Purpose The purpose of this study is to analyze how embedding of self-powered wireless sensors into cloud computing further enables such a system to become a sustainable part of work environment. Design/methodology/approach This is exemplified by an application scenario in healthcare that was developed in the context of the OpSIT project in Germany. A clearly outlined three-layer architecture, in the sense of Internet of Things, is presented. It provides the basis for integrating a broad range of sensors into smart healthcare (...) infrastructure. More specifically, by making use of short-range communication sensors, gateways which implement data transmission and low-level computation and cloud computing for processing the data. Findings A technical in-depth analysis of the first two layers of the infrastructure is given to prove reliability and to determine the communication quality and availability in real-world scenarios. Furthermore, two example use-cases that directly apply to a healthcare environment are examined, concluding with the feasibility of the presented approach. Practical implications Finally, the next research steps, oriented towards the semantic tagging and classification of data received from sensors, and the usage of advanced artificial intelligence-based algorithms on this information to produce useful knowledge, are described together with the derived social benefits. Originality/value The work presents an innovative, extensible and scalable system, proven to be useful in healthcare environments. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)