In human cancers, histone methyltransferase SETDB1 (SET domain, bifurcated 1) is frequently overexpressed but its significance in carcinogenesis remains elusive. A recent study shows that SETDB1 downregulation induces de‐repression of retroelements and innate immunity in cancer cells. The possibility of SETDB1 functioning as a surveillant of retroelement expression is discussed in this study: the cytoplasmic presence of retroelement‐derived nucleic acids (RdNAs) drives SETDB1 into the nucleus by the RNA‐interference route, rendering the corresponding retroelement transcriptionally inert. These RdNAs could, therefore, be (...) signals of genome instability sent out for SETDB1 present in the cytoplasm to maintain genome integrity. (shrink)

Der Autor legt eine engagierte Arbeit vor, in der er sich mit Nietzsches Kulturphilosophie auseinandersetzt. Speziell hat er die Modernekritik von Nietzsche im Visier, damit die ganzen Fragen der Décadence, das Nihilismusproblem etc. Angestoßen ist diese Problematik nicht zuletzt durch die Postmoderne-Diskussion. Diese Arbeit stellt sich das Problem, wie eine Kultur entwickelt werden kann, welche die negativen Nebenwirkungen der Moderne überwindet. Nietzsche ist dabei der wichtigste Gesprächpartner, auch M. Foucault und Th. W. Adorno treten als Gesprächpartner hinzu, so daß Nietzsches (...) Problem der Leibvergessenheit der Moderne mit Blick auf Foucaults Analyse der Disziplinierung des Leibes und Th. W. Adornos Theorie der Verdinglichung und der Ichschwäche erörtert wird. Ziel ist die Entwicklung einer Hermeneutik der Leiblichkeit, um auf dieser Grundlage eine Leibkultur zu entwickeln. Folgerichtig kulminiert die vorliegende Arbeit in einem Schlußkapitel über Leibverstehen und Leibbildung. (shrink)

The aim of this study is to examine the current profile of bioethics education in the nursing curriculum as perceived by nursing students and faculty in Korea. A convenience sampling method was used for recruiting 1223 undergraduate nursing students and 140 nursing faculty in Korea. Experience of Bioethics Education, Quality of Bioethics Education, and Demand for Bioethics Education Scales were developed. The Experience of Bioethics Education Scale showed that the nursing curriculum in Korea does not provide adequate bioethics education. The (...) Quality of Bioethics Education Scale revealed that the topics of human nature and human rights were relatively well taught compared to other topics. The Demand for Bioethics Education Scale determined that the majority of the participants believed that bioethics education should be a major requirement in the nursing curriculum. The findings of this study suggest that bioethics should be systemically incorporated into nursing courses, clinical practice during the program, and during continuing education. (shrink)

The technical term “ tarka ” in the Nyāya tradition is the object of the present investigation. Diverse texts including Buddhist ones exhibit a negative estimation of activities using tarka . In contrast, more often than not, later treatises dealing with logico-epistemic problems, especially certain Naiyāyika works, identify the methodological peculiarity of Nyāya with tarka . Such an ambivalent attitude toward tarka can be understood in a coherent way if the essential features of tarka that gave rise to it can (...) be grasped. Starting from the Nyāyasūtra 1.1.40 and the explanation given in the Nyāyabhāṣya on it, the present researcher sorted out three characteristic features of tarka in the early Nyāya tradition. These three features focus on the main feature of tarka : namely, reflective analysis without requiring further factual information on the object of investigation. Based on this, the present researcher critically reviewed what promoted an understanding of tarka as a reductio ad absurdum argument or an a priori reasoning. Furthermore, certain passages from the Nyāyamañjarī , Nyāyakalikā , and Tarkasaṅgraha were examined to demonstrate that the present researcher’s interpretative understanding of tarka was adequate for explaining the usage of this term in a broad sense, with positive connotations. (shrink)

All individual terms listed as jāti-s (sophisticated ripostes) in Nyāyasūtra V a 1 have the peculiar uniform ending -sama. The interpretation of this ending here reveals a greater nuance of meaning than the hitherto customary understanding of it. It will be demonstrated that the observable semantic difference is due to a historical shift of signification as a result of an enlarging and systematizing of the thematic group of jāti-s. In this paper, I examine relevant text material, including two very important (...) manuscripts of the Nyāyabhṣya to show this semantic difference. The understanding gained by this analysis will help to trace the historical development of the complex of jāti-s within the larger context of the ancient Indian tradition of debate. (shrink)

‘Tarka’ is a technical term that occupies a significant position in the logico-epistemological traditions in India. In this paper, it is attempted to expound the exact meaning of the term, in particular in the early Nyaya tradition, on the basis of the explanations found in the Nyayabhasya. The view that the essential feature of tarka consists in the differentiating approach (vibhaga) to the matter on discourse is substantiated, and with it a possible explanation is given for the well-known ambivalent valuations (...) that tarka was often loaded with a negative connotation on the one hand and, was considered as the positive characteristic feature of the Naiyayika approach to epistemological problems on the other. In the case of tarka, the general applicability and the impression of logically exhaustive access to any given problem was combined with the danger of misuse of the reason without any quasi-formal deficiency. It is hoped that my suggestion to characterize tarka as the differentiating approach to the given matter without any factual information may give a plausible explanation for the double-pole character of tarka in the history of Indian philosophy. (shrink)

The exhaustive explications on jāti-s (sophisticated ripostes) and their seemingly chaotic arrangement in early Indian philosophical texts arouses an expectation for a systematic taxonomy or typology. Such taxonomy would enormously increase the heuristic value of the list of jāti-s. The present article aims to reveal some interpretational problems relevant to the understanding of the jāti-s’ historical development, as well as the theoretical implications of their typology. Focusing historically on the early texts of debate manuals of Nyāya and Buddhist circles, this (...) article will excavate and explicate the vague and the obvious attempts to establish a typology of jāti-s. Given that Diṅnāga was the philosopher who shifted the history of Indian philosophy into the era of macro theory by integrating ontology and epistemology into a general system, the minimal changes of the order of the jāti-s in the list given in the Pramāṇasamuccaya, in contrast to the one found in the Nyāyamukha, will be interpreted as a paradigm shift. The rearrangement of the jāti list in the Pramāṇasamuccaya represents the paradigm shift from the debate (vāda) manual to the epistemological (pramāṇa) treatise, confirming Frauwallner’s ideas regarding the development of Diṅnāga’s thought. (shrink)

The structure and “metabolism” (movement and conversion of goods and energy) of urban areas has caused cities to be identified as “super‐organisms”, placed between ecosystems and the biosphere, in the hierarchy of living systems. Yet most such analogies are weak, and render the super‐organism model ineffective for sustainable development of cities. Via a cluster analysis of 15 shared traits of the hierarchical living system, we found that industrialized cities are more similar to eukaryotic cells than to multicellular organisms; enclosed systems, (...) such as factories and greenhouses, paralleling organelles in eukaryotic cells. We further developed a “super‐cell” industrialized city model: a “eukarcity” with citynucleus (urban area) as a regulating centre, and organaras (enclosed systems, which provide the majority of goods and services) as the functional components, and cityplasm (natural ecosystems and farmlands) as the matrix. This model may improve the vitality and sustainability of cities through planning and management. (shrink)

本书对马克思主义人学思维的历史渊源、马克思主义人学思维方式的生成逻辑过程、人学致思理路的理论及现实意义进行梳理与解读,系统展示出马克思主义的人学思想。.

1. Chŏngch'i ch'ŏrhak kwa chŏngsin punsŏkhak ŭi mannam -- 2. Han'gugin ŭi chamjae ŭisik kwa chŏngch'i pyŏngni.

Explores the resources for contemporary ethics found in the work of the Cheng brothers, canonical neo-Confucian philosophers. Yong Huang presents a new way of doing comparative philosophy as he demonstrates the resources for contemporary ethics offered by the Cheng brothers, Cheng Hao (1032–1085) and Cheng Yi (1033–1107), canonical neo-Confucian philosophers. Huang departs from the standard method of Chinese/Western comparison, which tends to interest those already interested in Chinese philosophy. While Western-oriented scholars may be excited to learn about Chinese philosophers (...) who have said things similar to what they or their favored philosophers have to say, they hardly find anything philosophically new from such comparative work. Instead of comparing and contrasting philosophers, each chapter of this book discusses a significant topic in Western moral philosophy, examines the representative views on this topic in the Western tradition, identifies their respective difficulties, and discusses how the Cheng brothers have better things to say on the subject. Topics discussed include why one should be moral, how weakness of will is not possible, whether virtue ethics is self-centered, in what sense the political is also personal, how a moral theory can be of an antitheoretical nature, and whether moral metaphysics is still possible in this postmodern and postmetaphysical age. “This book presents the philosophical ideas of the Cheng brothers intelligently, convincingly, and powerfully. It is among the best books ever written on the Cheng brothers, including works in the Chinese language.” — Kam-por Yu, coeditor of Taking Confucian Ethics Seriously: Contemporary Theories and Applications. (shrink)

Byun et al. describe how deaf signers deal with communication problems in first encounters with signers of different languages. They show that the basic Conversation Analytic repair mechanisms for dealing with verbal troubles are largely reproduced in gesture and sign, including details of turn‐taking structure, timing and form. This underlines the role of repair as a basic resource for linguistic and interactional creativity across modalities.

Byun et al. describe how deaf signers deal with communication problems in first encounters with signers of different languages. They show that the basic Conversation Analytic repair mechanisms for dealing with verbal troubles are largely reproduced in gesture and sign, including details of turn‐taking structure, timing and form. This underlines the role of repair as a basic resource for linguistic and interactional creativity across modalities.

Byun et al. describe how deaf signers deal with communication problems in first encounters with signers of different languages. They show that the basic Conversation Analytic repair mechanisms for dealing with verbal troubles are largely reproduced in gesture and sign, including details of turn‐taking structure, timing and form. This underlines the role of repair as a basic resource for linguistic and interactional creativity across modalities.

As the world struggles through the COVID‐19 pandemic, we should also be asking what systems‐level measures will be needed to prevent this or even worse disasters from happening in the future. We argue that the pandemic is merely one of potentially myriad and pleiomorphic future global disasters generated by the same underlying dynamical system. We explain that there are four broad but easily identifiable systemic, pathologically networked conditions that are hurtling civilization toward potential self‐destruction. As long as these conditions are (...) not resolved, we should consider catastrophe as an inevitable emergent endpoint from the dynamics. All four conditions can be reversed with collective action to begin creating an enduring and thriving post‐ COVID‐19 world. This will require maximal application of the precautionary principle. (shrink)

内容:外来冲击与传统中国道德伦理观的回应, 重商行为下的价值紊乱, 道德革命与政治革命, 文化断层与道德真空, 革命道德与道德革命等.

Graphical AbstractRecent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented, focusing in particular on the stochastic nature of cellular control processes.

Parrondo's paradox, in which losing strategies can be combined to produce winning outcomes, has received much attention in mathematics and the physical sciences; a plethora of exciting applications has also been found in biology at an astounding pace. In this review paper, the authors examine a large range of recent developments of Parrondo's paradox in biology, across ecology and evolution, genetics, social and behavioral systems, cellular processes, and disease. Intriguing connections between numerous works are identified and analyzed, culminating in an (...) emergent pattern of nested recurrent mechanics that appear to span the entire biological gamut, from the smallest of spatial and temporal scales to the largest—from the subcellular to the complete biosphere. In analyzing the macro perspective, the pivotal role that the paradox plays in the shaping of biological life becomes apparent, and its identity as a potential universal principle underlying biological diversity and persistence is uncovered. Directions for future research are also discussed in light of this new perspective. (shrink)

本书收辑的40篇论述,基本包括陈康先生用中外文发表的主要学术著作。全书分两部分,前一部分是研究希腊哲学的论文,后一部分是研究一般哲学问题的论述。.

We give a survey of current research on Gödel’s incompleteness theorems from the following three aspects: classifications of different proofs of Gödel’s incompleteness theorems, the limit of the applicability of Gödel’s first incompleteness theorem, and the limit of the applicability of Gödel’s second incompleteness theorem.

As symbols of adaptability and transformation, together with qualities of vigilance and intelligence, we argue the relevance of dragons for spatial planning in China. We develop a metaphorical concept – the green dragon – for grasping the condition of contemporary Chinese societies and for facilitating the development of theories and practices of spatial planning which are able to face the challenges of rapid change. We ask Chinese scholars and spatial planners to liberate Deleuzian potential for strategic spatial planning in a (...) ‘becoming-between, coming-together’ of concepts which can effectively make a difference in the world. Having outlined what we regard as key transversals or diagonals between our reading of Gilles Deleuze and aspects of Chinese philosophy, we then offer the metaphor of strategic spatial planning as Chinese literati landscape painting. This is a form of painting which rejects the idea of the world being supremely organised from a particular point of view, preferring to paint immanence and transformation. Chinese literati landscape paintings, like philosophy and strategic spatial planning, ‘look only at the movements’. We conclude that connections between what concepts of Chinese philosophy and those of Gilles Deleuze can do, suggest that in China, a conception of strategic spatial planning as metaphorical green dragon may offer academics and planning practitioners a transverse way to relate the legacies of past philosophies and current thinking. (shrink)

On the Rhetoric of Defining Confucianism as a Religion tackles the perennially controversial question of whether Confucianism is a religion and proposes a holistic and contextual approach to the issue.