Fog in August is a German film based on Robert Domes' historical novel of the same name. The film provides a fictionalized account of the institutionalization and eventual killing of children and adults labelled as a burden on the State and unworthy of life. On one level, this is a story of good versus evil, where innocent patients are manipulated by callous doctors and nurses. At a deeper level, however, it is possible to read the characters as more complex and (...) such a reading gives an insight into the paradox of how a genocidal policy was able to be systematically implemented by health care professionals who had previously taken an oath to provide care to all people. Carl Jung argued that powerful stories, told across generations, contain mythical archetypes that help drive the plot and convey beliefs about humanity. The aims of this paper are to explore Jungian ideas within Fog in August that help the historical story it is based on resonate with viewers today, and demonstrate how the application of these insights can help health care professionals more fully understand morally distressing events and, as a result, support and improve the safety of patients. (shrink)

Recent findings in evolutionary psychology explain how moral disciplining is connected to the need for collective action. Morals are strict in societies affected by war or perceived collective danger, but loose where peace and security prevail. This theory supplements the moral disciplining theory by providing an evolutionary explanation for the postulated link between puritanism and the need for cooperation.

A collective action problem exists not only in offensive warfare, but also in defensive situations. The collective action problem is dealt with in the same way in offensive and defensive warfare: by strong leadership, discipline, rewards and punishments, strong group identification, strict religiosity, and intolerance of deviants. This behavior is explained in terms of evolutionary psychology.

A group in intergroup conflict needs to overcome the collective action problem in order to defend itself against an external enemy. This leads to increasing complexity that cannot be adequately covered by just scaling up the model of intragroup conflicts. Research on cultural evolution and evolutionary psychology shows that external conflict has profound effects on group organization.

The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co‐factors or, more speculatively, confer methylation of non‐histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they (...) can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family. (shrink)

The idea of culture has been subject to critical debate in anthropology during the past decade as the result of a shift in emphasis from the bounded local culture to transnational cultural flows. But at the very same time that cultural mobility is being emphasized by anthropologists, the people they study are recasting culture as a place of belonging as they construct local identities. Siting Culture argues that it is only through rich ethnographic studies that anthropologists may explore the significance (...) of place in the global space of relations which mold the lives of people throughout the world. By examining the concept of culture through case studies from Europe, Africa, Oceania, Latin America and the Caribbean, it probes the methodological and theoretical implications of the divergent scholarly and popular concepts of culture. (shrink)

Since the 1970s, there has been an increased focus on gender in the research literature concerning British philosopher Mary Wollstonecraft, which most likely is caused by the increasing interest in the social aspects of gender inspired by poststructuralist thinking. Although such readings have been illuminative and fruitful, focusing on the social and the interconnections between Wollstonecraft and modernity seems to have brought with them a neglect of two interesting aspects of Wollstonecraft’s notion about gender. On the one hand, her thoughts (...) on the body seem somewhat underexposed, while her impact on the subsequent British romanticists is equally neglected. The article focuses on these two aspects. Here the analyses are based on Wollstonecraft’s discussions with Jean-Jacques Rousseau and Edmund Burke about the relations gender has to nature, bodies, and aesthetics; discussions which inform a conception of gender that the later romantics would take inspiration from. (shrink)

In Sandrine Bergès’s article ‘Revolution and Republicanism: Women Political Philosophers of Late Eighteenth-Century France and Why They Matter’ [2021], neo-Athenian and neo-Roman principles of republicanism are fused in order to show the idiosyncratic political position of Olympe de Gouges, Marie-Jeanne Phlipon Roland, and Sophie de Grouchy. As Bergès acknowledges, this amalgamation renders possible republican readings of women’s writings which so far have not been regarded as republican. Through my reading of Germaine de Staël and Mary Wollstonecraft, my aim will be (...) to show how Staël and Wollstonecraft embody the principles that Bergès highlights, but also venture into other areas tied to republican thinking that Bergès leaves untouched: religion and progress. Wollstonecraft and Staël both tie Christianity closely to their republicanism, maintaining that a future republican state will come through divine intervention. In this way, I hope to add complexity to Bergès’s project by expanding our knowledge of female republicans. (shrink)

Critics of mass culture often identify 1950s-style status competition as one of the central forces driving consumerism. Thomas Frank has challenged this view, arguing that countercultural rebellion now provides the primary source of consumerism in our society, and that ‘cool’ has become its central ideological expression. This paper provides a rearticulation and defense of Frank's thesis, first identifying consumerism as a type of collective action problem, then showing how the ‘hip consumer’ is one who adopts a free-rider strategy in this (...) context. (shrink)

In order to explore one aspect of the engaging nature of computer games, this study will propose a method that aims at classifying the experience of engagement in video games. Inspired by a literature review, we will focus on the fundamental causes of engagement that motivate a player so much that he or she wants to continue playing. By organizing this willingness to continue playing into six broad types of causes of engagement—intellectual, physical, sensory, social, narrative, and emotional—we describe a (...) typology of player engagement and a method that is intended to map players’ experience of engagement while playing video games. The engagement mapping method is inspired by card sorting found from a perspective of usability testing, and in order to exemplify the use of the method, occurrences of the six types of engagement were investigated during gameplay in Angry Birds and Wii Sports. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.

IntroductionConcussion is a growing public health concern. No uniformly established therapy exists; neurofeedback studies report treatment value. We use infralow frequency neuromodulation to remediate disabling neurological symptoms caused by traumatic brain injury and noted improved outcomes with a novel concussion protocol. Postconcussion symptoms and persistent postconcussion symptoms are designated timelines for protracted neurological complaints following TBI. We performed a retrospective study to explore effectiveness of ILF in PCS/PPCS and investigated the value of using this concussion protocol.MethodPatients with PCS/PPCS seen (...) for their first neurology office visit or received their first neurofeedback session between 1 August 2018 and 31 January 2021 were entered. Outcomes were compared following treatment as usual vs. TAU with ILF neurotherapy. The study cohort was limited to PPCS patients; the TAU+ILF group was restricted further to PPCS patients receiving at least 10 neurotherapy sessions. Within the TAU+ILF group, comparisons were made between those who trained at least 10 sessions using concussion protocol and those who trained for at least 10 sessions of ILF regardless of protocol.ResultsAmong our resultant PPCS cohort leading persistent neurological complaints were headache, memory impairment, and brain fog. PPCS patients in TAU+ILF+CP demonstrated greater net and percent improvement of symptoms compared to PPCS subjects in TAU. PPCS patients in TAU+ILF-CP trended toward significant symptom improvements compared to TAU, and TAU+ILF+CP trended toward greater efficacy than TAU+ILF-CP.ConclusionPPCS patients who received TAU+ILF+CP demonstrated significantly greater improvement as a group when compared to TAU. When used as an integrative modality to treatment as usual in managing patients with PPCS, ILF neuromodulation with use of concussion protocol provided significant symptom improvements. (shrink)

Abstract“Shut the door,” the chief resident said to me. While I was green enough at the beginning of my clinical clerkships to believe that most of my medical education would happen at the bedside, at that moment, I was learning another important fact: a large part of my ethical education was going to happen behind the closed doors of a call room. The health care team was polluted by a pervasive atmosphere of frustration, as silent but tangible as a (...) thick layer of fog, that obscured the patient's ability to evaluate the consequences of the choice that lay before her. The attending did not permit, let alone create, an environment that provided room for dissent.Institutions should encourage the leaders of clinical education to foster an emotionally safer learning environment in which honest moral dialogue may occur without fear of repercussions. If students cannot learn to apply the principles of ethics actively throughout their clerkships, it will be much harder to do so when they practice independently, and ultimately, patient care will suffer. Conversely, when students and trainees are empowered by their teachers, patient care improves. (shrink)

In May of 2020, reports of so-called "long-COVID" began to surface. Long COVID is a collection of post-COVID-19 physical, cognitive and psychological symptoms, such as depression, brain fog, fatigue, and dizziness. As long-COVID is considered a "new" disease, it is not always covered by health insurance or government programs, moreover it is a set of constantly evolving symptoms.While severe cases of COVID-19 itself tend to be mostly in males over fifty-years-old, those individuals affected by long-COVID tend to be mainly (...) female and younger in age. Data supporting the existence of the long-COVID syndrome... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Transformative Journey of TransplantationValen KeeferThe moisture from the ocean floated effortlessly through the air as it glided over the rocky cliff. The steady stream of mist covered my face and frizzy hair with beaded water droplets. I had been sitting on a bench alone for hours admiring the Northern California coast at a magnificent overlook featuring a bird’s-eye view of the endless sea and campground I called home (...) for the past month. The stunning mountain landscape behind me, the soothing colors of the coastal shrubbery, and the smell of eucalyptus made for a trifecta of surreal beauty. The ocean disappeared from my view and I became engulfed in the precipitation and felt like I was suspended in a cloud. I was soaking in every moment as it was the last day of my solo RV trip.The fog slowly separated and exposed bits and pieces of the ocean again and then a breathtaking rainbow came into sight. Each end appeared to be touching either side of the campground like it was giving it a hug. I was eye-level with the center and highest point of the rainbow, arching above our home on wheels. I stood on the bench with my arms wide open, embracing nature and the gift of life in all its glory. This moment would not have possessed such deep meaning if it wasn’t for the journey that came before it—the transformative journey of transplantation.Some may think of transplantation as a singular event when in reality, it’s a lifelong journey that can start with a diagnosis many years prior. My transplant journey began when I was diagnosed with polycystic kidney disease (PKD) at 10-years-old. Being diagnosed with a hereditary disease that has deeply impacted multiple generations of our family and with no known treatment or cure was a lot to carry as a child.My youth was full of love from my parents and filled with illness and the limitations and long-term impacts of growing up with multiple chronic illnesses. My education on PKD was the brutal real-life experiences of enduring it firsthand—with no support groups, resources, or internet to seek answers. I always felt different during a time when you’d do anything to fit in. I couldn’t play sports and had to sit on the sidelines in gym class. I was often in the nurse’s office, hospital, or recovering from a surgery. I hid my scars and unattractive body while changing in gym class. Friendships were really hard. Relationships were even harder.Growing up with chronic illnesses takes away from the fun of dreaming. It’s like that bright future full of endless possibilities is blocked by a huge mountain you know you have to summit first with no supplies, no friends, and no paved path to follow.Complications from PKD followed me from high school right into college, when I spent almost a year in the hospital. Both of my kidneys were removed, I was on dialysis, had pancreatitis, received over 70 blood transfusions, survived an internal bleed, and was in dire need of a lifesaving kidney transplant.At 19-years-old, I was too sick to be placed on the transplant waiting list, but needed a kidney to survive. My parents were living at the Ronald McDonald House, wondering if they would be the next ones to lose their teenage daughter. A close family friend forever changed our lives when she restored my health by selflessly donating her kidney to me. While it was an arduous path to transplantation, in some ways, the journey was just beginning.Fifteen years following my kidney transplant and summiting what I thought was going to be the most challenging mountain of my health journey, I found myself back on death’s doorstep with another battle ahead. I was in need of a second miracle, this time a lifesaving liver transplant. It was PKD again. The bile ducts in my liver were so gnarly that they looked like limbs of an oak tree rather than the desired smooth straw-like appearance. Their malformations led to chronic liver infections and multiple sepsis... (shrink)

The COVID-19 pandemic has brought considerable death and economic hardship to populations around the world. Yet, its legacy may be in the form of Long COVID, a condition in which individuals who have had COVID infection continue to experience symptoms often for many months after their acute illness. One group of symptoms is described by sufferers as “brain fog”. This expression captures a constellation of complaints that are cognitive-linguistic in nature, with affected individuals reporting a significant impact of these problems (...) on their occupational functioning and daily lives. This chapter reports the findings of case studies of two adults with Long COVID. Both adults enjoyed good health prior to their COVID infection. Neither was judged to be unwell enough to require hospitalization during the acute phase of their illness. Yet, they each reported an incomplete recovery and the persistence of debilitating symptoms over many months. The case studies provide a detailed account of their pre-morbid functioning and lifestyle, the onset and progression of their COVID illness, and a comprehensive analysis of their language skills. Both adults had intact structural language skills in the presence of high-level discourse difficulties. Specifically, they struggled to harness their strong skills in structural language to produce informative discourse, the transmission of which is an important pragmatic function of communication. The language profile associated with these cases of Long COVID is discussed in relation to other conditions that are assessed and treated by speech-language pathologists. (shrink)

While philosophical questions about health and disease have attracted much attention in recent decades, and while opinions are divided on most issues, influential accounts seem to embrace negativism about health, according to which health is the absence of disease. Some subscribe to unrestricted negativism, which claims that negativism applies not only to the concepts of health and disease as used by healthcare professionals but also to the lay concept that underpins everyday thinking. Whether people conceptualize (...) class='Hi'>health in this manner has implications for medical care and public health, and so we set out to examine this claim in two studies. Participants were asked to assess and compare the health states of two people presented in two vignettes. We found that both lay people and medical students conceptualize health as something more than the absence of disease. We argue that our findings highlight a need to rethink unrestricted negativism and indicate a need to rethink the way the debate has traditionally focused on disease. (shrink)

The infant mortality rate in Liberia is 50 times higher than it is in Sweden, whilst a child born in Japan has a life expectancy at birth of more than double that of one born in Zambia. 1 And within countries, we see differences which are nearly as great. For example, if you were in the USA and travelled the short journey from the poorer parts of Washington to Montgomery County Maryland, you would find that ‘for each mile travelled life (...) expectancy rises about a year and a half. There is a twenty-year gap between poor blacks at one end of the journey and rich whites at the other’. (Marmot, 2004, p.2). There are two types of questions which it is important to ask about inequalities in health such as these. The first are social scientific questions about the extent of inequalities in health and the factors which are causally responsible for these inequalities. Examples of social scientific questions to ask might be: how do infant mortality rates in the UK differ according to social class? What is the difference in life expectancy between Japanese who emigrate to the US and those who remain in Japan? Why do civil servants in higher ranked jobs tend to live longer than civil servants in lower ranked jobs? The second type are normative questions about the reasons we have to care about inequalities in health. Important normative questions to answer are: which inequalities in health should we care about (all inequalities or merely some of them)? When is an inequality in health unjust? How should we weigh our concern for equality in health against other factors such as maximising the.. (shrink)

The War on Terror is an ambiguous term that has been used to circumvent the international laws of warfare. Instead of moving toward peace by way of limited warfare, and instead of preserving the independence of war and peace, War on Terror advances by masking itself in a fog of peace; it proliferates by overlapping the logic of “war-time” and “peace-time” operations. The fog of peace—as it shall herein be called—is a condition wherein the uncertainty qua “fog” of war,2 along (...) with its militarized logic, overlaps with and eventually replaces civilian peace-time-and-spaces. The War on Terror is thus not a limiting of war by way of the conventional modern mechanisms of international law and diplomacy; it is a continuation of war by other means, including the use covert, often black-boxed methods of information-capture and surveillance. Globally, states are expanding the powers of intelligence organs and deploying covert mass surveillance programs in the name of counter-terrorism. In this manner, counter-terrorism policies become instruments enabling states to become predatory, especially in relation to civilians. Under the banner of fighting terrorism, peace-time has unwittingly become colonized by the logic of war. (shrink)

Health Recommender Systems are promising Articial-Intelligence-based tools endowing healthy lifestyles and therapy adherence in healthcare and medicine. Among the most supported areas, it is worth mentioning active aging. However, current HRS supporting AA raise ethical challenges that still need to be properly formalized and explored. This study proposes to rethink HRS for AA through an autonomy-based ethical analysis. In particular, a brief overview of the HRS’ technical aspects allows us to shed light on the ethical risks and challenges they (...) might raise on individuals’ well-being as they age. Moreover, the study proposes a categorization, understanding, and possible preventive/mitigation actions for the elicited risks and challenges through rethinking the AI ethics core principle of autonomy. Finally, elaborating on autonomy-related ethical theories, the paper proposes an autonomy-based ethical framework and how it can foster the development of autonomy-enabling HRS for AA. (shrink)

Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...) investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. (shrink)

Personal identity and social identity are two very different concepts and the idea of getting them together, as Bhikhu Parekh proposes, within an integrated bundle of some `overall identity' raises serious questions of coherence. Personal identity demands the `sameness' of a person (Who is this guy? Am I still the same person that I was ten years ago?). Social identity is focused instead on our social affiliations, such as identifying with others with, say, the same nationality, or the same religion, (...) or same political partnership. We can make reasoned choices about our priorities in social affiliation. Those who want to make our social affiliation a matter of `discovery' rather than of choice may frighten us by saying that we would lose our overall identity if we were to choose to affiliate differently (for example as an Indian and not just as a Hindu, or as British and not just as a Muslim). To understand that there is no threat to personal identity involved in such choices is important both for clarity of analysis and for standing up against the herd behaviour of identity politics. (shrink)

The fog of war—poor intelligence about the enemy—can frustrate even a well-prepared military force. Something similar can happen in intellectual debate. What I call the *fog of debate* is a useful metaphor for grappling with failures and dysfunctions of argumentative persuasion that stem from poor information about our opponents. It is distressingly easy to make mistakes about our opponents’ thinking, as well as to fail to comprehend their understanding of and reactions to our arguments. After describing the fog of debate (...) and outlining its sources in cognition and communication, I consider a few policies we might adopt upon learning we are in this fog. (shrink)

Cloud Computing paradigm has reached a high degree of popularity among all kinds of computer users, but it may not be suitable for mobile devices as they need computing power to be as close as possible to data sources in order to reduce delays. This paper focuses on achieving mathematical models for users moving around and proposes an overlay mobility model for Fog Data Centres based on traditional wireless mobility models aimed at better allocating edge computing resources to client demands. (...) Additionally, the focus is also on providing a model as to how the computing assets related to each user follow it through the fog infrastructure so as to minimise the distance to the user according to a Fat-Tree based Data Centre topology. (shrink)

Purpose The purpose of this study is to analyze how embedding of self-powered wireless sensors into cloud computing further enables such a system to become a sustainable part of work environment. Design/methodology/approach This is exemplified by an application scenario in healthcare that was developed in the context of the OpSIT project in Germany. A clearly outlined three-layer architecture, in the sense of Internet of Things, is presented. It provides the basis for integrating a broad range of sensors into smart healthcare (...) infrastructure. More specifically, by making use of short-range communication sensors, gateways which implement data transmission and low-level computation and cloud computing for processing the data. Findings A technical in-depth analysis of the first two layers of the infrastructure is given to prove reliability and to determine the communication quality and availability in real-world scenarios. Furthermore, two example use-cases that directly apply to a healthcare environment are examined, concluding with the feasibility of the presented approach. Practical implications Finally, the next research steps, oriented towards the semantic tagging and classification of data received from sensors, and the usage of advanced artificial intelligence-based algorithms on this information to produce useful knowledge, are described together with the derived social benefits. Originality/value The work presents an innovative, extensible and scalable system, proven to be useful in healthcare environments. (shrink)