Research ethics consultation services (RECS), which function as an advisory service to facilitate the resolution of complex ethical issues in clinical research, have been proliferating over the last decade. However, the qualification of an individual who provides RECS, or “a research ethics consultant,” has not been thoroughly investigated, in contrast to healthcare ethics consultants, whose core competencies have been discussed and clarified to a great extent. In this study, we investigated core competencies necessary for research ethics consultants, referring to the (...) core competency models of ethics consultants developed in the healthcare practice context, and propose a competency model for research ethics consultants. (shrink)

This note is a continuation of our former paper ''Complexity of the r-query tautologies in the presence of a generic oracle.'' We give a very short direct proof of the nonexistence of t-generic oracles, a result obtained first by Dowd. We also reconstitute a proof of Dowd's result that the class of all r-generic oracles in his sense has Lebesgue measure one.

Pyridoxal 5′‐phosphate, the vitamin B6 derivative, acts as the coenzyme of many enzymes involved in amino acid metabolism. Exceptionally, this compound was found covalently bound to glycogen phosphorylase, the key enzyme in the regulation of glycogen metabolism. Although it is essential for the function of phosphorylase, its direct role has remained an enigma. We have recently found that the glucose moiety of pyridoxal (5′)diphospho (1)‐α‐D‐glucose, a conjugate of pyridoxal 5′‐phosphate and glucose 1‐phosphate through a pyrophosphate linkage, is transferred to the (...) nonreducing end of glycogen, forming a new α‐1,4‐glucosidic linkage. This finding emphasizes the importance of the direct phosphate‐phosphate interaction between the coenzyme and the substrate in the phosphorylase catalytic reaction. We have proposed a catalytic mechanism for phosphorylase in which the phosphate group of pyridoxal 5′‐phosphate acts as an electrophile to the phosphate group of glucose 1‐phosphate. This appears to represent the first instance of the direct involvement of a phosphate group in catalysis by enzymes. (shrink)

The present study used the experience sampling method to detect fluctuations in thinking, such as self-focus or concreteness in daily life, and to examine their relationship with depressive symptoms and concurrent negative affect. Thirty-one undergraduates recorded their negative affect, ruminative self-focus, and concreteness of thinking eight times a day for 1 week. Multilevel modeling showed that individuals with increasing levels of depression showed lower levels of concreteness in their daily thinking. Further analysis revealed a significant positive association between momentary ruminative (...) self-focus and concurrent negative affect only with low concreteness of thinking. These results suggested that individuals with increasing levels of depression chronically process self-related information on an abstract level, which reflects a malfunction of their self-regulatory cycle and might serve to maintain or even exacerbate dysphoric moods. (shrink)

The modal logic S4.2 is S4 with the additional axiom ◊□A ⊃ □◊A. In this article, the sequent calculus GS4.2 for this logic is presented, and by imposing an appropriate restriction on the application of the cut-rule, it is shown that, every GS4.2-provable sequent S has a GS4.2-proof such that every formula occurring in it is either a subformula of some formula in S, or the formula □¬□B or ¬□B, where □B occurs in the scope of some occurrence of □ (...) in some formula of S. These are just the K5-subformulas of some formula in S which were introduced by us to show the modied subformula property for the modal logics K5 and K5D : 115–122, 2001). Some corollaries including the interpolation property for S4.2 follow from this. By slightly modifying the proof, the finite model property also follows. (shrink)

Those formulas which are valid in every Kripke model having constant domain whose base is the ordered set R of real numbers (or, the ordered set Q of rational numbers) are characterized syntactically.

A structure A for the language L, which is the first-order language (without equality) whose only nonlogical symbol is the binary predicate symbol , is called a quasi -struoture iff (a) the universe A of A consists of sets and (b) a b is true in A ([p) a = {p } & p b] for every a and b in A, where a(b) is the name of a (b). A quasi -structure A is called an -structure iff (c) {p (...) } A whenever p a A. Then a closed formula in L is derivable from Leniewski's axiom x, y[x y u (u x) u; v(u, v x u v) u(u x u y)] (from the axiom x, y(x y x x) x, y, z(x y z y x z)) iff is true in every -structure (in every quasi -structure). (shrink)

In the history of Newtonian Mechanics physicists and astronomers did not rely on so-called inertial frames, indeed they were not able to identify such frames. So the usual neo-Newtonian formalism of Newtonian Mechanics contains some superfluous components. In the present paper I will formulate a formal system for classical particle mechanics in Leibnizian space-time, where a relation, a counterpart of the second law of motion, between force on bodies and derivative of their momentum will be defined relative to every, inertial (...) or not, reference frame. And I will present a view that in the research process under Newtonian mechanics the accumulation of those models of the relation that satisfied some realistic conditions determined an additional structure of non-rotating frames to Leibnizian space-time. (shrink)

No agreed-upon account of mirror reversal is currently available although it has been discussed for more than two thousand years since Plato. Mirror reversal usually refers to recognized left-right reversal of a mirror image. Depending on the nature and layout of a reflected object, however, top-bottom reversal may be recognized instead of left-right reversal; no reversal at all may be recognized; and the presence or absence of reversal may not be decidable. Takano (1998) proposed a psycho-optic theory to explain (...) all these cases of mirror image recognition in a consistent manner. The proposed theory assumes different causes of mirror reversal depending on whether an object's left-right axis is parallel or perpendicular to a mirror's surface. This theory was later criticized in that it provided no explanation when the left-right axis is neither parallel nor perpendicular but at an intermediate angle between zero and 90 degrees with a mirror. This article completes the theory by presenting psycho-optic anal.. (shrink)

This paper offers some ideas and methods of consensus building towards integration of values in flood control, environment, and landscape. These three factors sometimes oppose to each other in the process of construction of public infrastructure such as roadbuilding and river improvement. It is crucial to avoid or resolute conflicts between the government and the local people through project management with the consensus building process. In public works in Japan, flood control has been given priority over the environmental preservation and (...) the landscape conservation due to the perception that it is through flood control that the life and property of individuals are adequately protected. As a consequence, the landscape and the environment have been paid only lip‐service. In the case of the Ohashi River Project in Izumo region presented in this paper, however, the river repair process might entail a severe blow to the tourism industry and have a dramatic impact on the fishery resources of the region, which would be considered a major loss in terms of the urban development of the city. One of our concerns is thus to avoid any losses, through proper consideration of the relationship between the three crucial factors. In this paper, the author reports some ideas and methods that appear in “Basic Policy for the Development of the Area around Ohashi River” composed by the Matsue Review Committee on the Development of the Area around the Ohashi River, in which the author is involved as a committee member. The most important task of the Committee wasto search for the ideas and methods to harmonize the values of flood control, environment, and landscape. (shrink)

The COVID-19 pandemic has put in the foreground the dramatic actuality of global and local inequalities, undermining neo-liberal, communitarian, democratic or cosmopolitan projects of collective id...

西田幾多郎の哲学は、単なる宗教体験の表現ではない合理的世界観である。その全貌を解読する時、われわれは、西田哲学が封印したもう一つの視点を発見する。そこであらわになるのは、驚くべき「時間」の真相―時間幻 想である。.

Let EOA be the elementary ontology augmented by an additional axiom S (S S), and let LS be the monadic second-order predicate logic. We show that the mapping which was introduced by V. A. Smirnov is an embedding of EOA into LS. We also give an embedding of LS into EOA.

Sequent calculi for trilattice logics, including those that are determined by the truth entailment, the falsity entailment and their intersection, are given. This partly answers the problems in Shramko-Wansing.

As its name implies, Vasubandhu’s _Vyākhyāyukti_ (VyY) explains the logic or methodology (_yukti_) of exegesis or sūtra interpretation (_vyākhyā_) and only survives in a Tibetan translation. In recent years, research on this treatise has been gradually accumulating. However, due to the difficulty of the Tibetan translation, some of the arguments therein have been misunderstood. In this article, after reviewing the general framework of Vasubandhu’s method of interpreting the sūtras, I will present a newly discovered parallel regarding his discussion of the (...) “purpose, _prayojana_” of the sūtras and reread it through a close philological examination of various sources in Sanskrit and Tibetan. Thus, this article will first elucidate the details of Vasubandhu’s explanation of the purpose of the Buddha’s preaching using synonyms and will clarify an aspect of his views on the Buddha’s word. In addition, concerning this “purpose,” I will elucidate the characteristics of the final chapter of this text, which provides stories about hearing the Buddha’s words with respect. By doing so, I would like to reveal the characteristics of the VyY as a manual for vivid preaching. (shrink)

The uncertainty relation in quantum mechanics has been explicated sometimes as a statistical relation and at other times as a relation concerning precision of simultaneous measurements. In the present paper, taking the indefiniteness of individual experiments as represented by diameters of Borel sets in projection-valued measure, we mathematically distinguish four expressions, two statistical and two concerning simultaneous measurements, of the uncertainty relation, study their interrelations, and prove that they are nonequivalent to each other and to the eigenvector condition (EV) in (...) infinite-dimensional Hilbert space. (shrink)

「教育学」の新しい領野を切り拓いてきた著者積年の集大成!日本の自生的な教育論の誕生に迫る。.