Über Kunst zu reden scheint so selbstverständlich zu sein, dass niemand systematisch der grundsätzlichen Frage nachzugehen scheint, worüber wir eigentlich reden, wenn wir über Kunst reden - weder im alltäglichen Kontext noch in dem der Kunstwelt. Mithilfe des Sprachwandelkonzepts des Linguisten Rudi Keller, der die Theorie der unsichtbaren Hand von Adam Smith aufgreift, sowie des handlungstheoretischen Modells des britischen Sprachphilosophen H. Paul Grice soll durch eine systematische Begriffsdifferenzierung versucht werden, Licht ins Dunkel des inflationären und chaotischen Gebrauchs des Wortes Kunst (...) und des daraus resultierenden Begriffs 'Kunst' zu bringen. Im Anschluss an Hans-Georg Gadamers rezeptionsästhetische Überlegungen wird eine strukturelle Differenzierung dessen vorgeschlagen, was gemeinhin Kunst resp. Kunstwerk genannt wird. Dabei werden zahlreiche für den aktuellen Stand der Kunstphilosophie relevante Positionen (von Wittgenstein, Derrida, Heidegger über Schmücker, Lüdeking bis hin zu Ziff, Weitz, Kennick, Gaut und Danto) einer kritischen Analyse unterzogen, um schliesslich heuristisch der Frage nachzugehen, ob es in der unmittelbaren Rezeption der Kunst um Aspekte des Verstehens geht oder nicht vielmehr um das, was Susan Sontag die 'Erotik der Kunst' nennt."--Page 4 of cover. (shrink)

Most accounts of our knowledge of the successor axiom claim that this is based on the procedure of adding one. While they usually don’t claim to provide an account of how children actually acquire this knowledge, one may well think that this is how they get that knowledge. I argue that when we look at children’s responses in interviews, the time when they learn the successor axiom and the intermediate learning stages they find themselves in, that there is an empirically (...) viable alternative. I argue that they could also learn it on the basis of a method that has to do with the structure of the numeral system. Specifically, that they (1) use the syntactic structure of the numeral system and (2) attend to the leftmost digits, the one with the highest place-value. Children can learn that this is a reliable method of forming larger numbers by combining two elements. First, a grasp of the syntactic structure of the numeral system. That way they know that the leftmost digit receives the highest value. Second, an interpretation of numerals as designating cardinal values, so that they also realise that increasing or adding digits on the lefthand side of a numeral produces a larger number. There are thus two, currently equally well-supported, ways in which children might learn that there are infinitely many natural numbers. (shrink)

This paper studies the epistemic failures to reach understanding in relation to scientific explanations. We make a distinction between genuine understanding and its negative phenomena—lack of understanding and misunderstanding. We define explanatory understanding as inclusive as possible, as the epistemic success that depends on abilities, skills, and correct explanations. This success, we add, is often supplemented by specific positive phenomenology which plays a part in forming epistemic inclinations—tendencies to receive an insight from familiar types of explanations. We define lack of (...) understanding as the epistemic failure that results from a lack of an explanation or from an incorrect one. This can occur due to insufficient abilities and skills, or to fallacious explanatory information. Finally, we characterize misunderstanding by cases where one’s epistemic inclinations do not align with an otherwise correct explanation. We suggest that it leads to potential debates about the explanatory power of different explanatory strategies. We further illustrate this idea with a short meta-philosophical study on the current debates about distinctively mathematical explanations. (shrink)

The manuscripts and writings of the fifteenth-century astronomer and physician Lewis Caerleon (d. c. 1495) have been largely overlooked. To fill this gap, this article focuses on his writings and working methods through a case study of his canons and table for the equation of time. In the first part, an account of his life and writings is given on the basis of new evidence. The context in which his work on the equation of time was produced is explored in (...) detail by reviewing the three key periods of his scientific production. His heavy reliance on Simon Bredon’s Commentum super Almagesti is also analyzed. The article also provides editions of Lewis Caerleon’s canons for calculating his table for the equation of time and a critical edition of Simon Bredon’s Commentum super Almagesti, III, 22–24. In the second part of this article, we analyze the table for the equation of time derived by Lewis around 1485. In addition to the final table, there is a unique table with intermediate results that records every step of his derivation. By following and discussing the details of this derivation, we shed a new light on tabular practices in mathematical astronomy. Following Lewis in his historical mathematical procedure, we argue, offers a novel historiographical approach that allows us to identify different sources and practices used by historical actors. Therefore, beyond the exchange of parameters residing in modern mathematical analysis, this novel approach offers a promising refinement for the analysis of the transmission of knowledge across space, time, and culture. (shrink)

Bostrom rejects Nietzsche as an ancestor of the transhumanist movement, as he claims that there were merely some “surface-level similarities with the Nietzschean vision” (Bostrom 2005a, 4). In contrast to Bostrom, I think that significant similarities between the posthuman and the overhuman can be found on a fundamental level. In addition, it seems to me that Nietzsche explained the relevance of the overhuman by referring to a dimension which seems to be lacking in transhumanism. In order to explain my position, (...) I will progress as follows. First, I will compare the concept of the posthuman to that of Nietzsche’s overhuman, focusing more on their similarities than their differences. Second, I will contextualise the overhuman in Nietzsche’s general vision, so that I can point out which dimension seems to me to be lacking in transhumanist thought. (shrink)

A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) results in a higher likelihood that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in a restricted scenario (Olsson and Schubert 2007, Synthese 157:297–308). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where it is any finite (...) number of witnesses that give equivalent reports. It is shown that only the so-called Shogenji measure is reliability conducive in this scenario. I take that to be an argument for the Shogenji measure being a fruitful explication of coherence. (shrink)

A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) among testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in scenarios of equivalent testimonies (Olsson and Schubert 2007; Schubert, to appear). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where the (...) testimonies do not have to be equivalent. It is shown that four measures are reliability conducive in the present scenario, all of which are ordinally equivalent to the Shogenji measure. I take that to be an argument for the Shogenji measure being a fruitful explication of coherence. (shrink)

A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (asmeasured) of a set of testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that the Shogenji measure of coherence is reliability conducive in restricted scenarios (e.g., Olsson and Schubert, Synthese, 157:297–308, 2007). In this article, I investigate whether the Shogenji measure, or any other coherence measure, is reliability conducive in general. An impossibility theorem is (...) proved to the effect that this is not the case. I conclude that coherence is not reliability conducive. (shrink)

Argues that content-independent reasons are intentions. Relies on Grice's distinction between natural and non-natural meaning. Rejects previous accounts, and argues that his account can understand the force of such reasons appropriately, through the conept of enabling-conditions. Illustrates through several paridigmatic types of content-independent reasons.

Reality has become an increasingly prominent topic in contemporary philosophy. The book’s contributors are responding to the challenge to use the philosophically underexplored potential of film to disclose what the editors propose to call “the real of reality.”.

Moral development has become an integral part in military training and the importance of moral judgment and behavior in military operations can hardly be overestimated. Many armed forces have integrated military ethics and moral decision-making interventions in their training programs. However, little is known about the effectiveness of these interventions. This study examined the effectiveness of a 1-week training program in moral decision making in the Swiss Armed Forces. The program was based on a strategy-based interactional moral dilemma approach. Results (...) of this quasi-experimental intervention study showed significant improvements in content-related (moral and instrumental awareness, quality of moral information processing, development of compensatory actions) as well as process-related (situational analysis, development and evaluation of alternative solutions, justification of decision) aspects in moral decision making. Results of a follow-up test indicated positive long-term effects with regard to moral and instrumental awareness and process-related aspects. Findings are discussed, and consequences for leadership development programs and further research are explored. (shrink)

This dataset documents results and code for the paper "Interdisciplinarity in the 17th Century? A Co-Occurrence Analysis of Early Modern German Dissertation Titles" by Stefan Heßbrüggen-Walter, forthcoming in *Synthese*. The data to be processed are contained in four files, derived from a larger dataset related to German dissertations and sourced from the national bibliography of 17th century German prints *VD 17* that will be released at a later date. More information can be found in the file `README.md`.

In der Auseinandersetzung mit Nietzsches Kritik der Menschenwürde nimmt dieses Buch zugleich Stellung zur aktuellen Diskussion. Wie ist die gegenwärtige Norm der Menschenwürde, wie sie auch im Grundgesetz enthalten ist, vor dem Hintergrund der Theorien des vehementen Moralkritikers Nietzsche einzuschätzen? Welchen Stellenwert hat die Würde des Menschen im Zeitalter des Posthumanismus überhaupt? Im ersten Teil skizziert der Autor zunächst die wichtigsten philosophischen Konzeptionen der Menschenwürde von Cicero bis Kant. Dabei macht er deutlich, welche Probleme die gegenwärtige Rezeption historischer Konzeptionen aufwirft. (...) Der zweite Teil ist der ausführlichen Darstellung von Nietzsches Kritik der Menschenwürde gewidmet. Daraus ergeben sich wichtige Impulse für die gegenwärtige Diskussion und konkrete Hinweise, wie ein tragbarer Begriff der Menschenwürde für die Zukunft aussehen könnte. (shrink)

Spoken communication between social robotic devices, powered by generative AI tools such as ChatGPT, and the senior population offers great potential for researching social interaction and robot identity perceptions as well as exploring the potential opportunities and challenges when implementing this human-machine interactions in real life situations and health care. In this paper we explore people’s perceptions of the social robot Furhat when administering verbal tasks similar to those used in screening for Alzheimer’s disease. We describe the Slovak system mounted (...) on the robot that includes a speech recognizer, the scenarios powered by generative large language model ChatGPT, and a speech synthesizer. We tested the functionality of the proposed approach with two groups of participants: attendees of a large science fair and a scientific conference. The observations from 87 collected questionnaires suggest good potential and applicability of such an approach for the given task and more positive attitudes of older subjects compared to younger ones. (shrink)

When making an assessment of animal welfare, it is important to take environmental (housing) or animal-based parameters into account. An alternative approach is to focus on the behavior and appearance of the animal, without making actual measurements or quantifying this. None of these tell the whole story. In this paper, we suggest that it is possible to find common ground between these (seemingly) diametrically opposed positions and argue that this may be the way to deal with the complexity of animal (...) welfare. The model will have to be acceptable for the different parties that will be affected by it and real benefits for the animal should result from it. This will be the basis of a practical ethical approach. All this can be condensed into a model that essentially is made up out of three basic elements: the classical welfare analysis with an existing welfare assessment tool, an assessment of the stockholder, and an implementation of the Free Choice Profiling technique. This new framework does not pretend to be a different or better animal welfare matrix; it is intended to integrate existing knowledge and to provide a practical tool to improve animal welfare. It identifies whether there are welfare problems on a farm, if present whether these problems are caused by the housing system or the stockholder, and what can be done to improve the situation. (shrink)

Let us by ‘first-order beliefs’ mean beliefs about the world, such as the belief that it will rain tomorrow, and by ‘second-order beliefs’ let us mean beliefs about the reliability of first-order, belief-forming processes. In formal epistemology, coherence has been studied, with much ingenuity and precision, for sets of first-order beliefs. However, to the best of our knowledge, sets including second-order beliefs have not yet received serious attention in that literature. In informal epistemology, by contrast, sets of the latter kind (...) play an important role in some respectable coherence theories of knowledge and justification. In this paper, we extend the formal treatment of coherence to second-order beliefs. Our main conclusion is that while extending the framework to second-order beliefs sheds doubt on the generality of the notorious impossibility results for coherentism, another problem crops up that might be no less damaging to the coherentist project: facts of coherence turn out to be epistemically accessible only to agents who have a good deal of insight into matters external to their own belief states. (shrink)

The article analyses the common notion that the consumer society is a reflection of those principles in the market that also provide the ideas of democracy and liberal constitutionalism with legitimacy in the political realm. The inalienable right to self-development and self-determination makes the individual the starting and ending point of life, rendering all spheres of market and society a ‘republic of choice’. But if consumer society shares the essentials of liberal constitutionalism and the rational, processual nature of democratic representation, (...) then its ontology needs to be investigated for the same reason and in the same manner as legal and political philosophy dissects the legitimacy and validity of the parliamentary institutions of modern democracy. Just as in the political philosophy of the constitutional structure of the democratic state, the question of who is sovereign is key to understanding the ontology of consumer society. But rather than simply placing sovereignty into the hands of the independent, self-determined consumer, the earliest ontologists of the consumer society took recourse to medieval political theology and presented the consumer market as a new corpus mysticum. Thus, it is medieval political theology, not modern liberal thought, which provided for an ontologization of the consumer. This, in turn, directly pertains to the questions of the legitimacy of consumer society per se, of consumer decisions in particular and of their sources of legitimacy. (shrink)

Abstract: We are all familiar with the way in which social roles, such as mother, father, professor, club football coach, citizen, and so on, confront us with clusters of duties that purport to bind us. Though we generally experience these role-duties as normatively binding, we might question this. What reason do role-occupants have for conforming to the duties that define their roles? I argue that the agent who identifies with her role thereby has a weighty and important justificatory reason for (...) conforming to the role's defining duties: namely, the identifying agent realizes the fundamental goods of meaning and self-determination by doing so. This is an important normative ground of role-duties because it, unlike the grounds of natural duty or voluntary assumption, ensures that the duties it grounds are not alien impositions but rather are elements of the identifying agent's wellbeing. I also argue that role-identification provides a reason that shares many of the characteristics of a moral reason, and I argue that role-identification in tandem with the principle of fair play grounds a moral duty to conform to one's role-duties. (shrink)

I am focusing here on the main counterarguments that were raised against a thesis I put forward in my article “Nietzsche, the Overhuman, and Transhumanism” (2009), namely that significant similarities can be found on a fundamental level between the concept of the posthuman, as put forward by some transhumanists, and Nietzsche’s concept of the overhuman. The articles with the counterarguments were published in the recent “Nietzsche and European Posthumanisms” issue of The Journal of Evolution and Technology (January-July 2010). As several (...) commentators referred to identical issues, I decided that it would be appropriate not to respond to each of the articles individually, but to focus on the central arguments and to deal with the counterarguments mentioned in the various replies. I am concerned with each topic in a separate section. The sections are entitled as follows: 1. Technology and evolution; 2. Overcoming nihilism; 3. Politics and liberalism; 4. Utilitarianism or virtue ethics?; 5. The good Life; 6. Creativity and the will to power; 7. Immortality and longevity; 8. Logocentrism; 9. The Third Reich. When dealing with the various topics, I am not merely responding to counterarguments; I also raise questions concerning transhumanism and put forward my own views concerning some of the questions I am dealing with. (shrink)

Heute tritt die berühmte Gretchenfrage in das Bewusstsein der Kultur- und Sozialwissenschaften vor allem durch die Diskussionen um die"Rückkehr der Religionen" und die Frage nach dem Umgang mit den verschiedenen Spielarten des politisch-religiösen Fundamentalismus. Die zahlreichen Diskussionen dieser Themen in der breiteren Öffentlichkeit machen eines deutlich: Wenn über das Verhältnis von autonomer Vernunft und Religion diskutiert wird, steht zumindest implizit nahezu immer die monotheistische Offenbarungsreligion im Zentrum. Der Anspruch dieses Typs von Religion scheint am stärksten mit dem Anspruch autonomer Rationalität (...) zu kollidieren. Der Frage nach dem Verhältnis von monotheistischer Religion und Vernunft kann besonders gut durch das Studium der religionsphilosophisch relevanten Schriften Immanuel Kants nachgegangen werden. Denn Kants Religionsphilosophie ist ein Exempel dafür, wie das Verhältnis von Vernunft und Religion in einer Weise gefasst werden kann, so dass weder Religion noch Vernunft ihre genuinen Rechte bestritten oder gar genommen werden. Der vorliegende Band ist als Vorschlag zu verstehen, wie Kants Religionsphilosophie in Hinsicht auf ihren Gehalt und ihre Relevanz angemessen erfasst werden kann. *** Today Gretchen s famous question to Faust about religion is asked in cultural and social studies primarily as part of the discussion about the "return of religion and the question of how to approach different forms of religious-political fundamentalism. The many discussions about these themes in the wider public sphere make one thing clear: when the relationship between autonomous reason and religion is discussed the monotheistic revealed religions are almost always at least implicitly the focus of debate. The demands of this form or religion seem to collide most powerfully with the demands of autonomous rationality. Immanuel Kant s works on the philosophy of religion form a particularly good basis for the investigation of this relationship between monotheistic religion and reason since Kant s religious philosophy is an example of how reason and religion can be conceived without the genuine rights of either being disputed or even lost. This volume should be seen as a proposal for understanding Kant s philosophy of religion with regard its content and relevance. (shrink)

A vernacular fifteenth-century sermon tells us, in order to warn of the threats to spiritual welfare posed by dance, that cyclic motion and centering of sensory impressions – amongst them intimate conversation – are essential elements of dance. When blending out the parenesis, implicit poetics of medieval dance can be distilled from that sermon. The way how these essential elements of dance are used for generating disruptions within literary plots will be demonstrated in three literary texts dating from the thirteenth (...) to the fifteenth century: Disruptions in connection with dance occur when contrary concepts of motion clash with each other, for example the linearity of the chivalrous way through the Other World with the cyclicity of round dances. ‚Der Württemberger‘, however, collides two contrary concepts of time which can be paraphrased as spatial metaphors, namely the linearity of earthly life which collides with the cyclicity of eternal damnation, a collision symbolized by the expulsion of life out of the dance of the death. Finally in ‚Ritter Sociabilis‘, dance generates a virtual space which subverts the courtly society. The protagonists of all these texts differently manage to resolve disruptions, namely by redemption, by repentance, or by continuing disruptions which they have caused themselves. (shrink)

Over the past 20 years, the participation of laypersons or representatives of civil society has become a guiding principle in processes of research and innovation. There is now a significant litera...

Ernst Haeckel (1834–1919) has become famous, and perhaps infamous, for many reasons. Presently, he is probably most widely-known for his paintings of plants and animals in his very popular book, Art Forms in Nature, originally collected and published in 1904. However, in addition to Haeckel’s art, he is also well-known for his advocacy of Darwinism and Social Darwinism, for first coining the term ‘ecology,’ for having his work utilized by Nazi pseudo-scientists (Dombrowksi in Tech Commun Q 12:303–319, 2003), and for (...) famously (perhaps fraudulently) producing drawings of animal and human embryos so as to confirm his biogenetic law (Gould in Nat Hist 109:44–45, 2000). Something Haeckel is not as well-known for today is the fact that he seemed to be both a strenuous critic of the metaphysical and moral philosophies of Immanuel Kant and yet also something of an adherent to Kant’s aesthetic views. In terms of metaphysics and morality, Haeckel sought to exorcise Kant’s ideas as much as possible from twentieth century views on science, humanity, and nature; however, in terms of aesthetic theory, Haeckel seemed to embrace a distinctly Kantian approach to art and artworks. This essay proposes to: (1) carefully examine Haeckel’s refutations of some of Kant’s central metaphysical concepts, (2) explore some of the, arguably Kantian, assumptions underlying Haeckel’s approach to aesthetics and his artistic practice, and (3) combine these two lines of inquiry into a portrait of Haeckel’s mind as one that is conflicted about the role Kantian philosophy, and more specifically Kantian noumena, should play in twentieth century science and art. This unresolved tension in Haeckel’s mind regarding Kant’s noumenal realm is what I propose to call his ‘Kant Problem’. (shrink)

For anyone interested in the world on the cusp of the seventeenth-eighteenth century “le Père” Coronelli is simply unavoidable. He has his own learned society today (Coronelli Weltbund...

On Shapiro’s view, any viable legal theory must successfully respond to his Possibility Puzzle and Humean Challenge. Moreover, he argues that Hartian legal theory fails in this respect. Here, I take issue with his characterization of these challenges and the Hartian response to them. I argue that he equivocates with respect to a number of the key terms and relations that inform his Possibility Puzzle, and I argue that if we disambiguate its terms consistently and plausibly, we will see that (...) its putative challenge to Hartian legal theory is illusory. I also argue that once we adequately characterize Hartian legal theory, it easily meets the Humean Challenge. If correct, these arguments undermine Shapiro’s larger project of defending his planning theory of law, for a key pillar supporting his theory is that it meets challenges that rival theories cannot. I also consider his planning theory directly, and I argue that it compares unfavourably to the Hartian approach in a crucial respect. It obscures the Hartian insight that customary practice is an ineliminable and fundamental feature of legal systems. Thus, I conclude that though Shapiro’s Legality brings to the fore many of the key issues in contemporary analytic jurisprudence and does so in an insightful and provocative way, it does not succeed in its ultimate ambition of improving upon and supplanting Hartian legal theory. (shrink)

In her very interesting paper, “Peter Singer on Expendability,” L. A. Kemmerer re-examines Peter Singer’s utilitarian argument implying that some being are replaceable and the implications of this argument for the issue of treating animals. I attempt to defend Singer, and more generally utilitarianism , against these objections. I argue that, given a utilitarian outlook, some animals are indeed replaceable. But I also argue that few animals are replaceable in practice.

This volume is an interdisciplinary attempt to insert a broader, historically informed perspective into current political and academic debates on the issue of evidence and the reliability of scientific knowledge. Evidence in Action is the perfect resource for all those interested in the relationship between science, technology, and the role of knowledge in society.

This article wants to recall a hitherto unnoticed edition of Cicero’s De Natura Deorum, which the classical philologist Matthäus Dresser (1536–1615) published with an extensive commentary. This edition, however, represents a remarkable peculiarity within the reception history of Cicero’s text, since Dresser neither claims to be a philologist, interested in textual criticism, nor a neutral historian of the philosophy of religion. Rather, as an apologetically oriented Protestant in times of confessional conflict, he is concerned with the argumentative validity of the (...) different answers to the questions discussed in Cicero’s text: Do gods exist? What qualities do they have? What activities do they display? And which relevance do these answers have for Christian monotheism? Hence, we may speak of a selective commentary, first and foremost interested in the truth or falsehood of the various answers to these main questions, in order to set contemporary readers (especially scholars and students) on the right track and to save them from severe religious errors. Dresser aims to achieve his goal by adding to the text not only extensive Annotationes, but also an introductory Argumentum to each of the three Ciceronian books of De Natura Deorum. He also gives two Disputationes (in the form of theses) at the end of each book, which provide a résumé and further guidance on interpretation. Thus he firmly rejects the atomism of Epicureanism and its denial of Providence, as explained in the first book. Dresser has to take a differentiated view of the views of Stoicism as presented in the second book: Besides many beneficial doctrines, this school of philosophers also holds fatalistic and pantheistic views which have to be rejected as dangerous to the Christian faith. As the sceptic Cotta radically rebukes the religious views of Epicureanism in the third book, but also attacks in large part Stoic theism and its idea of providence, which is also dear to Dresser’s heart, he is forced to oppose academic scepticism. This gives rise to a “theodicy” avant la lettre by Dresser, since Cottas denial of providence had also argued with the existence of evil in God’s creation. The Epicurean conceptions of God are thus not an option. Those of Stoicism are acceptable if purged of dangerous elements. Scepticism in its radical academic form must be eliminated by argument. In this article, these features of Dresser’s Annotationes and Disputationes are described and analysed in detail. Important parts of his commentaries are quoted in the author’s translation. Completely translated are the Disputationes 1 and 2 to Book III, dealing with the sceptical ’epoché’ or retention of judgement. Thus, the contribution not only represents a unique example of the reception of Cicero’s De Natura Deorum in the age of confessionalism, but also gives an insight into the reception of the three Hellenistic schools of philosophy in the early modern period in general, especially that of scepticism. (shrink)

Die Vita und die Sentenzen des Neopythagoreers Secundus wurden im Mittelalter in zahlreiche Sprachen ubersetzt und teilweise sehr frei bearbeitet. Eine kritische Edition der arabischen und der athiopischen Versionen blieb jedoch lange ein Desiderat der Forschung. Im Anschluss an die mehr als 120 Jahre alte Forschungsarbeit des Orientalisten Paulus Johannes Bachmann (1862-1894) schliesst Martin Heide nun diese Lucke unter Berucksichtigung samtlicher Handschriften. Die ausfuhrliche Einleitung widmet sich der Komposition des gesamten Buches in den verschiedenen Versionen, besonders aber der Frage nach (...) der Ubersetzungsvorlage der orientalischen Texte. Der kritischen Edition der arabischen, der athiopischen und der syrischen Versionen folgt eine deutsche Ubersetzung, die in zahlreichen Anmerkungen auf die jeweiligen Beziehungen zu ihren Vorlagen verweist. In dem erganzenden Beitrag von Stefan Weninger zur Ubersetzungssprache wird aufgezeigt, wie der athiopische Ubersetzer trotz enger Bindung an seine arabische Vorlage einen freien Ubersetzungsstil wahlte. Die besondere Sprache dieser Version liefert zudem neue Belege fur das athiopische Lexikon. Die hier vorgelegten Versionen des Secundus Taciturnus belegen einmal mehr die grosse Bedeutung und Langlebigkeit von popularphilosophischen Werken der Spatantike sowie die Flexibilitat der syrischen, der arabischen und der athiopischen Sprachen in der Wiedergabe ihrer Vorlagen. (shrink)

The pivotal role of the relation part-of in the description of living organisms is widely acknowledged. Organisms are open systems, which means that in contradistinction to mechanical artifacts they are characterized by a continuous flow and exchange of matter. A closer analysis of the spatial relations in biological organisms reveals that the decision as to whether a given particular is part-of a second particular or whether it is only contained-in the second particular is often controversial. We here propose a rule-based (...) approach which allows us to decide on the basis of well-defined criteria which of the two relations holds between two anatomical objects, given that one spatially includes the other. We discuss the advantages and limitations of this approach, using concrete examples from human anatomy. (shrink)

Deletions, duplications, insertions, inversions, and translocations, collectively called structural variations (SVs), affect more base pairs of the genome than any other sequence variant. The recent technological advancements in genome sequencing have enabled the discovery of tens of thousands of SVs per human genome. These SVs primarily affect non‐coding DNA sequences, but the difficulties in interpreting their impact limit our understanding of human disease etiology. The functional annotation of non‐coding DNA sequences and methodologies to characterize their three‐dimensional (3D) organization in the (...) nucleus have greatly expanded our understanding of the basic mechanisms underlying gene regulation, thereby improving the interpretation of SVs for their pathogenic impact. Here, we discuss the various mechanisms by which SVs can result in altered gene regulation and how these mechanisms can result in rare genetic disorders. Beyond changing gene expression, SVs can produce novel gene‐intergenic fusion transcripts at the SV breakpoints. (shrink)

Is there any good reason to believe in Nietzsche's metaphysics even thought he himself claims that it is not "the truth" in correspondence with the world? According to Danto, Nietzsche's metaphysics is only valid for Nietzsche himself. However, this answer does not take into consideration Nietzsche's claim for the general superiority of his philosophy. Nietzsche's view seems inconsistent: on the one hand, he claimed all perspectives are equally false in respect to "the truth," but on the other, he regarded his (...) view as superior. This book explains in which respect Nietzshe justifies his claims, that Nietzsche's position is not inconsistent, and why consistency is important for him. (shrink)