The type III secretion system (T3SS) is a specialized nanomachine that enables bacteria to secrete proteins in a specific order and directly deliver a specific set of them, collectively known as effectors, into eukaryotic organisms. The core structure of the T3SS is a syringe‐like apparatus composed of multiple building blocks, including both membrane‐associated and soluble proteins. The cytosolic components organize together in a chamber‐like structure known as the sorting platform (SP), responsible for recruiting, sorting, and initiating the substrates destined to (...) engage this secretion pathway. In this article, we provide an overview of recent findings on the SP's structure and function, with a particular focus on its assembly pathway. Furthermore, we discuss the molecular mechanisms behind the recruitment and hierarchical sorting of substrates by this cytosolic complex. Overall, the T3SS is a highly specialized and complex system that requires precise coordination to function properly. A deeper understanding of how the SP orchestrates T3S could enhance our comprehension of this complex nanomachine, which is central to the host‐pathogen interface, and could aid in the development of novel strategies to fight bacterial infections. (shrink)

La Ilustración es un gran torrente que marcó un hito en la Historia del mundo, por sus implicaciones po-líticas, sociales, culturales y económicas. Este fenómeno es conocido popularmente desde Kant como la en-trada en la mayoría de edad de la sociedad: abandonar viejos fanatismos y tener valor de servirse del propio entendimiento. El objetivo de este artículo es mostrar las interpretaciones dominantes de este fenómeno his-tórico que han marcado su recepción en la academia y mostrar la singular aproximación del filósofo (...) francés Michel Foucault. (shrink)

Conceptions of evil have changed dramatically over time, and though humans continue to commit acts of cruelty against one another, today we possess a clearer, more moral way of analyzing them. In _Narrating Evil_, María Pía Lara explores what has changed in our understanding of evil, why the transformation matters, and how we can learn from this specific historical development. Drawing on Immanuel Kant's and Hannah Arendt's ideas about reflective judgment, Lara argues that narrative plays a key (...) role in helping societies acknowledge their pasts. Particular stories haunt our consciousness and lead to a kind of examination and dialogue that shape notions of morality. A powerful description of a crime can act as a filter, helping us to draw conclusions about what constitutes a moral wrong, and public debates over these narratives allow us to construct a more accurate picture of historical truth, leading to a better understanding of why such actions are possible. In building her argument, Lara considers Greek tragedies, Shakespeare's depictions of evil, Joseph Conrad's literary metaphors, and movies that portray human cruelty. Turning to such philosophers and writers as Jürgen Habermas, Walter Benjamin, Primo Levi, Giorgio Agamben, and Ariel Dorfman, Lara defines a reflexive relationship between an event, the narrative of the event, and the public reception of the narrative, and she proves that the stories of perpetrators and sufferers are always intertwined. The process of disclosure, debate, and the public fashioning of collective judgment are vital methods through which we make sense not only of new forms of cruelty but of past crimes as well. _Narrating Evil_ describes the steps of this process and why they are a crucial part of our attempt to build a different, more just world. (shrink)

Postmodern political critiques speak of the death of ideology, the end of history, and the postsecular return of religious attitudes, yet radical conservative theorists such as Mark Lilla argue religion and politics are inextricably intertwined. Returning much-needed uncertainty to debates over the political while revitalizing the very terms in which they are defined, María Pía Lara explores the ambiguity of secularization and the theoretical potential of a structural break between politics and religion. For Lara, secularization means three (...) things: the translation of religious semantics into politics; a transformation of religious notions into political ideas; and the reoccupation of a space left void by changing political actors that gives rise to new conceptions of political interaction. Conceptual innovation redefines politics as a horizontal relationship between governments and the governed and better enables societies (and individual political actors) to articulate meaning through action--that is, through the emergence of new concepts. These actions, Lara proves, radically transform our understanding of politics and the role of political agents and are further enhanced by challenging the structural dependence of politics on religious phenomena. (shrink)

This paper employs network theory, mining data and bibliometric analysis when mapping the scientific contribution of Nobel Prize candidate; Manuel Sandoval Vallarta, the first and most renowned Mexican physicist and important figure in Latin American science. Vallarta died in 1977, and the existing literature is about his life and contributions to science but not about how those are still valuable today. This paper is the first to highlight, with mapping tools, that his contributions are relevant to the international community of (...) cosmic rays, quantum mechanics and relativity. These tools delivered three findings: Identify how he built his own field of study, same as universal knowledge. Unveil that the backward and forward Vallarta citations follow a scale-free network distribution. Determine social factors that benefited or affected his scientific activities—such as World War II interrupting Vallarta’s successful productivity at Massachusetts Institute of Technology. Furthermore, this study confirmed the interdisciplinary nature of the mapping studies of the scientist's contributions using scientometric tools. As a result, several interesting questions arose throughout our research, some of which were answered from the history and philosophy of science. However, others need to be analyzed by experts in the fields of Vallarta. Mapping research sends an invitation to interdisciplinary dialogue/research between experts in different areas of study to better understand the process of knowledge production both, individual and collective. (shrink)

BackgroundThe psychological burden possibly deriving from not immediately undergoing radical treatment for prostate cancer could be a potential disadvantage of active surveillance, especially in the eve of some relevant clinical exams [i.e., re-biopsy, prostate-specific antigen test, and medical examination]. Even if it is known from the literature that the majority of PCa men in AS do not report heightened anxiety, there is a minority of patients who show clinically significant levels of anxiety after diagnosis. The present study aimed to investigate (...) if demographic, clinical, and psychological variables at the entrance in AS were associated with the risk of developing clinically significant PCa-related anxiety 2 months before the first re-biopsy and to offer psychological support to improve quality of life.Materials and MethodsA total of 236 patients participated in the PCa Research International: AS protocol and in PRIAS-QoL study. Demographic/clinical features, health-related QoL domains, coping with cancer, PCa-related anxiety [Memorial Anxiety Scale for PCa ], personality traits, and decision-making-related factors were assessed at T0. MAX-PC was also administered at T1. PCa-related anxiety at T1 was considered to be of clinical significance if the MAX-PC score was ≥1.5. Multivariable logistic regression coupled to bootstrap was used to detect factors associated with high levels of anxiety.ResultsThe median age was 64.4 years. Fifty-six patients reported MAX-PC total score above the cutoff. Three factors were associated with a high level of PCa anxiety at T1: anxious preoccupation [odds ratio = 4.36], extraversion, and prostate-related symptoms. Physical well-being was associated with a low PCa anxiety subscale ; neuroticism and functional well-being were associated with PSA anxiety. Neuroticism and helplessness/hopelessness were associated with fear of progression.ConclusionOnly a partial portion of the sample experienced significant levels of anxiety after 10 months. Psychological assessment should be routinely conducted to detect risk factors for increased anxiety, offering tailored psychological interventions aimed at promoting interpersonal awareness and emotional well-being. (shrink)

In this article I deal with Kant's concept of reflective judgment, and recover it through its links to the aesthetic dimension as its fundamental scenario. Then I go on to explain why Hannah Arendt understood this important Kantian connection, and why she thought it would allow her to develop it through a political dimension. Last, having reviewed both Kant and Arendt's contributions to the concept of reflective judgment, I recover my own input to the concept by showing its linguistic dimension (...) based on the Heideggerian notion of world-disclosure. With this in mind, I show how the concept of reflective judgment is the most suitable to analyze evil actions. (shrink)

Actualmente la educación requiere la autonomía en el aprendizaje de los alumnos. Por ello, se realizó la siguiente investigación usando el aula invertida como metodología para mejorar la autonomía de los alumnos en materias como Desarrollo Humano, Instrumentos de Evaluación y Estrategias de Enseñanza de la Lengua Inglesa.Desde septiembre de 2021, los alumnos del programa educativo de Técnico Superior Universitario en Lengua Inglesa, trabajaron de manera híbrida, por esta razón, la metodología del aula invertida fue una herramienta útil para desarrollar (...) las competencias requeridas por el programa educativo, además de la autonomía. (shrink)

In this paper I want to leave behind the failed attempts to think about populism as ideology, strategy, style, or even discourse. I will focus on the ‘conceptual battles of politics’ and their potential to influence actors to pursue and effect specific ends. Reinhart Koselleck and his ideas about conceptual history will figure prominently in my discussion, as will his concept of asymmetrical combat-concept as a means of unleashing a theoretical and political war. The goal is to demonstrate that concepts (...) have taken the place of weapons of war among political actors. (shrink)

Following a previous article where I defined how a concept becomes a weapon of ideological wars, this article seeks to clarify why there are semantic connections of the actual concept of ‘populism’ with the semantics of the concept of crisis. My key argument is to focus on how actors use the concept of populism on the public sphere with the goal to inspire fear instead of allowing citizens and theorists to understand what is behind our present political–economic crisis. In my (...) view, both theorists and politicians should be aware how a concept that lacks any precision does not help us to understand our present moment of crisis. We must use other tools and the help of historians to understand why has neo-liberal politics unleashed this present crisis. (shrink)

In this article I deal with Kant's concept of reflective judgment, and recover it through its links to the aesthetic dimension as its fundamental scenario. Then I go on to explain why Hannah Arendt understood this important Kantian connection, and why she thought it would allow her to develop it through a political dimension. Last, having reviewed both Kant and Arendt's contributions to the concept of reflective judgment, I recover my own input to the concept by showing its linguistic dimension (...) based on the Heideggerian notion of world-disclosure. With this in mind, I show how the concept of reflective judgment is the most suitable to analyze evil actions. (shrink)

In this article I deal with Kant's concept of reflective judgment, and recover it through its links to the aesthetic dimension as its fundamental scenario. Then I go on to explain why Hannah Arendt understood this important Kantian connection, and why she thought it would allow her to develop it through a political dimension. Last, having reviewed both Kant and Arendt's contributions to the concept of reflective judgment, I recover my own input to the concept by showing its linguistic dimension (...) based on the Heideggerian notion of world-disclosure. With this in mind, I show how the concept of reflective judgment is the most suitable to analyze evil actions. (shrink)

This innovative volume will be welcomed by moral and political philosophers, social scientists, and anyone who reflects seriously on the twentieth century's heavy burden of war, genocide, ethnic cleansing, and other evidence of people's desire to harm one another. María Pía Lara brings together a provocative set of essays that reexamine evil in the context of a "postmetaphysical" world, a world that no longer equates natural and human evil and no longer believes in an omnipotent God. The question (...) of how and why God permits evil events to occur is replaced by the question of how and why humans perform radically evil acts. (shrink)

The subject of gender violence is complex because our conceptions of what constitutes violence have historically evolved. Therefore, I propose that we should try to understand gender violence neither in abstract nor in essentialist ways, but within historical frameworks and through concrete examples. In this essay I will focus on a historical genealogy of our moral views about gender violence, and, in particular, on the figure of what we call today “rape.” The question of rape is but one example of (...) the long history of gender violence. However, this example is important to understand how violence and gender violence are related to specific conceptions of political and sexual sovereignty. My claim is that we need to pay attention to how is it possible to understand the role of imagination to interpret gender violence nowadays. My conclusion is that the moral filters that configure our “feminist imaginary” have changed our views about rape. (shrink)

This paper deals with Claudia Card's important contributions to a theory of evil that steps out from traditional models of thinking about this problem . Instead, our author seeks to explore important elements from other theorists in order to build up her ideas of what she calls the "atrocity paradigm." This critical essay focuses mainly in the spaces where Card's conclusions need to rethink the limits and constraints of her theory.

Resumen: Spinoza afirma que las decisiones, elecciones y acciones de un agente son necesarias porque están determinadas causalmente. ¿Acaso los seres humanos no son agentes morales? ¿son sólo eslabones de una cadena de causas cuyo curso no pueden controlar y que los exime de las consecuencias de sus actos, así como de premios y castigos? ¿ser un individuo libre significa aceptar pasivamente lo que ocurre y abandonar la pretensión de modificarlo? Este artículo responde a estas preguntas mediante la distinción en (...) la obra spinoziana de dos conceptos de libertad, la verdadera libertad y el libre albedrío, así como con la distinción entre la responsabilidad civil fundada en el concepto de potestas humana -y no en la verdadera libertad, aunque la posibilita-.: Spinoza sustains that the agents' decisions are necessary because they are causally determined. But then, are humans really moral agents? Is it possible that they are only passengers in a train of causes, whose course they cannot control and exempts them from the consequences of their acts, of reward or punishment? Is accepting whatever happens and quitting the aspiration of changing things the hallmark of the free man? This paper answers these questions by distinguishing two concepts of freedom, real freedom and free will, as well as two concepts of responsibility. Civil responsibility is grounded in free will, whereas moral responsibility is not grounded in true freedom, but in human power. (shrink)

This paper summarizes (in German) recent tendencies in the philosophy of the life sciences.

I will critically explore Arato and Cohen’s work on populism acknowledging areas of agreement while noting gaps in their reasoning particularly regarding the complex relations between capitalism and democracy and the recent erosion of democracy replacing it with authoritarian regimes that are better suited for neoliberal policies.

Turing was an exceptional mathematician with a peculiar and fascinating personality and yet he remains largely unknown. In fact, he might be considered the father of the von Neumann architecture computer and the pioneer of Artificial Intelligence. And all thanks to his machines; both those that Church called “Turing machines” and the a-, c-, o-, unorganized- and p-machines, which gave rise to evolutionary computations and genetic programming as well as connectionism and learning. This paper looks at all of these and (...) at why he is such an often overlooked and misunderstood figure. (shrink)

This paper deals with Claudia Card's important contributions to a theory of evil that steps out from traditional models of thinking about this problem (theodicies, metaphysical theories, etc.). Instead, our author seeks to explore important elements from other theorists (such as Kant and Nietzsche) in order to build up her ideas of what she calls the "atrocity paradigm." This critical essay focuses mainly in the spaces where Card's conclusions need to rethink the limits and constraints of her theory.

La autora nos ubica en las discusiones más recientes de la filosofía política y de la ética. Su objetivo es plantear la posibilidad de encontrar una interrelación entre ambas sin que ello suponga un retorno a las ideas aristotélicas.

: The key concept is "vertigo of secularization." It relates to the fears that societies experience when understanding the need to ground their political orders as separated from religion. The erosion of values produces vertigos around the world. We need to understand better these kinds of processes because only by doing so can we keep that fear and violence from taking precedence over the hard working tasks of building up a global political community.

: My text is written to answer the questions asked at the APA Meeting's presentation of the book Moral Textures: Feminist Narratives in the Public Sphere by professors María Lugones and Eduardo Mendieta. The answer seeks to clarify that Lugones's infrapolitics position is not so distant from mine. I also address Mendieta's question directed more to the aesthetic domain. There, I seek to show how my position could be taken as a creative effort to extend some of Habermas's early (...) work on the public sphere, and to develop the thesis of the important relations between the aesthetic and the moral realms. (shrink)

My text is written to answer the questions asked at the APA Meeting's presentation of the book Moral Textures: Feminist Narratives in the Public Sphere by professors María Lugones and Eduardo Mendieta. The answer seeks to clarify that Lugones's infrapolitics position is not so distant from mine. I also address Mendieta's question directed more to the aesthetic domain. There, I seek to show how my position could be taken as a creative effort to extend some of Habermas's early work (...) on the public sphere, and to develop the thesis of the important relations between the aesthetic and the moral realms. (shrink)

This article offers a new interpretation of Mexico's transition to democracy that differs from the pessimistic and less culturally oriented ones that currently prevail. In the article I develop a normative model, which emphasizes the moral capacities of civil societies and their ability to inspire altruistic actions. I suggest that this approach is not only more compelling philosophically but also more plausible empirically. To demonstrate this, I reconstruct a series of events from Mexico's recent past. My discussion suggests that social (...) actors can reconfigure societal self-understandings through moral interventions in the public sphere and that such refigurations of the symbolic order are central for democratic transition. (shrink)

: This paper deals with Claudia Card's important contributions to a theory of evil that steps out from traditional models of thinking about this problem (theodicies, metaphysical theories, etc.). Instead, our author seeks to explore important elements from other theorists (such as Kant and Nietzsche) in order to build up her ideas of what she calls the "atrocity paradigm." This critical essay focuses mainly in the spaces where Card's conclusions need to rethink the limits and constraints of her theory.

Partimos de unas reflexiones sobre el Racionalismo y el Historicismo como dos enfoques con perfiles epistemológicos claramente diferenciados, que llevan a quien en ellos se sitúe a muy diversos planteamientos respecto a cualquier cuestión de carácter social. Examinamos el alcance y potencial de ambos en su argumentación cuando pretenden dar cuenta del origen de la sociedad política y todo lo que ello representa, instituciones, valores… Esbozada esta cuestión se recala en el análisis jovellanista de la mujer. Jovellanos conoce bien ambos (...) enfoques, sus lecturas de los autores aquí citados están plenamente contrastadas y no son objeto de este trabajo; apuesta por el enfoque historicista inglés para comprender el rol femenino, para situar a las instituciones que le niegan su ingreso en su decurso histórico, y curiosamente convierte el modelo historicista en una vía de análisis y acceso a propuestas de una extraordinaria modernidad. Analizamos desde estos enfoques los planes de estudio en los que estamos inmersos. (shrink)

This article deals with the empirical example of how social subjects, in this case women, have appropriated the language of rights in order to demand social inclusion. Since there are many different points of view in feminist theory with regard to how to deal with the idea of women’s rights, this article is divided into three sections. In the first section, I focus on how some important normative contents about democracy and rights have already been accepted by many different theorists (...) who speak from critical perspectives. In the second section, I deal with how women’s struggles have gained consensus about the importance of defending the idea of rights for their own struggles to overcome their exclusion. In the third and last section, I turn back to the theoretical efforts by leading feminists, in order to show how these struggles from women all over the world can be thematized in our global scenario. (shrink)

Richard Kearney’s new book, Touch: Recovering Our Most Vital Sense, has come as a way of illustrating the paradoxes of our times, most deeply felt as a result of the Covid-19 pandemic. Have a look...

This article deals with our constructed notions of evil and how an historical appraisal takes shape after specific stories and narratives become important objects of public deliberation, historical criticism, and disclosive views of what constitutes the moral harms of human cruelty. I analyze the historical representations of the meaning of evil in specific historical times through narratives that have made important contributions to our historical understanding of them. I also propose that our learning from them is the result of public (...) debates, of memory wars, and of important interventions from public intellectuals, writers, historians and witnesses. Therefore, deliberating about human cruelty is always a reconstructive effort to understand and judge what has happened and why it could have been prevented. The term evil is a moral filter that allows us to situate the kind of moral harm that needs a specific lens of moral understanding and a reconfiguration of actions that tie perpetrators to sufferers. Moral harms are better ways to describe the kind of actions that we call evil. The article highlights the relevance of language, disclosive views, criticism, public debate and the ways in which societies cope with their past in order to envision a different future. (shrink)

Occupational health remains neglected in developing countries because of competing social, economic and political challenges. Ethical issues in the workplace related to the hazards and risks of becoming infected by Leishmania (Leishmania) mexicana , through the bite of naturally infected sand flies, is another area of concern that has been neglected as well. We report here the results of reviewing two entomological field studies carried out in our research center from 2003 to 2006. Eight students from our School of Biology (...) were invited to catch sand flies. A total of six of the eight (75%) developed a typical clinical picture of Localized Cutaneous Leishmaniasis (LCL) caused by L. (L.) mexicana . In this article we identify the ethical issues related to these kinds of studies and propose some guidelines for conducting them. (shrink)