Results for 'MHC class I'

986 found
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  1.  4
    NLRC5/MHC class I transactivator: A key target for immune escape by SARS‐CoV‐2.Baohui Zhu, Ryota Ouda, Yusuke Kasuga, Paul de Figueiredo & Koichi S. Kobayashi - 2024 - Bioessays 46 (4):2300109.
    Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC (...) I genes. In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)
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  2. Aristotle's Metaphysics. Volume I. Textual Criticism.Wolfgang Class (ed.) - 2014 - Saldenburg: Verlag Senging.
    The present "philological commentary" is directed at those who have decided to take time for reading the original text, at least in an English translation. The first volume "Textual Criticism" is intended to meet the difficulties caused by the fact that our text editions are based on manuscripts separated from the original by more than a millennium.
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  3.  9
    Re‐expression of major histocompatibility complex (UMHC) class I molecules on malignant tumor cells and its effect on host‐tumor interaction.Kam M. Hui - 1989 - Bioessays 11 (1):22-26.
    The expression of products encoded by the major histocompatibility complex (MHC) on tumor cells has recently been studied extensively. It has been found that many malignant tumor cells have their MHC antigens ‘switched‐off’ but that these antigens are re‐expressed following DNA‐mediated gene transfer, with increased tumor immunogenicity as a result and the consequence that these ‘transformed’ tumor cells are rejected in vivo.: This review will discuss approaches that have been taken to induce strong tumor‐specific immunity by the manipulation of MHC (...)
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  4.  25
    Against Musical ἀτεχνία: Papyrus Hibeh I 13 and the Debate on τέχνη in Classical Greece.Francesco PelosiCorresponding authorScuola Normale Superiore – Classe di Scienze Umane Pisa & Toscana ItalyEmail: - forthcoming - Apeiron.
    Objective Apeiron was founded in 1966 and has developed into one of the oldest and most distinguished journals dedicated to the study of ancient philosophy, ancient science, and, in particular, of problems that concern both fields. Apeiron is committed to publishing high-quality research papers in these areas of ancient Greco-Roman intellectual history; it also welcomes submission of articles dealing with the reception of ancient philosophical and scientific ideas in the later western tradition. The journal appears quarterly. Articles are peer-reviewed on (...)
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  5.  31
    An infinite superstable group has infinitely many conjugacy classes.I. Aguzarov, R. E. Farey & J. B. Goode - 1991 - Journal of Symbolic Logic 56 (2):618-623.
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  6. Presupposition.David I. Beaver - 1997 - In Johan van Bentham & Alice ter Meulen (eds.), Handbook of Logic and Language. MIT Press.
    We discuss presupposition, the phenomenon whereby speakers mark linguistically the information that is presupposed or taken for granted, rather than being part of the main propositional content of a speech act. Expressions and constructions carrying presuppositions are called “presupposition triggers”, forming a large class including definites and factive verbs. The article first introduces the range of triggers, the basic properties of presuppositions such as projection and cancellability, and the diagnostic tests used to identify them. The reader is then introducedto (...)
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  7.  7
    Recognition of object classes from range data.I. D. Reid & J. M. Brady - 1995 - Artificial Intelligence 78 (1-2):289-326.
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  8.  9
    Specificity of sensorimotor integration in preschoolers attending and not attending additional classes.E. I. Nikolaeva & I. A. Fomina - 2017 - Liberal Arts in Russia 6 (3):223-229.
    The work is an attempt to assess individual capabilities of children to predict a sensor flow structure and to identify the parameters that contribute to an effective formation of a child’s mental picture of the external environment. For this experiment, a method has been developed, in which fractal stream of signals has a structure, where the same signals flow is repeated twice. The subjects were children 5-7-year-old. They made up three groups: children attending a kindergarten, a group of early development (...)
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  9.  20
    The fuzzy logic of chaos and probabilistic inference.I. Antoniou & Z. Suchanecki - 1997 - Foundations of Physics 27 (3):333-362.
    The logic of a physical system consists of the elementary observables of the system. We show that for chaotic systems the logic is not any more the classical Boolean lattice but a kind of fuzzy logic which we characterize for a class of chaotic maps. Among other interesting properties the fuzzy logic of chaos does not allow for infinite combinations of propositions. This fact reflects the instability of dynamics and it is shared also by quantum systems with diagonal singularity. (...)
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  10.  21
    Ideas in theoretical biology - failure of anti-tumor immunity in mammals - evolution of the hypothesis.I. Bubanovic & S. Najman - 2004 - Acta Biotheoretica 52 (1):57-64.
    Observations on the morphological and functional similarity between embryonic or trophoblast tissues and tumors are very old. Over a period of time many investigators have created different hypotheses on the origin of cancerogenesis or tumor efficiency in relation to the host immune system. Some of these ideas have been rejected but many of them are still current. A presumption of the inefficiency of anti-tumor immunity in mammals due to the high similarity between trophoblast and embryonic cells to tumor cells is (...)
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  11.  15
    Decidable classes of number‐theoretic sentences.I. J. Heath - 1969 - Mathematical Logic Quarterly 15 (26‐29):411-420.
  12.  22
    Decidable classes of number‐theoretic sentences.I. J. Heath - 1969 - Mathematical Logic Quarterly 15 (26-29):411-420.
  13.  11
    Historical Development of the Ensemble Playing of the Flute Group in a Symphony Orchestra. E. Golovashych & I. Tsebriy - 2023 - Philosophical Horizons 46 (46):29-39.
    The historical features of the playing of the flute group in the symphony orchestra, the ability of soloists-instrumentalists to be performers of a single group and a single whole among the large composition of members of the symphony orchestra are analyzed. The authors substantiate the expediency of the development of instrumental musicians first of all as orchestra players, and then as solo performers. The aim and the tasks: to analyze the historical development of the ensemble playing of the flute group (...)
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  14.  23
    Relations, Properties, Classes, and the Problem of Individuation.I.-Ierbert Hochberg - 1979 - Southwestern Journal of Philosophy 10 (2):105-112.
  15.  17
    Where Does the True Significance of the Theory of Mutual "Acceptance" of Ethics by Opposite Classes Lie?Hsü Ch'I.-Hsien - 1969 - Chinese Studies in History 3 (2):103-114.
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  16. Working-class and new social phenomenons.I. Hruza - 1987 - Filosoficky Casopis 35 (3):281-305.
     
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  17.  16
    Undecidability of the Equational Theory of Some Classes of Residuated Boolean Algebras with Operators.I. Nemeti, I. Sain & A. Simon - 1995 - Logic Journal of the IGPL 3 (1):93-105.
    We show the undecidability of the equational theories of some classes of BAOs with a non-associative, residuated binary extra-Boolean operator. These results solve problems in Jipsen [9], Pratt [21] and Roorda [22], [23]. This paper complements Andréka-Kurucz-Németi-Sain-Simon [3] where the emphasis is on BAOs with an associative binary operator.
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  18.  46
    Bounded query classes and the difference hierarchy.Richard Beigel, William I. Gasarch & Louise Hay - 1989 - Archive for Mathematical Logic 29 (2):69-84.
    LetA be any nonrecursive set. We define a hierarchy of sets (and a corresponding hierarchy of degrees) that are reducible toA based on bounding the number of queries toA that an oracle machine can make. WhenA is the halting problemK our hierarchy of sets interleaves with the difference hierarchy on the r.e. sets in a logarithmic way; this follows from a tradeoff between the number of parallel queries and the number of serial queries needed to compute a function with oracleK.
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  19. Tractability of multivariate integration for weighted Korobov classes, to appear in J.I. H. Sloan & H. Wozniakowski - forthcoming - Complexity.
     
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  20.  4
    The Future of Intellectuals and the Rise of the New Class.I. Szelenyi - 1980 - Télos 1980 (45):189-192.
  21. Materializm i rabochiĭ klass.I. M. Komarov - 2016 - Orël: Izdatelʹ Svetlana Zenina.
     
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  22.  13
    Relation algebras from cylindric and polyadic algebras.I. Nemeti & A. Simon - 1997 - Logic Journal of the IGPL 5 (4):575-588.
    This paper is a survey of recent results concerning connections between relation algebras , cylindric algebras and polyadic equality algebras . We describe exactly which subsets of the standard axioms for RA are needed for axiomatizing RA over the RA-reducts of CA3's, and we do the same for the class SA of semi-associative relation algebras. We also characterize the class of RA-reducts of PEA3's. We investigate the interconnections between the RA-axioms within CA3 in more detail, and show that (...)
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  23.  4
    Objective versus mentalist conceptions of social class: Some second thoughts.I. C. Jarvie - 1989 - In Leszek Nowak (ed.), Dimensions of the historical process. Amsterdam: Rodopi. pp. 13--53.
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  24. Mirror neurons and the simulation theory of mind-reading.Vittorio Gallese & Alvin I. Goldman - 1998 - Trends in Cognitive Sciences 2 (12):493-501.
    A new class of visuomotor neuron has been recently discovered in the monkey’s premotor cortex: mirror neurons. These neurons respond both when a particular action is performed by the recorded monkey and when the same action, performed by another individual, is observed. Mirror neurons appear to form a cortical system matching observation and execution of goal-related motor actions. Experimental evidence suggests that a similar matching system also exists in humans. What might be the functional role of this matching system? (...)
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  25. Towards a Global Ruling Class? Globalization and the Transnational Capitalist Class.William I. Robinson & Jerry Harris - 2000 - Science and Society 64 (1):11-54.
    A transnational capitalist class has emerged as that segment of the world bourgeoisie that represents transnational capital, the owners of the leading worldwide means of production as embodied in the transnational corporations and private financial institutions. The spread of TNCs, the sharp increase in foreign direct investment, the proliferation of mergers and acquisitions across national borders, the rise of a global financial system, and the increased interlocking of positions within the global corporate structure, are some empirical indicators of the (...)
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  26. Materialism, Class, and Feminism.Heidi I. Hartmann - 1994 - In Anne Herrmann & Abigail J. Stewart (eds.), Theorizing feminism: parallel trends in the humanities and social sciences. Boulder: Westview Press. pp. 171.
     
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  27.  40
    Finite algebras of relations are representable on finite sets.H. Andréka, I. Hodkinson & I. Németi - 1999 - Journal of Symbolic Logic 64 (1):243-267.
    Using a combinatorial theorem of Herwig on extending partial isomorphisms of relational structures, we give a simple proof that certain classes of algebras, including Crs, polyadic Crs, and WA, have the `finite base property' and have decidable universal theories, and that any finite algebra in each class is representable on a finite set.
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  28.  5
    A near-optimal polynomial time algorithm for learning in certain classes of stochastic games.Ronen I. Brafman & Moshe Tennenholtz - 2000 - Artificial Intelligence 121 (1-2):31-47.
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  29.  47
    Zero-place operations and functional completeness, and the definition of new connectives.I. L. Humberstone - 1993 - History and Philosophy of Logic 14 (1):39-66.
    Tarski 1968 makes a move in the course of providing an account of ?definitionally equivalent? classes of algebras with a businesslike lack of fanfare and commentary, the significance of which may accordingly be lost on the casual reader. In ?1 we present this move as a response to a certain difficulty in the received account of what it is to define a function symbol (or ?operation symbol?). This difficulty, which presents itself as a minor technicality needing to be got around (...)
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  30.  48
    Functional dependencies, supervenience, and consequence relations.I. L. Humberstone - 1993 - Journal of Logic, Language and Information 2 (4):309-336.
    An analogy between functional dependencies and implicational formulas of sentential logic has been discussed in the literature. We feel that a somewhat different connexion between dependency theory and sentential logic is suggested by the similarity between Armstrong's axioms for functional dependencies and Tarski's defining conditions for consequence relations, and we pursue aspects of this other analogy here for their theoretical interest. The analogy suggests, for example, a different semantic interpretation of consequence relations: instead of thinking ofB as a consequence of (...)
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  31. Smelai︠a︡ chestnostʹ.I︠U︡. V. Feofanov - 1965
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  32.  11
    Constructive Models.I͡Uriĭ Leonidovich Ershov - 2000 - Consultants Bureau. Edited by S. S. Goncharov.
    The theory of constructive (recursive) models follows from works of Froehlich, Shepherdson, Mal'tsev, Kuznetsov, Rabin, and Vaught in the 50s. Within the framework of this theory, algorithmic properties of abstract models are investigated by constructing representations on the set of natural numbers and studying relations between algorithmic and structural properties of these models. This book is a very readable exposition of the modern theory of constructive models and describes methods and approaches developed by representatives of the Siberian school of algebra (...)
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  33.  37
    The Fin De Siede Debate: Globalization as Epochal Shift.Roger Burbach & William I. Robinson - 1999 - Science and Society 63 (1):10 - 39.
    Behind the economic turbulence and political transformations of recent decades is the transition from the nationstate phase of world capitalism to a new transnational phase. While many detractors of globalization focus on global trade, the process is driven by the transnationalization of capital ownership, which in turn leads to the rise of a transnational bourgeoisie that sits at the apex of the global order. Parallel to the transatlantic and transpacific integration of capital there has been an integration of Southern capitalists (...)
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  34.  32
    The Crystallization of Pre-Ch 'in Legalist Thought'.Liang Ling-I. - 1976 - Contemporary Chinese Thought 7 (4):35-56.
    Han Fei was a fierce general in the anti-Confucian struggle of the late Warring States period and was also an outstanding pre-Ch'in Legalist theoretician. Han Fei Tzu, this piece of writing, which was critical of Confucius and full of a violently militant spirit, vividly recorded the course of the difficult combat of the landowning class which led to its victory over the slave-owning class. It summed up the historical experience of the struggle between the Confucian and Legalist lines (...)
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  35.  17
    Driving Style: Determining Factors, Characteristics, Optimization Directions.I. I. Lobanova - 2015 - Liberal Arts in Russiaроссийский Гуманитарный Журналrossijskij Gumanitarnyj Žurnalrossijskij Gumanitaryj Zhurnalrossiiskii Gumanitarnyi Zhurnal 4 (1):76.
    A system of description, identification and classification of factors determining driving style is proposed in the article; stable and variable factors determining driving style are studied. Driving style is analyzed within the framework of structural approach. The variable factor are: specifications and technical condition of the vehicle, class of the car, its prestige, training of the driver, social regulators, features of the road environment, psychophysiological condition of the driver. The stable factors are: individual-typological properties, the level of suitability for (...)
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  36.  15
    Modeling of attack detection system based on hybridization of binary classifiers.Beley O. I. & Kolesnyk K. K. - 2020 - Artificial Intelligence Scientific Journal 25 (3):14-25.
    The study considers the development of methods for detecting anomalous network connections based on hybridization of computational intelligence methods. An analysis of approaches to detecting anomalies and abuses in computer networks. In the framework of this analysis, a classification of methods for detecting network attacks is proposed. The main results are reduced to the construction of multi-class models that increase the efficiency of the attack detection system, and can be used to build systems for classifying network parameters during the (...)
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  37.  3
    Black Hole Entropy from Non-dirichlet Sectors, and a Bounce Solution.I. Y. Park - 2023 - Foundations of Physics 53 (4):1-21.
    The relevance of gravitational boundary degrees of freedom and their dynamics in gravity quantization and black hole information has been explored in a series of recent works. In this work we further progress by focusing keenly on the genuine gravitational boundary degrees of freedom as the origin of black hole entropy. Wald’s entropy formula is scrutinized, and the reason that Wald’s formula correctly captures the entropy of a black hole examined. Afterwards, limitations of Wald’s method are discussed; a coherent view (...)
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  38.  14
    The Influence of Scientific Criticism and Self-Criticism on the Forming of the New Human Being.V. I. Danilenko - 1976 - Russian Studies in Philosophy 15 (1):71-72.
    Under the conditions of the revolution in science and technology, of tremendous social changes, of the tempestuous and significant growth in the prestige of scientific knowledge, and of the exacerbation of the ideological struggle, there has been an immeasurable broadening of the social tasks and spheres of operation of such social phenomena as scientific criticism and self-criticism. Study of social, theoretical, and psychological cross-sections of these phenomena is one of the necessary conditions for cultivating lofty civic qualities, a communist world-view, (...)
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  39. Finite Algebras of Relations are Representable on Finite Sets.H. Andreka, I. Hodkinson & I. Nemeti - 1999 - Journal of Symbolic Logic 64 (1):243-267.
    Using a combinatorial theorem of Herwig on extending partial isomorphisms of relational structures, we give a simple proof that certain classes of algebras, including Crs, polyadic Crs, and WA, have the `finite base property' and have decidable universal theories, and that any finite algebra in each class is representable on a finite set.
     
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  40.  53
    The Relation of Stoic Intermediates to the Summum Bonum, with Reference to Change in the Stoa.I. G. Kidd - 1955 - Classical Quarterly 5 (3-4):181-.
    The Stoics maintained that virtue was the only good; everything else, therefore, was not-good. On the other hand, regarded by itself, this huge class was not equally valueless. Vice, of course, was bad; but everything else was thought to be ‘indifferent’: wealth, health, for example; indifferent, that is, with regard to the summum bonum. Of these Intermediates, men, from human nature, had a leaning to some; these were , had value, were called , that is, preferred, and virtue itself (...)
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  41.  20
    The Relation of Stoic Intermediates to the Summum Bonum, with Reference to Change in the Stoa.I. G. Kidd - 1955 - Classical Quarterly 5 (3-4):181-194.
    The Stoics maintained that virtue was the only good; everything else, therefore, was not-good. On the other hand, regarded by itself, this huge class was not equally valueless. Vice, of course, was bad; but everything else was thought to be ‘indifferent’: wealth, health, for example; indifferent, that is, with regard to the summum bonum. Of these Intermediates, men, from human nature, had a leaning to some; these were, had value, were called, that is, preferred, and virtue itself lay in (...)
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  42. Pokhishtenie na krasotata.Nikolaĭ Ĭordanov Antonov - 1974
     
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  43. Perception and other minds.Fred I. Dretske - 1973 - Noûs 7 (1):34-44.
    We ordinarily speak of being able to see that there are people on the bus, Students in the class, And children playing in the street. If human beings are understood to be conscious entities, Then one of our ways of knowing that there are other conscious entities in the world besides ourselves is by seeing that there are. We also speak of seeing that he is angry, She is depressed, And so on. It is argued that this is, Indeed, (...)
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  44.  14
    On the Social-Ethical Ideas of the Decembrists.I. Ia Matkovskaia - 1976 - Russian Studies in Philosophy 15 (2):23-45.
    In the heroic chronicle of Russia's revolutionary movement, the Decembrists - representatives of the first stage of that movement - hold a special place. The boldness of the initiative they displayed, the self-sacrifice of the heroes who rose in struggle against the autocracy, the at least partly conscious intention of creating - albeit at the price of their own lives! - a historic precedent: all this compels one to look closely at the moral content of their activity. The significance of (...)
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  45.  49
    The Statistical Nature of Laws of Social Development.I. A. Matsiavichius - 1983 - Russian Studies in Philosophy 22 (3):82-85.
    The laws of social development are objective in content and, in contrast to the laws of nature, are manifested and function only through the activity of human beings. The development of all spheres of human activity, in turn, cannot be conceived of as independent of the will, consciousness, moods and beliefs, propensities and preferences of human beings, nor as independent of the effectiveness of forms of social organization, etc. The social specificity of laws of social development in turn defines another (...)
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  46. Nihilism today.I︠U︡. V. Sogomonov - 1977 - Moscow: Progress. Edited by P. A. Landesman.
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  47.  63
    Expressive power and semantic completeness: Boolean connectives in modal logic.I. L. Humberstone - 1990 - Studia Logica 49 (2):197 - 214.
    We illustrate, with three examples, the interaction between boolean and modal connectives by looking at the role of truth-functional reasoning in the provision of completeness proofs for normal modal logics. The first example (§ 1) is of a logic (more accurately: range of logics) which is incomplete in the sense of being determined by no class of Kripke frames, where the incompleteness is entirely due to the lack of boolean negation amongst the underlying non-modal connectives. The second example (§ (...)
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  48.  10
    Gender, class, family, and migration: Puerto Rican women in chicago.Maura I. Toro-Morn - 1995 - Gender and Society 9 (6):712-726.
    Using in-depth interviews with women in the Puerto Rican community of Chicago, this article explores how migration emerged as a strategy for families across class backgrounds and how gender relations within the family mediate the migration of married working-class and middle-class Puerto Rican women. The women who followed their husbands to Chicago participated in another form of labor migration, since some wives joined their husbands in the paid economy and those who did not contributed with the reproductive (...)
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  49. Rossiyskiy srednyy klass: sotsial'naya real'nost'i politicheskiy fantom (Russian middle class: social reality and political phantom).V. I. Umov - 1993 - Polis 4:26-40.
  50.  41
    When must a patient seek healthcare? Bringing the perspectives of islamic jurists and clinicians into dialogue.Omar Qureshi & Aasim I. Padela - 2016 - Zygon 51 (3):592-625.
    Muslim physicians and Islamic jurists analyze the moral dimensions of biomedicine using different tools and processes. While the deliberations of these two classes of experts involve judgments about the deliverables of the other's respective fields, Islamic jurists and Muslim physicians rarely engage in discussions about the constructs and epistemic frameworks that motivate their analyses. The lack of dialogue creates gaps in knowledge and leads to imprecise guidance. In order to address these discursive and conceptual gaps we describe the sources of (...)
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