Oscar de Beaux was professor of Zoology at Genova University and then director of Civil Museum of Natural History in the same town. The first contributions of de Beaux which included elements of biological ethics concerned the european bison of Bialowieza and the brown bear of the Alps between 1923–1929. In 1930 de Beaux published his most important study called “Biological ethics: an attempt to arouse a naturalistic conscience”, translated also in german (1932) and in english (1933). According to Oscar (...) de Beaux, biological ethics is the study and definition of man's moral position before the living beings which do not belong to the humane race, beginning with the morale premise that man was not able to create the species. With these outlook, man takes on a decisively active and intelligent position regarding the problem of conserving nature and its resources; on the basis of this definition of morality man becomes the wise administrator of life on earth. (shrink)

Neuropalliative care developed to address the needs of patients living with life‐limiting neurologic disease. One critical consideration is that disease‐related changes to cognition, communication, and function challenge illness experiences and care practices. We conducted an ethnography to understand neuropalliative care as a phenomenon; how it was experienced, provided, conceptualized. Personhood served as our conceptual framework; with its long philosophical history and important place in nursing theory, we examined the extent to which it captured neuropalliative experiences and concerns. Personhood contextualized complex (...) losses, aligning the impact of functional and relational changes. Cognition, communication, and functional alterations stretched conceptions of personhood, insinuating it can be relational, fluid, adaptive. Although normative conceptions of personhood guided research and decision‐making, ethical considerations suggested personhood could be transformed, remade. We consider the implications of our findings through three themes. First, we examine how literature on illness experience fails to integrate the realities of people living with and dying from neurologic disease; we counter this by interrogating the concept of experience. Second, we turn to Ricoeur's work on recognition to illuminate relational conceptions of personhood to inform care practices. Finally, we reflect on how personhood can bridge the gap left by functional changes, enhance relational engagement, and promote dignity at the end of life. (shrink)

Since ancient times, character, virtue, and happiness have been central to thinking about how to live well. Yet until recently, philosophers have thought about these topics in an empirical vacuum. Taking up the general challenge of situationism – that philosophers should pay attention to empirical psychology – this interdisciplinary volume presents new essays from empirically informed perspectives by philosophers and psychologists on western as well as eastern conceptions of character, virtue, and happiness, and related issues such as personality, emotion and (...) cognition, attitudes and automaticity. Researchers at the top of their fields offer exciting work that expands the horizons of empirically informed research on topics central to virtue ethics. (shrink)

It is shown that for arithmetical interpretations that may include free variables it is not the Guaspari-Solovay system R that is arithmetically complete, but their system R –. This result is then applied to obtain the nonvalidity of some rules under arithmetical interpretations including free variables, and to show that some principles concerning Rosser orderings with free variables cannot be decided, even if one restricts oneself to usual proof predicates.

This article compares the political philosophies of Michael Oakeshott and Isaiah Berlin, probably the two most important political philosophers in postwar Britain, who, strangely, had very little to do with one another during their illustrious careers. The article focuses on their respective critiques of rationalism and theories of liberal pluralism, arguing that Oakeshott provides the more consistent and philosophically satisfying account in both instances.

Después de la celebración del Concilio de Trento, muchos obispos intentaron poner en práctica tanto los decretos doctrinales como los disciplinares para llevar a cabo una reforma de la Iglesia "in capite et in membris". El obispo de Ginebra, Francisco de Sales, aplica los diferentes decretos, no sólo con firmeza y frialdad, sino también con la dulzura del buen pastor y la dulzura salesiana. Su reforma alcanza tanto al clero secular como al religioso, así como a las instituciones eclesiásticas y (...) a los laicos. Los sínodos diocesanos, su acción pastoral y su doctrina, tanto teológica como espiritual, hicieron posible la reforma de la diócesis, que había sufrido la decadencia típica de su época y que había estado dominada por la doctrina calvinista en gran parte. (shrink)

The tricarboxylic acid (TCA) or Krebs cycle, which takes place in prokaryotic cells and in the mitochondria of eukaryotic cells, is central to life on Earth and participates in key events such as energy production and anabolic processes. Despite its relevance, it is not perceived as tightly regulated compared to other key metabolisms such as glycolysis/gluconeogenesis. A better understanding of the functioning of the TCA cycle is crucial due to mitochondrial function impairment in several diseases, especially those that occur with (...) neurodegeneration. This article revisits what is known about the regulation of the Krebs cycle and hypothesizes the need for large‐scale, rapid regulation of TCA cycle enzyme activity. Evidence of mitochondrial enzyme activity regulation by activation/deactivation of protein kinases and phosphatases exists in the literature. Apart from indirect regulation via G protein‐coupled receptors (GPCRs) at the cell surface, signaling upon activation of GPCRs in mitochondrial membranes may lead to a direct regulation of the enzymes of the Krebs cycle. Hormonal‐like regulation by posttranscriptional events mediated by activable kinases and phosphatases deserve proper assessment using isolated mitochondria. Also see the video abstract here: https://youtu.be/aBpDSWiMQyI. (shrink)

Recent work in the history of philosophy of science details the Kantianism of philosophers often thought opposed to one another, e.g., Hans Reichenbach, C.I. Lewis, Rudolf Carnap, and Thomas Kuhn. Historians of philosophy of science in the last two decades have been particularly interested in the Kantianism of Reichenbach, Carnap, and Kuhn, and more recently, of Lewis. While recent historical work focuses on recovering the threatened-to-be-forgotten Kantian themes of early twentieth-century philosophy of science, we should not elide the differences between (...) the Kantian strands running throughout this work. In this paper, I disentangle a few of these strands in the work of Reichenbach and Lewis focusing especially on their theories of relativized, constitutive a priori principles in empirical knowledge. In particular, I highlight three related differences between Reichenbach and Lewis concerning their motivations in analyzing scientific knowledge and scientific practice, their differing conceptions of constitutivity, and their relativization of constitutive a priori principles. In light of these differences, I argue Lewis’s Kantianism is more similar to Kuhn’s Kantianism than Reichenbach’s, and so might be of more contemporary relevance to social and practice-based approaches to the philosophy of science. (shrink)

An examination of new forms of alienation in our never-off, plugged-in culture—and a clarion call for a “conspiracy of estranged people.” We can reach every point in the world but, more importantly, we can be reached from any point in the world. Privacy and its possibilities are abolished. Attention is under siege everywhere. Not silence but uninterrupted noise, not the red desert, but a cognitive space overcharged with nervous incentives to act: this is the alienation of our times... —from The (...) Soul at Work Capital has managed to overcome the dualism of body and soul by establishing a workforce in which everything we mean by the Soul—language, creativity, affects—is mobilized for its own benefit. Industrial production put to work bodies, muscles, and arms. Now, in the sphere of digital technology and cyberculture, exploitation involves the mind, language, and emotions in order to generate value—while our bodies disappear in front of our computer screens. In this, his newest book, Franco “Bifo” Berardi—key member of the Italian Autonomist movement and a close associate of Félix Guattari—addresses these new forms of estrangement. In the philosophical landscape of the 1960s and 1970s, the Hegelian concept of alienation was used to define the harnessing of subjectivity. The estrangement of workers from their labor, the feeling of alienation they experienced, and their refusal to submit to it became the bases for a human community that remained autonomous from capital. But today a new condition of alienation has taken root in which workers commonly and voluntarily work overtime, the population is tethered to cell phones and Blackberries, debt has become a postmodern form of slavery, and antidepressants are commonly used to meet the unending pressure of production. As a result, the conditions for community have run aground and new philosophical categories are needed. The Soul at Work is a clarion call for a new collective effort to reclaim happiness. The Soul at Work is Bifo's long overdue introduction to English-speaking readers. This Semiotext edition is also the book's first appearance in any language. (shrink)

The Tattvapaplavasimha is a philosophical text unique of its kind it is the only text of the Carvaka Lokayata school which has survived and the only Sanskrit work in which full-fledged scepticism is propounded. Notwithstanding that it has been hitherto almost completely ignored. The present book consists of an introduction detailed analysis edition translation with extensive notes of the first half of the text. In the introduction Jayarasi`s affiliation to the Lokayata school is reassessed and his place in the historical (...) development of Indian Philosophy evaluated. New evidence for the dating of Jayarasi is examined and a new dating is suggested. (shrink)

The concept of scaffolding has wide resonance in several scientific fields. Here we attempt to adopt it for the study of development. In this perspective, the embryo is conceived as an integral whole, comprised of several hierarchical modules as in a recurrent circularity of emerging patterns. Within the developmental hierarchy, each module yields an inter-level relationship that makes it possible for the scaffolding to mediate the production of selectable variations. A wide range of genetic, cellular and morphological mechanisms allows the (...) scaffolding to integrate these modular variations into a functionally coordinate unit. A genetic scaffolding accounts for the inherited invariance of pattern formation during the embryo’s growth. At higher level, cells behave as agents endowed with the capacity to interpret any scaffolding variation as signs. The full hierarchy of a multi-level scaffolding is eventually attained when the embryo acquires the capacity to impose a number of developmental constraints on its constituting parts in a top-down direction. The acquisition of this capacity allows a semiotic threshold to emerge between the living cellular world and the underlying non-living molecular world. As this boundary is gradually defined during development, cells enter into new functional relationships, while, at the same time, are relieved from their physical determinism. The resulting constraints can thus become the driving forces that upgrade embryonic scaffolding from the simple molecular signalling to the complexity of sign recognition proper of a cellular community. In this semiotic perspective, the apparent goal directness of any developmental strategy should no longer be accounted for by a predetermined genetic program, but by the gradual definition of the relationships selected amongst the ones historically explored. (shrink)

ABSTRACTThis paper analyses the discourses produced on their websites by the two organisations that conducted the official ‘leave’ and ‘remain’ campaigns in the Brexit referendum. The analysis, whi...

A wide-ranging exploration of the present, and the future, of the Unconscious. The Unconscious knows no time, it has no before-and-after, it does not have a history of its own. Yet, it is not always the same. As it emerges in the life of people and societies, the Unconscious is shaped by ever-changing historical conditions: its form depends on the unique 'psychosphere' of each historical age. In the early twentieth century, Freud characterised the Unconscious as the dark side of the (...) well-ordered framework of Progress and Reason. At the end of the past century, Deleuze and Guattari described it as a laboratory: the magmatic force that ceaselessly brings about new possibilities of imagination. Today, at a time of viral pandemics and in the midst of the catastrophic collapse of capitalism, the Unconscious has begun to emerge in yet another form. In this book, Franco 'Bifo' Berardi vividly illustrates the form in which the Unconscious will make itself manifest for decades to come, and the challenges that it will pose to our possibilities of political action, poetic imagination, and therapy."--Publisher's description. (shrink)

_The Uprising_ is an Autonomist manifesto for today's precarious times, and a rallying cry in the face of the catastrophic and irreversible crisis that neoliberalism and the financial sphere have established over the globe. In his newest book, Franco "Bifo" Berardi argues that the notion of economic recovery is complete mythology. The coming years will inevitably see new surges of protest and violence, but the old models of resistance no longer apply. Society can either stick with the prescriptions and (...) "rescues" that the economic and financial sectors have demanded at the expense of social happiness, culture, and the public good; or it can formulate an alternative. For Berardi, this alternative lies in understanding the current crisis as something more fundamental than an economic crisis: it is a crisis of the social imagination, and demands a new language by which to address it. This is a manifesto against the idea of growth, and against the concept of debt, the financial sector's two primary linguistic means of manipulating society. It is a call for exhaustion, and for resistance to the cult of energy on which today's economic free-floating market depends. To this end, Berardi introduces an unexpected linguistic political weapon--poetry: poetry as the insolvency of language, as the sensuous birth of meaning and desire, as that which cannot be reduced to information and exchanged like currency. If the protests now stirring about the world are to take shape and direction, then the revolution will be neither peaceful nor violent--it will be linguistic, or will not be at all. (shrink)

We prove that the sets of standard tautologies of predicate Product Logic and of predicate Basic Logic, as well as the set of standard-satisfiable formulas of predicate Basic Logic are not arithmetical, thus finding a rather satisfactory solution to three problems proposed by Hájek in [H01].

Film emotions are genuine emotions whose formation and development is affected by conflictive factors. Whereas their arousal, similar to that of real-life emotions, is disproportionately strengthened by the cinematographic medium, their subsequent course is both weakened and interrupted. Their objects, which I view as members of our personal emotional world (not in terms of their supposed fictionality, as often assumed), are also proper intentional objects of emotions: our fear is about the shark on the screen, our pity about the main (...) character. This view allows also for an explanation of two of film emotions’ neglected features: (a) the viewer's emotional attachment and empathy toward film objects and (b) the long-lasting emotional impact films can have on viewers. (shrink)

We live in an age of impotence. Stuck between global war and global finance, between identity and capital, we seem to be incapable of producing the radical change that is so desperately needed. Is there still a way to disentangle ourselves from a global order that shapes our politics as well as our imagination? In his most systematic book to date, renowned Italian theorist Franco Berardi tackles this question through a solid yet visionary analysis of the three fundamental concepts (...) of Possibility, Potency, and Power. Characterizing Possibility as the content, Potency as the energy, and Power as the form, Berardi suggests that the road to emancipation unravels from the awareness that the field of the possible is only limited, and not created, by the power structures that implement it. Other futures and other worlds are always already inscribed within the present, despite power's attempt at keeping them invisible. Overcoming any temptation of giving in to despair or nostalgia, Berardi proposes the notion of 'futurability' as a way to remind us that even within the darkness of our current crisis lies dormant the horizon of possibility. (shrink)

The issue of the ordering of the ten trichotomies is one among the many questions still open regarding Peirce’s extended theory of signs. A proper decision regarding the order of the ten trichotomies demands a discussion of the entire semiotic process. The aim of this paper is to discuss the order of the trichotomies related to the mode of being of the immediate and dynamical objects. Therefore, it addresses only one part of this process, which concerns the relationship between the (...) sign and its objects. When subdividing the object, Peirce begins to consider the immediate and the dynamic objects as trichotomies, that is, aspects to be considered in the definition of the classes of signs. The introduction of these two trichotomies brings in a problem: how to order them in the system of ten trichotomies. Diverging opinions regarding this ordering are found in Peirce’s texts, and in his commentators. We will investigate this problem by seeking a sort of pragmatic clarification of the matter, presenting a reflection about the philosophical and semiotic consequences of the different proposals for the ordering of these trichotomies. Placing the dynamic object after the sign may even help to explain the functioning of fictional signs, but is this coherent with Peirce’s philosophy? On the other hand, would it be possible to talk about lying signs if every object was determined by its own sign? (shrink)

The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...) the number of cell functions they can actually control, both GPCRs and their associated signal transduction pathways are extremely well conserved, for only a few alleles with null or minor functional alterations have so far been found. This would seem to suggest that, beside a mechanism for DNA repairing, there must be another level of quality control that may help maintaining GPCRs rather stable throughout evolution. We propose here receptor oligomerization to be a basic molecular mechanism controlling GPCRs redundancy in many different cell types, and the plasma membrane as the first hierarchical cell structure at which selective categorical sensing may occur. Categorical sensing can be seen as the cellular capacity for identifying and ordering complex patterns of mixed signals out of a contextual matrix, i.e., the recognition of meaningful patterns out of ubiquitous signals. In this context, redundancy and degeneracy may appear as the required feature to integrate the cell system into functional units of progressively higher hierarchical levels. (shrink)

Abstract:I defend that the distinctive object of our aesthetic evaluation of films is the full emotional experience, taken as a unified whole, that we go through as we watch a film and that I call the viewer's film emotional life. The aesthetic value itself—the positive quality we perceive in the experience of having had a certain film emotional life—is in the significance we experience in that film emotional life insofar as it contributes to the discovery and the exploration of the (...) viewer's human and individual emotional nature. I finally suggest that the explanation of the positive felt quality of such experience is in the progress it represents regarding our resourcefulness as emotional subjects toward the realization of our individual ideal of life. (shrink)

Questo saggio esplora la critica a Marx e al “marxismo” sviluppata da Simone Weil nel corso della sua opera. Vengono identificati tre nuclei principali della critica weiliana al marxismo: la validità del metodo materialistico per lo studio delle scienze sociali; il presunto “messianesimo” di Marx, inteso come la concezione della storia come un progresso intelligente verso il meglio; e l’identificazione del marxismo tout court con una filosofia determinista e meccanicista. Si cerca di definire a quale “Marx” effettivamente sia rivolta la (...) critica di Weil: si sostiene infatti che alcune delle sue argomentazioni siano riferibili alla “vulgata” marxiana, ossia a una lettura semplificata e schematica del marxismo, o alla “tendenza deteriore” del marxismo caratterizzata dall’economicismo e dal meccanicismo, dibattuta anche all’interno della Seconda Internazionale, o a posizioni di Engels e Lenin, o ancora all’operato del PCF o delle organizzazioni operaie, piuttosto che all’effettiva opera di Marx. (shrink)

Volume 16, Issue 4, September 2019, Page 381-388.

The present paper deals with the predicate version MTL of the logic MTL by Esteva and Godo. We introduce a Kripke semantics for it, along the lines of Ono''s Kripke semantics for the predicate version of FLew (cf. [O85]), and we prove a completeness theorem. Then we prove that every predicate logic between MTL and classical predicate logic is undecidable. Finally, we prove that MTL is complete with respect to the standard semantics, i.e., with respect to Kripke frames on the (...) real interval [0,1], or equivalently, with respect to MTL-algebras whose lattice reduct is [0,1] with the usual order. (shrink)