BackgroundPrevious studies on voxel-based morphometry have found that there were gray matter alterations in patients with hepatic encephalopathy. However, the reported results were inconsistent and lack a quantitative review. Therefore, this study aims for a quantitative meta-analysis of VBM analysis on patients with HE.MethodsThe studies in our meta-analysis were collected from Pubmed, Web of Science, and Embase, which were published from January 1947 to October 2021. The seed-based d mapping method was applied to quantitatively estimate the regional gray matter abnormalities (...) in patients with HE. A meta-regression analysis was applied to evaluate the relationship between plasma ammonia and gray matter alteration.ResultsThere were nine studies, with sixteen datasets consisting of 333 participants with HE and 429 healthy controls. The pooled and subgroup meta-analyses showed an increase in gray matter volume in the bilateral thalamus and the calcarine fissure but a decrease in the GMV in the bilateral insula, the basal ganglia, the anterior cingulate gyrus, and the cerebellum. The meta-regression showed that plasma ammonia was positively associated with the GMV in the left thalamus but was negatively associated with the GMV in the cerebellum and the bilateral striatum.ConclusionGray matter volume in patients with HE largely varied and could be affected by plasma ammonia. The findings of this study could help us to better understand the pathophysiology of cognitive dysfunction in patients with HE. (shrink)

This research uses an experimental approach to investigate the relationship between market orientation of a company and its level of success in international business. The aim of the study was to develop and use a market orientation scale that is appropriate to the sector. It was discovered that there are four hidden traits that drive market orientation. These include customers, rivals, departmental response, and overall customer satisfaction. According to the results, orientation toward one's customers is more essential than any of (...) the other traits, while orientation toward one's competitors has an inverted U-shaped connection with performance. The performance of the firm was not found to correlate in any way with the responsiveness of its departments. With the help of the comprehensive conceptualization, managers are able to develop specific kinds of orientations that are essential for higher levels of performance. (shrink)

With the advancement of human microbiome research, it is inevitable that a growing number of biobanks will include a collection of microbiota specimens to characterize the microbial communities that inhabit the human body and explore the relationships between the microbiota and their human hosts. Biobanks of human microbiota and their associated genetic information may become a valuable health resource. But, this area of research also presents ethical and social problems, some of which are distinct from those faced by biobanks that (...) store human tissue samples. This paper examines four core issues which are considered highly relevant to microbiome biobanking: the nature of human microbiome samples and how different understandings have an impact on benefit/risk evaluation, privacy, informed consent, and returning the result to participants. We argue that these issues should be addressed early on in microbiome research projects and also call for adjusting or developing new governance mechanism to better accommodate these changes. (shrink)

Decision-making competence refers to the ability to make better decisions, as defined by decision-making principles posited by models of rational choice. The adult decision-making competence (A-DMC) scale is a relatively mature evaluation tool used for decision-making competence. However, the A-DMC is yet far from other mature psychological evaluation tools, and especially the structure of A-DMC remains unclear. In the current study, we estimated a regularized partial correlation network of decision-making competence in a Chinese sample consisting of 339 adults who were (...) evaluated by the A-DMC, and then the centrality indicators were calculated. The results revealed that all nodes of the decision-making competence networks are positively associated, except for the association of resistance to framing (RF) and resistance to sunk costs (SC). The strongest edge was between RF and applying decision rules (DR; regularized partial correlation = 0.37). The centrality indicators of RF and applying DR were highest, revealing that these two variables may play important roles in the decision-making competence network. Our study conceptualizes the decision-making competence from network perspectives, so as to provide some insights for future researches. (shrink)

Research on the relationship between emotions and job performance is ubiquitous, yet few scholars have examined the combined effects of different emotions. Drawing on the broaden-and-build theory and conservation of resources theory, we propose that employees’ daily emotion fluctuations will affect their service performance in opposite directions. Furthermore, we propose these effects will be moderated by psychological [i.e., regulatory emotional self-efficacy ] and physiological characteristics of the employees. Based on the experience sampling method, data obtained from 187 frontline employees of (...) 35 bank branches over 18 consecutive days supports our hypotheses. (shrink)

This paper addresses the sliding mode control problem for a class of networked control systems with long time delay and consecutive packet dropout. A new modeling method is proposed, through which time delay and packet dropout are modeled in a unified model described by one Markov chain. To avoid the chattering problem of classic reaching law, a new chattering-free reaching law is proposed. Then with a focus on the problem that controller-actuator channel network condition cannot be foreseen by the controller, (...) a new compensation strategy is proposed, which can effectively compensate for the effect of time delay and packet dropout in controller-actuator channel. Finally, a simulation example is presented to demonstrate the effectiveness of the proposed approach. (shrink)

Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the (...) right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs. (shrink)

Tian dao guan shi Zhongguo zhe xue de zhong yao gai nian, ye shi ru jiao de yi ge zhong yao wen ti, ji, shen me shi tian dao? Qi jin wei zhi, ji hu suo you de Zhongguo zhe xue zhu zuo, dou ren wei tian dao jiu shi zi ran gui lü. Ben shu jiang tong guo wen xian zi liao xiang dang dai de du zhe shuo ming, Zhongguo gu dai de tian dao, jiu shi tian zhi (...) dao, shang tian zhi dao. (shrink)

本书包括:哲学认识方式的历史考察;哲学认识方式的理论分析;哲学思辨的自我定位;哲学思辨的实践根源和价值层面等内容。.

This article consists of four parts. In the first part it briefly describes the history of body‐to‐head transplantation (BHT) and the surgical plan proposed by Drs. Sergio Canavero and Ren Xiaoping on a human subject. In the second part it argues that the BHT procedure that they propose is scientifically invalid and technically infeasible so therefore would end in failure. In the third part it argues that the present conceivable procedure of BHT cannot be ethically justified because it would bring (...) great harm to the human subject, it is uncertain who would be the possible beneficiary, and valid informed consent cannot be obtained. In the fourth part it argues that the action of performing the procedure of BHT might violate China’s current criminal and civil laws. The conclusion that follows from the arguments above is that BHT should be prohibited now and also in the near future. However, this conclusion does not preclude scientists, neurosurgeons and bioethicists doing research into scientific, technical, surgical and ethical issues raised by BHT. (shrink)

Jiren (畸人), literally translated as irregular (Ji) person (ren), is a critical concept in the classical Daoist text the Zhuangzi (5th–3rd century BC.).1 The concept refers to individuals with atypical body shapes. Some of them lack body parts of the standard human body, like a leg or toes. Some others have an atypical anatomy, like having a chin stuck down their navel; and some of them are, by social standards of the time, considered to be extremely ugly.1 These individuals are (...) described as incredibly virtuous. The description of Jiren individuals as virtuous does not simply aim to show there may be hidden virtues that social conventions blur. The point is not to show that we should also care for those with atypical bodies who have a hidden virtue. Rather, the point is to show that all human beings have an unconditional intrinsic value and moral worth. So, Jiren prescribes that an atypical body shape does not reflect inferiority. The variation of body anatomies should be understood as how the world is, not a value hierarchy. The concept of Jiren encourages, therefore, to consider one’s own and others’ value beyond their physical appearance. What’s more, Jiren encourages individuals to resist social pressures to fit a standard and to search inward for who they really are and accept it. This ethical groundwork set by the Jiren aims at freeing people from existing physical and mental boundaries to their well-being and helping them rethink …. (shrink)

本书从法理的角度对基因权利进行论述,将基因权利存在的基础,权利的来源,以及具体基因权利的完善皆放入当今科技发展这个动态的背景之下展开讨论.首先从科技发展的角度切入,深入思索基因科技发展所涵盖的伦理,法 律,社会意涵,并在伦理语境下对基因科技展开分析,对传统伦理原则进行反思.最后在经过深入研究基因权利理论基础上,探讨了人类基因权利的保障制度.

本书内容分5部分:哲学理论基础,哲学自身问题,哲学的发展,马克思主义哲学的总体问题,附录。对马克思主义哲学的基本问题提出了一些新的理解和解释。.

Di 1 juan. Ren lei di ben zhi: dong wu + wen hua. -- di 2 juan. Ren lei di zu he: cong ge ti, qun ti dao zheng ti. -- di 3 juan. Ren lei di huan jing: zi ran yu wen hua. -- di 4 juan. Ren lei di jie ju: i ge quan xin di shi jie.

我們已有的知識，雖然作為學科各有領域，但並不是孤立地存在，而是互為聯繫、互為影響。這些知識的積累，會逐漸地擴大認知領域，由此及彼、由近到遠，由小到大，由現象而至規律，由規律而至本質，直至去認識終極事物 ——宇宙——世界的本質。.

本书收录的10篇讲稿,是作者于1994年至1998年间记录下来的。其中7篇以“文化格局与人的表述”为名于1997年结集出版,8年后在此改版,补充了3篇而成本书。.

本书以人类辅助生殖法律制度为研究对象,对这一制度在不同国家,我国不同法域的产生,发展及未来方向作了全面分析,以比较分析的视角,从中总结出可为我国借鉴吸收的优秀成果,对于未来法制发展方向与具体制度的建构 提出了可行化的学者建议.

本书是作者的一些理论文章的汇集。内容有《应该怎样评价洛克的物性论》、《第三大人学问题》等文章。.

本书内容包括:哲学探寻录、说天人新义、历史本体论、论实用理性与乐感文化、有关伦理学的答问、实践美学短记、哲学自传。.

本书是国内第一部研究卡西勒符号形式哲学的专著,详细论述了他的语言哲学、神话-宗教哲学、科学哲学以及由苏珊·朗格按照卡西勒体系发展的艺术哲学。.

本书回顾社会认识论研究的发展历程和三个阶段的主要学术进展,提出并初步解决了社会认识论研究中的十个难题,预示其在21世纪的发展方向。.