Background Sharing anonymized/de-identified clinical trial data and publishing research outcomes in scientific journals, or presenting them at conferences, is key to data-driven scientific exchange. However, when data from scientific publications are linked to other publicly available personal information, the risk of reidentification of trial participants increases, raising privacy concerns. Therefore, we defined a set of criteria allowing us to determine and minimize the risk of data reidentification. We also implemented a review process at Takeda for clinical publications prior to submission (...) for publication in journals or presentation at medical conferences. Methods Abstracts, manuscripts, posters, and oral presentations containing study participant information were reviewed and the potential impact on study participant privacy was assessed. Our focus was on direct and indirect identifiers, such as sex, age or geographical indicators in rare disease studies or studies with small sample size treatment groups. Risk minimization was sought using a generalized presentation of identifier-relevant information and decision-making on data sharing for further research. Additional risk identification was performed based on study participant/personnel parameters present in materials destined for the public domain. The potential for participant/personnel identification was then calculated to facilitate presentation of meaningful but de-identified information. Results The potential for reidentification was calculated using a risk ratio of the exposed versus available individuals, with a value above the threshold of 0.09 deemed an unacceptable level of reidentification risk. We found that in 13% of Takeda clinical trial publications reviewed, either individuals could potentially be reidentified or inappropriate data sharing plans could pose a data privacy risk to study participants. In 1/110 abstracts, 58/275 manuscripts, 5/87 posters and 3/58 presentations, changes were necessary due to data privacy concerns/rules. Despite the implementation of risk-minimization measures prior to release, direct and indirect identifiers were found in 11% and 34% of the analysed documents, respectively. Conclusions Risk minimization using de-identification of clinical trial data presented in scientific publications and controlled data sharing conditions improved privacy protection for study participants. Our results also suggest that additional safeguards should be implemented to ensure that higher data privacy standards are met. (shrink)

Summary The question underlying this article is whether the Kantian transcendental philosophy is wide enough to constitute the objects of quantum physics as objects of possible experience and consequently to found the objectivity of quantum physical knowledge. It is shown that the Kantian determinations of the categories (quality, substance, causality) can be interpreted and elaborated in such a way that the quantum physical concept of an object characterized by nonobjectivity of properties is conceived. Therefore the categories are valid in quantum (...) mechanics and warrant the objectivity of quantum physical experience. By the interpretation of the Kantian infinite judgement as an indefinite proposition it is possible to define the non-objectivity of properties categorially as indefiniteness of qualities. In particular by the indefiniteness of the position-quality the non-permanent localizability of quantum mechanical objects can be understood a priori. However the object of possible experience, especially the quantum mechanical object is underdetermined by the categories of substance and causality: If the object is determined to be a substance it is not yet conceived to be an individual; its characterization by means of probability laws is categorially indeterminate. In so far the significance of transcendental philosophy for the foundation of quantum physics is limited. (shrink)

Hannah Arendt und Karl Jaspers – zwei herausragende Persönlichkeiten der Philosophiegeschichte des 20. Jahrhunderts, die eine vor allem politische Denkerin, der andere ursprünglich Mediziner und Psychologe, die beide mit den Erschütterungen der Welt und ihres persönlichen Lebens durch Nationalsozialismus und Zweiten Weltkrieg zurechtkommen mussten und dabei doch der Welt immer zugewandt blieben. Sie haben viele bedeutende Schriften hinterlassen, Denkansätze, deren Relevanz bis heute nicht nachgelassen hat.über beide ist viel geschrieben und geforscht worden – allein ihre sehr tiefe und besondere, fast (...) lebenslange Freundschaft, beginnend mit Arendts Studium bei Jaspers ab 1926, ist bislang seltsam unerforscht. Zwar ist der umfangreiche Briefwechsel ediert, es existiert jedoch keine einzige Monographie zum Thema. Diesem Umstand will das vorliegende Buch abhelfen. Ingeborg Gleichauf, Philosophin und Schriftstellerin, nähert sich der Beziehung von Arendt und Jaspers über die Beschäftigung mit den großen Fragen und Themen, die die beiden zeit ihres Lebens umtrieben und legt den Focus auf das über lange Zeiträume und große Distanzen nie versiegende Gespräch zwischen ihnen, ob persönlich oder in Briefen – auf den fruchtbaren, auch manchmal streitbaren, immer vertrauensvollen, von Neugier, Offenheit und Redlichkeit geprägten Austausch. (shrink)

The social and technological developments, social movements, scientific discoveries, economic growth or diseconomies give rise to many problems for human beings. Many disciplines such as economics, political science, architecture, sociology and psychology discuss these problems and offer solutions from different perspectives. Philosophy has its own way of dealing with these problems. As opposed to the common belief, philosophy does not only deal with ideals independently of what is going on in real life. The problems of the contemporary philosophy are also (...) the problems of the contemporary world. For this reason, this book aims to present and discuss certain philosophical problems in the contemporary world and to suggest solutions to them. (shrink)

This article theorizes the connection between political distrust and conspiracy theories through a post-political framework. Following Luc Boltanski’s focus on the critical capacities of ordinary actors, it builds on interviews with participants of the Yellow Vest Movement in France who hold conspiratorial views of Covid-19 and the vaccine. The article explores how the interviewees’ critique mirrors that of post-political theorists. In particular, I use Rancière’s notion of subjectification and politics to theorize how conspiracy theories function as a means of dissent (...) in the interviewees’ understanding of their experiences as well as in their own critique of and disillusionment with politics in France. As such, this article explores how political trust affected reactions to the pandemic, how political trust is interconnected with conspiracy theories and finally how such conspiracy theories can be viewed as biproducts of the post-political order. (shrink)

Nach Max Weber ist Politik das "geduldige Bohren harter Bretter mit Augenmass und Geduld". Was hinzukommen muss, sind ethische Orientierungen. Vor allem in einer Zeit rasanter politischer und gesellschaftlicher Umbrüche braucht es dringlich einen ethischen Kompass. Es gilt demnach die Grundlagen der modernen politischen Ordnung sowie ihre Ziele zu reflektieren, um sie dann unter neuen politischen Bedingungen bestmöglich zur Geltung zu bringen. Der vorliegende Band stellt dazu sozialethische Koordinaten bereit, davon ausgehend, dass in einer Demokratie eine Ethik des Politischen alle (...) Bürger und Bürgerinnen angeht. Der erste Teil behandelt wesentliche Eckpfeiler des Politischen in der Moderne: Menschenrechte/Grundrechte - Demokratie - Nation/Internationale Gemeinschaft. Der folgende Überblick über Prinzipien politischer Ethik (Gemeinwohl, Solidarität, Versöhnung) reflektiert grundlegende Massstäbe. Konkretionen zu zentralen Politikfeldern (Friedens-, Flüchtlings- und Religionspolitik) runden den Band ab und regen zum Weiterdenken an"-- Back cover. (shrink)

Diese Wirtschaft totet! besonders dieser Satz von Papst Franziskus hat beachtliche Aufmerksamkeit gefunden. Aber: Welche Wirtschaft totet? Und welche fordert Leben? Dieser Band stellt wirtschaftswissenschaftliche, ethische und theologische Ansatze vor, die Verengungen in gegenwartigen Theorien uberwinden: Welche Bedeutung haben offentlicher Guter? Wie lassen sich soziale und okologische Dimensionen in die Wirtschaftstheorie integrieren? Wie sollte eine Finanzwirtschaft aussehen, die der Realwirtschaft dient? Was ist die Verantwortung des Konsumenten? Diese und weitere Grundfragen, die in den wirtschaftswissenschaftlichen Mainstream-Theorien zu kurz kommen, erinnern die (...) Wirtschaft daran, dem Leben dienen zu mussen. (shrink)

A political philosophy that no longer wants to be a philosophy inevitably runs into contradictions. The productive transparency of Arendt's philosophical experiment becomes visible, however, if we avoid simple mappings to Aristotle, Kant and Heidegger in order to emphasize the point and counterpoint of Arendt's message. The connections she draws, unusual in the world of philosophical thinking, have an obvious and a hidden side. The hidden side can be frequently found in the nuances, and these will be pursued inasmuch as (...) they allow an entirely new reading of Arendt's relationship to practical philosophy. (shrink)

We trained a computational model (the Chunk-Based Learner; CBL) on a longitudinal corpus of child–caregiver interactions in English to test whether one proposed statistical learning mechanism—backward transitional probability—is able to predict children's speech productions with stable accuracy throughout the first few years of development. We predicted that the model less accurately reconstructs children's speech productions as they grow older because children gradually begin to generate speech using abstracted forms rather than specific “chunks” from their speech environment. To test this idea, (...) we trained the model on both recently encountered and cumulative speech input from a longitudinal child language corpus. We then assessed whether the model could accurately reconstruct children's speech. Controlling for utterance length and the presence of duplicate chunks, we found no evidence that the CBL becomes less accurate in its ability to reconstruct children's speech with age. (shrink)