Sensory organs are specialized to receive different kinds of input from the outside world. However, common features of their development suggest that they could have a shared evolutionary origin. In a recent paper, Niwa et al.1 show that three Drosophila adult sensory organs all rely on the spatial signals Decapentaplegic and Wingless to specify their position, and the temporal signal ecdysone to initiate their development. The proneural gene atonal is an important site for integration of these regulatory inputs. These results (...) suggest the existence of a primitive sensory organ precursor, which would differentiate according to the identity of its segment of origin. The authors argue that the eyeless gene controls eye disc identity, indirectly producing an eye from the sensory organ precursor within this disc. BioEssays 26:825–828, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The discovery of conserved protein domains found in many Drosophila and mammalian developmental gene products suggests that fundamental developmental processes are conserved throughout evolution. Our understanding of development has been enhanced by the discovery of the widespread role of the homeodomain (HD). The action of HD‐containing proteins as transcriptional regulators is mediated through a helix‐turn‐helix motif which confers sequence specific DNA binding. Unexpectedly, the well conserved structural homology between the HD and the prokaryotic helix‐turn‐helix proteins contrasts with their divergent types (...) of physical interaction with DNA. A C‐terminal extension of the HD recognition helix has assumed the role that the N‐terminus of the prokaryotic helix plays for specification of DNA binding preference. However, the HD appears also capable of recognizing DNA in an alternative way and its specificity in vivo may be modified by regions outside the helix‐turn‐helix motif. We propose that this intrinsic complexity of the HD, as well as its frequent association with other DNA binding domains, explains the functional specificity achieved by genes encoding highly related HDs. (shrink)

How should physical entities be characterized? Physicalists, who have most to do with the notion, usually characterize the physical by reference to two components: 1. The physical entities are the entities treated by fundamental physics with the proviso that 2. Physical entities are not fundamentally mental (that is, do not individually possess or bestow mentality) Here I explore the extent to which the appeals to fundamental physics and to the NFM (“no fundamental mentality”) constraint are appropriate for characterizing the physical, (...) especially for purposes of formulating physicalism. Ultimately, I motivate and defend a version of an account incorporating both components: The physics-based NFM account: An entity existing at a world w is physical iff (i) it is treated, approximately accurately, by current or future (in the limit of inquiry, ideal) versions of fundamental physics at w, and (ii) it is not fundamentally mental (that is, does not individually either possess or bestow mentality). (shrink)

Fallibilists claim that one can know a proposition on the basis of evidence that supports it even if the evidence doesn't guarantee its truth. Jessica Brown offers a compelling defence of this view against infallibilists, who claim that it is contradictory to claim to know and yet to admit the possibility of error.

Research groups around the world are currently busy trying to invent new life in the laboratory, looking for extraterrestrial life, or making machines increasingly more life-like. In the case of astrobiology, any newly discovered life would likely be very old, but when discovered it would be new to us. In the case of synthetic organic life or life-like machines, humans will have invented life that did not exist before. Together, these endeavors amount to what we call the emerging plurality of (...) lives because we see a future where we are surrounded by, and interact with, life of many different origins, as well as entities that we have not traditionally seen as being alive. In the future these entities will likely possess properties that we so far have only associated with living beings, thereby transcending and perhaps blurring the borders between life and non-life. (shrink)

RésuméL'ouvrage de Sophia Moreau, Faces of Inequality, adopte une méthodologie philosophique provocatrice. Moreau puise dans les expériences des victimes de discrimination et à même les contours fondamentaux du droit à la non-discrimination afin d’élaborer sa théorie de la discrimination répréhensible. Cependant, si nous prenons au sérieux les enseignements des études féministes et critiques de la « race », une tension émerge au sein de la dyade méthodologique de Moreau : si les lois contre la discrimination sont souvent elles-mêmes source d'hostilité (...) et d'invalidation pour les victimes de discrimination, comment ces expériences et ces lois peuvent-elles toutes deux faire autorité pour déterminer la nature de la discrimination répréhensible? Cet article explore cette tension à l’œuvre dans Faces of Inequality à la lumière de la théorie de la « conscience multiple » de Mari Matsuda. (shrink)

Increased technological and pharmacological interventions in patient care when patient outcomes are uncertain have been linked to the escalation in moral and ethical dilemmas experienced by health care providers in acute care settings. Health care research has shown that facilities that are able to attract and retain nursing staff in a competitive environment and provide high quality care have the capacity for nurses to process and resolve moral and ethical dilemmas. This article reports on the findings of a systematic review (...) of the empirical literature (1980 — February 2007) on the effects of unresolved moral distress and poor ethical climate on nurse turnover. Articles were sought to answer the review question: Does unresolved moral distress and a poor organizational ethical climate increase nurse turnover? Nine articles met the criteria of the review process. Although the prevailing sentiment was that poor ethical climate and moral distress caused staff turnover, definitive answers to the review question remain elusive because there are limited data that confidently support this statement. (shrink)

A persuasive monograph that answers the keyepistemological arguments against anti-individualism in thephilosophy of mind.

I årtusenden har människan försökt definiera livet – hur levande djur och växter skiljer sig från död materia. Problemet är dock att livet är mångfacetterat, och varje regel har sitt undantag. Vi försöker möta kommande utmaningar med nya livsformer, genom att lyfta fram en ny definition av liv.

The debate about the ethical implications of Artificial Intelligence dates from the 1960s :741–742, 1960; Wiener in Cybernetics: or control and communication in the animal and the machine, MIT Press, New York, 1961). However, in recent years symbolic AI has been complemented and sometimes replaced by Neural Networks and Machine Learning techniques. This has vastly increased its potential utility and impact on society, with the consequence that the ethical debate has gone mainstream. Such a debate has primarily focused on principles—the (...) ‘what’ of AI ethics —rather than on practices, the ‘how.’ Awareness of the potential issues is increasing at a fast rate, but the AI community’s ability to take action to mitigate the associated risks is still at its infancy. Our intention in presenting this research is to contribute to closing the gap between principles and practices by constructing a typology that may help practically-minded developers apply ethics at each stage of the Machine Learning development pipeline, and to signal to researchers where further work is needed. The focus is exclusively on Machine Learning, but it is hoped that the results of this research may be easily applicable to other branches of AI. The article outlines the research method for creating this typology, the initial findings, and provides a summary of future research needs. (shrink)

Contextualists such as Cohen and DeRose claim that the truth conditions of knowledge attributions vary contextually, in particular that the strength of epistemic position required for one to be truly ascribed knowledge depends on features of the attributor's context. Contextualists support their view by appeal to our intuitions about when it's correct (or incorrect) to ascribe knowledge. Someone might argue that some of these intuitions merely reflect when it is conversationally appropriate to ascribe knowledge, not when knowledge is truly ascribed, (...) and so try to accommodate these intuitions even on an invariantist view. DeRose (Blackwell Guide to Epistemology, 1998; Philosophical Review, 2002) argues that any such 'warranted assertibility manoeuvre', or 'WAM', against contextualism is unlikely to succeed. Here, I argue that his objections to a WAM against contextualism are not persuasive and offer a pragmatic account of the data about ascriptions of knowledge. (shrink)

A core principle of modern science holds that a scientific explanation must not attribute will or agency to natural phenomena.The Restless Clock examines the origins and history of this, in particular as it applies to the science of living things. This is also the story of a tradition of radicals—dissenters who embraced the opposite view, that agency is an essential and ineradicable part of nature. Beginning with the church and courtly automata of early modern Europe, Jessica Riskin guides us (...) through our thinking about the extent to which animals might be understood as mere machines. We encounter fantastic robots and cyborgs as well as a cast of scientific and philosophical luminaries, including Descartes and Leibnitz, Lamarck and Darwin, whose ideas gain new relevance in Riskin's hands. The book ends with a riveting discussion of how the dialectic continues in genetics, epigenetics, and evolutionary biology, where work continues to naturalize different forms of agency.The Restless Clock reveals the deeply buried roots of current debates in artificial intelligence, cognitive science, and evolutionary biology. (shrink)

This volume is about the notion of 'defeat' in philosophy. The idea is that someone who has some knowledge, or a justified belief, can lose this knowledge or justified belief if they acquire a 'defeater' - evidence that undermines it. The contributors examine the role of defeat not just in epistemology but in practical reasoning and ethics.

When subjects violate epistemic standards or norms, we sometimes judge them blameworthy rather than blameless. For instance, we might judge a subject blameworthy for dogmatically continuing to believe a claim even after receiving evidence which undermines it. Indeed, the idea that one may be blameworthy for belief is appealed to throughout the contemporary epistemic literature. In some cases, a subject seems blameworthy for believing as she does even though it seems prima facie implausible that she is morally blameworthy or professionally (...) blameworthy. Such cases raise the question of whether one can be blameworthy for a belief in a specifically epistemic sense rather than in some already recognised sense, such as being morally or professionally blameworthy. A number of authors have recently argued that there is a moral or social sense in which one ought to conform one’s beliefs to the evidence. In this paper, I argue that even while accepting that there are moral and social norms governing belief, there are cases in which a subject is blameworthy for a belief but isn’t plausibly morally or socially blameworthy. If this latter view is correct, then we may need to develop a new account of blame which can be applied to beliefs which are not morally or socially blameworthy. (shrink)

Liv är ett centralt begrepp inom många forskningsområden, exempelvis inom biologi, astrobiologi, kemi och medicin, såväl som inom juridik, teologi och filosofi. Liv är också ett centralt tema i konsten. Det behandlas och begrundas i åtskilliga konstverk, i dikt, roman och film. Hur vi skall förstå, värdera och skydda livet, är oerhört fundamentala frågor. I framtiden kommer dessa frågor att bli än svårare och om möjligt ännu viktigare. Forskargrupper från hela världen arbetar idag med att skapa liv i laboratoriet, leta (...) efter liv i rymden och förse maskiner med egenskaper som tidigare bara har varit förunnade levande varelser, och utvecklingen går fort. Det är viktigt att vi samtidigt funderar över de utmaningar som detta innebär. Det kommer att ta tid att hitta sätt att leva i en värld där liv finns i former vi idag knappt kan föreställa oss och där gränsen mellan levande varelser och maskiner blir alltmer suddig. De beslut vi fattar idag kommer också att påverka utvecklingen inom samhälle, forskning och utveckling under lång tid framöver. -/- Den här boken är ett resultat av ett tvärvetenskapligt projekt vid Pufendorfinstitutet, Lunds universitet. Tolv forskare från lika många discipliner har ingått i projektet. Syftet har varit att belysa utmaningar som följer med utomjordiskt, artificiellt och syntetiskt liv. Det tvärvetenskapliga angreppssättet har gett oss möjlighet att belysa frågorna från alla upptänkliga vinklar, men också att hitta helt nya kombinationer av metoder och synsätt. Med tanke på livets mångsidighet och stora betydelse ur så många olika perspektiv, har detta grepp varit helt nödvändigt. -/- Vår förhoppning är att boken skall inspirera till nya tankar och diskussioner om liv. Boken vänder sig både till de som redan är intresserade och de som ännu inte har börjat fundera kring de utmaningar som utomjordiskt, artificiellt och syntetiskt liv innebär. (shrink)

This book argues that the major traditions in the philosophy of language have mistakenly focused on highly idealized linguistic contexts. Instead, it presents a non-ideal foundational theory of language that contends that the essential function of language is to direct attention for the purpose of achieving diverse social and political goals. Philosophers of language have focused primarily on highly idealized linguistic contexts in which cooperative agents are working toward the shared goal of gaining information about the world. This approach abstracts (...) away from important issues like power, ideology, social position, and diversity of goals which are crucial to explaining linguistic phenomena both at the semantic and pragmatic levels. This book begins by examining the work of some of the pioneers of this tradition--primarily David Lewis, Paul Grice, and Robert Stalnaker. The author shows that various problems have their source in idealizations made at the foundational level of linguistic theory and proposes to rebuild from the ground-up. She presents a non-ideal foundational theory of language which retains the major insights of traditional frameworks while rejecting the social idealizations that guide them. Then, she explores the social and political applications of her account to issues such as dog whistling, propaganda, slurs and racist speech, silencing, and manipulation. Non-Ideal Foundations of Language will appeal to researchers and advanced students in philosophy of language who are interested in the social and political applications of language, as well as traditional metasemantic theory. (shrink)

According to the naïve, pre-theoretic conception, lying seems to be characterized by the intent to deceive. However, certain kinds of bald-faced lies appear to be counterexamples to this view, and many philosophers have abandoned it as a result. I argue that this criticism of the naïve view is misplaced; bald-faced lies are not genuine instances of lying because they are not genuine instances of assertion. I present an additional consideration in favor of the naïve view, which is that abandoning it (...) comes at an extremely high price; alternative accounts which eschew the intent-to-deceive condition on lying have difficulty distinguishing lies from non-literal speech. (shrink)

Technologies to rapidly alert people when they have been in contact with someone carrying the coronavirus SARS-CoV-2 are part of a strategy to bring the pandemic under control. Currently, at least 47 contact-tracing apps are available globally. They are already in use in Australia, South Korea and Singapore, for instance. And many other governments are testing or considering them. Here we set out 16 questions to assess whether — and to what extent — a contact-tracing app is ethically justifiable.

Assertion is a fundamental feature of language. This volume will be the place to look for anyone interested in current work on the topic.

The term "fake news" ascended rapidly to prominence in 2016 and has become a fixture in academic and public discussions, as well as in political mud-slinging. In the flurry of discussion, the term has been applied so broadly as to threaten to render it meaningless. In an effort to rescue our ability to discuss—and combat—the underlying phenomenon that triggered the present use of the term, some philosophers have tried to characterize it more precisely. A common theme in this nascent philosophical (...) discussion is that contemporary fake news is not a new kind of phenomenon, but just the latest iteration of a broader kind of phenomenon that has played out in different ways across the history of human information-dissemination technologies. While we agree with this, we argue that newer sorts of fake news reveal substantial flaws in earlier understandings of this notion. In particular, we argue that no deceptive intentions are necessary for fake news to arise; rather, fake news arises when stories which were not produced via standard journalistic practice are treated as though they had been. Importantly, this revisionary understanding of fake news allows us to accommodate and understand the way that fake news is plausibly generated and spread in a contemporary setting, as much by non-human actors as by ordinary human beings. (shrink)

Pt. I. The apparent good. Evaluative cognition -- Perceiving the good -- Phantasia and the apparent good -- pt. II. The apparent good and non-rational motivation. Passions and the apparent good -- Akrasia and the apparent good -- pt. III. The apparent good and rational motivation. Phantasia and deliberation -- Happiness, virtue, and the apparent good -- Practical induction -- Conclusion : Aristotle's practical empiricism.

It has become recently popular to suggest that knowledge is the epistemic norm of practical reasoning and that this provides an important constraint on the correct account of knowledge, one which favours subject-sensitive invariantism over contextualism and classic invariantism. I argue that there are putative counterexamples to both directions of the knowledge norm. Even if the knowledge norm can be defended against these counterexamples, I argue that it is a delicate issue whether it is true, one which relies on fine (...) distinctions among a variety of relevant notions of propriety which our intuitions may reflect. These notions variously apply to the agent herself, her character traits, her beliefs, her reasoning and any resultant action. Given the delicacy of these issues, I argue that the knowledge norm is not a fixed point from which to defend substantive and controversial views in epistemology. Rather, these views need to be defended on other grounds. (shrink)

A number of examples of studies from the field ‘The Philosophy of Mathematical Practice’ (PMP) are given. To characterise this new field, three different strands are identified: an agent-based, a historical, and an epistemological PMP. These differ in how they understand ‘practice’ and which assumptions lie at the core of their investigations. In the last part a general framework, capturing some overall structure of the field, is proposed.

Jessica Flanigan defends patients' rights of self-medication on the grounds that same moral reasons against medical paternalism in clinical contexts are also reasons against paternalistic pharmaceutical policies, including prohibitive approval processes and prescription requirements.

As the range of potential uses for Artificial Intelligence, in particular machine learning, has increased, so has awareness of the associated ethical issues. This increased awareness has led to the realisation that existing legislation and regulation provides insufficient protection to individuals, groups, society, and the environment from AI harms. In response to this realisation, there has been a proliferation of principle-based ethics codes, guidelines and frameworks. However, it has become increasingly clear that a significant gap exists between the theory of (...) AI ethics principles and the practical design of AI systems. In previous work, we analysed whether it is possible to close this gap between the ‘what’ and the ‘how’ of AI ethics through the use of tools and methods designed to help AI developers, engineers, and designers translate principles into practice. We concluded that this method of closure is currently ineffective as almost all existing translational tools and methods are either too flexible or too strict. This raised the question: if, even with technical guidance, AI ethics is challenging to embed in the process of algorithmic design, is the entire pro-ethical design endeavour rendered futile? And, if no, then how can AI ethics be made useful for AI practitioners? This is the question we seek to address here by exploring why principles and technical translational tools are still needed even if they are limited, and how these limitations can be potentially overcome by providing theoretical grounding of a concept that has been termed ‘Ethics as a Service.’. (shrink)

Stanley and Williamson have defended the intellectualist thesis that knowing-how is a subspecies of knowing-that by appeal to the syntax and semantics of ascriptions of knowing-how. Critics have objected that this way of defending intellectualism places undue weight on linguistic considerations and fails to give sufficient attention to empirical considerations from the scientific study of the mind. In this paper, I examine and reject Stanley's recent attempt to answer the critics.