This is not a work of mine. For some reason, I am unable to remove it from my page. It is a list of Dr. Reiner Schürmann's lecture notes for courses that he taught at the New School for Social Research (aka The New School).

Pathogenic variants occurring in protein‐coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant‐negative (DN) effects, counteracting the activity of the normal gene‐product, and gain of function (GOF) are also mechanisms driving dominance. Here, I discuss a few papers on these specific mechanisms. In short, there is accumulating evidence pointing to differences between LOF versus non‐LOF variants (DN and GOF). (...) The latter are thought to have milder effects on protein structure and, as expected, DN variants are enriched at protein interfaces. This tendency to cluster in 3D space can help improve the ability of computational tools to predict the pathogenicity of DN variants, which is currently a challenging issue. More recent results support the hypothesis whereby cotranslational assembly of macromolecular complexes can buffer deleterious consequences of variants that would otherwise lead to DN effects (DNEs). Indeed, subunits the variants of which are responsible for DNEs tend to elude cotranslational assembly, thus poisoning complexes involving wild‐type subunits. The constraints explaining why the buffering of DNEs is not universal require further investigation. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

Sollen und Sein klaffen bei uns weiter auseinander als bei anderen, weil eben das Sollen sehr hoch gesetzt ist. Thomas Mann, Doctor Faustus.

In late 2009, e-mails from a server at the Climate Research Unit at the University of East Anglia were released that showed some climate scientists in an unfavorable light. Soon this scandal was known as “Climategate” and a highly charged debate started to rage on blogs and in the mass media. Much of the debate has been about the question whether anthropogenic global warming was undermined by the revelations. But ethical issues, too, became part and parcel of the debate. This (...) article aims to contribute to this debate, assessing the e-mail affair in the light of two normative analyses of science, one proposed by Robert Merton, the second by a recent suggestion to use the concept of honest brokering in science policy interactions. On the basis of these analyses, different aspects of malpractice will be discussed and possible solutions will be suggested. (shrink)

Am Leitfaden des Begriffs Malum oeconomicum fuhrt das Buch seine Leser in einen Dialog mit klassischen und zeitgenossischen Denkern uber die abgrundigen Seiten der Wirtschaft und ihre Spiegelungen in der Seele. In der Wirtschaft erscheinen Menschen tendenziell fureinander als blosse Werkzeuge ihrer Bedurfnisbefriedigung, andererseits wird wirtschaftliche Leistung mit Bedeutungen aufgeladen, die an das Heil in der religiosen Sphare gemahnen. Im Kapitalismus der Moderne entfaltet sich aus der Wechselwirkung zwischen einer entfesselten Produktion und den Antrieben des Innenlebens eine zuvor unbekannte Dynamik. (...) Ist diese in liberalen Theorien ein Anlass, das Malum oeconomicum fur verschwunden zu erklaren, so machen Fundamentalkritiker des globalen Kapitalismus geltend, dass dieser illusionare Bedurfnisse weckt und unversohnliche Gegensatze zwischen Arm und Reich hervorruft, deren Sprengkraft jeden sozialen Zusammenhalt gefahrdet. Aus der Lekture von Platon, Aristoteles, Thomas Hobbes, Bernard Mandeville, Adam Smith, Thomas Robert Malthus, Karl Marx, Max Weber, Georg Simmel, John Maynard Keynes, Martin Heidegger, Herbert Marcuse, John Rawls und Amartya Sen ergeben sich Aussichten auf das Wirtschaftsgeschehen, die uber die Engfuhrungen heutiger Debatten weit hinausweisen. (shrink)

The article presents the sociology of knowledge approach to discourse (SKAD). SKAD, which has been in the process of development since the middle of the 1990s, is now a widely used framework among social scientists in discourse research in the German-speaking area. It links arguments from the social constructionist tradition, following Berger and Luckmann, with assumptions based in symbolic interactionism, hermeneutic sociology of knowledge, and the concepts of Michel Foucault. It argues thereby for a consistent theoretical and methodological grounding of (...) a genuine social sciences perspective on discourse interested in the social production, circulation and transformation of knowledge, that is in social relations and politics of knowledge in the so-called ‘knowledge societies’. Distancing itself from Critical Discourse Analysis, Linguistics, Ethnomethodology inspired discourse analysis and the Analysis of Hegemonies, following Laclau and Mouffe, SKAD’s framework has been built up around research questions and concerns located in the social sciences, referring to public discourse and arenas as well as to more specific fields of (scientific, religious, etc.) discursive struggles and controversies around problematizations (Foucault). (shrink)

« La déconstruction, c’est la pulvérisation d’un socle spéculatif où la vie trouverait son assise, sa légitimation, sa paix. » Autrefois son élève, Reiner Schürmann identifie dans l’oeuvre de Heidegger un impensé, le principe d’anarchie. Contre cette métaphysique occidentale qu'il s'applique à déconstruire, le penseur de la présence aurait fait de l'être et de l'agir une seule et même question. Et sapé ainsi toute possibilité de définir un fondement rationnel sur lequel construire une philosophie pratique. Que l'agir humain, à (...) l'époque technologique, se trouve privé d'arché : voilà ce que cette étude majeure, lisant Heidegger à rebours, a permis de dévoiler. (shrink)

Keine ausführliche Beschreibung für "Reflexion und Gefühl" verfügbar.

Obwohl der Stringansatz als Versuch einer nomologisch vereinheitlichten Erfassung aller Wechselwirkungen, inklusive der Gravitation, schon über drei Jahrzehnte existiert, sind die ihm zugrundeliegenden physikalischen Prinzipien noch völlig unklar; und es gibt nicht die geringste empirisch überprüfbare, quantitative Vorhersage. Ohne empirische Daten, die mit den etablierten Theorien - quantenfeldtheoretischem Standardmodell und Allgemeiner Relativitätstheorie - unvereinbar wären, liefert nur die konzeptionelle Inkompatibilität beider, gemeinsam mit der Vereinheitlichungsidee, eine Motivation für den Stringansatz. Mit diesem droht jedoch die Physik, unter konsequenter Weiterführung ihrer bisher (...) erfolgreichen Strategien, den methodologischen Rahmen der empirischen Wissenschaften zu überschreiten. (shrink)

Michael Walzer is one of the world's most important political thinkers. In this book, Toby J. Reiner provides the most wide-ranging and up-to-date introduction to his work available. Examining Walzer's multivarious writings and work, Reiner develops an illuminating new interpretation of his thought that no political theorist can afford to miss.

Today political competition and thus the politicians’ incentives to cater for the citizens’ preferences are weakened by protectionist regulations aiming at the politicians’ origin, their incomes and the ‘production process of politics’. This paper suggests abolishing these regulations and institutionalizing an open, international market for politics. Foreign as well as profit-seeking ‘policy producers’ should be allowed to run directly for office without nominating specific individuals. This enables a policy supplier to become active in several countries and jurisdictions and thus to (...) build up an international reputation for being credible, i.e. of sticking to his promises and not exploiting the voters after election. The deregulation programme strengthens the influence of the weakly organized social groups and the governments' incentives to pursue what is of general interest. (shrink)

Cooperative discourse procedures produce consensual siting proposals for NIMBY-projects-but only if these proposals do not affect the final siting decision. Then, the members of the discourse commissions stay independent and face few incentives to pursue consequentialist interests. However, the more influential discourse procedures become, the stronger the interest groups’ incentives are to take advantage of them. Thus, cooperative discourses turn into competitive, interest-centred procedures whose outcome is rejected by the less influential groups. The evolution of discourse procedures into functionally specialized (...) parliaments or even into FOCJ (Functional, Overlapping, Competing Jurisdictions) seems worth pursuing. (shrink)

Often denied scientific status, Völkerpsychologie was set forth as a psychological program endeavoring to find insights into the structure and content of the ‘mind’ of social groups, especially ‘peoples’, which were regarded as the prototypical manifestation of those groups. This article examines how Moritz Lazarus and Heymann Steinthal’s nineteenth-century Völkerpsychologie came to be regarded as having the status of a science, by analyzing its scientific program. I claim that these founders of Völkerpsychologie developed a moderate methodological materialism by embracing a (...) historical turn in psychology, which—to a degree—enabled a synthesis of the methodologies of the social and the natural sciences. This approach is correlated with their modus operandi, collaboration through the medium of a journal. (shrink)

The development of personal technologies has recently shifted from devices that seek to capture user attention to those that aim to improve user well-being. Digital wellness technologies use the same attractive qualities of other persuasive apps to motivate users towards behaviors that are personally and socially valuable, such as exercise, wealth-management, and meaningful communication. While these aims are certainly an improvement over the market-driven motivations of earlier technologies, they retain their predecessors’ focus on influencing user behavior as a primary metric (...) of success. Digital wellness technologies are still persuasive technologies, and they do not evade concerns over whether their influence on users is ethically justified. In this paper, we describe several ethical frameworks with which to assess the justification of digital wellness technologies’ influence on users. We propose that while some technologies help users to complete tasks and satisfy immediate preferences, other technologies encourage users to reflect on the values underlying their habits and teach them to evaluate their lives’ competing demands. While the former approach to digital wellness technology is not unethical, we propose that the latter approach is more likely to lead to skillful user engagement with technology. (shrink)