Fetal alcohol spectrum disorder is a multifaceted disability, characterized not only by brain- and body-based challenges, but also high rates of environmental adversity, lifelong difficulties with daily living, and distinct sociocultural considerations. FASD is one of the most common neurodevelopmental disabilities in the Western world and associated with significant social and economic costs. It is important to understand the complexities of FASD and the ways in which FASD requires unique consideration in research, practice, and policy. In this article, we discuss (...) our perspectives on factors that distinguish FASD from other disabilities in terms of complexity, co-occurrence, and magnitude. We provide an overview of select literature related to FASD as a socially rooted disability with intergenerational impacts and multiple layers of stigma. These social issues are intertwined with notable experiences of adversity across the lifespan and high rates of co-occurring health concerns for individuals with FASD, all of which present unique challenges for individuals, caregivers, families, service providers, and policy makers. Understanding these factors is the first step in developing and implementing specialized initiatives in support of positive outcomes for individuals with FASD and their families. Future directions are proposed for advancing research, practice, and policy, and responding to the unique complexities of FASD. (shrink)

The arts of rule cover the exercise of power by princes and popular sovereigns, but they range beyond the domain of government itself, extending to civil associations, political parties, and religious institutions.

Objectives To investigate empirically the motivations for not consenting to DNA biobanking in a Swedish population-based study and to discuss the implications. Design Structured questionnaires and semistructured interviews. Setting A longitudinal epidemiological project (PART) ongoing since 1998 in Stockholm, Sweden. The DNA-collection wave took place during 2006–7. Participants 903 individuals completed the questionnaire (participation rate 36%) and 23 were interviewed. All individuals had participated in both non-genetic waves of the project, but refused to contribute saliva samples during the DNA-collection wave. (...) Main outcome measures Motivations behind refusing to consent to DNA biobanking, with subsequent focus on participants' explanations regarding this unwillingness. Results Public refusal to consent to DNA biobanking, as revealed by the questionnaire, was mainly explained by a lack of personal relevance of DNA contribution and feelings of discomfort related to the DNA being used for purposes other than the respective study. Interviews of individuals representing the second motivation, revealed a significant mistrust of DNA biobank studies. The underlying beliefs and attitudes were associated with concerns about integrity, privacy, suspiciousness and insecurity. However, most interviewees were supportive of genetic research per se and interpreted their mistrust in the light of distressing environmental influences. Conclusion The results suggest a need for guidelines on benefit sharing, as well as trustworthy and stable measures to maintain privacy, as a means for increasing personal relevance and trust among potential participants in genetic research. Measures taken from biobanks seem insufficient in maintaining and increasing trust, suggesting that broader societal measures should be taken. (shrink)

It is a common opinion that chance events cannot be understood in causal terms. Conversely, according to a causal view of chance, intersections between independent causal chains originate accidental events, called “coincidences”. Firstly, this book explores this causal conception of chance and tries to shed new light on it. Such a view has been defended by authors like Antoine Augustine Cournot and Jacques Monod. Second, a relevant alternative is provided by those accounts that, instead of acknowledging an intersection among causal (...) lines, claim to track coincidences back to some common cause. Third, starting from Herbert Hart and Anthony Honoré’s view of coincidences (Causation in the Law. Clarendon Press, Oxford, 1959). This book provides a more detailed account of coincidences, according to which coincidental events are hybrids constituted by ontic (physical) components, which is the intersection between independent causal chains, plus epistemic aspects, including but not limited to, access to information, expectations, relevance, significance, desires, which in turn are psychological aspects. -/- The main target of the present work is to show that the epistemic aspects of coincidences are, together with the independence between the intersecting causal chains, a constitutive part of coincidental phenomena. This book aims to introduce and discuss recent work in psychology concerning one’s judgment about coincidences; this data offers further materials and reasons to reflect upon our understanding of coincidences and to refine our hybrid conception. (shrink)

The global pesticide complex has transformed over the past two decades, but social science research has not kept pace. The rise of an enormous generics sector, shifts in geographies of pesticide production, and dynamics of agrarian change have led to more pesticide use, expanding to farm systems that hitherto used few such inputs. Declining effectiveness due to pesticide resistance and anemic institutional support for non-chemical alternatives also have driven intensification in conventional systems. As an inter-disciplinary network of pesticide scholars, we (...) seek to renew the social science research agenda on pesticides to better understand this suite of contemporary changes. To identify research priorities, challenges, and opportunities, we develop the pesticide complex as a heuristic device to highlight the reciprocal and iterative interactions among agricultural practice, the agrochemical industry, civil society-shaped regulatory actions, and contested knowledge of toxicity. Ultimately, collaborations among social scientists and across the social and biophysical sciences can illuminate recent transformations and their uneven socioecological effects. A reinvigorated critical scholarship that embraces the multifaceted nature of pesticides can identify the social and ecological constraints that drive pesticide use and support alternatives to chemically driven industrial agriculture. (shrink)

Machiavelli's New Modes and Orders is the only full-length interpretive study on Machiavelli's controversial and ambiguous work, Discourses on Livy. These discourses, considered by some to be Machiavelli's most important work, are thoroughly explained in a chapter-by-chapter commentary by Harvey C. Mansfield, one of the world's foremost interpreters of this remarkable philosopher. Mansfield's aim is to discern Machiavelli's intention in writing the book: he argues that Machiavelli wanted to introduce new modes and orders in political philosophy in order (...) to make himself the founder of modern politics. Mansfield maintains that Machiavelli deliberately concealed part of his intentions so that only the most perceptive reader could see beneath the surface of the text and understand the whole of his book. Previously out of print, Mansfield's penetrating study brings to light the hidden thoughts lurking in the details of the Discourses on Livy to inform and challenge its readers at every step along the way. (shrink)

Drug promotion should be evaluated according to its impact on health, access to information, informed consent, and wealth. Drug promotion currently does more harm than good to each of these objectives because it is usually misleading. This is a systemic problem. Whilst improved regulation and education will address it to some degree, major reforms to payment systems for drug companies and doctors are also required. Until all these systemic reforms can be put in place, the best policy option is to (...) ban the promotion of drugs to doctors and the public. Consequently, pending major reforms, it is appropriate for governments to restrict drug promotion as much as is politically achievable. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

It is a common opinion that chance events cannot be understood in causal terms. Conversely, according to a causal view of chance, intersections between independent causal chains originate accidental events, called “coincidences.” The present paper takes into proper consideration this causal conception of chance and tries to shed new light on it. More precisely, starting from Hart and Honoré’s view of coincidental events, this paper furnishes a more detailed account on the nature of coincidences, according to which coincidental events are (...) hybrids constituted by ontic components, that is the intersections between independent causal chains, plus epistemic aspects; where by “epistemic” we mean what is related, in some sense, to knowledge: for example, access to information, but also expectations, relevance, significance, that is psychological aspects. In particular, this paper investigates the role of the epistemic aspects in our understanding of what coincidences are. In fact, although the independence between the causal lines involved plays a crucial role in understanding coincidental events, that condition results to be insufficient to give a satisfactory definition of coincidences. The main target of the present work is to show that the epistemic aspects of coincidences are, together with the independence between the intersecting causal chains, a constitutive part of coincidental phenomena. Many examples are offered throughout this paper to enforce this idea. This conception, despite—for example—Antoine Augustine Cournot and Jacques Monod’s view, entails that a pure objectivist view about coincidences is not tenable. (shrink)

According to Antoine Augustine Cournot, chance events are the result of the intersection between independent causal chains. This coincidental notion of chance is not a new one, but—as Cournot remarks—it comes from Saint Thomas Aquinas, Boethius, and more probably from Jean de La Placette. Such a conception of chance phenomena seems to be very important, not only because it is closely related to the Principle of Causality, but also since it grounds Cournot’s theory of objective probability. Starting from Martin’s work, (...) the main attempt of this survey is to endorse the idea that Cournot’s coincidental notion of hasard is objective, that is it is ontic and it does not depend—in some sense—on our degree of knowledge. In order to do that, a central role in the discussion will be given to the meaning of the independence between the intersecting causal chains and to Cournot’s conception of causation. (shrink)

Uniting thirty years of authoritative scholarship by a master of textual detail, _Machiavelli's Virtue_ is a comprehensive statement on the founder of modern politics. Harvey Mansfield reveals the role of sects in Machiavelli's politics, his advice on how to rule indirectly, and the ultimately partisan character of his project, and shows him to be the founder of such modern and diverse institutions as the impersonal state and the energetic executive. Accessible and elegant, this groundbreaking interpretation explains the puzzles and (...) reveals the ambition of Machiavelli's thought. "The book brings together essays that have mapped [Mansfield's] paths of reflection over the past thirty years.... The ground, one would think, is ancient and familiar, but Mansfield manages to draw out some understandings, or recognitions, jarringly new."—Hadley Arkes, _New Criterion_ "Mansfield's book more than rewards the close reading it demands."—Colin Walters, _Washington Times_ "[A] masterly new book on the Renaissance courtier, statesman and political philosopher.... Mansfield seeks to rescue Machiavelli from liberalism's anodyne rehabilitation."—Roger Kimball, _The Wall Street Journal_. (shrink)

Background Pediatric critical care physician attitudes about withdrawal of ventricular assist devices and extracorporeal membrane oxygenation in cases of medical futility are poorly defined. Our aim was to define current attitudes regarding the withdrawal of these devices. Methods IRB-approved, cross-sectional observational survey conducted among pediatric critical care attending physicians and fellow physicians in the United States between 2016 and 2017. Data was collected anonymously and statistically analyzed. Results A total of 158 physicians responded with 67% being attending physicians. Compared to (...) a VAD, a higher percentage had taken care of a patient on ECMO where the device was turned off because care was believed to be futile, including currently. Nearly all reported that it can be ethically permissible to withdraw support from a patient with a VAD and on ECMO, but varied opinions existed as to who should ultimately make this decision if the patient/their family disagrees. More respondents agreed that a patient/their family should agree to withdrawal of VAD or ECMO support prior to initiation if futility is later determined and that protocols should be created for VAD and ECMO withdrawal. Conclusion Most pediatric critical care physicians felt that it can be ethically permissible to withdraw VAD and ECMO support. Our study indicates that pediatric VAD and ECMO withdrawal protocols are desired, but further investigation is needed to determine how to best design protocols that would incorporate multiple stakeholders. (shrink)

Uniting thirty years of authoritative scholarship by a master of textual detail, Machiavelli's Virtue is a comprehensive statement on the founder of modern politics. Harvey Mansfield reveals the role of sects in Machiavelli's politics, his advice on how to rule indirectly, and the ultimately partisan character of his project, and shows him to be the founder of such modern and diverse institutions as the impersonal state and the energetic executive. Accessible and elegant, this groundbreaking interpretation explains the puzzles and (...) reveals the ambition of Machiavelli's thought. "The book brings together essays that have mapped [Mansfield's] paths of reflection over the past thirty years. . . . The ground, one would think, is ancient and familiar, but Mansfield manages to draw out some understandings, or recognitions, jarringly new."--Hadley Arkes, New Criterion "Mansfield's book more than rewards the close reading it demands."--Colin Walters, Washington Times "[A] masterly new book on the Renaissance courtier, statesman and political philosopher. . . . Mansfield seeks to rescue Machiavelli from liberalism's anodyne rehabilitation."--Roger Kimball, The Wall Street Journal. (shrink)

This paper attempts to provide, through a reading of Derrida's Rogues, an account of the political phenomenon where regimes of sovereignty are resisted in the name of the very values — freedom, democracy and human rights, for example — they purport to stand for. To Derrida, sovereignty must simultaneously conform to a logic of both self-identity and of unconditionality. However, the unconditionality that makes sovereignty possible will always threaten and exceed it, something that other accounts like Agamben's try implicitly to (...) deny. In the end, for Derrida, our present political challenge is to recognize, and even affirm, the way the unconditionality of sovereignty is turned against itself. Sovereignty, then, is most effectively dealt with not by imagining a world in which it will no longer occur, nor by simple opposition, but by committing to the very logic of sovereignty itself. (shrink)

_Discourses on Livy_ is the founding document of modern republicanism, and Harvey C. Mansfield and Nathan Tarcov have provided the definitive English translation of this classic work. Faithful to the original Italian text, properly attentive to Machiavelli's idiom and subtlety of thought, it is eminently readable. With a substantial introduction, extensive explanatory notes, a glossary of key words, and an annotated index, the _Discourses_ reveals Machiavelli's radical vision of a new science of politics, a vision of "new modes and (...) orders" that continue to shape the modern ethos. "[Machiavelli] found in Livy the means to inspire scholars for five centuries. Within the _Discourses_, often hidden and sometimes unintended by their author, lie the seeds of modern political thought.... [Mansfield and Tarcov's] translation is careful and idiomatic."—Peter Stothard, _The Times_ "Translated with painstaking accuracy—but also great readability."—_Weekly Standard_ "A model of contemporary scholarship and a brave effort at Machiavelli translation that allows the great Florentine to speak in his own voice."—_Choice_. (shrink)

The most famous book on politics ever written, _The Prince_ remains as lively and shocking today as when it was written almost five hundred years ago. Initially denounced as a collection of sinister maxims and a recommendation of tyranny, it has more recently been defended as the first scientific treatment of politics as it is practiced rather than as it ought to be practiced. Harvey C. Mansfield's brilliant translation of this classic work, along with the new materials added for (...) this edition, make it the definitive version of _The Prince_, indispensable to scholars, students, and those interested in the dark art of politics. This revised edition of Mansfield's acclaimed translation features an updated bibliography, a substantial glossary, an analytic introduction, a chronology of Machiavelli's life, and a map of Italy in Machiavelli's time. "Of the other available [translations], that of Harvey C. Mansfield makes the necessary compromises between exactness and readability, as well as providing an excellent introduction and notes."—Clifford Orwin, _The Wall Street Journal_ "Mansfield's work... is worth acquiring as the best combination of accuracy and readability."—_Choice_ "There is good reason to assert that Machiavelli has met his match in Mansfield.... [He] is ready to read Machiavelli as he demands to be read—plainly and boldly, but also cautiously."—John Gueguen, _The Sixteenth Century Journal_. (shrink)

During sudden school closures in spring 2020 due to the COVID-19 pandemic, teachers had to move to distance teaching. This unprecedented situation could be expected to influence teacher well-being and schools as organizations. This article reports a qualitative study that aims at understanding how changes in teachers’ professional lives that were related to school closure affected Swiss primary teachers’ professional well-being. In semi-structured online-interviews, 21 teachers from 15 schools sampled by snowball method reported their experiences during school closure and distance (...) teaching and how this situation influenced their professional well-being. Results showed that medium to high levels of teacher well-being could accompany a general negative evaluation of the move to distance teaching. Factors such as high work-load, social distancing and feelings of lack of competence and self-efficacy were among the most aversive aspects of distance teaching and associated with deteriorating professional well-being. Among a plethora of factors that supported teachers in maintaining their well-being, contextual work-related aspects such as school resources, collegial support or leadership support along with individual aspects such as resilience, coping strategies, and clear work structures were important. Additionally, it was found that teacher well-being was nourished by positive experiences with the new forms of distance teaching and feelings of professional mastery. Despite methodological limitations, the findings of this study could inform schools and authorities about what is needed to support teacher well-being and might help to develop organizational strategies that aim at preventing harmful declines in teacher well-being during challenging and difficult times such as a pandemic. (shrink)

Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.

The pioneering analysis of synchronicity was given by Jung, yet despite the concept's momentous significance in Jung's work, and despite the widespread dissemination of the term 'synchronicity' even within pop culture, synchronicity is often badly misconstrued and remains "perhaps the least understood of Jung's theories". Synchronicity, Science, and Soul-Making has already been hailed as the most important analysis of synchronicity since Jung himself.

People with dementia have commonly been excluded from research. The adverse impacts of this exclusion are now being recognized and research literature, position statements, and ethics guidelines increasingly call for inclusion of people with dementia in research. However, few published studies investigate the views of potential participants on taking part in research should they experience dementia-related cognitive impairment. This cross-sectional survey examined the views of people aged sixty and older attending hospital outpatient clinics about clinical research participation if they had (...) dementia and impaired decision-making ability. Over 90 percent of respondents were agreeable to participating in a wide range of research activities, such as cognitive testing, physical measurements, imaging procedures, and blood draws. For drug studies, however, agreement dropped to 60 percent. Altruism was a strong motivator for research participation. In regard to who should be involved in decisions about their participation in research during periods of incapacity, respondents mostly preferred the person they appoint as their substitute decision-maker for healthcare matters or a doctor or health professional on the research team. Over three-quarters expressed interest in making an advance research directive. The study findings are discussed in relation to law reforms in Australia that aim to strengthen respect and inclusion for people with impaired decision-making capacity, especially by providing frameworks for advance planning for research participation. (shrink)

This study applied psychographic segmentation theory to explore the psychological type profile of 1082 visitors to four cathedrals (three in England and one in Wales) and to set this profile alongside the published national normative data. Data provided by the Francis Psychological Type Scales demonstrated that among cathedral visitors there were more introverts (60%), sensing types (72%) and judging types (80%), with a balance between thinking types (49%) and feeling types (51%). Comparisons with the population norms demonstrated that extraverts and (...) perceiving types were significantly underrepresented among visitors to these four cathedrals. The implications of these findings are discussed for enhancing the visitor experience of those currently visiting and for attracting those psychological types currently less likely to visit. CONTRIBUTION: Situated within the science of cathedral studies, this article demonstrates (by means of applying psychographic segmentation theory and gathering data from four cathedrals) that extraverts and perceiving types were significantly under-represented among cathedral visitors. These data are important for understanding limitations on the reach of cathedrals within the wider community. (shrink)

One reason that Gramsci's writings are becoming ever more studied in the English-speaking world is their non-reductive approach. Today, the fact that a general theory of language informs Gramsci's Prison Notebooks is increasingly being recognized. While some parts of the writings on language have been translated into English, so far only the Italian editions have allowed an evaluation of the significance and role of linguistic issues in Gramsci. The following will seek to reconstruct the connections between die theory of language (...) and the more familiar elements of Gramsci's thought. In the translated Selections from the Prison Notebooks several passages suggest the centrality of linguistics in Gramsci's overall project. (shrink)