Allusions to a cosmogony contained in a Vedic hymn present striking analogies to a cosmogony attributed to the Pythagoreans by Aristotle, Simplicius and Stobaeus. The aim of the paper is to evaluate the extent to which they are similar and to which their differences respond to different cultural premises.

According to the ancient Greek Stoics, the cosmos regularly transitions between periods of conflagration, during which only fire exists, and periods of cosmic order, during which the four elements exist. This paper examines the cosmogonic process by which conflagrations are extinguished and cosmic orders are restored, and it defends three main conclusions. First, I argue that not all the conflagration’s fire is extinguished during the cosmogony, against recent arguments by Ricardo Salles. Second, at least with respect to the cosmogony, it (...) is not necessary to posit the existence of proto-elements. Third, while scholars such as Salles and David Hahm have argued that Cleanthes held a distinct theory of cosmogony from Zeno and Chrysippus, I argue that each of these Stoics endorse the same cosmogonic theory. (shrink)

How should we treat the cosmogonies of the early ancient Greek philosophers? Much work has been done in showing how these cosmogonies differ from creation myths and how they relate to philosophical issues such as change, persistence through change and matter theory. Here, using Leucippus and Democritus as examples, Gregory tries to show that interesting light can be shed on these cosmogonies by looking at them in relation to perennial problems in cosmogony and perennial types of solutions to these problems. (...) Ancients and moderns have formulated both in different ways, but there are significant structural similarities. To understand ancient cosmogonies, we need to understand how these perennial problems were perceived, and what types of solutions were available. We then need to analyse how the basic ontological and aetiological principles of their systems lead them to choose certain types of solution over others. (shrink)

This book is a general survey of the Greeks' extraordinarily rapid advance from a mythological to a rational view of the world and of man's origins and place in the universe. The continuity of this development and the influence of myth on philosophy are closely studied. There is also a constant assessment of the Greeks' approach to modern scientific and philosophical conceptions, including the Darwinian theory, but the affinity of our civilization to theirs is never overstressed.

The extent of the dependence of early Greek cosmogony on mythical conceptions has long been a prolific source of controversy. Views on the subject have varied from Professor Cornford's claim that ‘there is a real continuity between the earliest rational speculation and the religious representation that lay behind it’ to Professor Burnet's extreme statement, ‘it is quite wrong to look for the origins of Ionian science in mythological ideas of any kind.’ The solution of the problem that I wish to (...) suggest is one which should satisfy those who insist on ‘the scientific character of the early Greek cosmology,’ while retaining a direct connection with pre-scientific beliefs—namely, that some, at least, of the earliest philosophers founded their doctrines of the beginning of the universe on a deliberate rationalization of earlier and contemporary mythical ideas. The appearance of notions like the ‘world-egg’ in a number of passages, too well known for quotation, shows that primitive cosmogony assumed an analogy between the generation of the world and the generation of animate creatures. I believe it can be proved that, so far from the ‘renunciation of sexual imagery’ which even Professor Cornford has recently attributed to Anaximander, he and other philosophers retained the habit of regarding cosmogony and anthropogony as parallel phenomena, only substituting for the mythical ‘world-egg’ a more scientific view of the embryo and its development. They looked at the world through the same spectacles as their predecessors, but after wiping from them the rose tint of mythological fancy. (shrink)

Herennius Philo of Byblos is the subject of a notice in the Suda, which states that he was a grammarian born in Nero's time who lived to such an advanced age that he was still composing works in the reign of Hadrian. The titles listed include: On the Acquisition and Choice of Books; On Cities and their Eminent Citizens; and On the Reign of Hadrian . His name, like that of Flavius Josephus, could imply the patronage of a Roman family; (...) we may suppose that, like Porphyry and Maximus of Tyre, he was a Phoenicean by origin who had adopted the tongue and culture of the Greeks. (shrink)

In our article, we will focus on an analysis of the relationship between man and the cosmos, set against the backdrop of ancient Greek ideas about the origin of the world. On the one hand, we will deal with the images of the creation of the world provided in Greek mythology and the religious tradition associated with it (in particular Hesiod); on the other hand, we will approach the anthropomorphic elements within the framework of philosophical cosmogonies (Plato’s dialogue, the Timaeus). (...) Our aim is to show that Greek philosophical thought was never able to fully relinquish this anthropomorphism but nonetheless it did move away from a purely mythological tradition (as found in Hesiod and the pre-Socratics) and, in some measure towards a more scientific interpretation of the cosmos (as found in Plato). (shrink)

Herennius Philo of Byblos is the subject of a notice in the Suda, which states that he was a grammarian born in Nero's time who lived to such an advanced age that he was still composing works in the reign of Hadrian. The titles listed include: On the Acquisition and Choice of Books; On Cities and their Eminent Citizens; and On the Reign of Hadrian. His name, like that of Flavius Josephus, could imply the patronage of a Roman family; we (...) may suppose that, like Porphyry and Maximus of Tyre, he was a Phoenicean by origin who had adopted the tongue and culture of the Greeks. (shrink)

According to Democritus' anthropogeny is a microcosmic consequence within the process of cosmogony. However, the case of man is a peculiarity: man, this atom complex, is well aware of himself, yet is not aware of what he must do. Man does not naturally do that which promotes the harmonious ordering of his atoms. We must create a second nature. Now it becomes possible for us to be as we must be according to our first nature. Democritus is the is first (...) thinker who explains to us what our nature is and who, from our being, derives an ought: he who wishes to do the right thing for both himself and others finds himself subject to the ought requirement to do that which brings the most calm to the atoms. This is a direct connection between being and ought, an extravagant mechanical existentialism. (shrink)

Within the pantheon of the great television series of recent decades, "The Wire" (D. Simon & E. Burns, HBO, 2002-2006) undoubtedly occupies a prominent place for critics and audiences. “The Wire”, disguised as a police thriller, is a serial story that stands out for its cyclical structure, tragic archetypes and a choral look that makes the difference from the rest of current television content. Three characteristics (the corality, the tragedy, and the cyclical time) that make up the essence of Greek (...) theater. And as soon as we start analyzing The Wire we see what is hidden in the characters and plots of one of the most prestigious series in history owe their essence to the cosmogony and Greek mythology, the root of all our culture. (shrink)

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised.

The current use of animals to test for potential teratogenic effects of drugs and other chemicals dates back to the thalidomide disaster of the late 1950s and early 1960s. Controversy surrounds the following questions: 1. What was known about placental transfer of drugs when thalidomide was developed? 2. Was thalidomide tested on animals for teratogenicity prior to its release? 3. Would more animal testing have prevented the thalidomide disaster? 4. What lessons should be learned from the thalidomide disaster regarding animal (...) testing for teratogenicity? We review the literature in order to address these questions. (shrink)

The requirement that animals be used in research and testing in order to protect humans was formalized in the Nuremberg Code and subsequent national and international laws, codes, and declarations. We review the history of these requirements and contrast what was known via science about animal models then with what is known now. We further analyze the predictive value of animal models when used as test subjects for human response to drugs and disease. We explore the use of animals for (...) models in toxicity testing as an example of the problem with using animal models. We conclude that the requirements for animal testing found in the Nuremberg Code were based on scientifically outdated principles, compromised by people with a vested interest in animal experimentation, serve no useful function, increase the cost of drug development, and prevent otherwise safe and efficacious drugs and therapies from being implemented. (shrink)

Dear Editor,The April 2014 issue of Theoretical Medicine and Bioethics [1] presented eight essays regarding the use of nonhuman animals in biomedical research. While I appreciate the essays concerning contemporary research—which were well written and offered new thinking from the fields of ethics and ethology—I believe the journal, via the topics and the authors chosen, failed to communicate the most important fact regarding the current science pertinent to the use of nonhuman animals in research.The foundational reason for using chimpanzees and (...) other animals in research is their predictive value for human response to drugs and disease. This was alluded to by several of the authors when they discussed the necessity of using nonhuman animals. For example, Smith writes: “A common assumption in the selection of nonhuman animal subjects for research and the approval of research is that, if the risks of a procedure are too great for humans, and if there is a so-called scientific necessity, .. (shrink)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically (...) analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics. (shrink)

Pharmaceutical firms seek to fulfill their responsibilities to stakeholders by developing drugs that treat diseases. We evaluate the social and financial costs of developing new drugs relative to the realized benefits and find the industry falls short of its potential. This is primarily due to legislation-mandated reliance on animal test results in early stages of the drug development process, leading to a mere 10 percent success rate for new drugs entering human clinical trials. We cite hundreds of biomedical studies from (...) journals including Nature, Science, and the Journal of the American Medical Association to show animal modeling is ineffective, misleading to scientists, unable to prevent the development of dangerous drugs, and prone to prevent the development of useful drugs. Legislation still requires animal testing prior to human testing even though the pharmaceutical sector has better options that were unavailable when animal modeling was first mandated. We propose that the U.S. Food and Drug Administration and Congress should work together to abolish regulations and policies that require animal use. Doing so will benefit pharmaceutical industry stakeholders, including patients whose health depends on drugs and the many people who rely on the financial well-being of pharmaceutical firms. (shrink)