In the half century since the formulation of the prokaryote : eukaryote dichotomy, many authors have proposed that the former evolved from something resembling the latter, in defiance of common (and possibly common sense) views. In such ‘eukaryotes first’ (EF) scenarios, the last universal common ancestor is imagined to have possessed significantly many of the complex characteristics of contemporary eukaryotes, as relics of an earlier ‘progenotic’ period or RNAworld. Bacteria and Archaea thus must have lost these complex features secondarily, through (...) ‘streamlining’. If the canonical three-domain tree in which Archaea and Eukarya are sisters is accepted, EF entails that Bacteria and Archaea are convergently prokaryotic.We ask what this means and how it might be tested. (shrink)

In this chapter, I shall consider a number of connections between various ideas of the theory of styles of reasoning and the issue of the contingency and inevitability of science. By ‘contingency issue’ it is meant the question as to whether the history of a particular branch of our science could have taken a different route and provided results incompatible with those of our actual science. Apart from Hacking’s recent comments, the discussions on the contingency issue have not involved the (...) notion of style of reasoning. I will fill this gap in the literature by drawing some important implications for the issue of contingency from the theory of styles of reasoning that I have developed so far. I shall address four fundamental questions. First of all, in the next section I shall discuss to which extent the emergence of styles of reasoning at a certain point of history is a contingent circumstance. In the following section I shall ask whether the endurance of styles of reasoning was inevitable by tackling the connected question as to why the styles are long lasting. Afterwards, I shall focus on the growth of knowledge by dealing with questions such as: if a certain style of reasoning continues to be employed and if Q is a ‘live question’, is science bound to converge on a single answer to Q? Finally, on the basis of my previous reflections I shall look into the question of the convergence of science in the long run. The answers to these questions will rely on some basic assumptions of the theory of style of reasoning and imply a picture of the evolution of sciences in which both contingency and inevitability play a key role. (shrink)

The general structure of Steels & Belpaeme's (S&B's) central premise is appealing. Theoretical stances that focus on one type of mechanism miss the fact that multiple mechanisms acting in concert can provide convergent constraints for a more robust capacity than any individual mechanism might achieve acting in isolation. However, highlighting the significance of complex constraint interactions raises the possibility that some of the relevant constraints may have been left out of S&B's own models. Although abstract modeling can help clarify issues, (...) it also runs the risk of oversimplification and misframing. A more subtle implication of the significance of interacting constraints is that it calls for a close relationship between theoretical and empirical research. (shrink)

Emphatic claims of a “microbiome revolution” aside, the study of the gut microbiota and its role in organismal development and evolution is a central feature of so-called postgenomics; namely, a conceptual and/or practical turn in contemporary life sciences, which departs from genetic determinism and reductionism to explore holism, emergentism and complexity in biological knowledge-production. This paper analyses the making of postgenomic knowledge about developmental symbiosis in Drosophila melanogaster by a specific group of microbiome scientists. Drawing from both practical philosophy of (...) science and Science and Technology Studies, the paper documents epistemological questions of artefactuality and representativeness of model organisms as they emerge in the day-to-day labour producing and being produced by the “microbiome revolution." Specifically, the paper builds on all the written and editorial exchanges involved in the troubled publication of a research paper studying the symbiotic role of the microbiota in the flies’ development. These written materials permit us to delimit the network of justifications, evidence, standards of knowledge-production, trust in the tools and research designs that make up the conditions of possibility of a postgenomic fact. More than reframing the organism as a radically novel multiplicity of reactive genomes, we conclude, doing postgenomic research on the microbiota and symbiosis means producing a story that deviates from the scripts embedded into the sociotechnical experimental systems of post-Human Genome Project life sciences. (shrink)

A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron‐rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution (...) are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification. (shrink)

Recent sequencing of the metazoan Oikopleura dioica genome has provided important insights, which challenges the current understanding of eukaryotic genome evolution. Many genomic features of O. dioica show deviation from the commonly observed trends in other eukaryotic genomes. For instance, O. dioica has a rapidly evolving, highly compact genome with a divergent intron‐exon organization. Additionally, O. dioica lacks the minor spliceosome and key DNA repair pathway genes. Even with a compact genome, O. dioica contains tandem repeats, comparable to other eukaryotes, (...) and shows lineage‐specific expansion of certain protein domains. Here, we review its genomic features in the context of current knowledge, discuss implications for contemporary biology and identify areas for further research. Analysis of the O. dioica genome suggests that non‐adaptive forces such as elevated mutation rates might influence the evolution of genome architecture. The knowledge of unique genomic features and splicing mechanisms in O. dioica may be exploited for synthetic biology applications, such as generation of orthogonal splicing systems. (shrink)

Current climate change has raised concerns over the fate of the stenothermal Antarctic marine fauna (animals that evolved to live in narrow ranges of cold temperatures). The present paper focuses on Notothenioidei, a taxonomic group that dominates Antarctic fish. Notothenioids evolved in the Southern Ocean over the last 20 million years, providing an example of a marine species flock with unique adaptations to the cold at morphological, physiological and biochemical levels. Their phenotypic modifications are often accompanied by ‘irreversible’ genomic losses (...) or gene amplifications. On a micro‐evolutionary scale, relatively ‘shallow’ genetic variation is observed, on account of past fluctuations in population size, and a significant genetic structure is evident, suggesting low population connectivity. These features suggest that Antarctic fish might have relatively little potential to adapt to global warming, at least at a genetic level. The extent of their phenotypic plasticity, which is evident to some degree, awaits further research. (shrink)

Current climate change has raised concerns over the fate of the stenothermal Antarctic marine fauna (animals that evolved to live in narrow ranges of cold temperatures). The present paper focuses on Notothenioidei, a taxonomic group that dominates Antarctic fish. Notothenioids evolved in the Southern Ocean over the last 20 million years, providing an example of a marine species flock with unique adaptations to the cold at morphological, physiological and biochemical levels. Their phenotypic modifications are often accompanied by ‘irreversible’ genomic losses (...) or gene amplifications. On a micro‐evolutionary scale, relatively ‘shallow’ genetic variation is observed, on account of past fluctuations in population size, and a significant genetic structure is evident, suggesting low population connectivity. These features suggest that Antarctic fish might have relatively little potential to adapt to global warming, at least at a genetic level. The extent of their phenotypic plasticity, which is evident to some degree, awaits further research. (shrink)

In contrast to vertical gene transfer from parent to offspring, horizontal (or lateral) gene transfer moves genetic information between different species. Bacteria and archaea often adapt through horizontal gene transfer. Recent analyses indicate that eukaryotic genomes, too, have acquired numerous genes via horizontal transfer from prokaryotes and other lineages. Based on this we raise the hypothesis that horizontally acquired genes may have contributed more to adaptive evolution of eukaryotes than previously assumed. Current candidate sets of horizontally acquired eukaryotic genes may (...) just be the tip of an iceberg. We have recently shown that adaptation of the thermoacidophilic red algaGaldieria sulphurariato its hot, acid, toxic‐metal laden, volcanic environment was facilitated by the acquisition of numerous genes from extremophile bacteria and archaea. Other recently published examples of horizontal acquisitions involved in adaptation include ice‐binding proteins in marine algae, enzymes for carotenoid biosynthesis in aphids, and genes involved in fungal metabolism.Editor's suggested further reading in BioEssaysJumping the fine LINE between species: Horizontal transfer of transposable elements in animals catalyses genome evolution Abstract. (shrink)

Biologists have long theorized about the evolution of life cycles, meiosis, and sexual reproduction. We revisit these topics and propose that the fundamental difference between life cycles is where and when multicellularity is expressed. We develop a scenario to explain the evolutionary transition from the life cycle of a unicellular organism to one in which multicellularity is expressed in either the haploid or diploid phase, or both. We propose further that meiosis might have evolved as a mechanism to correct for (...) spontaneous whole‐genome duplication (auto‐polyploidy) and thus before the evolution of sexual reproduction sensu stricto (i.e. the formation of a diploid zygote via the fusion of haploid gametes) in the major eukaryotic clades. In addition, we propose, as others have, that sexual reproduction, which predominates in all eukaryotic clades, has many different advantages among which is that it produces variability among offspring and thus reduces sibling competition. (shrink)

Marine interstitial environments are teeming with an extraordinary diversity of coexisting microeukaryotic lineages collectively called “meiofauna.” Interstitial habitats are broadly distributed across the planet, and the complex physical features of these environments have persisted, much like they exist today, throughout the history of eukaryotes, if not longer. Although our general understanding of the biological diversity in these environments is relatively poor, compelling examples of developmental heterochrony (e.g., pedomorphosis) and convergent evolution appear to be widespread among meiofauna. Therefore, an improved understanding (...) of meiofaunal biodiversity is expected to provide some of the deepest insights into the following themes in evolutionary biology: (i) the origins of novel body plans, (ii) macroevolutionary patterns of miniaturization, and (iii) the intersection of evolution and community assembly – e.g., “community convergence” involving distantly related lineages that span the tree of eukaryotes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Can Creatures Cause Forms?Aquinas on Cosmology and EvolutionLucas PrietoThus formulated, the question may seem odd. It is enough to look at nature to see that many of the relations that are established between substances are causal relations that results in the production of a form. So, for example, the fire from a match in contact with a piece of paper produces fire, in such a way that the agent (...) causes a new form because it communicates its own actuality. In this sense, at the natural level, we can even say that all production involves the causation of a form. The question becomes meaningful, however, when we distinguish between being the cause of this form inasmuch as it actualizes a matter and being the cause of the form as such—that is, between causing a particular order in a matter and being the cause of the reason for this order.1 Continuing with the example: the fire of the match is specifically the same as the fire found in the paper, so that the former cannot be the cause per se of the fire of the latter—that is, the fire of the match is not that which gives reason for the formality of the fire—because in that case it would be the cause of its own formality. The argument leads us to postulate another agent that is the cause of fire as such.So, we can now ask: can creatures be ultimately responsible (at the created level) for this particular ontological configuration? That is, can creatures cause a natural form as such? Aquinas answers yes, and his answer is of particular importance in explaining the causal order among creatures [End Page 441] and the possibility of true specific novelty in the universe. In this article I will advance how Aquinas justifies ontological novelty by resorting to intra-mundane causes and then show how this causal model allows us to understand the transformism of species (evolution) in a Thomistic framework. To do so, we will formulate our argument in three steps: (1) first we will analyze the notion of form that Aquinas handles in order to understand also how it can be caused in an individual, (2) then we will study the various ways in which the causation of a form can occur, and (3) finally, we will apply these conclusions to the problem of evolution.Form and IndividualFor Aquinas, form is a fundamental ontological principle of the corporeal entity because it structures matter according to a determined order of perfection. By the form we can distinguish between different entities because a formal perfection supposes a certain term or limit of the act that implies the deprivation of the perfection of another form. A dog indicates a certain degree of perfection, but by the fact of being a dog it lacks the perfection of being a cat. Now, in the physical world, we find an innumerable diversity of entities that differ from each other not only in their form or essence, but also as individuals, which shows that, ultimately, the fundamental distinction is not between being a cat and being a dog, but between being this cat and being this dog, or more clearly, between this dog and that dog. Aquinas holds that this diversity and inequality, both specific and numerical, is something positively willed and caused by God as first agent.2 But does this mean that the diverse structuring of matter is produced by a special divine action? That is, is the formal difference the effect of a creative act of God?In the Summa theologiae, Thomas directly addresses this problem by asking whether creation is mixed in the works of nature and of the arts, which is equivalent, in the last analysis, to the question of the origin of novelty in the physical world.3 Indeed, when an entity is generated, a substance appears that is not absolutely contained in the preceding causes. The agent certainly communicates his actuality by resembling the effect to himself, but in the effect, there is always something else that escapes the essential principles. Therefore, how can this novelty of the effect be founded? Before answering this question... (shrink)

The field of language evolution has recently made Gricean pragmatics central to its task, particularly within comparative studies between human and non-human primate communication. The standard model of Gricean communication requires a set of complex cognitive abilities, such as belief attribution and understanding nested higher-order mental states. On this model, non-human primate communication is then of a radically different kind to ours. Moreover, the cognitive demands in the standard view are also too high for human infants, who nevertheless do engage (...) in communication. In this paper I critically assess the standard view and contrast it with an alternative, minimal model of Gricean communication recently advanced by Richard Moore. I then raise two objections to the minimal model. The upshot is that this model is conceptually unstable and fails to constitute a suitable alternative as a middle ground between full-fledged human communication and simpler forms of non-human animal communication. (shrink)

The cryptomonads and chlorarachniophytes are two unicellular algal lineages with complex cellular structures and fascinating evolutionary histories. Both groups acquired their photosynthetic abilities through the assimilation of eukaryotic endosymbionts. As a result, they possess two distinct cytosolic compartments and four genomes—two nuclear genomes, an endosymbiont‐derived plastid genome and a mitochondrial genome derived from the host cell. Like mitochondrial and plastid genomes, the genome of the endosymbiont nucleus, or ‘nucleomorph’, of cryptomonad and chlorarachniophyte cells has been greatly reduced through the combined (...) effects of gene loss and intracellular gene transfer. This article focuses on the structure, function, origin and evolution of cryptomonad and chlorarachniophyte nucleomorph genomes in light of recent comparisons of genome sequence data from both groups. It is now possible to speculate on the reasons that nucleomorphs persist in cryptomonads and chlorarachniophytes but have been lost in all other algae with plastids of secondary endosymbiotic origin. BioEssays 29:392–402, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

My hypothesis is that the cognitive challenge posed by death might have had a co-evolutionary role in the development of linguistic faculties. First, I claim that mirror neurons, which enable us to understand others’ actions and emotions, not only activate when we directly observe someone, but can also be triggered by language: words make us feel bodily sensations. Second, I argue that the death of another individual cannot be understood by virtue of the mirror neuron mechanism, since the dead provide (...) no neural pattern for mirroring: this cognitive task requires symbolic thought, which in turn involves emotions. Third, I describe the symbolic leap of the human species as a cognitive detachment from the here and now, allowing displaced reference: through symbols the human mind can refer to what is absent, possible, or even impossible (like the presence of a dead person). Such a detachment has had a huge adaptive impact: adopting a coevolutionary standpoint can help explain why language is as effective as environmental inputs in order to stimulate our bodily experience. In the end I suggest a further coevolutionary reversal : if language is necessary to understand the death of the other, it might also be true that the peculiar cognitive problem posed by the death of the other (the corpse is present, but the other is absent) has contributed to the crucial transition from an indexical sign system to the symbolic level, i.e., the cognitive detachment . Death and language, as Heidegger claimed, have an essential relation for humans, both from an evolutionary and a phenomenological perspective: they have shaped the symbolic consciousness that make us conceive of them. (shrink)

The Tang has often been considered the historical high point of Chinese “cosmopolitanism.” Recent scholarship, however, has been divided on the questions of just how tolerant the era actually was of ethnocultural difference and of whether it represented a turning point in Chinese history toward increasing xenophobia or, on the contrary, toward a less exclusive conception of Chinese identity. This essay suggests that surviving evidence is susceptible to contradictory interpretations on account of its preservation in textual genres characterized by complex (...) motivations that, moreover, changed dramatically over the course of the dynasty. We should not, therefore, uncritically accept statements concerning ethnocultural identity and difference in preserved texts as representative of the thoughts or feelings of even the literati class. A better understanding of the evolution of Chinese attitudes on these questions, instead, will require attention to the ways Tang ideas about texts shaped the attitudes literati felt worthy of expression in them, and how they did so differently in different periods. (shrink)

A strong case has been made for the role and value of mechanistic reasoning in process-oriented sciences, such as molecular biology and neuroscience. This paper shifts focus to assess the role of mechanistic reasoning in an area where it is neither obvious nor expected: population genetics. Population geneticists abstract away from the causal-mechanical details of individual organisms and, instead, use mathematics to describe population-level, statistical phenomena. This paper, first, develops a framework for the identification of mechanistic reasoning where it is (...) not obvious: mathematical and mechanistic styles of scientific reasoning. Second, it applies this framework to demonstrate that both styles are integrated in modern investigations of evolutionary biology. Characteristic of the former, applied population genetic techniques provide statistical evidence for associations between genotype, phenotype, and fitness. Characteristic of the latter, experimental interventions provide causal-mechanical evidence for associations between the very same relationships, often in the same model organisms. The upshot is a richer perspective of how evolutionary biologists build evidence for hypotheses regarding adaptive evolution and a general framework for assessing the scope of mechanistic reasoning across the sciences. (shrink)

Graphical AbstractThe fungus Neurospora comprises a novel model for testing hypotheses involving the role of sex and reproduction in eukaryotic genome evolution. Its variation in reproductive mode, lack of sex-specific genotypes, availability of phylogenetic species, and young sex-regulating chromosomes make research in this genus complementary to animal and plant models.

In this paper I will reconstruct and analyze a famous argument by Stuart Kauffman about complex systems and evolution, in order to highlight the use in theoretical biology of a kind of non-mechanistic and non-causal explanation which I propose to call, following Kauffman, ensemble explanation. The aim is to contribute to the ongoing philosophical debate about non-causal explanations in the special sciences, kinds of explanation apparently extraneous to the received causal-mechanistic view. Ensemble explanations resemble quite closely the explanations of the (...) structural kind proposed by Philippe Huneman, which—unlike mechanistic explanations—do not explain by exposing the causal structure of a phenomenon, but... (shrink)

"Habermas introduces the concept of “reconstructive science” with a double purpose: to place the “general theory of society” between philosophy and social science and reestablish the rift between the “great theorization” and the “empirical research”. The model of “rational reconstructions” represents the main thread of the surveys about the “structures” of the life-world (“culture”, “society” and “personality”) and their respective “functions” (cultural reproductions, social integrations and socialization). For this propose, the dialectics between “symbolic representation” of “the structures subordinated to all (...) worlds of life” (“internal relationships”) and the “material reproduction” of the social systems in their complex (“external relationships” between social systems and environment) has to be considered. This model finds an application, above all, in the “theory of the social evolution”, starting from the reconstruction of the necessary conditions for a phylogeny of the socio-cultural-life forms (the “hominization”) until an analysis of the development of “social formations”, which Habermas subdivides into primitive, traditional, modern and contemporary formations. This paper is an attempt, primarily, to formalize the model of “reconstruction of the logic of development” of “social formations” summed up by Habermas through the differentiation between vital world and social systems (and, within them, through the “rationalization of the life-world” and the “growth in complexity of the social systems”). Secondly, it tries to offer some methodological clarifications about the “explanation of the dynamics” of “historical processes” and, in particular, about the “theoretical meaning” of the evolutional theory’s propositions. Even if the German sociologist considers that the “ex-post rational reconstructions” and “the models system/environment” cannot have a complete “historiographical application”, these certainly act as a general premise in the argumentative structure of the “historical explanation”.". (shrink)

The cerebral cortex controls our most distinguishing higher cognitive functions. Human‐specific gene expression differences are abundant in the cerebral cortex, yet we have only begun to understand how these variations impact brain function. This review discusses the current evidence linking non‐coding regulatory DNA changes, including enhancers, with neocortical evolution. Functional interrogation using animal models reveals converging roles for our genome in key aspects of cortical development including progenitor cell cycle and neuronal signaling. New technologies, including iPS cells and organoids, offer (...) potential alternatives to modeling evolutionary modifications in a relevant species context. Several diseases rooted in the cerebral cortex uniquely manifest in humans compared to other primates, thus highlighting the importance of understanding human brain differences. Future studies of regulatory loci, including those implicated in disease, will collectively help elucidate key cellular and genetic mechanisms underlying our distinguishing cognitive traits. (shrink)

This paper explores the perversion of reality in the context of advanced technologies, such as AI, VR, and AR, through the lens of Jean Baudrillard’s theory of hyperreality and the precession of simulacra. By examining the transformative effects of these technologies on our perception of reality, with a particular focus on the usage of digital avatars, the paper highlights the blurred distinction between the real and the simulated, where the copy becomes more ‘real’ than the original. Drawing on Baudrillard’s concept (...) of hyperreality, the paper delves into the perversion of reality as individuals seek refuge in virtual pleasure paradises and embrace artificial pleasures through their digital avatars, disconnecting from genuine human experiences. The convergence of AI, VR, and AR technologies amplifies this hyperreal condition, where digital avatars mimic or surpass the depth of human relationships, challenging our understanding of what is real. In line with Baudrillard’s theory, the paper explores the objectification and commodification of reality within digital spaces, specifically examining the digital avatars’ role in the erosion of genuine human connections. It explores the implications of these avatars in terms of consent, exploitation, and loss of authenticity, echoing Baudrillard’s concerns about the distortion of reality in contemporary society. Recognizing the implications of these technologies, the paper calls for a critical reflection on their transformative power. It emphasizes the need for a nuanced understanding of the hyperreal condition and ethical responsibility in engaging with AI, VR, and AR, particularly in relation to the usage of digital avatars. By resisting the seductive allure of digital escapism and preserving genuine human connections, we can navigate the perversion of reality and cultivate empathy, compassion, and meaningful interactions that transcend the simulated experiences offered by technology. (shrink)

In this contribution I will retrace the main stages of my research on the objectification problem in quantum mechanics by highlighting some personal memories of my supervisor, the theoretical physicist Giovanni Morchio. The central aim of my MSc thesis was to ask whether the hypothesis of objectification, which is currently added to the formalism, is not, at least in one case, deducible from it and in particular from the dynamics of the temporal evolution. The case study we were looking for (...) had to: 1) represent a situation similar to that in which a macroscopic system such as a measurement apparatus, following interaction with a system, assumes a well-defined state (which or for example represents the fact that the result of a measurement is a particular value), i.e becomes objective 2) represent a fact in nature in which it is not clear whether its explanation can be derived from the formalism of quantum mechanics or whether a hypothesis of objectification is necessary for its explanation. Proving that such a fact can be deduced from the time evolution of quantum mechanics allowed us to conclude that there are cases in which the hypothesis of objectification is superfluous or, in other words, obtainable from the formalism. (shrink)

The goal of this dissertation is twofold. First, we aim to identify the source of distributivity in natural language. Our hypothesis is that throughout the grammar, distributivity can be tracked down to a single operator. Two converging lines of reasoning help us identify this operator. One line emerges as a result of generalizing and unifying previously disparate treatments of distributivity in the domain of nominal quantifiers. The other line comes from analyzing the meaning of durative adverbials, with special attention to (...) their interaction with cumulative readings. Second, we aim to provide a unified formal semantic framework for the treatment of interactions between verbs and their arguments, most importantly aspect, plurality, and quantification, and to shed light on the way in which thematic arguments are associated with the verb in the lexicon and in the compositional process. Although existing frameworks deal with parts of this picture, no such unified framework exists to date. The theoretical results presented in this proposal include a novel argument in favor of a quantificational analysis of durative adverbials (Dowty, 1979; Moltmann, 1991); a novel account of cumulativity and distributivity that covers both the two-quantifier and three-quantifier case in the nominal domain, including readings prominently discussed by Schein (1993); a reason for severing not only the external, but also the internal argument from the semantics of the verb, in response to Kratzer (1996); and the first event-based semantics for Tree-adjoining grammar (TAG, Joshi et al., 1975). (shrink)

Thomas Kuhn’s relativistic position is usually expounded in terms of its subjectivist and irrationalist consequences and, accordingly, as a contribution to anti-scientificism. This paper explains his pluralism in semantics and ontology and shows in it a kind of relativism from which those consequences do not follow. It is also argued that, despite that, this version does not converge to empiricism or scientific realism.

Après avoir introduit la notion d’espace public dans le contexte de la « théorie générale de la société » avec laquelle Habermas a entrepris une reconstruction de l’évolution des systèmes sociaux et, aussi, de la naissance de la sphère publique au cœur des sociétés bourgeoises et des changements à travers et au-delà des sociétés de masse, cet article se propose d’élaborer un cadre analytique du modèle habermasien de la sphère politique publique, décrivant aujourd’hui sa structure et ses fonctions spécifiques, par (...) rapport à la société civile et au système politique (fonctions de «caisse de résonance », « filtre », « contrôle » et « pression de rationalisation »). Dans un effort pour clarifier le «sens critique» d’un modèle de recherche « normatif » dans son contenu, mais suffisamment « réaliste », Habermas remonte à deux questions essentielles pour des sciences de la communication: a) l’indépendance des médias de masse; et b) les leur effets sur l’auditoire. Ce passage permet de mettre en évidence la « structure » et la « qualité » de la discussion publique. (shrink)

In August of 2018, the results of the largest genomic investigation in human history were published. Scanning the DNA of over one million participants, a genome‐wide association study was conducted to identify genetic variants associated with the number of years of education a person has completed. This measure, called “educational attainment,” is often treated as a proxy for intelligence and cognitive ability. The study raises a host of hard philosophical questions about study design and strength of evidence. It also sets (...) the basis for something far more controversial. Using a new genomic method that generates “polygenic scores,” researchers are now able to use the results of the study to predict a person's educational potential from a blood or saliva sample. Going a step further, some researchers have begun to promote “precision education,” which would tailor students’ school plans to their genetic profiles. The idea of precision education provokes concerns about stigma and self‐fulfilling prophecies. (shrink)

This article intends to be a simple guide to understand how Hoppe built the Argumentation Ethics. In my early studies of libertarian ideas, and of Argumentation Ethics in particular, I could not find a unique text that would explain how Hoppe put the necessary bricks together to build the Ethics. As I was curious about this issue, I assumed others would also like to know it. To write this article, I reviewed the main literature on Argumentation Ethics, starting with Kinsella’s (...) Concise Guide [9]. Then, I interviewed Stephan Kinsella and Prof. Walter Block. Finally, I synthesized the main ideas from the literature and the interviews elaborating an interpretative model, presented in this article. (shrink)

The discoveries, advancements and continuing controversies in the field of molecular evolution are reviewed. Topics summarized are (1) the evolution of the genetic code, (2) gene evolution including the demonstration of homology, estimation of sequence divergence, phylogenetic trees, the molecular clock and the origin of genes and gene families by various genetic mechanisms, and (3) eukaryotic genome evolution, including the highly repeated satellite sequences, the interspersed and potentially mobile repeated sequences and the unique sequence fraction of the genome.

This paper explores the intersection of René Girard's mimetic theory and the algorithmic society, particularly in the context of the potential advent of Artificial General Intelligence (AGI). Girard's theory, which elucidates the dynamics of desire, rivalry, scapegoating, and the sacrificial crisis, provides a unique lens through which to examine the complexities of our relationship with AI and its role in the creation of the sacred. As individuals increasingly rely on AI recommendations, the distinction between personal choice and algorithmic manipulation becomes (...) less clear, raising concerns about the authenticity of cultural expressions and the role of algorithms in shaping cultural narratives. The triangular structure of desire, with AI as the model and individuals as the imitators, underscores the power of algorithms in this process. The sacrificial crisis, a key concept in Girard's theory, becomes a critical point of reflection in the algorithmic society. The exposure of the scapegoating mechanism reveals the destructive potential of algorithmic manipulation and calls for new forms of understanding, empathy, and non-violent solutions. This paper argues that recognizing the sacrificial crisis can prompt individuals and society to critically examine the impact of AI's influence, challenge the narratives it perpetuates, and reclaim agency in the face of algorithmic dominance. This paper further discusses the potential implications of the emergence of AGI, which could intensify the influence of algorithms on the creation of the sacred due to its advanced cognitive capabilities and deep understanding of human desires and behaviors. This could fuel a rapid evolution of the mimetic ecosystem, with profound implications for personal freedom, independent decision-making, and the formation and preservation of individual identity. This paper concludes by emphasizing the need for responsible algorithmic practices and ethical considerations to ensure that the creation of the sacred serves the common good in the algorithmic society. (shrink)

ABSTRACT (ENG) The recent evolution of the most advanced societies is characterized by the increasing use of hypertext. The latter is an electronic text with hyperlinks to other text that a user can immediately access. The World Wide Web itself is a sort of global hypertext that can be viewed as a network of nodes, represented by individual elements connected through the so-called links. In this paper, I ask myself in what sense reading with new technologies is a different cognitive (...) experience from reading a printed text. In the first part, I examine the conditions that made the emergence of hypertext possible by examining some mutations in human thought. In the second part, I argue that the emergence of hypertext has not only made the reading experience different but has also reshaped the figure of the reader. -/- ABSTRACT (ITA) L’evoluzione recente delle società più avanzate è caratterizzata dall’uso crescente dell’ipertesto. Quest’ultimo è un testo elettronico con riferimenti ad altri documenti, accessibili cliccando su parole chiave. Lo stesso World Wide Web una sorta di ipertesto globale che si può immaginare come una rete di nodi, rappresentati da singoli elementi connessi attraverso i cosiddetti link. In questo articolo ci chiediamo in che senso leggere con le nuove tecnologie sia un’esperienza cognitiva differente rispetto a quella di leggere un testo stampato. Nella prima parte esaminiamo le condizioni che hanno reso possibile l’emergere dell’ipertesto considerando alcune mutazioni in seno al pensiero umano. Nella seconda parte argomentiamo che con l’ipertesto è nata una nuova forma di lettura che ha a sua volta costituito una nuova figura di lettore. (shrink)

I argue that ontologies of words should engage with the emergence of lexical communication in the deep history of our line. It may seem that the evolutionary origins of words are orthogonal to the analytical project of establishing the defining features of wordhood, and that an adequate ontology of words requires nothing more than an observation of the properties of modern languages. I suggest instead that models of the initial stages of language evolution can offer valuable insights into the matter. (...) There is consensus that lexical communication was an early achievement in the phylogeny of our language capacities, and that words became available to our ancestors before the maturation of other components of the grammar. At the beginning of their evolutionary trajectory, words are thus likely to have been significantly different from the vocabulary items of contemporary languages. Careful appreciation of such differences could be instrumental to a complete theory of the hallmarks of wordhood. (shrink)

Aquí se analiza la crítica al utopismo realizada por Hans Jonas y se compara su propuesta de una élite responsable con la propuesta platónica de una polis de guardianes-filósofos, para poner de manifiesto el carácter sesgado de su concepción de la responsabilidad. En contrapartida, se ofrece una con..

When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive plasticity is documented for triggers including ischemic, tumoral, and epileptic focal lesions, with effects in clinical practice. Many questions remain regarding language plasticity. Different lesions may induce different patterns of reorganization depending on pathologic features, location in the brain, and timing of onset. Neuroimaging provides insights into language plasticity due to its non-invasiveness, ability (...) to image the whole brain, and large-scale implementation. This review provides an overview of language plasticity on MRI with insights for patient care. First, we describe the structural and functional language network as depicted by neuroimaging. Second, we explore language reorganization triggered by stroke, brain tumors, and epileptic lesions and analyze applications in clinical diagnosis and treatment planning. By comparing different focal lesions, we investigate determinants of language plasticity including lesion location and timing of onset, longitudinal evolution of reorganization, and the relationship between structural and functional changes. (shrink)

In this chapter I shall present two different notions of the concept of ‘ways of thinking’ named ‘style of reasoning’ and ‘epistemic virtue’, which have been proposed, respectively, by Ian Hacking and by Peter Galison and Lorraine Daston. To explain how the former characterizes the notion of style of reasoning, I shall reread his book The Emergence of Probability in terms of the notion of ‘statistical style of reasoning’ and Shapin and Schaffer’s Leviathan and the Air Pump in terms of (...) the notion of ‘laboratory style of reasoning’. My analysis will show that many points of Hacking’s styles project need to be developed in order to make his suggestions into a full-fledged theory. A salient point of my analysis will be that Hacking’s is another of the projects of historical epistemology that historicize Kant. I shall also show that there are substantial convergences between the styles project and Daston and Galison’s study on objectivity. Finally, following Williams’s account of truth and truthfulness, I shall argue that styles of reasoning are ways of telling the truth and ways of looking at the world. (shrink)

Humans have attained an unparalleled level of sophistication when engaging in collaborative and cooperative activities. Remarkably, the skills and motivation to engage in complex forms of collaboration and cooperation seem to emerge early on during infancy and childhood. In this paper, I extensively review the literature on the evolution and development of human cooperation, emphasizing important aspects of inter-cultural variation in collaborative and cooperative behaviour. This will not only allow us to confront the different evolutionary scenarios in which cooperation may (...) have emerged, but will especially provide the reader with a first orientation in the abundant literature on human cooperation. (shrink)

Merleau-Ponty’s notion of expression originates from his interests in the bodily subjectivity and is rooted in his phenomenology of perception, where he discusses language and speech in the light of his notion of embodiment. Yet this first achievement leaves some questions open. In his deepening of the problems of perception Merleau-Ponty is led to relate perception and expression in the light of a renovated investigation of the ontological implications of the former, which also leads to articulate more widely the latter. (...) Merleau-Ponty encounters De Saussure’s diacritical and structural approach to language and integrates it within a processual understanding of Being. In this paper some aspects of the evolution of this themes are discussed and evaluated. (shrink)

Sir Austin Bradford Hill’s ‘aspects of causation’ represent some of the most influential thoughts on the subject of proximate causation in health and disease. Hill compiled a list of features that, when present and known, indicate an increasing likelihood that exposure to a factor causes—or contributes to the causation of—a disease. The items of Hill’s list were not labelled ‘criteria’, as this would have inferred every item being necessary for causation. Hence, criteria that are necessary for causation in health, disease (...) and intervention processes, whether known, knowable, or not, remain undetermined and deserve exploration. To move beyond this position, this paper aims to explore factors that are necessary in the constitution of causative relationships between health, disease processes, and intervention. To this end, disease is viewed as a causative pathway through the often overlapping stages of aetiology, pathology and patho-physiology. Intervention is viewed as a second, independent causative pathway, capable of causing changes in health for benefit or harm. For the natural course of a disease pathway to change, we argue that intervention must not only occupy the same time and space, but must also share a common form; the point at which the two pathways converge and interact. This improved conceptualisation may be used to facilitate the interpretation of clinical observations and inform future research, particularly enabling predictions of the mechanistic relationship between health, disease and intervention. (shrink)

Causation is important when considering how an organism maintains health, why disease arises in a healthy person, and how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that psychological (...) and social constructs be considered objects. We think that this 'biopsychosocial dispositionalism' offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

Causation is important when considering: how an organism maintains health; why disease arises in a healthy person; and, how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that psychological (...) and social constructs be considered objects. We think that this ‘biopsychosocial dispositionalism’ offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

Lucas Matthews and I substantially revised my SEP entry on Heritability. This version includes discussion of the missing heritability problem and other issues that arise from the use of Genome Wide Association Studies by Behavioral Geneticists.

Political metaphors do more than punch up messages; they can systematically bias observers’ attitudes toward the issue at hand. What, then, is an effective strategy for counteracting a metaphor’s influence? One could ignore or criticize the metaphor, emphasizing strong counterarguments directly pertaining to the target issue. Yet if observers rely on it to understand a complicated issue, they may be reluctant to abandon it. In this case, a “metaphor extension” strategy may be effective: Encourage observers to retain the metaphor but (...) reinterpret its meaning by considering other, less obvious implications. The current studies support this claim. Under conditions where participants gained a strong epistemic benefit from a rhetorical metaphor, they were more persuaded by a rebuttal that extended that metaphor. The studies use converging operational definitions of epistemic benefit and offer insight into how political attitudes are made and unmade. (shrink)

DNA methylation constitutes one of the pillars of epigenetics, relying on covalent bonds for addition and/or removal of chemically distinct marks within the major groove of the double helix. DNA methyltransferases, enzymes which introduce methyl marks, initially evolved in prokaryotes as components of restriction‐modification systems protecting host genomes from bacteriophages and other invading foreign DNA. In early eukaryotic evolution, DNA methyltransferases were horizontally transferred from bacteria into eukaryotes several times and independently co‐opted into epigenetic regulatory systems, primarily via establishing connections (...) with the chromatin environment. While C5‐methylcytosine is the cornerstone of plant and animal epigenetics and has been investigated in much detail, the epigenetic role of other methylated bases is less clear. The recent addition of N4‐methylcytosine of bacterial origin as a metazoan DNA modification highlights the prerequisites for foreign gene co‐option into the host regulatory networks, and challenges the existing paradigms concerning the origin and evolution of eukaryotic regulatory systems. (shrink)

Microsatellites are among the most versatile of genetic markers, being used in an impressive number of biological applications. However, the evolutionary dynamics of these markers remain a source of contention. Almost 20 years after the discovery of these ubiquitous simple sequences, new genomic data are clarifying our understanding of the structure, distribution and variability of microsatellites in genomes, especially for the eukaryotes. While these new data provide a great deal of descriptive information about the nature and abundance of microsatellite sequences (...) within eukaryotic genomes, there have been few attempts to synthesise this information to develop a global concept of evolution. This review provides an up‐to‐date account of the mutational processes, biases and constraints believed to be involved in the evolution of microsatellites, particularly with respect to the creation and degeneration of microsatellites, which we assert may be broadly viewed as a life cycle. In addition, we identify areas of contention that require further research and propose some possible directions for future investigation. BioEssays 28: 1040–1050, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

© 2006 Konrad Lorenz Institute for Evolution and Cognition Research.

Using ideas from evolution and postformal stages of hierarchical complexity, a hypothetical scenario, premised on genetic engineering advances, portrays the development of a new humanoid species, Superions. How would Superions impact and treat current humans? If the Superion scenario came to pass, it would be the ultimate genocidal terrorism of eliminating an entire species, Homo Sapiens. We speculate about defenses Homo Sapiens might mount. The tasks to relate two species (systems) constitutes a postformal, Metasystematic task. Developing a system of discourse (...) to prevent destruction requires postformal Paradigmatic-stage tasks. Implications are twofold: species survival and sufficient evolution to survive. (shrink)

The experimental and highly regarded Gifford Lectures at Edinburgh University was endowed in the late nineteenth century. Over the years, participants have including many leading representatives of religion, science, and philosophy. This series has as its subject, The Development of Mind. First published in 1972, the series continues to attract widespread interest. In this volume, contributors argue about the mind from diverse analytical standpoints. The focus of the series remains the relationship between religion, science, and philosophy. This volume attempts to (...) achieve a comprehensive view of the subject of mind. The mental development of children in the light of modern psychology is discussed, and the distinction between "how" and "why" questions is put forward with clarity. The development of mind is further contrasted with the evolution of embryos in the young. The mind is considered as a capacity for intellectual activity, and as a multi-purpose program. Goal-directed behavior and language development are given importance, and issues of cosmic purpose, and the how and why of evolution, are never far from the surface of the argument. The lecturers know their opposition and their positions, and the cut-and-thrust of the discussion has much acumen and wit to it. Issues ranging from the impact of mind on theories of religion, causation, and rational will are examined in an informal, yet compelling, manner. (shrink)