underlying processes to specific sport environments, but lack 'specificity of transfer' to contextualize actual performance behaviors. A major weakness of process training methods is their focus on enhancing performance in body “modules” (e.g., eye, brain, memory, anticipatory sub-systems). What is lacking is evidence on how these isolated components are modified and subsequently interact with other process “modules”, which are considered to underlie sport performance. Finally, we propose how an ecological dynamics approach, aligned with an embodied framework of cognition undermines the rationale that modularised processes can enhance performance in competitive sport. An ecological dynamics perspective proposes that the body is a complex adaptive system, interacting with performance environments in a functionally integrated manner, emphasising that the inter-relation between motor processes, cognitive and perceptual functions and the constraints of a sport task is best understood at the performer-environment scale of analysis. (shrink)

The development of the mind follows the path of biological evolution towards the accumulation and transmission of information with increasing efficiency. In addition to the cognitive constants of speech (Solntsev, 1974), which greatly improved the transmission of information, people have created computing devices, from the abacus to the quantum computer. The capabilities of computers classified as artificial intelligence are developing at a rapid pace. However, at the present stage, artificial intelligence (AI) lacks an emotion module, and this makes AI fundamentally (...) different from human intelligence, since the life of the mind in humans cannot be separated from their feelings (Damasio, 2010; Panksepp, 1997). Consciousness itself is formed through the sensory and motor systems, that is, it is embodied (Foglia & Wilson, 2013), which means that our mental life is inseparable from our sensory motor experience (Wellsby & Pexman, 2014). Evolutionarily, our minds rely on ancient survival mechanisms that influence our decisions and choices. Hence, for example, the question whether the choice of Artificial Intelligence will always be favorable for humanity. (shrink)

Clinical and experimental evidence suggests that hippocampal damage causes more severe disruption of episodic memories if those memories were encoded in the recent rather than the more distant past. This decrease in sensitivity to damage over time might reflect the formation of multiple traces within the hippocampus itself, or the formation of additional associative links in entorhinal and association cortices. Physiological evidence also supports a two-stage model of the encoding process in which the initial encoding occurs during active waking and (...) deeper consolidation occurs via the formation of additional memory traces during quiet waking or slow-wave sleep. In this article I will describe the changes in cholinergic tone within the hippocampus in different stages of the sleep-wake cycle and will propose that these changes modulate different stages of memory formation. In particular, I will suggest that the high levels of acetylcholine that are present during active waking might set the appropriate dynamics for encoding new information in the hippocampus, by partially suppressing excitatory feedback connections and so facilitating encoding without interference from previously stored information. By contrast, the lower levels of acetylcholine that are present during quiet waking and slow-wave sleep might release this suppression and thereby allow a stronger spread of activity within the hippocampus itself and from the hippocampus to the entorhinal cortex, thus facilitating the process of consolidation of separate memory traces. (shrink)

Several research groups have identified a network of regions of the adult cortex that are activated during social perception and cognition tasks. In this paper we focus on the development of components of this social brain network during early childhood and test aspects of a particular viewpoint on human functional brain development: “interactive specialization.” Specifically, we apply new data analysis techniques to a previously published data set of event-related potential ~ERP! studies involving 3-, 4-, and 12-month-old infants viewing faces of (...) different orientation and direction of eye gaze. Using source separation and localization methods, several likely generators of scalp recorded ERP are identified, and we describe how they are modulated by stimulus characteristics. We then review the results of a series of experiments concerned with perceiving and acting on eye gaze, before reporting on a new experiment involving young children with autism. Finally, we discuss predictions based on the atypical emergence of the social brain network. (shrink)

The authors outline a theory of conditionals of the form If A then C and If A then possibly C. The 2 sorts of conditional have separate core meanings that refer to sets of possibilities. Knowledge, pragmatics, and semantics can modulate these meanings. Modulation can add information about temporal and other relations between antecedent and consequent. It can also prevent the construction of possibilities to yield 10 distinct sets of possibilities to which conditionals can refer. The mental representation of a (...) conditional normally makes explicit only the possibilities in which its antecedent is true, yielding other possibilities implicitly. Reasoners tend to focus on the explicit possibilities. The theory predicts the major phenomena of understanding and reasoning with conditionals. (shrink)

We challenge Gallagher’s distinction between the sense of ownership and the sense of agency as two separable modalities of experience of the minimal self and argue that a careful investigation of the examples provided to promote this distinction in fact reveals that SO and SA are intimately related and modulate each other. We propose a way to differentiate between the various notions of SO and SA that are currently used interchangeably in the debate, and suggest a more gradual reading (...) of the two that allows for various blends of SO and SA. Such an approach not only provides us with a richer phenomenology but also with a more parsimonious view of the minimal self. (shrink)