Michael J. Zimmerman explores whether and how our ignorance about ourselves and our circumstances affects what our moral obligations and moral rights are. He rejects objective and subjective views of the nature of moral obligation, and presents a new case for a 'prospective' view.

Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

Jian Zhou,* Weiqiang Ju,* Xiaopeng Yuan, Xiaofeng Zhu, Dongping Wang, Xiaoshun HeOrgan Transplant Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China *These authors contributed equally to this work: Hyperosmolar nonketotic hyperglycemic coma is a serious, rare complication induced by methylprednisolone pulse therapy for acute rejection after orthotopic liver transplantation. Herein, we report an unusual case of a 58-year-old woman who experienced acute rejection at 30 months after OLT, only one case in which HNKHC resulted in MP (...) pulse therapy for acute rejection in all 913 recipients in our center. The general morbidity of HNKHC was 1.09‰ in this study. HNKHC is characterized by rapid onset, rapid progression, and a lack of specific clinical manifestations. High-dose MP management was a clear risk factor. The principle of treatment included rapid rehydration, low-dose insulin infusion, and correcting disorders of electrolytes and acidosis. In conclusion, clinicians considering MP pulse therapy after OLT should be alert to the occurrence of HNKHC. Keywords: liver transplantation, complications, hyperosmolar nonketotic hyperglycemic coma, methylprednisolone pulse therapy, principle of treatment. (shrink)

Pocock, J. G. A. (John Greville Agard) 1924- "Quentin Skinner: The History of Politics and the Politics of History" Common Knowledge - Volume 10, Issue 3, Fall 2004, pp. 532-550.

In this book, J.H. Plumb investigates the way that humankind has, since the beginning of recorded time, molded the past to give sanction to their institutions of government, their social structure and morality. The past has also been called upon to explain the nature of our destiny in order both to strengthen the objectives of society and to reconcile us to our lot. J.H. Plumb questions this sanction of the past, the force that it has on our sense of destiny (...) and its relevance to our own times. This classic text is now reissued with a new introduction by Niall Ferguson, placing it within a contemporary context, and with a new foreword by the eminent historian Simon Schama, a former student of J.H.Plumb himself. (shrink)

This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper (...) summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including—the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. (shrink)

J.N. Findlay was a South African philosopher who published from the late 1940s into the 1980s. He had a prestigious international academic career, holding many academic posts around the world. This article uses a textual comparative approach and focuses on Findlay’s Gifford Lecture at St Andrews University between 1965 and 1970. The objective of the article is to highlight the extent to which Findlay’s philosophical writings were influenced by Mahāyāna Buddhism. Although predominantly a Platonist, Findlay drew influence from Asian philosophy (...) and religion, particularly Mahāyāna Buddhism. In these lectures, he applies the metaphor of the Platonic Cave to investigate Hegelian and Husserlian approaches to knowledge. Though he was a leading Hegel and Husserl scholar, his reading of these two philosophers is strongly influenced by Mahāyāna Buddhism, resulting in a unique mystical interpretation of these two philosophers. Revisiting Findlay’s writings is significant for two reasons; firstly, he investigated Buddhism prior to the Asian religions being included in Religious Studies departments’ purview in South African universities, and secondly, his interpretation of two prominent Western philosophers along Buddhist lines provides an early attempt at decolonising the predominance of Western philosophical views of knowledge.Contribution: This contribution forms part of a larger collection of essays investigating philosophical works that have had a significant impact on the study of religion. This contribution investigates the Buddhist influence on J.N. Findlay’s philosophical readings of Husserl and Hegel. (shrink)

Pocock, J. G. A. The myth of John Locke and the obsession with liberalism.--Ashcraft, R. The two treatises and the exclusion crisis: the problem of Lockean political theory as bourgeois ideology.

On its first appearance in 1960, J.O. Urmson's Concise encyclopedia of Western philosophy and philosophers established itself as a classic. Its contributors included many of the leading philosophers of the English-speaking world: Ryle, Hare, Strawson, Ayer, Dummett, Williams and many others. They wrote with an authority and individuality which made the Encyclopedia into a lively and engaging introduction to philosophy as well as a convenient reference work. For this edition, supervised by Jonathan Rée, the original articles have been revised and (...) updated, and eighty articles by thirty one new authors have been added. The additions take account of recent developments in philosophy, of literary, historical and political issues in philosophy, and of developments in continental thought, including in Marxism, psychoanalysis, phenomenology, existentialism, structuralism, post-structuralism and deconstruction. There is a clear, integral cross-referencing system which allows the reader to identify points of overlap between philosophical traditions and their personalities at a glance. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Reading of Bayle: An Inquiry into the Source and Role of the Memoranda J. P. PITTION MY PURPOSE IN THIS PAPER is to discuss an aspect of Hume's reading of Pierre Bayle, the French "Philosopher of Rotterdam. ''1 I am not concerned here with the identification of Hume's direct borrowings from Bayle in the Treatise, nor with the much wider problem of a probable influence of Bayle on (...) Hume. It is indeed possible to identify in the Treatise a number of specific points taken from Bayle. Kemp Smith listed four at least: the account of skepticism, the discussion of Spinoza, the discussion of animal intelligence, and the criticism of the argument from design. 2 All of these come from Bayle's Dictionnaire. External evidence confirms that in 1732 Hume had a work of Bayle, presumably a copy of the Dictionnaire. Other borrowings from Bayle have been identified in the Treatise and in Hume's other works. This is no surprise, for in the eighteenth century Bayle's Dictionnaire was used as it was intended in the first instance, that is, as a reference work. In detailing the borrowings from Bayle, Kemp Smith also touched upon the broader question of influence when he stated that Hume's Pyrrhonism, particularly in relation to his treatment of religion, may also come from Bayle. Many recent scholars have followed suit. A problem of influence however is always a difficult one, and particularly so in this case. There was, as R. H. Popkin has pointed out, a broad awareness of continental skepticism among British philosophers of the eighteenth century. 3 However, apropos Berkeley, A. A. Luce has remarked that the trouble with eighteenth-century continental skepticism was that it had various objectives and took various forms. 4 This is true of Bayle himself. Within skepticism Bayle's position was known for its extremism, and it was this extremism that brought him notoriety. During the eighteenth century Bayle was the philosopher who promoted a systematic use of the Pyrrhonic mode of argument. He was acknowledged above all for having set up a double paradox: that any attempt at a rational theodicy must lead to Manicheism and that to argue for a rationalist Christian ethics is to argue the case of an atheistic one as well. In other words, in the early eighteenth century Bayle played the part of a contemporary Pyrrho and Zeno of Elea: he was known for this double stance, and it is for ' This is a slightly revised version of a paper read at the McGill Bicentennial Hume Conference, held at McGiUUniversity, Montreal, in September, 1976. I wishto offer my thanks to Professors H. M. Bracken and D. F. Norton for their assistanceon this version, and I am particularly grateful to Professor James Moore of Concordia University for his comments on the interpretation put forward here in relation to section III of the Memoranda (seen. 8). 2N. KempSmith, The Philosophy of David Hume (NewYork, 1964),pt. III, chap. XIV, app. C. 3 "David Hume and the Pyrrhonian Controversy," Review of Metaphysics VI (September, 1952):65-81. 4 The Dialectic of Immaterialisrn (London, 1963),p. 67. [373] 374 HISTORY OF PHILOSOPHY this stance that he was mentioned. It is doubtful whether many of those who do refer to Bayle during this period understood him beyond these terms, whether they sought to understand, or whether they even bothered to read Bayle's lengthy arguments. It is clear that few really grasped his complex, often ambiguous objectives. Mention of a Baylian position by an eighteenth-century writer is therefore no guarantee that the writer has actually read Bayle's works: Bayle is a sort of figurehead for Pyrrhonism, Manicheism, or often even atheism, but one can doubt that there is behind the mention of these basic positions any serious reflection on his thought. There are exceptions of course. Luce and H. M. Bracken have shown that Bayle played a seminal role in the formation of Berkeley's thought? But as a rule, knowledge of Bayle among writers of the Enlightenment was vague; references to him, nonspecific. In most cases it is scarcely possible to speak of an influence. My aim in this... (shrink)

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

In recent years the issue of whether mysticism can be induced by drugs has been pursued by both scholars of mystical literature and psychological researchers. R. C. Zaehner is perhaps the best known among the scholars of religious literature who have addressed the issues of drug-induced mysticism. While on the side of empirical psychology investigators such as Walter N. Pahnke, R. E. L. Masters, and Jean Houston have pursued some of the same issues using the techniques of laboratory experimentation. Zaehner, (...) who was familiar with both Eastern and Western mysticism, argued that drug-induced experiences are not the same as religious mystical experiences of the theistic variety. It was farcical, he argued, for Aldous Huxley to posit a connection between his preternatural feeling of oneness with his chair and the Beatific Vision. The issue between Zaehner and Huxley was not over the veridicality of Huxley's mystical experience. It was over the significance of Huxley's experience: Was it or was it not a drug-induced mystical experience of the sort attained by mystics after heroic struggles of self-discipline? This was the issue again when Zaehner came to address himself to the claims of Timothy Leary, a chief proponent of ‘the LSD experience’, and, in general terms, this has been the central issue pursued by the psychological researchers. (shrink)

In focusing on the story of Darwin's religious doubts, scholars too often overlook Darwin's positive contribution to the study of religion. J. David Pleins traces Darwin's journey in five steps. He begins with Darwin's global voyage, where his encounter with religious and cultural diversity transformed his understanding of religion. Surprisingly, Darwin wrestles with serious theological questions even as he uncovers the evolutionary layers of religion from savage roots. Next, we follow Darwin as his doubts about traditional biblical religion take root, (...) affecting his career choice and marriage to Emma Wedgwood. Pleins then examines Darwin's secret notebooks as he searches for a materialist theory of religion. Again, other surprises loom as Darwin's reading of Comte's three stages of religion's development actually predate his reading of Malthus. Pleins explores how Darwin applied his discovery to the realm of ethics by formulating an evolutionary view of the "Golden Rule" in his Descent of Man. Finally, he considers Darwin's later reflections on the religion question, as he wrestled with whether his views led to atheism, agnosticism, or a new kind of theism. The Evolving God concludes by looking at some of the current religious debates surrounding Darwin and suggests the need for a deeper appreciation for Darwin as a religious thinker. Though he grew skeptical of traditional Christian dogma, Darwin made key discoveries concerning the role and function of religion as a natural evolutionary phenomenon. (shrink)