Mechanical pain sensing, adipogenesis, and STING‐dependent innate immunity seem three distinct biological processes without substantial relationships. Intriguingly, TMEM120A, a transmembrane protein, has been shown to detect mechanical pain stimuli as a mechanosensitive channel, contribute to adipocyte differentiation/function by regulating genome organization and promote STING trafficking to active cellular innate immune response. However, the role of TMEM120A as a mechanosensitive channel was challenged by recent studies which cannot reproduce data supporting its role in mechanosensing. Furthermore, the molecular (...) mechanism by which TMEM120A contributes to adipocyte differentiation/function and promotes STING trafficking remains elusive. In this review, we discuss these multiple proposed functions of TMEM120A and hypothesize the molecular mechanism underlying TMEM120A's role in fatty acid metabolism and STING signaling. (shrink)

In 1738, Jacques Vaucanson unveiled his masterpiece before the court of Louis XV: a gilded copper duck that ate, drank, quacked, flapped its wings, splashed about, and, most astonishing of all, digested its food and excreted the remains. The imitation of life by technology fascinated Vaucanson's contemporaries. Today our technology is more powerful, but our fascination is tempered with apprehension. Artificial intelligence and genetic engineering, to name just two areas, raise profoundly disturbing ethical issues that undermine our most fundamental beliefs (...) about what it means to be human. In The Vital Machine, David Channell examines the history of our relationship with technology and argues that, while the resolution of these issues may not be imminent, a philosophical framework for dealing with them is already in place. The source of our fears, he suggests, lies in an outmoded distinction between organic life and machines, a distinction rooted in the two world-views that have defined and guided Western civilization: the mechanical and the organic. The mechanical view holds that the universe is basically a machine--we can understand it by breaking it down into its smallest components. Even organisms are machines. The organic view claims that there is something more, some vital, directive force. The whole is more than just the sum of its parts. Even machines are organisms. Channell presents these polar views in a fascinating chronicle of human thought and achievement, ranging over the discoveries of Galileo, Copernicus, Newton, and Einstein, the philosophies of Plato, Descartes, Kant, and Marx, the fields of alchemy, physics, astrology, and biology. We see not only how the two views progressed independently, but also how they influenced each other, not only how they persisted, but also how they changed. Most fascinating of all, we follow the emergence of a third, all-embracing world view as developments in genetics, relativity, quantum mechanics, and computer intelligence force both science and philosophy to come to a more complex understanding of the universe. As a central metaphor for this third view Channell proposes "the vital machine." And in this stimulating work by the same name, he reveals how this new metaphor may provide us with the philosophical understanding we need to address the ethical issues our science has created. (shrink)

IntroductionApproaches to improve heart rate variability and reduce stress such as breathing retraining are more frequently being integrated into psychotherapy but little research on their effectiveness has been done to date. Specifically, no studies to date have directly compared using a breathing pacer at 6 breaths per minute with compassion focused soothing rhythm breathing.Current StudyIn this randomized controlled experiment, 6 breaths per minute breathing using a pacer was compared with compassion focused soothing rhythm breathing, with a nature video being used (...) as a control group condition.MethodsHeart rate variability measures were assessed via electrocardiogram and respiration belt, and an automated blood pressure machine was used to measure systolic diastolic blood pressure, and heart rate. A total of 96 participants were randomized into the three conditions. Following a 5-min baseline, participants engaged in either 6 breath per minute breathing, soothing rhythm breathing, or watched a nature video for 10 min. To induce a stressful state, participants then wrote for 5 min about a time they felt intensely self-critical. Participants then wrote for 5 min about a time they felt self-compassionate, and the experiment ended with a 10-min recovery period.ResultsConditions did not significantly differ at baseline. Overall, HRV, as measured by standard deviation of NN intervals, low frequency HRV, and LF/HF ratio, increased during the intervention period, decreased during self-critical writing, and then returned to baseline levels during the recovery period. High frequency HRV was not impacted by any of the interventions. The participants in the 6 breath per minute pacer condition were unable to consistently breathe at that rate and averaged about 12 breaths per minute. Time by Condition analyses revealed that both the 6 breaths per minute pacer and soothing breathing rhythm conditions lead to significantly higher SDNN than the nature video condition during breathing practice but there were no significant differences between conditions in response to the self-critical and self-compassionate writing or recovery periods. The 6 breath per minute pacer condition demonstrated a higher LF HRV and LF/HF ratio than the soothing rhythm breathing condition, and both intervention conditions had a higher LF HRV and LF/HF ratio than the nature video.ConclusionsAlthough the 6 breath per minute pacer condition participants were not able to breath consistently at the low pace, both the participants attempting to breathe at 6 breaths per minute as well as those in the soothing rhythm breathing condition effectively increased HR variability as measured by SDNN, and attempting to breathe at 6 breaths per minute led to the highest LF HRV and LF/HF ratio. Both breathing approaches impacted HRV more than watching a relaxing nature video and can potentially be used as key adjuncts in psychotherapy to aid in regulating physiological functioning, although it appears that consistent breathing practice would be needed. (shrink)

Ion channels mediate ion flux across biological membranes and regulate important organellar and cellular tasks. A recent study revealed the presence of four new proteins, the MIM complex (composed by Mim1 and Mim2), Ayr1, OMC7, and OMC8, that are able to form ion‐conducting channels in the outer mitochondria membrane (OMM). These findings strongly indicate that the OMM is endowed with many solute‐specific channels, in addition to porins and known channels mediating protein import into mitochondria. These solute‐specific channels provide essential pathways (...) for the controlled transport of ions and metabolites and may thus add a further layer of specificity to the regulation of mitochondrial function at the organelle‐cytosol and/or inter‐organellar interface. Future studies will be required to fully understand the way(s) of regulation of these new channels and to integrate them into signaling pathways within the cells. (shrink)

Electrical signaling by neurons depends on the precisely ordered distribution of a wide variety of ion channels on the neuronal surface. The mechanisms underlying the targeting of particular classes of ion channels to specific subcellular sites are poorly understood. Recent studies have identified a new class of protein‐protein interaction mediated by PDZ domains, protein binding modules that recognize specific sequences at the C terminus of membrane proteins. The PDZ domains of a family of synaptic cytoskeleton‐associated proteins, typified by PSD‐95, bind (...) to the intracellular C‐terminal tails of NMDA receptors and Shaker‐type K+ channels. This interaction appears to be important in the clustering and localization of these ion channels at synaptic sites. Recognition of specific C‐terminal peptide sequences by different PDZ domain‐containing proteins may be a general mechanism for differential targeting of proteins to a variety of subcellular locations. (shrink)

The use of cross-media and transmedia-based art installation has generated new ways for the audience to appreciate, understand and experience art. Transmedia, the integration of multiple media forms to augment a single narrative, has not only been largely used in commercial films, but has also been used by artists to communicate their message more effectively. In this article, we explore some remarkable multi-channel video installations and transmedia artworks to highlight how this technology has shaped new uses of technology as (...) a new medium to express artistic concepts. We discuss one artwork, an experimental collaboration between artists and scientists, entitled Reefs on the Edge, which communicates valuable information about climate change to a general audience. (shrink)

In this paper we prove the space of unital qubit channels is a Scott domain. In the process we provide a simple protocol to achieve Holevo capacity for these channels.

Philosophical views of language have traditionally been focused on notions of truth. This is a reconstructive view in that we try to extract from an utterance in context what the sentence and speaker meaning are. This focus on meaning extraction from word sequences alone, however, is challenged by utterances which combine different types of figures. This paper argues that what appears to be a special case of ironic utterances—ironic metaphorical compounds—sheds light on the requirements for psychological plausibility of a theory (...) of communication and thus presents a different view of communication and language to that dominant in philosophy of language. In the view presented here, the hearer does not extract the speaker’s communicative intention from the sequence of words in the utterance, but from other channels, so as to constrain the inferential space for the sentence and speaker meaning. Specifically, we examine an example of ironic metaphor discussed by Stern. He argues that ironic content is logically dependent on metaphorical content, but makes no claims about how psychologically plausible this is in terms of the processing order. We argue that a straightforward translation of logical order into temporal order makes little sense. The primary sticking point is that without a prior understanding of the speaker’s communicative intentions, it is computationally more challenging to process the sub-component meanings. An alternative solution based on communicative channels leads us to a more psychologically plausible account of the structure of communicative acts and intentions. This provides support for the psychological realism of a richer theory of communicative intent. (shrink)

Associated with the sharing economy, collaborative consumption behaviors often take place among customers. Different from the traditional consumption that customers purchase the product and own it, in the sharing economy, customers can access the product only for a particular period and the ownership of the product also belongs to the firm. In this paper, we develop a theoretical analysis model, and investigate the intrinsic connection between collaborative consumption and the sharing channel strategy. Adopting the sharing channel strategy, the (...) firm has a chance to expand the market demand and improve its profit. In addition, we examine the impacts of other influential factors on a firm’s decisions, such as the unit product cost, surplus-value, and service capability coefficient. (shrink)

Media critics invariably disparage the quality of programming produced by the U.S. television industry. But why the industry produces what it does is a question largely unasked. It is this question, at the crux of American popular culture, that Switching Channels explores.

The developmental properties of organisms play important roles in the generation of variation necessary for evolutionary change. But how can individual development steer the course of evolution? To answer this question, we introduce developmental channeling as a disposition of individual organisms that shapes their possible developmental trajectories and evolutionary dappling as an evolutionary outcome in which the space of possible organismic forms is dappled—it is only partially filled. We then trace out the implications of the channeling-dappling framework for contemporary debates (...) in the philosophy of evolution, including evolvability, reciprocal causation, and the extended evolutionary synthesis. (shrink)

Analysis of three kinds of flow of viscous, incompressible, electrically conducting fluids in high-aspect-ration rectangular channels subjected to transverse magnetic fields: turbulent flow in the presence of a d-c magnetic field, and both laminar and turbulent induction-driven flows.

The identification of additional subunits of the cGMP-gated cation channel suggests exciting questions about their regulatory roles and about structure/functional relationships. How do the different subunits interact? How is the complex assembled into the plasma membrane? Divalent cations have been implicated in the regulation of adaptation. One often overlooked cation is magnesium. Could this ion play a role in phototransduction?

An increasing number of studies indicate that changes in cytosolic free Ca2+ ([Ca2+]c) mediate specific types of signal transduction in plant cells. Modulation of [Ca2+]c is likely to be achieved through changes in the activity of Ca2+ channels, which catalyse passive influx of Ca2+ to the cytosol from extracellular and intracellular compartments. Voltage‐sensitive Ca2+ channels have been detected in the plasma membranes of algae, where they control membrane electrical properties and cell turgor. These channels are sensitive to 1,4‐dihydropyridines, which in (...) animal cells specifically affect one class of voltage‐regulated plasma membrane Ca2+ channel. Ca2+‐permeable channels with different pharmacological properties have been found in the plasma membrane of higher plants. Recent evidence suggests the existence of two discrete classes of Ca2+ channel co‐resident in the vacuolar membrane (tonoplast) of higher plants. The first is gated by inositol 1,4,5‐trisphosphate, and bears a number of similarities to its animal counterpart which is located in the endoplasmic reticulum (ER). The second tonoplast Ca2+ channel is voltage‐operated. However, the specific roles of these tonoplast channels in signal transduction have yet to be elucidated. (shrink)

Current research in molecular epidemiology uses biomarkers to model the different disease phases from environmental exposure, to early clinical changes, to development of disease. The hope is to get a better understanding of the causal impact of a number of pollutants and chemicals on several diseases, including cancer and allergies. In a recent paper Russo and Williamson address the question of what evidential elements enter the conceptualisation and modelling stages of this type of biomarkers research. Recent research in causality has (...) examined Ned Hall’s distinction between two concepts of causality: production and dependence. In another recent paper, Illari examined the relatively under-explored production approach to causality, arguing that at least one job of an account of causal production is to illuminate our inferential practices concerning causal linking. Illari argued that an informational account solves existing problems with traditional accounts. This paper follows up this previous work by investigating the nature of the causal links established in biomarkers research. We argue that traditional accounts of productive causality are unable to provide a sensible account of the nature of the causal link in biomarkers research, while an informational account is very promising. (shrink)

Expert Systems (ES) are as yet imperfectly defined. Their two consistently cited characteristics are domain knowledge and expert-level performance. We propose that current structural definitions are inadequate and suggest a view of ES as communication channels. We proceed to explore the factors influencing applicability of ES technology to an enterprise and the impacts that could be expected. A consequence of this view is the idea of incremental information loss on the path from the expert to the ES user. Strategies for (...) minimizing this loss derive naturally from our perspective and are evident in successful ES. (shrink)

Culture and social structure may affect the testosterone–behavior link by shaping the way we construe events; by muting, channelling, or amplifying the drives that testosterone produces; and by affecting the distribution and level of testosterone in various parts of the population. Research on testosterone, culture, and social class has produced suggestive results, opening broad areas for research.

This article presents an overview of the single-channel dereverberation methods suitable for distant speech recognition application. The dereverberation methods are mainly classified based on the domain of enhancement of speech signal captured by a distant microphone. Many single-channel speech enhancement methods focus on either denoising or dereverberating the distorted speech signal. There are very few methods that consider both noise and reverberation effects. Such methods are discussed under a multistage approach in this article. The article concludes with a (...) hypothesis that the methods that do not require an a priori reverberation impulse response is desirable in varying the environmental conditions for DSR applications such as intelligent home and office environments, humanoid robots, and automobiles rather than the methods that require an a priori reverberation impulse response. (shrink)

The cyclic GMP-gated channel responds to changes in free intracellular cGMP, and as a result, it plays a central role in the phototransduction process in rod and cone photoreceptor cells. Recent biochemical, immunochemical, and molecular biology studies indicate that this channel consists of a complex of two distinct subunits and one or more associated proteins. Primary structural analysis indicates that the a and (3 subunits contain a cGMP-binding domain, an even number of membrane-spanning segments, a voltage sensor motif (...) and a pore region. The latter two features are found in voltage-gated channels and suggest that these two classes of channels have evolved from the same ancestral channel protein. A working model for the membrane topography of the channel subunits is proposed based on immunogold labeling studies and sequence analysis. Recent studies also indicate that calmodulin binds to the 240 kDa protein of the channel complex and modulates the sensitivity of the channel for cGMP in a Ca2+-dependent manner. The molecular properties of the channel complex and the possible role of Ca2+-calmodulin modulation of the channel during photoactivation and photorecovery are discussed in relation to the current mechanism of phototransduction in photoreceptor cells. (shrink)

Chloride channels are probably found in every cell, from bacteria to mammals. Their physiological tasks range from cell volume regulation to stabilization of the membrane potential, signal transduction, transepithelial transport and acidification of intracellular organelles. These different functions require the presence of many distinct chloride channels, which are differentially expressed and regulated by various stimuli. These include various intracellular messengers (like calcium and cyclic AMP), pH, extracellular ligands and transmembrane voltage. Three major structural classes of chloride channels are known to (...) date, but there may be others not yet identified. After an overview of the general functions of chloride channels, this review will focus on these cloned chloride channels: the CLC chloride channel family, which includes voltage‐gated chloride channels, and the cystic fibrosis transmembrane regulator (CFTR), which performs other functions in addition to being a chloride channel. Finally, a short section deals with GABA and glycine receptors. Diseases resulting from chloride channel defects will be specially emphasized, together with the somewhat limited information about how these proteins work at the molecular level. (shrink)

One potentially ethically relevant feature of an utterance is that utterance's influence on the likelihoods that our future discourses wind up with one Stalnakerian ‘common ground’ or body of shared information rather than another. Such likelihoods matter ethically, so the ways our utterances influence them can matter ethically, despite the fact that such influences are often unintended, and often hard to see. By offering a relatively neutral descriptive framework that can enhance our collective sensitivity to and discussion of ethically, socially, (...) and politically important features of language use, this paper contributes to the ethics of language use. It discusses ways in which utterances can influence the likelihoods of future common grounds by deploying one system of categorization rather than another, and argues that language’s effects on the evolution of discourse can affect the paths to and probabilities of different sorts of consensus. (shrink)

With the development of wireless technology, two basic wireless network models that are commonly used, known as infrastructure and wireless ad hoc networks, have been developed. In the literature, it has been observed that channel contention is one of the main reasons for packet drop in WANETs. To handle this problem, this paper presents a routing protocol named CCBR. CCBR tries to determine a least contended path between the endpoints to increase packet delivery ratio and to reduce packet delay (...) and normalized routing overhead. Moreover, throughout the active data section, each intermediate node computes its channel contention value. If an intermediate node detects an increase in channel contention, it notifies the source node. Then the source node determines another least contended route for transmission. The advantages of CCBR are verified in our NS2-based performance study, and the results show that CCBR outperforms ad hoc on-demand distance vector in terms of packet delivery ratio, end-to-end delay, and routing overhead by 4% to 9%. (shrink)

SummaryMuch excitement surrounded the proposal that a family of endo‐lysosomal channels, the two‐pore channels (TPCs) were the long sought after targets of the Ca2+‐mobilising messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, the role of TPCs in NAADP signalling may be more complex than originally envisaged. First, NAADP may not bind directly to TPCs but via an accessory protein. Second, two papers recently challenged the notion that TPCs are NAADP‐regulated Ca2+ channels by suggesting that they are highly selective Na+ channels (...) regulated by the lipid phosphatidylinositol 3,5‐bisphosphate and by ATP. This paper aims critically to evaluate the evidence for TPCs as NAADP targets and to discuss how the new findings fit in with what we know about endo‐lysosomal Ca2+ stores. (shrink)

This paper studies the implication of channel discrepancy between the retail and direct channels in a dual-channel supply chain consisting of one common retailer and two manufacturers in which the manufacturers may have different market powers. Each manufacturer provides a substitutable product and opens an online channel to customers directly. We develop an analytical model to derive the optimal pricing strategies by using game theory and the backward induction method, and we examine related properties under three market (...) power structures while considering channel discrepancy, including the Nash equilibrium, the Manufacturers leader Stackelberg, and the M1 leader Stackelberg models. Numerical simulations are examined to reveal and verify the effect of channel discrepancy on optimal prices, demands, and profits. We find that a higher level of channel discrepancy induces higher prices, demands, and profits for each member in both channels, while this kind of stimulating impact for the leader manufacturer who obtains a higher level of channel discrepancy will be more significant than it is for the other members in the three models. In addition, the profit of the supply chain in the N model is always higher than it is in the MS model, while it may be higher or lower than it is in the M1S model depending on the level of channel discrepancy. (shrink)

To improve the accuracy of the multiple channel integration quality evaluation, this paper proposes a comprehensive evaluation method using the nonlinear autoregressive exogenous model and constructs an index system. First, the entropy method is used to determine the objective weight of each indicator. The indicators used in this paper are process consistency, information consistency, emotional value, procedural value, service structure transparency, online result value, business relevance, and online purchase intention. Second, an improved gray relational analysis algorithm is used to (...) obtain the comprehensive gray relational degree between the above eight indicators’ standard samples and the tested samples. Then, this study uses the dataset preprocessed with the GRA algorithm for training the NARX model. Then, this study uses the trained model to evaluate the quality of multiple channel integration comprehensively. Next, this study uses standardized methods to quantify the evaluation results to provide new ideas and theoretical guidance for teaching traditional retailers to use the advantages of multiple channels to expand their online business. This paper uses 50,000 consecutive samples of a product for 3 months as a dataset in the experimental part. Through the GRA method and the NARX model, the comprehensive gray relational degree between the test sample and the ideal sample is obtained, and the results are quantified. Experiments show that, compared with the GRA method, this paper’s method has a higher degree of fit between the output value and the target value. (shrink)

Ion channels play key roles in the generation and propagation of nerve impulses by mediating ionic fluxes across excitable membranes. Elucidation of the structure and function of these proteins is a major goal in understanding the molecular mechanisms of membrane excitability. Much work has focused on sodium channels, whose activity is of primary importance in producing nerve impulses. Despite the recent cloning and sequencing of a sodium channel structural gene, many unanswered questions remain. To address some of these question (...) genetically, Drosophila mutants with altered sodium channels are being isolated and subjected to multidisciplinary analyses. Ultimately, these can provide novel approaches for understanding the function and regulation of sodium channels at a molecular level. (shrink)

Polish intellectual historian Leszek Kołakowski proposed in the 1960s an innovative, now virtually forgotten, reimagining of a crucial concept in the history of Roman Catholicism: the idea of "Counter-Reformation." Kołakowski's lifelong affinity for early modern Europe's Catholic dissidents led him into dialogue in the era of Vatican II with Tadeusz Mazowiecki, the leader of a movement of young Polish reformers who styled themselves "Catholic socialists." Seeing them as the bedrock of a new Catholic Counter-Reformation, Kołakowski sketched the role he hoped (...) Poland might play in reinventing not only Catholicism, but religious life in the modern world. (shrink)

Philosophy and Phenomenological Research, Volume 104, Issue 1, Page 171-185, January 2022.

In special application scenarios, such as portable anesthesia depth monitoring, portable emotional state recognition and portable sleep monitoring, electroencephalogram (EEG) signal acquisition equipment is required to be convenient and easy to use. It is difficult to remove electrooculogram (EOG) artifacts when the number of EEG acquisition channels is small, especially when the number of observed signals is less than that of the source signals, and the overcomplete problem will arise. The independent component analysis (ICA) algorithm commonly used for artifact removal (...) requires the number of basis vectors to be smaller than the dimension of the input data due to a set of standard orthonormal bases learned during the convergence process, so it cannot be used to solve the overcomplete problem. The empirical mode decomposition method decomposes the signal into several independent intrinsic mode functions so that the number of observed signals is more than that of the source signals, solving the overcomplete problem. However, when using this method to solve overcompleteness, the modal aliasing problem will arise, which is caused by abnormal events such as sharp signals, impulse interference, and noise. Aiming at the above problems, we propose a novel EEG artifact removal method based on discrete wavelet transform, complete empirical mode decomposition for adaptive noise (CEEMDAN) and ICA in this paper. First, the input signals are transformed by discrete wavelet (DWT), and then CEEMDAN is used to solve the overcomplete and mode aliasing problems, meeting the a priori conditions of the ICA algorithm. Finally, the components belonging to EOG artifacts are removed according to the sample entropy value of each independent component. Experiments show that this method can effectively remove EOG artifacts while solving the overcomplete and modal aliasing problems. (shrink)

A session-based recommendation system is designed to predict the user’s next click behavior based on an ongoing session. Existing session-based recommendation systems usually model a session into a sequence and extract sequence features through recurrent neural network. Although the performance is greatly improved, these procedures ignore the relationships between items that contain rich information. In order to obtain rich items embeddings, we propose a novel Recommendation Model based on Multi-channel Convolutional Neural Network for session-based recommendation, RMMCNN for brevity. Specifically, (...) we capture items' internal features from three dimensions through multi-channel convolutional neural network firstly. Next, we merge the internal features with external features obtained by a GRU unit. Then, both internal features and external features are merged by an attention mechanism together as the input of the transformation function. Finally, the probability distribution is taken as the output after the softmax function. Experiments on various datasets show that our method's precision and recommendation performance are better than those of other state-of-the-art approaches. (shrink)