Nicholas Maxwell's provocative and highly-original philosophy of science urges a revolution in academic inquiry affecting all branches of learning, so that the single-minded pursuit of knowledge is replaced with the aim of helping people realize what is of value in life and make progress toward a more civilized world. This volume of essays from an international, interdisciplinary group of scholars engages Maxwell in critical evaluation and celebrates his contribution to philosophy spanning forty years. Several of the contributors, like Maxwell, took (...) their inspiration from Sir Karl Popper’s philosophy of science and were connected to the department he created at the London School of Economics. In the introductory chapter, Maxwell provides an overview of his thought and then defends his views against objections in a concluding essay. -/- . (shrink)

In this monograph, I argue that Whitehead's metaphysics provides a more adequate basis for achieving a unification of physical theory than a traditional substance metaphysics. I investigate the influence of Maxwell's electromagnetic field, Einstein's theory of relativity and quantum mechanics on the development of the ontology of events and compare Whitehead’s theory to his contemporaries, C. D. Broad and Bertrand Russell, as well as another key proponent of this theory, W. V. Quine. In this manner, I defend the naturalized and (...) speculative approach to metaphysics as opposed to analytical and linguistic methods that arose in the 20th century. (shrink)

In this paper, I examine some of the most important theories of modern physics that support the notion that events are the basic ontological units of reality. The two main themes of this paper include: (1) physical evidence in support of an ontology of events, and (2) the increasing unification of physical theory until we arrive at the current state of two highly successful theories that are presently disunified within the search for a comprehensive, unified theory. With the revolutionary developments (...) in physics at the end of the nineteenth century, the mechanistic materialism of Newtonian physics began to break down and the ancient trinity of space, time and matter has been gradually replaced by the notion of the energy field. Physicists and philosophers who have held an event ontology specifically for its compatibility with electromagnetism, relativity theory and quantum mechanics include: Albert Einstein, Alfred North Whitehead, Bertrand Russell, C. D. Broad, W. V. Quine, John Bell, Henry Stapp, and Milič Čapek among many others. For these theorists, events are the most fundamental entities of physical reality in contrast to the Aristotelian tradition which contends that events are secondary or dependent on physical substance. (shrink)

Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.

In this case study from litigation, we show how ghostwriting of clinical trial results can contribute to the manipulation of data to favor the study medication. Study 329 for paroxetine pediatric use was negative for efficacy and positive for harm. Yet the ghostwritten publication from this study concluded that paroxetine provided evidence of efficacy and safety and continues to be influential. Despite the role of named authors in revisions of the manuscript, the sponsor company remained in control of the message.

Ghostwriting for medical journals has become a major, but largely invisible, factor contributing to the problem of credibility in academic medicine. In this paper I argue that the pharmaceutical marketing objectives and use of medical communication firms in the production of ghostwritten articles constitute a new form of sophistry. After identifying three distinct types of medical ghostwriting, I survey the known cases of ghostwriting in the literature and explain the harm done to academic medicine and to patients. Finally, I outline (...) steps to address the problem and restore the integrity of the medical literature. (shrink)

This paper is a deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in the United States. Court documents revealed that protocol-specified outcome measures showed no statistically significant difference between citalopram and placebo. However, the published article concluded that citalopram was safe and significantly more efficacious than placebo for children and adolescents, with possible adverse effects on patient safety.

Karl Popper's celebrated theory of falsification provides a rigorous view of science but it has been criticized as failing to explain how science makes progress. In this essay, I compare Popper's falsificationism with Nicholas Maxwell's aim-oriented empiricism and examine the role that metaphysics plays in explaining scientific progress.

We live in an age alleged devoted to evidence-based medicine. Evidence-based medicine, however, depends on reliable data and if the data are largely, if not completely, manipulated by the manufacturer of pharmaceuticals, then the data are not reliable. Evidence-based medicine is an illusion. This book raises and attempts to answer the following questions: What are the ways in which the profit motive of industry undermines the integrity of science? How is science protected from corporate malfeasance in a capitalist economy? Our (...) particular focus is the relationship between the pharmaceutical industry and medicine. We argue that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry and re-affirm the ideal of evidence-based medicine. In our view, Karl Popper’s philosophy of science, Falsificationism and Critical Rationalism, provides a rigorous conception of science required to preserve the integrity of the scientific basis of medicine against the commercial influences. (shrink)

In his magnum opus, Process and Reality, Alfred North Whitehead claims a special affinity to Oxford philosopher Francis Herbert Bradley. McHenry clarifies exactly how much of Whitehead's metaphysics is influenced by and accords with the main principles of Bradley's absolute idealism. He argues that many of Whitehead's doctrines cannot be understood without an adequate understanding of Bradley, in terms of both affinities and contrasts. He evaluates the arguments between them and explores several important connections with William James, Josiah Royce, George (...) Santayana, Bertrand Russell, and Charles Hartshorne. (shrink)

Medical ghostwriting is the practice in which pharmaceutical companies engage an outside writer to draft a manuscript submitted for publication in the names of “honorary authors,” typically academic key opinion leaders. Using newly-posted documents from paroxetine litigation, we show how the use of ghostwriters and key opinion leaders contributed to the publication of a medical journal article containing manipulated outcome data to favor the proprietary medication. The article was ghostwritten and managed by SmithKline Beecham, now GlaxoSmithKline (GSK) and Scientific Therapeutics (...) Information, Inc. without acknowledging their contribution in the published article. The named authors with financial ties to GSK, had little or no direct involvement in the paroxetine 352 bipolar trial results and most had not reviewed any of the manuscript drafts. The manuscript was originally rejected by peer review; however, its ultimate acceptance to the American Journal of Psychiatry was facilitated by the journal editor who also had financial ties to GSK. Thus, GSK was able to take an under-powered and non-informative trial with negative results and present it as a positive marketing vehicle for off-label promotion of paroxetine for bipolar depression. In addition to the commercial spin of paroxetine efficacy, important protocol-designated safety data were unreported that may have shown paroxetine to produce potentially harmful adverse events. (shrink)

W. V. Quine has been interpreted as a contemporary adaption of the American pragmatist movement that originated with Peirce, James and Dewey. While pragmatism plays some role in Quine's views on theory choice in science and ontology, I argue that this is insufficient for classifying his work with the early pragmatists or with recent revivals of pragmatism.

The problem of ghostwriting in corporate-sponsored clinical trials is of concern to medicine, bioethics, and government agencies. We present a study of the ghostwritten archival report of an industry-sponsored trial comparing antidepressant treatments for bipolar depression: GlaxoSmithKline (GSK) paroxetine study 352.

W.V.O. Quine and A.N. Whitehead shared a dualistic ontology of concrete and abstract objects but differed sharply on the status of properties. In this essay, we explore Whitehead’s reasons for admitting properties into his ontology and Quine’s objections. In the course of examining Quine’s position we demonstrate some deficiencies in his position and conclude that in spite of his claims, neither space-time coordinate systems nor classes can do all the ontological work of properties.

In this essay I make a case for a number of common themes between A. N. Whitehead and W. V. Quine in their approach to ontology. Both philosophers espoused a view of metaphysics as continuous with natural science and stressed the importance of physics in the development of ontology. As a consequence of the revolutionary developments in modern physics, both Whitehead and Quine contend that events are ontologically basic, but differ on the status of properties in their respective systems.

In this essay I examine the concept of an event within the context of P. F. Strawson's distinction between descriptive and revisionary metaphysics. As opposed to the linguistic treatment of events in the descriptive approach of Strawson and Donald Davidson, I make a case for the revisionary approach of A. N. Whitehead and W. V. Quine, according to which events are basic rather than dependent on substances.

This case study reports an instance of SmithKline Beecham's behind-the-scenes ghostwriting a letter to the editor in a medical journal article in the name of an academic physician. In order to respond to criticism that paroxetine caused severe withdrawal effects, SmithKline Beecham's marketing department hired a PR firm to ghostwrite three separate letters to spin a favorable impression of paroxetine vs fluoxetine and published one in the Journal of Clinical Psychiatry.

In this case study from litigation, I examine the origin of Monsanto-sponsored articles published in toxicology journals and the lay media that were designed to create doubt in critical evaluations of the herbicide, glyphosate. The role of ghostwriting and the use of third-party academics in the corporate defense of glyhphosate reveal that this practice extends beyond the corruption of medical journals and persists in spite of efforts to enforce transparency in industry manipulation of the scientific literature.

In this essay, I argue that A. N. Whitehead's novel concept of prehension only makes sense as a form of panpsychistic idealism. After making the case for this view, I critical evaluate Lewis Ford's interpretation of prehension from his compositional analysis of Whitehead's metaphysical works.

While Whitehead and Russell’s collaboration on the foundations of mathematics ended with the publication of Principia Mathematica, both philosophers separately developed a philosophy of physics in the 1920s that was based on the revolutionary advances in modern physics. This essay explores the affinities and contrasts in Whitehead and Russell’s event ontology as a metaphysical foundation of physics and demonstrates the influence of Whitehead’s method of extensive abstraction on Russell’s metaphysics and epistemology.

In this Festschrift honoring the work of Timothy L. S. Sprigge, Sprigge summarizes his philosophy (a synthesis of absolute idealism, panpsychism, and utilitarianism), defends his position against criticism raised by philosophers in the preceding chapters of this volume, and offers in an addendum a proof for the existence of the Absolute, namely, a final and all-embracing Consciousness akin in many ways to Spinoza’s God. This defense of his philosophy consists mainly of responses to various points of criticism raised about his (...) view of time, the relation between his metaphysics and ethics, panpsychism, the Absolute, and animal rights. (shrink)

This essay examines A. N. Whitehead’s philosophy of organism as a basis for an ecological ethics. His views are compared with those of deep ecologists and several problems with his panpsychism are considered in connection with the notion of intrinsic value in nature. In spite of problems raised by critics, this essay concludes that Whitehead’s philosophy provides a world view that offers a corrective to the disastrous course set by views that regard nature as an inert mechanism.

All’inizio del secolo XX, tre filosofi di Cambridge, Alfred North Whitehead, Bertrand Russell, e Charlie Dunbar Broad, sostennero un’ontologia basata sugli eventi che si riteneva fosse compatibile con la recente teoria della relatività . Gli eventi, perciò, rimpiazzavano le sostanze aristoteliche in veste di componenti primari dell’universo – essi erano concepiti come unità di spazio-tempo che si estendevano spazio-temporalmente e che si sovrapponevano al campo elettromagnetico. Via via che la fisica moderna progrediva, le ontologie basate sugli eventi sembrarono guadagnare ulteriore (...) supporto dal comportamento inaspettato delle particelle elementari descritte a livello quantistico. Dall’espansione dell’universo alle traiettorie delle particelle subatomiche, sembrava che tutto potesse essere sistematicamente interpretato in termini di eventi. (shrink)

This essay examines the question of the ontological basis for historical propositions and contrasts the positions of A. N. Whitehead and George Santayana, i.e., presentism vs. eternalism. I argue that Whitehead's presentism is a more satisfactory solution to how propositions refer to the past.

In this introduction to philosophy, philosophers in their areas of specialization have produced essays written specifically for the novice. The collection includes traditional topics such as logic, metaphysics, epistemology, ethics, political philosophy, aesthetics, philosophy of religion , personal identity, and contemporary topics such as philosophy of mind and cognitive science.

In this volume of the Dictionary of Literary Biography, notable philosophers of the Anglo-American tradition, analytical philosophy, are represented as well as other philosophers who made significant contributions to American philosophy in the latter half of the twentieth century.

In this volume of the Dictionary of Literary Biography, early philosophers of the classical period, the "golden age," are represented as well as a number of other figures whose contributions gave shape and direction to philosophy in America in the nineteenth and twentieth century.

The lingering controversy concerning the usefulness and safety of antidepressants for children and adolescents is likely to confuse clinicians. Recent papers perpetuate the claim that antidepressants are shown to be safe and effective in randomised controlled trials. Others claim that antidepressants have been shown to prevent suicides. In this editorial we address the manipulation of outcomes that result from academics’ alliance with industry. We explain how industry and key opinion leaders have distorted the clinician’s perception of the safety and usefulness (...) of antidepressants for the treatment of depression in children and adolescents through publication bias, poor methodology, and selective reporting. (shrink)

ABSTRACT:Analytic philosophers have criticized A. N. Whitehead's metaphysics for being obscure, yet several such philosophers have espoused positions in metaphysics and philosophy of mind that were advanced by Whitehead in the 1920s. In this paper, we evaluate the merits and demerits of these criticisms by Bertrand Russell, W. V. Quine, Karl Popper, and others and then demonstrate the affinities and contrasts in the positions advanced by Galen Strawson, David Chalmers, Thomas Nagel, and Whitehead regarding so-called ‘analytic panexperientialism’.

Corporate interests corrupt clinical trials, physicians and universities, undermining the foundation of evidence-based medicine. Philosopher Leemon McHenry and psychiatrist Jon Jureidini argue that the principles underlying Popper’s philosophy of science can protect clinical research from corporate malfeasance in a capitalist economy. -/- Evidence-based medicine was a paradigm shift that is often praised as one of the greatest achievements of medicine in the twentieth century. This radical change in medical practice is based on epistemological hierarchies of evidence, from opinions of respected (...) authorities, mechanistic reasoning and reports of expert committees at the bottom to various levels of observational studies and finally to randomized, placebo-controlled clinical trials at the apex. Randomized, placebo-controlled clinical trials, recognized as the gold standard of clinical experimentation, generally maintain their position in the hierarchies because when well-designed and well-conducted, they provide a basis for assessing harms and benefits, and help deter extravagant claims of efficacy and safety. (shrink)

Editorial independence is a bedrock principle of academic publishing. The growing domination of academic publishing by large, for-profit corporations threatens this independence. There is alarming evidence that large companies too often serve their own business interests and those of powerful clients rather than serving the scientific community and the general public. This evidence includes the publication of infelicitous commercial science and concealing scientific misconduct. We present two case studies in which the UK-based publisher Taylor & Francis interfered in the editorial (...) process by blocking publication of legitimate criticism that had been reviewed and approved for publication by its specialized editors. The integrity of science depends in part on the transparency and intellectual honesty of all stakeholders. The widely acknowledged inadequacies of English libel law are reviewed as context for some of Taylor & Francis’s fearful decisions. (shrink)

This article makes a distinction between pure and naturalized metaphysics and characterized F. H. Bradley's metaphysics as the former, according to which pure reason alone independent of the natural sciences discovers the true nature of reality. Bradley's view is critically evaluated via the the naturalized views of A. N. Whitehead and W. V. Quine.

In this essay, I provide an exposition of F. H. Bradley's arguments against relations and then critically evaluate his view using arguments advanced by William James and A. N. Whitehead. Against Bradley, I argue for the reality of relations as concrete aspects of the temporal process.

This article presents an overlooked case of research misconduct and violations of basic principles of medical and business ethics. When Bayer’s Cutter Laboratories realized that their blood products, Factor VIII and IX or antihemophiliac factor (AHF), were contaminated with human immunodeficiency virus (HIV), the financial investment in the product was considered too high to destroy the inventory. Cutter misrepresented the results of its own research and sold the contaminated AHF to overseas markets in Asia and Latin America without the precaution (...) of heat treating the product recommended for eliminating the risk. As a consequence, hemophiliacs who infused the HIV-contaminated Factor VIII and IX tested positive for HIV and developed AIDS. (shrink)

In this volume of the Dictionary of Literary Biography, notable British philosophers from the nineteenth and twentieth centuries are represented, including thinkers from the traditions of empiricism, idealism, logical positivism, and analytical philosophy.

T. L. S. Sprigge produced an eclectic yet highly original system of metaphysics and ethics, a synthesis of panpsychism, absolute idealism, and utilitarianism, at a time in which orthodox analytical philosophy could only view this system as an anachronism of the nineteenth century. His critics claim that his philosophy has only historical interest to a small group of specialists in the relatively dormant tradition of British Idealism, that an attempt to defend his view of consciousness is a hopeless nonstarter, and (...) that his Spinozistic monism can have no relevance in our intellectual culture.1 Yet others have defended Sprigge as the "most independent of thinkers within the field of metaphysics" and salute him as "a .. (shrink)

C .H. Waddington was one of the founders of the Theoretical Biology Club at Cambridge in the 1930s whose members advanced a philosophy of biology, “organicism,” that would offer an alternative to the reductionism of mechanistic materialism and the obscurity of vitalism in coming to terms with the dynamic, interdependent, and purposeful character of life. This view was embraced in one form or another by E. S. Russell, John Scott Haldane, C. Lloyd Morgan, Lawrence J. Henderson, C. D. Broad, and (...) Alfred North Whitehead. Waddington, in particular, was devoted to the integration of genetics, development, and evolution within the context of theoretical biology. This article explains the influence of Alfred North Whitehead's philosophy of organism on C. H. Waddington's work. (shrink)

This essay examines the effects of commercialization on education with particular focus on corporatization of academic research. This trend results from a business model of education, which I identify as profit-based inquiry. I contrast profit-based inquiry with Nicholas Maxwell's conception of wisdom-based inquiry and conclude that the business model fails to achieve enduring value and results in a promotional or ideological emphasis rather than one that stresses the importance of critical rationalism. In order to make my case for this failure, (...) I focus attention on the current state of commercialization in research of medicines. (shrink)

Despite growing concern about medical ghostwriting, pharmaceutical companies, universities, medical journals, and communication companies employing ghostwriters have thus far failed to adequately stem the problem. As a result, some commentators have proposed that legal remedies could be sought by patients harmed by drugs publicized in ghostwritten papers. In this Essay, we build on a recent analysis by Stern and Lemmens in PLoS Medicine to outline specific areas of legal liability.

Journals are failing in their obligation to ensure that research is fairly represented to their readers, and must act decisively to retract fraudulent publications. Recent case reports have exposed how marketing objectives usurped scientific testing and compromised the credibility of academic medicine. But scant attention has been given to the role that journals play in this process, especially when evidence of research fraud fails to elicit corrective measures. Our experience with The Journal of the American Academy of Child and Adolescent (...) Psychiatry (JAACAP) illustrates the nature of the problem. The now-infamous Study 329 of paroxetine in adolescent depression was negative for efficacy on all eight protocol-specified outcomes and positive for harm, but JAACAP published a report of this study that concluded that “paroxetine is generally well tolerated and effective for major depression in adolescents.” The journal’s editors not only failed to exercise critical judgment in accepting the paper, but when shown evidence that the paper misrepresented the science, refused either to convey this information to the medical community or to retract the article. (shrink)

In this chapter I provide an elementary exposition of the development of Whitehead's view of objectivity and his theory of extension, with particular focus on explaining how macroscopic objects of ordinary perception and the whole structure of space-time arise out of the units of his ontology, namely, the actual occasions. I also review the scholarship on Whitehead's view of extension and discuss the major problems that arise in connection with the theory in his magnum opus, Process and Reality.

Sergio Sismondo argues that pharmaceutical industry-sponsored research and ghostwriting produce genuine knowledge and science (albeit commercial science) not different from established medical science. In this essay I critically evaluate Sismondo' view and conclude that the commercial medical science that has created the ghostwriting industry is a corruption of science and not merely science done in a new corporate mode. Serious harm to patients has resulted from misrepresented commercial biomedical research.

The goal of this paper is to expose the research misconduct of pharmaceutical industry-sponsored clinical trials via three short case studies of corrupted psychiatric trials that were conducted in the United States. We discuss the common elements that enable the misrepresentation of clinical trial results including ghostwriting for medical journals, the role of key opinion leaders as co-conspirators with the pharmaceutical industry and the complicity of top medical journals in failing to uphold standards of science and peer review. We conclude (...) that the corruption of industry-sponsored clinical trials is one of the major obstacles facing evidence-based medicine. (shrink)