La teoría de los espines por Julio Calvo alcanza en este libro su desarrollo más completo, adquiriendo en conjunto la categoría de una nueva fundación de la Semántica desde principios cognitivos y perceptivos.

Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin’s (1871) work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on (...) the evolution of related behaviors and brain circuitry. Birds and mammals are thought to have evolved from different groups of Mesozoic reptiles, theropod dinosaurs and therapsids, respectively, and therefore their common ancestor is likely to be a basal reptile living about 300 million years ago, during the Carboniferous or Permian. Yet, birds and mammals exhibit extensive convergence in terms of relative brain size, high levels of activity, sleep/wakefulness cycles, endothermy, and social behavior, among others. This article focuses on two basic emotions with negative valence: fear and frustration. Fear is related to the anticipation of dangerous or threatening stimuli (e.g., predators or aggressive conspecifics). Frustration is related to unexpected reward omissions or devaluations (e.g., loss of food or sexual resources). These results have implications for an understanding of the conditions that promote fear and frustration, and for the evolution of supporting brain circuitry. (shrink)

Este trabajo plantea, en primer lugar, una visión global acerca de la evolución de la representación de la naturaleza en la cultura artística visual europea del Alto Medievo. Resultado de la misma es la detección de una parálisis en la evolución estética de la representación de la naturaleza que sin embargo había pasado previamente por fases de esplendor decorativo y simbólico. A continuación se examinan diferentes propuestas historiográficas acerca de la evolución de la relación entre ser humano y naturaleza en (...) la Alta Edad Media y su posible contextualización con el cuadro evolutivo artístico trazado. Esa contextualización lleva finalmente a la búsqueda de una relación del fenómeno detectado con los fundamentos teológicos de la cultura monástica y sus planteamientos escatológicos. This paper first presents an overview about the evolution of the representation of nature in European artistic culture of the High Middle Ages. A result of this is the detection of a paralysis in the aesthetic evolution of nature in visual arts after previous phases of decorative and symbolic richness. Different historiographic proposals on the evolution of the relationship between man and nature in the Middle Ages show a possible contextualization with the artistic paralysis we have stated. That path leads to the search for a relation of the phenomenon detected with the theological foundations of the monastic culture and its eschatological discourses. (shrink)

A large part of technological advances, especially in the field of industry, have been focused on the optimization of productive processes. However, the detection of anomalies has turned out to be a great challenge in fields like industry, medicine or stock markets. The present work addresses anomaly detection on a control level plant. We propose the application of different intelligent techniques, which allow to obtain one-class classifiers using real data taken from the correct plant operation. The performance of each classifier (...) is assessed and validated with real created faults, achieving successful overall results. (shrink)

The present study aims to explore whether the symptoms associated with fibromyalgia are contextually influenced by the area of residence. Furthermore, it is analyzed whether the effect of the acceptance of the disease on the emotional, cognitive and physical symptoms is moderated by the patients’ place of residence. Using a cross-sectional design, a total of 234 women with fibromyalgia were surveyed, of which 55.13% resided in rural areas and 44.87% in urban areas. Self-reported questionnaires were used to assess pain severity, (...) anxiety and depression, functional limitation, physical and mental fatigue and acceptance of the disease. The results show significant differences in acceptance, pain, and physical and mental fatigue between patients from rural and urban areas. The rural area patients presented higher levels of acceptance and pain and lesser levels of physical and mental fatigue compared to the urban area. The moderation analysis add that, only in patients from the rural area, the variables of physical symptoms were significantly and negatively associated with acceptance. This study addresses for the first time the role of the place of residence in suffering from fibromyalgia, suggesting that the rural or urban environment plays a relevant role in the severity and/or management of symptoms in fibromyalgia women. Limitations and practical implications are also discussed. (shrink)

Nowadays, batteries play an important role in a lot of different applications like energy storage, electro-mobility, consumer electronic and so on. All the battery types have a common factor that is their complexity, independently of its nature. Usually, the batteries have an electrochemical nature. Several different test are accomplished to check the batteries performance, and commonly, it is predictable how they work depending of their technology. The present research describes the hybrid intelligent system created to accomplish fault detection over a (...) Lithium Iron Phosphate—LiFePO4 power cell type, commonly used in electro-mobility applications. The approach is based on the cell temperatures behaviour for voltage and current specific values. Taken into account the operating range of a real system based on a LiFePO4 cell, a large set of points of operation have been used to achieve the dataset. The different behaviour zones have been obtained by clustering as a first step. Then, different regression techniques have been used over each cluster. Polynomial regression, artificial neural networks and support vector regression were the combined techniques to develop the hybrid intelligent model proposed. The intelligent system gives very good results over the operating range, detecting all the faults tested during the validation. (shrink)

One of the main challenges in medicine is to guarantee an appropriate drug supply according to the real needs of patients. Closed-loop strategies have been widely used to develop automatic solutions based on feedback variables. However, when the variable of interest cannot be directly measured or there is a lack of knowledge behind the process, it turns into a difficult issue to solve. In this research, a novel algorithm to approach this problem is presented. The main objective of this study (...) is to provide a new general algorithm capable of determining the influence of a certain clinical variable in the decision making process for drug supply and then defining an automatic system able to guide the process considering this information. Thus, this new technique will provide a way to validate a given physiological signal as a feedback variable for drug titration. In addition, the result of the algorithm in terms of fuzzy rules and membership functions will define a fuzzy-based decision system for the drug delivery process. The method proposed is based on a Fuzzy Inference System whose structure is obtained through a decision tree algorithm. A four-step methodology is then developed: data collection, preprocessing, Fuzzy Inference System generation, and the validation of results. To test this methodology, the analgesia control scenario was analysed. Specifically, the viability of the Analgesia Nociception Index as a guiding variable for the analgesic process during surgical interventions was studied. Real data was obtained from fifteen patients undergoing cholecystectomy surgery. (shrink)

Student performance and its evaluation remain a serious challenge for education systems. Frequently, the recording and processing of students’ scores in a specific curriculum have several flaws for various reasons. In this context, the absence of data from some of the student scores undermines the efficiency of any future analysis carried out in order to reach conclusions. When this is the case, missing data imputation algorithms are needed. These algorithms are capable of substituting, with a high level of accuracy, the (...) missing data for predicted values. This research presents the hybridization of an algorithm previously proposed by the authors called adaptive assignation algorithm, with a well-known technique called multivariate imputation by chained equations. The results show how the suggested methodology outperforms both algorithms. (shrink)

Closed-loop administration of propofol for the control of hypnosis in anesthesia has evidenced an outperformance when comparing it with manual administration in terms of drug consumption and post-operative recovery of patients. Unlike other systems, the success of this strategy lies on the availability of a feedback variable capable of quantifying the current hypnotic state of the patient. However, the appearance of anomalies during the anesthetic process may result in inaccurate actions of the automatic controller. These anomalies may come from the (...) monitors, the syringe pumps, the actions of the surgeon or even from alterations in patients. This could produce adverse side effects that can affect the patient postoperative and reduce the safety of the patient in the operating room. Then, the use of anomaly detection techniques plays a significant role to avoid this undesirable situations. This work assesses different one-class intelligent techniques to detect anomalies in patients undergoing general anesthesia. Due to the difficulty of obtaining real data from anomaly situations, artificial outliers are generated to check the performance of each classifier. The final model presents successful performance. (shrink)

This work focuses on the application of machine learning techniques to assist the clinicians in the administration of analgesic drug during general anaesthesia. Specifically, the main objective is to propose the basis of an intelligent system capable of making decisions to guide the opioid dose changes based on a new nociception monitor, the analgesia nociception index. Clinical data were obtained from 15 patients undergoing cholecystectomy surgery. By means of an off-line study, machine learning techniques were applied to analyse the possible (...) relationship between the analgesic dose changes performed by the physician due to the hemodynamic activity of the patients and the evolution of the ANI. After training different classifiers and testing the results under cross validation, a preliminary relationship between the evolution of ANI and the dosage of remifentanil was found. These results evidence the potential of the ANI as a promising index to guide the infusion of analgesia. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Automatic control of physiological variables is one of the most active areas in biomedical engineering. This paper is centered in the prediction of the analgesic variables evolution in patients undergoing surgery. The proposal is based on the use of hybrid intelligent modelling methods. The study considers the Analgesia Nociception Index to assess the pain in the patient and remifentanil as intravenous analgesic. The model proposed is able to make a one-step-ahead prediction of the remifentanil dose corresponding to the current state (...) of the patient. The input information is the previous remifentanil dose, the ANI variable and the electromyogram signal. Modelling techniques used are Artificial Neural Networks and Support Vector machines for Regression combined with clustering methods. Both training and validation were done with a real dataset from different patients. Results obtained show the potential of this methodology to calculate the drug dose corresponding to a given analgesic state of the patient. (shrink)

In this study, a hybrid model based on intelligent techniques is developed to predict the active power generated in a bioclimatic house by a low power wind turbine. Contrary to other researches that predict the generated power taking into account the speed and the direction of the wind, the model developed in this paper only uses the speed of the wind, measured mainly in a weather station from the government meteorological agency (MeteoGalicia). The wind speed is measured at different heights, (...) against the usual measurements in others researches, which uses the wind speed and the direction measured in a weather station on the wind turbine nacelle. The prediction is performed 30 minutes ahead, what ensures that the Building Management System knows the energy generated by the low power wind turbine 30 minutes before, and it can adapt the consumption of different equipment in the house to optimize the power use. The main objective is to allow the Building Management System to optimize the uses of energy, taking into account the predicted amount of energy that will be produced and the energy consumed in the house. The developed model uses a hybrid topology with four clusters to improve the prediction, achieving an error lower than 6.5% for Mean Absolute Error measured in a final test. To perform this test, part of the original dataset was isolated from the beginning of the training process to check the model with a dataset that is not used before, simulating the model as it is receiving new data. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

El viernes 01 de julio de 2022 se realizó, en el edificio Sergio Karakachoff de la UNLP, la presentación de los dos volúmenes de la "Antología comentada" de la obra de José Sazbón compilados por Alberto Pérez y Daniel Lvovich. La antología reúne el trabajo realizado durante décadas por el intelectual argentino José Sazbón, quien fuera profesor e investigador de la Facultad de Humanidades y Ciencias de la Educación y el primer Director de la Maestría en Historia y (...) Memoria. Recopilamos aquí las intervenciones de Fernanda Tocho (Secretaria Académica de la Maestría en Historia y Memoria), Mariana Canavese (UBA-CONICET), María Belforte (UBA-CONICET), Marcelo Starcenbaum (UNLP-CONICET), quienes oficiaron de presentadores de la antología, junto a sus compiladores, Daniel Lvovich (UNGS) y Alberto Pérez (UNLP), acompañados además por Carlos Gazzera (Director de Eduvim) y Ayelén Sidún (Decana de la Facultad de Periodismo y Comunicación Social). (shrink)

¿Por qué democracia? Referencia a los derechos humanos y a la ciudadanía. Why democracy? Reference to human rights and citizenship. Bozo de Carmona, Ana Julia Libertad de expresión y "libertad cómica". Free speech and "comical liberty".Calvo González, José La justicia según J. Finnis. Justice according to John Finnis. Hocevar G., Mayda G. El lenguaje sagrado y su escritura. The sacred language and its writing. Lizaola, Julieta Del carácter coactivo de la μετηνεστασζ en Tucídides. On cornening to compelling nature of (...) Thucydides' μετηνεστασζ. Meabe, Joaquín E. Apuntes para una filosofía crítica de la historia regional. Notes for a critical philosophy concern to the regional history. Mora García, José Pascual Competencia política partidista en los textos de Simón Bolívar . The defender political competition in the Simon Bolivar’s writings . Ortiz Palanques, Marco Fundamentación socio-jurídica de los procesos normativos. Social and juridical reasoning about the normatives changes. Pavó Acosta, Rolando Filosofía y psicopatología en Karl Jaspers: los entramados de la existencia. Philosophy and psychopathology in Karl Jaspers: the studworks of the existence. Portuondo Pajón, Gladys L. La doctrina platónica del alma en la «república». The platonic doctrine of the soul in the «republic» dialogue. Suzzarini, Andrés Una aproximación a la concepción romana del derecho. An estimate study to the roman concept of law. Terán Pimentel, Milagros Interdisciplinares Lo dionisíaco y lo apolíneo en Don Juan Tenorio. The dionysiac and the apolline in Don Juan Tenorio. Pérez Lo Presti, Alirio. (shrink)

Artículos ¿Por qué democracia? Referencia a los derechos humanos y a la ciudadanía. Why democracy? Reference to human rights and citizenship. Bozo de Carmona, Ana Julia Libertad de expresión y "libertad cómica". Free speech and "comical liberty".Calvo González, José La justicia según J. Finnis. Justice according to John Finnis. Hocevar G., Mayda G. El lenguaje sagrado y su escritura. The sacred language and its writing. Lizaola, Julieta Del carácter coactivo de la μετηνεστασζ en Tucídides. On cornening to compelling nature (...) of Thucydides' μετηνεστασζ. Meabe, Joaquín E. Apuntes para una filosofía crítica de la historia regional. Notes for a critical philosophy concern to the regional history. Mora García, José Pascual Competencia política partidista en los textos de Simón Bolívar . The defender political competition in the Simon Bolivar’s writings . Ortiz Palanques, Marco Fundamentación socio-jurídica de los procesos normativos. Social and juridical reasoning about the normatives changes. Pavó Acosta, Rolando Filosofía y psicopatología en Karl Jaspers: los entramados de la existencia. Philosophy and psychopathology in Karl Jaspers: the studworks of the existence. Portuondo Pajón, Gladys L. La doctrina platónica del alma en la «república». The platonic doctrine of the soul in the «republic» dialogue. Suzzarini, Andrés Una aproximación a la concepción romana del derecho. An estimate study to the roman concept of law. Terán Pimentel, Milagros Interdisciplinares Lo dionisíaco y lo apolíneo en Don Juan Tenorio. The dionysiac and the apolline in Don Juan Tenorio. Pérez Lo Presti, Alirio. (shrink)

Most technology is used properly for their intended purpose, but certain technological breakthroughs have a dual-use nature, pose risks or lead to unintended consequences when applied in some areas...

SUMARIO Artículos ¿Por qué democracia? Referencia a los derechos humanos y a la ciudadanía. Why democracy? Reference to human rights and citizenship. Bozo de Carmona, Ana Julia Libertad de expresión y "libertad cómica". Free speech and "comical liberty".Calvo González, José La justicia según J. Finnis. Justice according to John Finnis. Hocevar G., Mayda G. El lenguaje sagrado y su escritura. The sacred language and its writing. Lizaola, Julieta Del carácter coactivo de la μετηνεστασζ en Tucídides. On cornening to compelling (...) nature of Thucydides' μετηνεστασζ. Meabe, Joaquín E. Apuntes para una filosofía crítica de la historia regional. Notes for a critical philosophy concern to the regional history. Mora García, José Pascual Competencia política partidista en los textos de Simón Bolívar . The defender political competition in the Simon Bolivar’s writings . Ortiz Palanques, Marco Fundamentación socio-jurídica de los procesos normativos. Social and juridical reasoning about the normatives changes. Pavó Acosta, Rolando Filosofía y psicopatología en Karl Jaspers: los entramados de la existencia. Philosophy and psychopathology in Karl Jaspers: the studworks of the existence. Portuondo Pajón, Gladys L. La doctrina platónica del alma en la «república». The platonic doctrine of the soul in the «republic» dialogue. Suzzarini, Andrés Una aproximación a la concepción romana del derecho. An estimate study to the roman concept of law. Terán Pimentel, Milagros Interdisciplinares Lo dionisíaco y lo apolíneo en Don Juan Tenorio. The dionysiac and the apolline in Don Juan Tenorio. Pérez Lo Presti, Alirio. (shrink)

The ethics of deceased organ procurement (OP) is supposedly based on individual consent to donate, either explicit (opt-in) or presumed (opt-out). However, in many cases, individuals fail to express any preference regarding donation after death. When this happens, the decision to remove or not to remove their organs depends on the policy’s default option or on family preferences. Several studies show that in most countries the family plays a significant and often decisive role in the process of decision-making for OP. (...) Depending on the country, the family may be allowed to take different kinds of actions in different situations, and this may be granted either by law or by clinical practice only. This adds much complexity to the usual classification of consent policies in two categories: opt-in and opt-out. Here we propose a novel and comprehensive taxonomy of the models of consent for OP according to three variables: (1) the deceased’s wishes, if any, (2) family wishes, if any, and (3) default policies. By analysing these models of consent, we show that they rely on at least three different concepts of autonomy: individual autonomy, relational autonomy, and family autonomy. In light of this analysis, we discuss the ethical debates surrounding two policy approaches: presumed consent and family veto. (shrink)

Este artículo se propone confrontar el concepto de opinión pública con la realidad y las expectativas de una sociedad digitalizada para analizar si la actual colonización algorítmica exige un nuevo cambio estructural de la opinión pública o más bien la retirada de este concepto. Los datos y metadatos masivos se han vuelto un arma de doble filo para la sociedad democrática digitalmente hiperconectada. Mientras que, por un lado, el increíble potencial que atesora el _big data_ y sus diferentes técnicas y (...) tecnologías de explotación de los datos y metadatos lo convierten en un producto codiciado por sistema de instituciones que componen tanto el estado como la sociedad civil; por otro, los altos impactos negativos que su uso instrumental e irresponsable está produciendo y puede llegar a producir, hacen del _big data_ una herramienta controvertida y altamente criticada por alejarnos de cualquier intento de construir una ciudadanía digital. Si bien la democracia algorítmica no se apoya solo en la opinión pública, el objetivo es mostrar la incompatibilidad entre opinión pública artificial y democracia. Nuestro hilo conductor es el concepto habermasiano de opinión pública, puesto que será precisamente la fuerza de la sociedad civil, a través del diseño en su seno de espacios de participación, de donde podemos extraer el potencial necesario para enfrentarnos a la actual colonización algorítmica, para recuperar una deliberación autónoma y crítica sin la cual no existe opinión pública alguna y, por tanto, tampoco democracia. (shrink)

The classification of preserved hypothalamic activity in brain death and brainstem death as functional or non-functional has become a subject of debate. While proponents of the neurological criterion claim that these activities lack functional significance (Shemie et al. 2014), Nair-Collins and Joffe (2023) argue for their functional physiological role. However, the interpretation of the term "function" within the medico-legal framework, where death is characterized by the irreversible cessation of all brain functions, remains unclear. -/- My intention here is not to (...) engage in a debate over the validity of different viewpoints regarding the functional significance of preserved activities in the hypothalamus or the heart. Rather, I aim to highlight the critical importance of exploring and defining the concept of function in medicine, which currently lacks clarity. My point is that, whatever our position in the brain death debate, reaching a consensus on this conceptual matter would minimize misunderstandings and establish a robust foundation for further insightful analysis. (shrink)

SUMARIO Artículos ¿Por qué democracia? Referencia a los derechos humanos y a la ciudadanía. Why democracy? Reference to human rights and citizenship. Bozo de Carmona, Ana Julia Libertad de expresión y "libertad cómica". Free speech and "comical liberty".Calvo González, José La justicia según J. Finnis. Justice according to John Finnis. Hocevar G., Mayda G. El lenguaje sagrado y su escritura. The sacred language and its writing. Lizaola, Julieta Del carácter coactivo de la μετηνεστασζ en Tucídides. On cornening to compelling (...) nature of Thucydides' μετηνεστασζ. Meabe, Joaquín E. Apuntes para una filosofía crítica de la historia regional. Notes for a critical philosophy concern to the regional history. Mora García, José Pascual Competencia política partidista en los textos de Simón Bolívar . The defender political competition in the Simon Bolivar’s writings . Ortiz Palanques, Marco Fundamentación socio-jurídica de los procesos normativos. Social and juridical reasoning about the normatives changes. Pavó Acosta, Rolando Filosofía y psicopatología en Karl Jaspers: los entramados de la existencia. Philosophy and psychopathology in Karl Jaspers: the studworks of the existence. Portuondo Pajón, Gladys L. La doctrina platónica del alma en la «república». The platonic doctrine of the soul in the «republic» dialogue. Suzzarini, Andrés Una aproximación a la concepción romana del derecho. An estimate study to the roman concept of law. Terán Pimentel, Milagros Interdisciplinares Lo dionisíaco y lo apolíneo en Don Juan Tenorio. The dionysiac and the apolline in Don Juan Tenorio. Pérez Lo Presti, Alirio. (shrink)