The multifunctional zinc‐finger protein CCCTC‐binding factor (CTCF) is a very strong candidate for the role of coordinating the expression level of coding sequences with their three‐dimensional position in the nucleus, apparently responding to a “code” in the DNA itself. Dynamic interactions between chromatin fibers in the context of nuclear architecture have been implicated in various aspects of genome functions. However, the molecular basis of these interactions still remains elusive and is a subject of intense debate. Here we discuss the nature (...) of CTCF‐DNA interactions, the CTCF‐binding specificity to its binding sites and the relationship between CTCF and chromatin, and we examine data linking CTCF with gene regulation in the three‐dimensional nuclear space. We discuss why these features render CTCF a very strong candidate for the role and propose a unifying model, the “CTCF code,” explaining the mechanistic basis of how the information encrypted in DNA may be interpreted by CTCF into diverse nuclear functions. (shrink)

In "De anima" 3.5, Aristotle argues for the existence of a second intellect, the so-called "Agent Intellect." The logical structure of his argument turns on a distinction between different types of soul, rather than different faculties within a given soul; and the attributes he assigns to the second species make it clear that his concern here -- as at the climax of his other great works, such as the "Metaphysics," the "Nicomachean" and the "Eudemian Ethics" -- is the difference between (...) the human and the divine. If this is right, we needn't go on a wild goose chase trying to invent a role for the so-called Agent Intellect to play. God moves our intellects as he moves the heavenly spheres, "as a beloved": he constitutes the complete actualization towards which all of our intellectual striving is directed. Aristotle regards such final causation as an efficient cause, but not in a way that would make it part of what we would call the causal processes or mechanisms of human psychology. But, he would insist, it is essential for appreciating who we are and what our place is in the world. (shrink)

The majority of world religions have developed in the course of overcoming tribal and clan identity. The idea of "One God" carries the implication, overtly or not, of uniting mankind on basis of religious belief. The rise of world religions was associated with rise of huge empires and states where various ethnic groups coexisted, not only on the basis of force alone, but also on basis of common religious belief and value systems imposed by religious ideology. Governing polyethnic territories, developments (...) in economy and trade and consistent humanization of human spirit resulted in the development of common human values.Mankind started perceiving itself as a single species sharing a common world history. The concept of 'mankind' came to unite people irrespective of their race, religion and nationality. Objective of our study was cross-confessional investigation of value systems in religions spread in Russia and establishing to what extent they are spiritually acceptable to Russians. We used the semantic space technique for the analysis of religious mentalities. (shrink)

In the fall semester of 1772/73 at the Albertus University of Königsberg, Immanuel Kant, metaphysician and professor of logic and metaphysics, began lectures on anthropology, which he continued until 1776, shortly before his retirement from public life. His lecture notes and papers were first published in 1798, eight years after the publication of the _Critique of Judgment, _the third of his famous _Critiques. _The present edition of the _Anthropology _is a translation of the text found in volume 7 of _Kants (...) gesammelte Schriften, _edited by Oswald Külpe. Kant describes the _Anthropology _as a systematic doctrine of the knowledge of humankind. Kant’s lectures stressed the "pragmatic" approach to the subject because he intended to establish pragmatic anthropology as a regular academic discipline. He differentiates the physiological knowledge of the human race—the investigation of "what Nature makes of man"—from the pragmatic—"what man as a free being makes of himself, what he can make of himself, and what he ought to make of himself." Kant believed that anthropology teaches the knowledge of humankind and makes us familiar with what is pragmatic, not speculative, in relation to humanity. He shows us as world citizens within the context of the cosmos. Summarizing the cloth edition of the _Anthropology, Library Journal _concludes: "Kant’s allusions to such issues as sensation, imagination, judgment, taste, emotion, passion, moral character, and the character of the human species in regard to the ideal of a cosmopolitan society make this work an important resource for English readers who seek to grasp the connections among Kant’s metaphysics of nature, metaphysics of morals, and political theory. The notes of the editor and translator, which incorporate material from Ernst Cassirer’s edition and from Kant’s _marginalia _in the original manuscript, shed considerable light on the text.". (shrink)

Saturation, intoxication to the medias of realization and porsuit of happyness.

The social and personal utility of mental and physical suffering, exploration of the ideia that pain can be tolerated if we belive and so on euthanasia is not mandatory to several cases.

Can psychiatry be read from an anthropological point of view? What is normal? What is pathological? Social order and pathos in question on this essay.

Is art and wrting a pagan manifestation of profane thoughts and feelings? What about the sacred art? Is there a link between the two? In other hand, the social status of the artist and semo processes of artistic creation, his strategy, his willing, his fundamentals.

sublime and sublimation, between ascetism en religious practice, social order and cultural feelings.

Two theories of excuses are currently popular in criminal law theory: the character theory and the capacity theory. In the former the defendant claims that although he performed a wrongful action, it did not properly reflect his character. In the latter, the defendant claims that although he performed a wrongful action he lacked the capacity to do otherwise. In John Gardner's view neither claim is adequate to provide the defendant with an excuse. Excuses, Gardner thinks, are only appropriate where the (...) defendant can claim that he has lived up to the standards reasonably to be expected of a person performing the role that the defendant was performing. The view defended here is that whilst the Gardner style excuse is an excuse, both of the claims that he rejects properly ground excuses in the criminal law as well. Furthermore, they do not exhaust the field of excuses. Excuses are best seen as defences that mop up where an application of the other rules of the criminal law would not adequately serve its principles. No further ordering of excuses is possible. (shrink)

The Higgs particle has been detected a few years ago, that is what newspapers tell us. For many physicists, the Standard Model of particle physics has accomplished all the jobs. Or to put it simply: The game is over. Is it true? Then some physicists began to ask: can go beyond the Standard Model? Because the supersymmetric extension of the Standard Model has failed. If you feel that theoretical physics is becoming boring, you are not alone. Fortunately, there is good (...) news: a new generation of physicists are doing table-top experiments in their basements. Can we expect new results later? If so, what will the future of physics look like? This article discusses this question, starting with a blunt look at the relationship between mathematics and physical reality, written from the perspectives of a mathematician and a cosmologist. (shrink)

El deseo y oraciones de Juan XXIII pidiendo que el Vaticano II fuera un Pentecostés para la Iglesia, fue ampliamente escuchado por el Señor. El Vaticano II fue una auténtica irrupción del Espíritu sobre la Iglesia, un acontecimiento salvífico, un kairós. Hay un “antes” un “después” del Vaticano II.

following Spinoza an, somewhat, Locke, trough a luminous path of a unique philosophical adventure.

cinematic proposition to the field of philosophical cinema and literature, in hommage to Henry-Lévi.

From aesthetics to social anthropology and art, this essay is pretending to be an approach to some relevant works on the vision to a better man.

A new approach to Nietzsche, so called Nietzeche sindrom.

Signs evolve on colective inconsciousness.