The functions of the Bloom syndrome helicase and its orthologs are well characterized in mitotic DNA damage repair, but their roles within the context of meiotic recombination are less clear. In meiotic recombination, multiple repair pathways are used to repair meiotic DSBs, and current studies suggest that BLM may regulate the use of these pathways. Based on literature from Saccharomyces cerevisiae, Arabidopsis thaliana, Mus musculus, Drosophila melanogaster, and Caenorhabditis elegans, we present a unified model for a critical meiotic role of (...) BLM and its orthologs. In this model, BLM and its orthologs utilize helicase activity to regulate the use of various pathways in meiotic recombination by continuously disassembling recombination intermediates. This unwinding activity provides the meiotic program with a steady pool of early recombination substrates, increasing the probability for a DSB to be processed by the appropriate pathway. As a result of BLM activity, crossovers are properly placed throughout the genome, promoting proper chromosomal disjunction at the end of meiosis. This unified model can be used to further refine the complex role of BLM and its orthologs in meiotic recombination. In meiotic recombination, Blm utilizes its helicase activity to disassemble early recombination intermediates, thereby retaining a pool of recombination sites from which some can be selected to enter the Class I crossover pathway while simultaneously promoting SDSA and preventing the use of the Class II pathway. (shrink)

Although a large literature demonstrates that object‐extracted relative clauses (ORCs) are harder to process than subject‐extracted relative clauses (SRCs), there is less agreement regarding where during processing this difficulty emerges, as well as how best to explain these effects. An eye‐tracking study by Staub, Dillon, and Clifton (2017) demonstrated that readers experience more processing difficulty at the matrix verb for ORCs than for SRCs when the matrix verb immediately follows the relative clause (RC), but the difficulty is eliminated if a (...) prepositional phrase (PP) intervenes. A careful examination of Staub et al.’s materials reveals that the types of PPs used in the experiment were a mixture of locative and temporal PPs. This is important in that locative PPs can modify either a noun phrase or a verb phrase (VP), whereas temporal PPs typically modify VPs, resulting in systematic differences in PP attachment across ORCs versus SRCs. In the current eye‐tracking experiment, we systematically manipulated RC type and PP type in the same sentences used by Staub et al. The manipulation of PP type resulted in a crossover pattern at the matrix verb such that there was a trend for reading times to be longer for ORCs than SRCs when the PP was locative, but reading times were longer for SRCs than ORCs when the PP was temporal. These results provide important information regarding the locus of RC‐processing effects and highlight the importance of carefully considering how intervening material might unintentionally alter the structure or the meaning of a sentence. (shrink)

The Montagovian hypothesis of direct model-theoretic interpretation of syntactic surface structures is supported by an account of the semantics of binding that makes no use of variables, syntactic indices, or assignment functions & shows that the interpretation of a large portion of so-called variable-binding phenomena can dispense with the level of logical form without incurring equivalent complexity elsewhere in the system. Variable-free semantics hypothesizes local interpretation of each surface constituent; binding is formalized as a type-shifting operation on expressions that denote (...) functions, & sentences containing a free pronoun are analyzed as a function from individuals to propositions having a meaning of type (e,t). Standard weak crossover effects & binding patterns in sentences with multiple pronouns are shown to submit to straightforward type-theoretic treatments that do not rely on indexation. The variable-free semantics smoothly implements full surface compositionality & requires less machinery than standard accounts to handle functional questions, their answers, sloppy inferences, & across-the-board binding. 73 References. J. Hitchcock. (shrink)

This paper studies the distribution of ‘list readings’ in questions like who does everyone like? vs. who likes everyone?. More generally, it focuses on the interaction between wh-words and quantified NPs. It is argued that, contrary to widespread belief, the pattern of available readings of constituent questions can be explained as a consequence of Weak Crossover, a well-known property of grammar. In particular, list readings are claimed to be a special case of ‘functional readings’, rather than arising from quantifying (...) into questions. Functional readings are argued to be encoded in the syntax as doubly indexed traces, which straightforwardly leads to a Crossover account of the absence of list readings in who likes everyone?. Empirical and theoretical consequences of this idea for the syntax and semantics of questions are considered. (shrink)

The ‘European Green Deal’ (EGD) is a set of communications from the European Commission that outlines EU roadmap to climate neutrality by 2050. The policy envisions that, with the facilitation of speedy and just ‘green transition’, the goals of environmental protection and economic development can be reconciled. This article offers a language-focused critical study of the EGD. After giving an overview of neoliberal ‘discourses of sustainability’ and explaining the notion of ‘interdiscursivity’ in CDS, it presents the results of a close (...) thematic analysis supported by keyword and concordance analysis of representations of ‘environment’ and ‘climate’ on the one hand, and ‘economy’ and ‘transition’ on the other. This study attends to salient language patterns and reveals how interdiscursive crossovers are established to normalise ‘sustainability’ as the contingency between environmental and economic orders of discourse. Also, it identifies the discursive strategies of nomination, predication, argumentation, perspectivisation and mitigation or intensification and shows how tensions between discourses are smoothened. This analysis of EGD’s ideological hybridity also sheds light onto how EU institutions are (self)authorised to lead actions on environmental challenges on behalf of European citizens. (shrink)

This squib presents a rebuttal to two of King’s (Complex demonstratives: A quantificational account. Cambridge, Mass.: MIT Press, 2001) arguments that complex demonstratives are quantifier phrases like every man. The first is in response to King’s argument that because complex demonstratives induce weak crossover effects, they are quantifier phrases. I argue that unlike quantifier phrases and like other definite determiner phrases, complex demonstratives in object position can corefer with singular pronouns contained in the subject DP. Although complex demonstratives could (...) undergo LF-movement, the ruling out by weak crossover is empirically undetectable. The second rebuttal is in response to King’s argument that because complex demonstratives allow antecedent-contained deletion, they are quantifier phrases. I present data showing that along with quantifier phrases, complex demonstratives pattern with proper names in allowing ACD with restrictive modification, but usually not with non-restrictive modification. (shrink)

BackgroundExercise is primarily sustained by energy derived from lipids, and glucose. Substrate utilization is the pattern by which these fuel sources are used during activity. There are many factors that influence substrate utilization. We aim to delineate the effect of exercise intensity and body composition on substrate utilization.ObjectiveThe objective of our study was to discern the differences in substrate utilization profiles during a maximal and submaximal graded exercise test, and to determine the extent to which body composition influences substrate utilization (...) during the exercise tests.MethodsA total of 27 male athletes, 32.5 ± 11 years of age, were recruited for this study. Body composition was analyzed using a bioelectrical impedance analyzer. Maximal and submaximal exercise tests were performed on a treadmill. A novel graded submaximal treadmill protocol was used for the submaximal test.ResultsAverage percent body fat was 15.8 ± 5%. Average maximal oxygen consumption was 47.6 ± 9 mL/kg/min, while the average exercise intensity at which participants were shifting to glucose predominance for energy during the maximal and submaximal tests were 76 ± 8.3% and 58.4 ± 21.1%, respectively. A paired-samples t-test was conducted to compare percent VO2max at crossover point in maximal and submaximal graded exercise tests. There was a significant difference in percent VO2max at the crossover point for maximal and submaximal tests. A linear regression was performed to elucidate the interaction between exercise intensity at the crossover point and body composition during a maximal and submaximal graded exercise test. There was a significant effect of PBF on percent VO2max at crossover point during the maximal graded exercise test [F = 9.10, P = 0.006] with an R2 of 0.245. However, there was no significant effect of PBF on percent VO2max at crossover point during the submaximal graded exercise test.ConclusionSubstrate utilization, represented by the crossover point, is dependent on the rate of increase in exercise intensity. At maximal efforts, the crossover to carbohydrates from fats as the predominant fuel source occurs at a significantly later stage of percent VO2max than at submaximal efforts. Furthermore, body composition represented by PBF is a significant predictor of substrate utilization during maximal efforts. Athletes with a relatively higher PBF are more likely to have increased lipid oxidation during high intensity exercises than those with a lower body fat percentage. (shrink)

In the realistic world, various individuals have distinct personalities, preferences, and attitudes toward new information and behavior acceptance, called population heterogeneity. It is seldom taken into account and theoretically analyzed in information propagation on a weighted network. Therefore, we divide individuals into fashionable and conservative individuals according to their passion degree and willingness for novel behaviors acceptance. Then, we build two behavior adoption threshold models corresponding to fashionable and conservative individuals on the weighted network to explore the effect of population (...) heterogeneity on information propagation. Next, a partition theory based on edge weight and population heterogeneity is proposed to qualitatively analyze the information propagation mechanism. The theoretical analyses and simulation results show that fashionable individuals promote information propagation and behavior adoption. More importantly, the crossover phenomena of phase transition appear. When the fraction of fashionable individuals is relatively large, the increasing pattern of the final adoption size shows a second-order continuous phase transition. In comparison, the increasing pattern alters to first-order discontinuous phase transition with the decrease of the fraction of fashionable individuals. Moreover, reducing weight distribution heterogeneity promotes information propagation and slightly accelerates the change of the phase transition pattern from the first-order discontinuous to the second-order continuous. Besides, increasing the degree distribution heterogeneity accelerates the change of the phase transition pattern. Finally, our theoretical analyses coincide well with the simulation results. (shrink)

Many of Margaret Cavendish’s criticisms of Thomas Hobbes in the Philosophical Letters (1664) relate to the disorder and damage that she holds would result if Hobbesian pressure were the cause of visual perception. In this paper, I argue that her “two men” thought experiment in Letter IV is aimed at a different goal: to show the explanatory potency of her account. First, I connect Cavendish’s view of visual perception as “patterning” to the “two men” thought experiment in Letter IV. (...) Second, I provide a potential reply on Hobbes’s behalf that appeals to physiological differences between perceivers’ sense organs, drawing upon Hobbes’s optics in De homine. Third, I argue that such a reply would misunderstand Cavendish’s objective of showing the limited explanatory resources available in understanding visual perception as pressing when compared to her view of visual perception as patterning. (shrink)

Secreted signaling molecules act as morphogens to control patterning and growth in many developing tissues. Since locally produced morphogens spread to form a concentration gradient in the surrounding tissue, spreading is generally thought to be the key step in the non‐autonomous actions. Here, we review recent advances in tool development to investigate morphogen function using the role of decapentaplegic (Dpp)/bone morphogenetic protein (BMP)‐type ligand in the Drosophila wing disc as an example. By applying protein binder tools to distinguish between (...) the roles of Dpp spreading and local Dpp signaling, we found that Dpp signaling in the source cells is important for wing patterning and growth but Dpp spreading from this source cells is not as strictly required as previously thought. Given recent studies showing unexpected requirements of long‐range action of different morphogens, manipulating endogenous morphogen gradients by synthetic protein binder tools could shed more light on how morphogens act in developing tissues. (shrink)

Two major works in recent evolutionary biology have in different ways touched upon the issue of cultural replicators in language, namely Dawkins’ Selfish Gene and Maynard Smith and Szathmáry’s Major Transitions in Evolution. In the latter, the emergence of language is referred to as the last major transition in evolution, a claim we argue to be derived from a crucial property of language, called Duality of Patterning. Prima facie, this property makes natural language look like a structural equivalent to (...) DNA, and its peer in terms of expressive power. We will argue that, if one takes seriously Maynard Smith and Szathmáry’s outlook and examines what has been proposed as linguistic replicators, amongst others phonemes and words, the analogy meme-gene becomes problematic. A key issue is the fact that genes and memes are assumed to carry and transmit information, while what has been described as the best candidate for replicatorhood in language, i.e. the phoneme, does by definition not carry meaning. We will argue that semiotic systems with Duality of Pattering force us to reconsider either the analogy between replicators in the biological and the cultural domain, or what it is to be a replicator in linguistics. (shrink)

Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...) Hydra raises the question of whether, in early metazoan evolution, cell–cell communication was based mainly on these small molecules rather than on the growth‐factor‐like cytokines that control differentiation and development in higher animals. BioEssays 23:420–427, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The complex organization of syntax in hierarchical structures is one of the core design features of human language. Duality of patterning refers, for instance, to the organization of the meaningful elements in a language at two distinct levels: a combinatorial level, where meaningless forms are combined into meaningful forms; and a compositional level, where meaningful forms are composed into larger lexical units. The question remains wide open regarding how such structures could have emerged. The aim of this paper is (...) to address these two aspects in a self-consistent way. First, we introduce suitable measures to quantify the level of combinatoriality and compositionality in a language, and we present a framework to estimate these observables in human natural languages. Second, we show that a recently introduced multi-agent modeling scheme, namely the Blending Game, provides a mathematical framework to address the problem of how a population of individuals can bootstrap combinatoriality and compositionality. Theoretical predictions based on this model turn out to be in good agreement with empirical data. It is remarkable that the two sides of duality of patterning emerge simultaneously as a consequence of a pure cultural dynamics in a simulated environment that contains meaningful relations, provided a simple constraint on message transmission fidelity is also considered. (shrink)

Two general features of metameric patterning in Drosophilaare considered: (1) maintenance of a constant number of metameres (segments or parasegments) in the face of variation in length of the embryo; (2) expression of pattern by on‐off switchings of particular genes, with only three or four rows of cells to each element of pattern. For each of these features, the general strategic question is raised: could reaction‐diffusion theory account for this? In both cases, it is answered affirmatively. For the second (...) feature, this review contains some hitherto unpublished computer simulations by one of us (K. Y. T.), illustrating that a reaction‐diffusion mechanism can be transformed into a patterned switching mechanism by nothing more than compartmenting of the diffusion region. For the scale of three compartments to one pattern repeat unit (representing three rows of cells to a segment) the switching pattern predicted by computation is two‐off to one‐on. This resembles the pattern of expression of the engrailed gene, posteriorly localized in each segment. (shrink)

Understanding how and why practices may be transformed is vital for any transition towards socio-environmental sustainability. However, theorising and explaining the role of individual agency in practice change continues to present challenges. In this paper we propose that theories of practice can be usefully combined with a psychosocial framework to explain how agency is biographically patterned and how this patterning is a product of attachment relationships and emergent strategies for dealing with uncertainty. Biographical interview data from the project Energy (...) Biographies is used to illustrate the ways in which this theoretical approach can enhance understanding of how potential for practice change may be opened up or obstructed. (shrink)

Construction of the trunk/caudal region of the vertebrate embryo involves a set of distinct molecules and processes whose relationships are just coming into focus. In addition to the subdivision of the embryo into head and trunk domains, this “caudalisation” process requires the establishment and maintenance of a stem zone. This sequentially generates caudal tissues over a long period which then undergo differentiation and patterning in the extending body axis. Here we review recent studies that show that changes in the (...) signalling properties of the paraxial mesoderm act as a switch that controls onset of differentiation and pattern in the spinal cord. These findings identify distinct roles for different caudalising factors; in particular, Fibroblast Growth Factor (FGF) inhibits differentiation in the caudal stem zone, while Retinoic acid (RA) provided rostrally by somitic mesoderm is required for neuronal differentiation and establishment of ventral neural pattern. Furthermore, the mutual opposition of FGF and RA pathways controls not only neural differentiation but also mesoderm segmentation and might also underlie the progressive assignment of rostrocaudal identity by regulating Hox gene availability and activation. BioEssays 26:857–869, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

In a series of works, different models have shed light on the acoustic properties of air sacs, an organ located in the laryngeal region that is present in all great apes with the exception of humans. These works have shown how the loss of air sacs expands the number of possible digits but not the amount of signals per se. The number of signals in human language increased when the codifying property known as duality of patterning became characteristic of (...) the codifying system, allowing digits to be combined in order for new signals to be codified. A direct relationship between air sacs and duality is presently being plotted, integrating linguistic theory and data from computational models into an evolutionary and developmental perspective of the evolution of modern speech. (shrink)

Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor‐β family member dpp patterns the embryonic dorsalventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp‐4, the dpp homolog, in patterning the dorsalventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal‐ventral patterning in the zebrafish Danio rerio(1). Characterization of these mutations parallels findings from Drosophila, thus establishing (...) a genetic framework for the analysis of dorsalventral patterning in a vertebrate. (shrink)

Selecting a large and diverse sample of 5–6-year-old preschool children, we aimed to extend previous findings on variability in children’s home math environment and its association with children’s mathematical skills. We operationalized mathematics in a broader way than in previous studies, by considering not only children’s numerical skills but also their patterning skills as integral components of early mathematical development. We investigated the effects of children’s gender and socioeconomic status on their home math environment, examined the associations between children’s (...) home math environment and their mathematical skills, and verified whether these associations were moderated by children’s gender and/or SES. Parents of 353 children completed a home math environment questionnaire and all children completed measures of their numerical and patterning skills. Results indicated no effect of children’s gender on their home math environment. There was no effect of SES on the performed home math activities, but small SES differences existed in parents’ math-related expectations and their attitudes. We found no evidence for associations between children’s home math environment and their mathematical skills. Furthermore, there were no moderating effects of gender or SES on these associations. One explanation for these findings might relate to the characteristics of the general preschool system in the country of the present study. Future studies should consider the effect of the preschool learning environment because it might explain differences between studies and countries with regard to the home math environment and its association with mathematical skills. (shrink)

Current phylogenies show that paired fins and limbs are unique to jawed vertebrates and their immediate ancestry. Such fins evolved first as a single pair extending from an anterior location, and later stabilized as two pairs at pectoral and pelvic levels. Fin number, identity, and position are therefore key issues in vertebrate developmental evolution. Localization of the AP levels at which developmental signals initiate outgrowth from the body wall may be determined by Hox gene expression patterns along the lateral plate (...) mesoderm. This regionalization appears to be regulated independently of that in the paraxial mesoderm and axial skeleton. When combined with current hypotheses of Hox gene phylogenetic and functional diversity, these data suggest a new model of fin/limb developmental evolution. This coordinates body wall regions of outgrowth with primitive boundaries established in the gut, as well as the fundamental nonequivalence of pectoral and pelvic structures. BioEssays 20:371–381, 1998. © 1998 John Wiley & Sons Inc. (shrink)

This book analyzes--in terms of branching--the pervasive reorganization of Latin syntactic and morphological structures: in the development from Latin to French, a shift can be observed from the archaic, left-branching structures (which Latin inherited from Proto-Indo-European) to modern right-branching equivalents. Brigitte Bauer presents a detailed analysis of this development based on the theoretical discussion and definition of "branching" and "head." Subsequently she relates the diachronic shift to psycholinguistic evidence, arguing that the difficuly of LB complex structures as reflected in their (...) painstaking and delayed acquisition accounts for the extensive typological shift from left to right branching that took place in Latin/French and the other Indo-European languages. (shrink)

COVID-19 vaccine research success and emergency use authorizations have shown the life sciences’ potential for positive health impact. But they also underscore potentially divergent and conf...

A striking feature of human female sexual reproduction is the high level of gametes that exhibit an aberrant number of chromosomes (aneuploidy). A high baseline observed in women of prime reproductive age is followed by a dramatic increase in older women. Proper chromosome segregation requires one or more DNA crossovers (COs) between homologous maternal and paternal chromosomes, in combination with cohesion between sister chromatid arms. In human females, CO designations occur normally, according to the dictates of CO interference, giving early (...) CO-fated intermediates. However, ≈25% of these intermediates fail to mature to final CO products. This effect explains the high baseline of aneuploidy and is predicted to synergize with age-dependent cohesion loss to explain the maternal age effect. Here, modern advances in the understanding of crossing over and CO interference are reviewed, the implications of human female CO maturation inefficiency are further discussed, and areas of interest for future studies are suggested. (shrink)