The structure of the brain and the nature of evolution suggest that, despite its uniqueness, language likely depends on brain systems that also subserve other functions. The declarative / procedural model claims that the mental lexicon of memorized word- specific knowledge depends on the largely temporal-lobe substrates of declarative memory, which underlies the storage and use of knowledge of facts and events. The mental grammar, which subserves the rule-governed combination of lexical items into complex representations, depends on a distinct neural (...) system. This system, which is composed of a network of specific frontal, basal - ganglia, parietal and cerebellar structures, underlies procedural memory, which supports the learning and execution of motor and cognitive skills, especially those involving sequences. The functions of the two brain systems, together with their anatomical, physiological and biochemical substrates, lead to specific claims and predictions regarding their roles in language. These predictions are compared with those of other neurocognitive models of language. Empirical evidence is presented from neuroimaging studies of normal language processing, and from developmental and adult- onset disorders. It is argued that this evidence supports the DP model. It is additionally proposed that “ language ” disorders, such as specific language impairment and non-fluent and fluent aphasia, may be profitably viewed as impairments primarily affecting one or the other brain system. Overall, the data suggest a new neurocognitive framework for the study of lexicon and grammar. (shrink)

Paulin and Cahill‐Lane explore the origins of event processing and event prediction in animal evolution. They propose that the evolutionary benefit of being able to predict and thus to quickly react to anticipated events may have triggered the evolution of the earliest nervous systems.

Background: Short latency afferent inhibition provides a method to investigate mechanisms of sensorimotor integration. Cholinergic involvement in the SAI phenomena suggests that SAI may provide a marker of cognitive influence over implicit sensorimotor processes. Consistent with this hypothesis, we previously demonstrated that visual attention load suppresses SAI circuits preferentially recruited by anterior-to-posterior -, but not posterior-to-anterior -current induced by transcranial magnetic stimulation. However, cerebellar modulation can also modulate these same AP-sensitive SAI circuits. Yet, the consequences of concurrent (...) cognitive and implicit cerebellar influences over these AP circuits are unknown.Objective: We used cerebellar intermittent theta-burst stimulation to determine whether the cerebellar modulation of sensory to motor projections interacts with the attentional modulation of sensory to motor circuits probed by SAI.Methods: We assessed AP-SAI and PA-SAI during a concurrent visual detection task of varying attention load before and after cerebellar iTBS.Results: Before cerebellar iTBS, a higher visual attention load suppressed AP-SAI, but not PA-SAI, compared to a lower visual attention load. Post-cerebellar iTBS, the pattern of AP-SAI in response to visual attention load, was reversed; a higher visual attention load enhanced AP-SAI compared to a lower visual attention load. Cerebellar iTBS did not affect PA-SAI regardless of visual attention load.Conclusion: These findings suggest that attention and cerebellar networks converge on overlapping AP-sensitive circuitry to influence motor output by controlling the strength of the afferent projections to the motor cortex. This interaction has important implications for understanding the mechanisms of motor performance and learning. (shrink)

Schizophrenia is a serious mental illness characterized by a disconnection between brain regions. Transcranial magnetic stimulation is a non-invasive brain intervention technique that can be used as a new and safe treatment option for patients with schizophrenia with drug-refractory symptoms, such as negative symptoms and cognitive impairment. However, the therapeutic effects of transcranial magnetic stimulation remain unclear and would be investigated using non-invasive tools, such as functional connectivity. A longitudinal design was adopted to investigate the alteration in FC dynamics using (...) a dynamic functional connectivity approach in patients with schizophrenia following high-frequency repeated transcranial magnetic stimulation with the target at the left dorsolateral prefrontal cortex. Two groups of schizophrenia inpatients were recruited. One group received a 4-week high-frequency rTMS together with antipsychotic drugs, while the other group only received antipsychotic drugs. Resting-state functional magnetic resonance imaging and psychiatric symptoms were obtained from the patients with schizophrenia twice at baseline and after 4-week treatment. The dynamics was evaluated using voxel- and region-wise FC temporal variability resulting from fMRI data. The pattern classification technique was used to verify the clinical application value of FC temporal variability. For the voxel-wise FC temporary variability, the repeated measures ANCOVA analysis showed significant treatment × time interaction effects on the FC temporary variability between the left DLPFC and several regions, including the thalamus, cerebellum, precuneus, and precentral gyrus, which are mainly located within the cortico-thalamo-cerebellar circuit. For the ROI-wise FC temporary variability, our results found a significant interaction effect on the FC among CTCC. rTMS intervention led to a reduced FC temporary variability. In addition, higher alteration in FC temporal variability between left DLPFC and right posterior parietal thalamus predicted a higher remission ratio of negative symptom scores, indicating that the decrease of FC temporal variability between the brain regions was associated with the remission of schizophrenia severity. The support vector regression results suggested that the baseline pattern of FC temporary variability between the regions in CTCC could predict the efficacy of high-frequency rTMS intervention on negative symptoms in schizophrenia. These findings confirm the potential relationship between the reduction in whole-brain functional dynamics induced by high-frequency rTMS and the improvement in psychiatric scores, suggesting that high-frequency rTMS affects psychiatric symptoms by coordinating the heterogeneity of activity between the brain regions. Future studies would examine the clinical utility of using functional dynamics patterns between specific brain regions as a biomarker to predict the treatment response of high-frequency rTMS. (shrink)

This paper introduces the concept of performance circuits as a means for understanding economic transactions. The concept of the performance circuits emphasizes the script-like sequences and the existing cultural narratives that enable the believable performances of those scripts. The concept of performance circuits allows for Zelizer’s concept of relational work to be applied in ethnographic studies of economic life, decomposing the constituent parts that enable the accomplishment of value in the marketplace. The paper opens with a (...) dramaturgical performance at the United States Federal Reserve and then turns to microstudies of handicraft production, modern art markets, and neighborhood branding to demonstrate how one can study market dramas unfolding, sometimes unremarkably, emotions being generated, and background representations making loosely scripted actions understandable. (shrink)

Prism Adaptation is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of great interest both for understanding the nature of sensorimotor transformations and for clinical purposes. However, the processes of transfer and their underlying neural substrates remain poorly understood. Transfer from throwing to pointing is (...) known to occur only in individuals who had previously reached a good level of expertise in throwing, not in novices. The aim of this study was to ascertain whether anodal stimulation of the cerebellum could boost after-effects transfer from throwing to pointing in novice participants. Healthy participants received anodal or sham transcranial direction current stimulation of the right cerebellum during a PA procedure involving a throwing task and were tested for transfer on a pointing task. Terminal errors and kinematic parameters were in the dependent variables for statistical analyses. Results showed that active stimulation had no significant beneficial effects on error reduction or throwing after-effects. Moreover, the overall magnitude of transfer to pointing did not change. Interestingly, we found a significant effect of the stimulation on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment. These results provide new insights on the implication of the cerebellum in transfer and on the possibility to use anodal tDCS to enhance cerebellar contribution during PA in further investigations. From a network approach, we suggest that cerebellum is part of a more complex circuitry responsible for the development of transfer which is likely embracing the primary motor cortex due to its role in motor memories consolidation. This paves the way for further work entailing multiple-sites stimulation to explore the role of M1-cerebellum dynamic interplay in transfer. (shrink)

Newborn neurons are generated in the adult hippocampus from a pool of self‐renewing stem cells located in the subgranular zone (SGZ) of the dentate gyrus. Their activation, proliferation, and maturation depend on a host of environmental and cellular factors but, until recently, the contribution of local neuronal circuitry to this process was relatively unknown. In their recent publication, Song and colleagues have uncovered a novel circuit‐based mechanism by which release of the neurotransmitter, γ‐aminobutyric acid (GABA), from parvalbumin‐expressing (PV) interneurons, can (...) hold radial glia‐like (RGL) stem cells of the adult SGZ in a quiescent state. This tonic GABAergic signal, dependent upon the activation of γ2 subunit‐containing GABAA receptors of RGL stem cells, can thus prevent their proliferation and subsequent maturation or return them to quiescence if previously activated. PV interneurons are thus capable of suppressing neurogenesis during periods of high network activity and facilitating neurogenesis when network activity is low. (shrink)

This commentary is intended to illuminate Gold's & Stoljar 's main contentions by exploiting a favorite comparison, namely, that between biology and electronics. Roughly, and leaving out Darwinian theory and the like, biology is physics and chemistry plus natural history just as electronics is physics plus wiring diagrams. Natural history contains generalizations, not laws. Psychology and cognitive science typically give more abstract explanations, as do “block diagrams” in electronics, and are less dispensable.

ABSTRACT LeDoux's pioneering work on the neurobiology of fear has played a crucial role in informing debates in the philosophy of emotion. For example, it plays a key part in Griffiths’ argument for why emotions don’t form a natural kind. Likewise, it is employed by Faucher and Tappolet to defend pro-emotion views, which claim that emotions aid reasoning. LeDoux, however, now argues that his work has been misread. He argues that using emotion terms, like ‘fear’, to describe neurocognitive data (...) adds a ‘surplus meaning’: it attributes phenomenal properties to survival circuits which they don’t possess. This paper aims to explore LeDoux's new proposal, and examine the potentially devastating consequences that ensue for the aforementioned views. I end by addressing the worry that these lessons are conditional on LeDoux's own higher-order theory of emotional consciousness being true. (shrink)

The Meaning Circuit Hypothesis (MCH) is a synthesis of ideas providing John Wheeler’s outline of ultimate physics, which he fine-tuned over several decades from the 1970s onward. It is a ‘working hypothesis’ in which ‘existence is a ‘meaning circuit”’ that portrays the world as a “system self-synthesized by quantum networking.” It was strongly advocated by him for roughly two decades and since then has had an increasingly strong impact on the approach of many investigators of quantum theory; in particular, elements (...) such as the quantum participator and ‘it from bit’ are now considered by others as candidate components of a foundation for quantum theory in which information is involved essentially. Therefore, it is worthy of review and critique. (shrink)

This paper is devoted to introduce a novel fourth-order hyperchaotic system. The hyperchaotic system is constructed by adding a linear feedback control level based on a modified Lorenz-like chaotic circuit with reduced number of amplifiers. The local dynamical entities, such as the basic dynamical behavior, the divergence, the eigenvalue, and the Lyapunov exponents of the new hyperchaotic system, are all investigated analytically and numerically. Then, an active control method is derived to achieve global chaotic synchronization of the novel hyperchaotic (...) system through making the synchronization error system asymptotically stable at the origin based on Lyapunov stability theory. Next, the proposed novel hyperchaotic system is applied to construct another new hyperchaotic system with circuit deformation and design a new hyperchaotic secure communication circuit. Furthermore, the implementation of two novel electronic circuits of the proposed hyperchaotic systems is presented, examined, and realized using physical components. A good qualitative agreement is shown between the simulations and the experimental results around 500 kHz and below 1 MHz. (shrink)

In the dyadic and triadic sharing of emotions, intentions, and behaviors in families, interactive synchrony is important to the early life experiences that contribute to the development of cultural cognition. This synchrony likely depends on neurobiological circuits, currently under study with brain imaging, that involve attention, stress response, and memory.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.1 (2002) 105-128 [Access article in PDF] The Metaphoric Circuit: Organic and Technological Communication in the Nineteenth Century Laura Otis [Figures]In a public lecture in 1851, Emil DuBois-Reymond proposed that the wonder of our time, electrical telegraphy, was long ago modeled in the animal machine. But the similarity between the two apparatus, the nervous system and the electric telegraph, has a much deeper (...) foundation. It is more than similarity; it is a kinship between the two, an agreement not merely of the effects, but also perhaps of the causes. 1In 1851 the telegraph and the nervous system appeared to be doing the same things and for the same reasons. Their common purpose was the transmission of information, and they both conveyed this information as alterations in electrical signals. By calling the nervous system a "model" for the telegraph, DuBois-Reymond suggested that organic communications systems offered solutions to problems encountered by technological ones.In the same decade, however, Claude Bernard remained skeptical about the epistemological value of metaphor. From the classical notion of nervous fluid to the more recent ones of animal spirits and animal electricity, he pointed out, people's "knowledge" of the nervous system had consisted largely of a series of comparisons, "the expression of a way of seeing meant to explain the facts." 2 Priding himself on his empiricism, Bernard mistrusted analogy as a means of constructing knowledge. Does one know more or less about something, if one asserts that it is like something else? What exactly is the relationship between metaphor and knowledge? [End Page 105]Many scientific investigators have shared Bernard's concern that claims of likeness will change their perceptions of physiological systems, but for the same reason some scholars of language are more optimistic about the epistemological possibilities of metaphor. George Lakoff and Mark Johnson assert that the role of metaphor in scientific thinking provides one of the best illustrations of how metaphors reflect and influence what we see and do. "Formal scientific theories are attempts to consistently extend a set of ontological and structural metaphors," they argue. 3 This "extension," though, is just what worried Bernard. Metaphors provoke and give birth to new images. By establishing and reinforcing connections, they encourage us to see in new ways. While Bernard is correct that assertions of likeness alter the way we see, Lakoff and Johnson are equally correct in claiming that "much of cultural change arises from the introduction of new metaphorical concepts and the loss of old ones." 4 Alterations in the way we see can be extremely productive.One of the most intriguing cases through which to study the epistemological role of metaphor is that of comparisons between physiological and technological communications systems. Throughout the nineteenth century scientists' electrophysiological understanding of the nervous system closely paralleled technological knowledge that allowed for the construction of telegraph networks. Timothy Lenoir has demonstrated that Hermann Helmholtz and Emil DuBois-Reymond, the nineteenth-century scientists who made some of the greatest contributions to neurophysiology, worked closely with communications engineers like Werner Siemens. By developing models that reflected the apparatus they had adapted from physics and media technology, Helmholtz, and DuBois-Reymond changed people's understanding of the way nerves transmitted impulses. I agree with Lenoir that these comparisons between organic and technological systems were not mere devices for popularization but became incorporated into the scientists' own vision and understanding of the nervous system. 5 When one reads the proposals of nineteenth-century engineers, one begins to suspect that communication in the body and in society can only be understood in terms of each other. But can one claim that comparisons of communication mediated by bodies and machines actually contributed to knowledge of the nervous system and of early telecommunications networks?From the late eighteenth century onward, scientists studying organic and technological communications systems continually inspired one another. As Friedrich Kittler argues in Discourse Networks, nineteenth-century media for writing and communication—the telegraph, typewriter, and telephone—affected not just the way people wrote and... (shrink)

I show that the Pinkerton rule in conspiracy law is doctrinally and morally flawed. Unlike past critics of the rule, I propose a statutory fix that preserves and reforms it rather than abolishing it entirely. As I will show, this accommodates authors like Neil Katyal who have defended the rule as an important crime fighting tool while also fixing most of the traditional problems with it identified by critics like Wayne LaFave. Pinkerton is a vicarious liability rule that (...) makes conspirators criminally responsible for the foreseeable crimes of their coconspirators committed in furtherance of the conspiracy. It has two big problems: (1) Doctrinally, it breaks the logic of the many state criminal codes that are based on the Model Penal Code. (2) Ethically, it infringes the culpability constraint on the criminal law by imposing excessive punishments on defendants who did not even consciously suspect that their coconspirators would commit additional crimes that were not the object of the conspiracy. These problems are most acute in Texas, where Pinkerton can be combined with capital murder charges to produce automatic life without parole sentences. The Texas example is an extreme illustration of the problem of unintended consequences when state legislators tinker with the carefully drafted, interlocking provisions of a model code. The new statute I propose would put the penal code back in order and respect the culpability constraint. In the latter aspect, it is informed by leading work in philosophical ethics on blameworthiness and culpability. (shrink)

In the past decade many studies have demonstrated the existence of a mirror mechanism that matches the sensory representation of a biological stimulus with its somatomotor and visceromotor representation. This mechanism, likely phylogenetically very old, explains several types of mirroring behaviours, at different levels of complexity. The presence in primates of dedicated neuroanatomical pathways for specific sensorimotor integrations processes implies, at least in the primate lineage, a hard-wired mirror mechanism for social cognitive functions.

The human brain is the first computer to which all others are compared. Yet we know painfully little about how a brain accomplishes its peculiar computations. In particular, consciousness is at once familiar and mysterious, and needs to be understood both for science and for medicine. Boldly, but gently this book introduces a reader to the neural circuitry that achieves consciousness. This amazing interconnection enables consciousness to flow like a stream, intimately relevant to the outside world; and for this (...) to happen, fundamental cues emerge from mental images to bring forth associated recalls. Alas cues can be inconsistent, causing memory failure; fortunately a subliminal cue editor encourages remembering forgotten items. Furthermore, cues generally address several memories, forcing the brain to make a selection. This necessitates another special circuit whose purpose is subliminal editing. The simplified explanations provided in this book make it clear that neurons do far more than ordinary devices, since a single neuron is capable of remarkably dense combinational and sequential logic. Beginning with their interesting and unexpected logical behavior, the reader will genuinely enjoy Dr. Burger's synthesis of a system for biological consciousness, a system that may someday result in credible artificial consciousness. (shrink)

Early theorists speculated that extremely shy children, or those with anxious temperament, were likely to have anxiety problems as adults. More recent studies demonstrate that these children have heightened responses to potentially threatening situations reacting with intense defensive responses that are characterized by behavioral inhibition and physiological arousal. Confirming the earlier impressions, data now demonstrate that children with this disposition are at increased risk to develop anxiety, depression, and comorbid substance abuse. Additional key features of anxious temperament are that it (...) appears at a young age, it is a stable characteristic of individuals, and even in non-threatening environments it is associated with increased psychic anxiety and somatic tension. To understand the neural underpinnings of anxious temperament, we performed imaging studies with 18- fluoro-deoxyglucose high-resolution Positron Emission Tomography in young rhesus monkeys. Rhesus monkeys were used because they provide a well validated model of anxious temperament for studies that cannot be performed in human children. Imaging the same animal in stressful and secure contexts, we examined the relation between regional metabolic brain activity and a trait-like measure of anxious temperament that encompasses measures of BI and pituitaryadrenal reactivity. Regardless of context, results demonstrated a trait-like pattern of brain activity that is predictive of individual phenotypic differences. Importantly, individuals with extreme anxious temperament also displayed increased activity of this circuit when assessed in the security of their home environment. These findings suggest that increased activity of this circuit early in life mediates the childhood temperamental risk to develop anxiety and depression. (shrink)

Development in animals is frequently characterized by periods of heightened capacity for both neural and behavioral change. So‐called sensitive periods of development are windows of opportunity in which brain and behavior are most susceptible to modification. Understanding what factors regulate sensitive periods constitutes one of the main goals of developmental neuroscience. Why is the ability to learn complex behavioral patterns often restricted to sensitive periods of development? Songbirds provide a model system for unraveling the mysteries of neural mechanisms of learning (...) during development. Like many songbirds, zebra finches (Taeniopygia guttata) learn a specific vocal pattern during a restricted period early in life. Young birds must hear songs produced by members of their species; this auditory experience is thought to engender specific changes in the brain to guide the process of vocal learning. Many studies of the songbird system have focused on examining relationships between brain development and learning. One goal of this work is to elucidate mechanisms that regulate basic processes of neural development, and in so doing to shed light on factors governing the emergence of a complex learned behavior. (shrink)

Who would have thought it? Poker has become a mass-audience spectator sport. Names like Chris ‘Jesus’ Ferguson, Phil ‘Unabomber’ Laak, and Dave ‘The Devilfish’ Ulliott may not be familiar to all readers of the TLS, but on any normal night you can see these top poker professionals on the nether reaches of the satellite channels, as they bluff and bully their way to pots worth hundreds of thousands of dollars. Like their counterparts in tennis and golf, they tour (...) the world, playing in lucrative tournaments which are avidly followed on television by millions of amateur enthusiasts whose own poker experience is mostly limited to small-stakes games played with faceless strangers on internet poker sites. (shrink)

Elite conferences, such as the Nobel Symposia organized by the Nobel Foundation since 1965, have often put a premium on the uninhibited exchange of ideas rather than the broad exchange of information. Nobel Symposium 14, The Place of Value in a World of Fact (1969), combined this ethos with the ambition to engage with ‘world problems’ that were thought by many at the time to constitute a global crisis. This paper examines the relationship between the Nobel Foundation's ideal of scientific (...) neutrality/objectivity and the ‘neutral activism’ in Swedish 1960s foreign policy. Furthermore, it investigates the social networking that preceded and followed the symposium, arguing that these processes were more important for the symposium's impact than the actual meeting. They formed channels through which it was able to influence other larger meetings, like the 1972 UN conference on the human environment, and contributed to the creation of international organizations, most importantly the International Federation of Institutes for Advanced Study. This suggests that the common historiographic focus on science meetings as events should be complemented by analytical perspectives that also view them as processes. (shrink)

This article is a continuation of our search for tautologies that are hard even for strong propositional proof systems like EF, cf. [Kra-wphp,Kra-tau]. The particular tautologies we study, the τ-formulas, are obtained from any.

continent. 2.3 (2012): 224–228 Introduction Jamie Allen Thierry Geoffroy’s conceptual, event- and environment-based art practice has generated over two-decades of definitional activity around what he terms “format art.” The works re-galvanize the energies of a syndicatable, open and atmospheric arrangement, of varying specifics dependent on context, participants and environment. With formats like the Emergency Room, Biennalist, and the Critical Run, Geoffroy endeavors to imbricate art and artist in the most exigent and current of social, political and mediatised spectacles. The (...) result seems to plant us at a triangulation of the configurations proposed by Alan Kaprow, Andrea Fraser and Alan Abel. Geoffroy plays up a guileless innocence (at times sporting the “Naive Blue Helmet”) as he interviews spectactors at the 2012 dOCUMENTA13 exhibitions in Kassel, Germany. What he evokes is a declamation of the appropriative, unenthusiastic, cool inclinations of the mainstream art festival, the profligate biennial (triennial, quadrennial, etc.) circuit and national and global ideological cultural-engines. In propositional artifacts, definitional articles and direct transmissions from Geoffroy’s Emergency Room field office at dOCUMENTA13, the masking of an emergency is here questioned: Can an art show like dOCUMENTA be dangerous? —JA Is dOCUMENTA designed to make people cry about something and not make them see something else? Is the contemporary a distraction from the present? Can art in delay have any impact with today? Do we learn anything by seeing art shows reflecting on history? Could 860,000 visitors have been intoxicated by an apathic gaze than keep them away from reacting? Why is dOCUMENTA proud of having recieve no critic? Why is proximity less important? Why was dOCUMENTA in Kabul? Can weapons designed to kill protesters sold to a repressing regime be contradictory to the support of the Arab Spring? Is the contemporary like a flea market to avoid to debating the important topics of today? Can art be in advance of the broken arm, and avoid accident? Is the goal of dOCUMENTA to create a revolution or to entertain? Is dOCUMENTA betterly done than Disney Land? Is it better to watch Fox News for two years or to go to dOCUMENTA for two days? If a curator, curating a contemporary art show about war, forgets to debate about the weapons factories next door, should it be considered as a professional mistake? Is it OK to employ philosophers to promote vodka? Is navigation a threat? Can an art show like dOCUMENTA be dangerous? Thierry Geoffroy / Colonel author of the month Global Art and the Museum @ZKM: " THE NEXT DOCUMENTA SHOULD BE CURATED BY A TANK " Link to Emergency Room Dictionary < /a> "COOLNESS" from the EMERGENCY ROOM DICTIONARY by COLONEL MUSIC Biennalist at dOCUMENTA 13 "TIRED" from the EMERGENCY ROOM DICTIONARY by COLONEL MUSIC Link to " APATHY " (from the Emergency Room Dictionary ) AWARENESS MUSCLE [fr. muscle de la conscience ] In the same sense memory can be trained, an awareness muscle can be developed by an effort. To develop the awareness muscle, the artist has to reduce his gesticulations. When an artist is busy the artist is not very aware the artist is occupied. A daily training is necessary But how to train? Scanning the news in a critical way could be one exercise. Daily debating politics with others could be another. Looking at other point of views usually produces significant improvements. Fighting prejudice is an excellent exercise. Many other forms of training could also produce beneficial effects for the awareness muscle. Continuous and daily training is important. For instance rewinding and slow motioning what has been absorbed getting away the sugar from the propaganda machines talking to everyone excercise comparatif critical run. If not daily trained the awareness muscle can degrade into atrophy To develop the awareness muscle requires will-power Thierry Geoffroy / Colonel. (shrink)

Deep Brain Stimulation is an invasive device-based neuromodulation technique that allows the therapeutic direct stimulation of subcortical and deep cortical structures following the surgical placement of stimulating electrodes. DBS is approved by the U.S. Federal Drug Administration for the treatment of movement disorders and obsessive-compulsive disorder, while new indications, including Major Depressive Disorder, are in experimental development. We report the case of a patient with MDD who received DBS to the ventral internal capsule and ventral striatum bilaterally and presented with (...) 2 weeks of voltage-dependent Tourette-like symptoms including brief transient episodes of abrupt-onset and progressively louder coprolalia and stuttered speech; tic-like motor behavior in his right arm and leg; rushes of anxiety, angry prosody, angry affect; and moderate amnesia without confusion. We describe the results of the inpatient neuropsychiatric workup leading to the diagnosis of iatrogenic voltage-dependent activation of cortico-subcortical circuits and discuss insights into the pathophysiology of Tourette as well as safety considerations raised by the case. (shrink)

Modern knowledge of servo systems and computing machines makes it possible to specify a circuit that can and will induce the rules and winning moves in a game like chess when they are given only ostensibly, that is, by playing against opponents who quit when illegal or losing moves are made. Such circuits enjoy a value social in the sense that it is shared by the players.La connaissance moderne des servomécanismes et des machines à calculer permet de concevoir (...) un circuit qui pourra suivre des règles et décider les coups décisifs dans un jeu comme le jeu d'échecs tout au moins quand les coups sont joués de faÇon apparente, c'est-à-dire contre des adversaires qui abandonneront dans le cas de coups irréguliers ou de coups absurdes.De tels circuits possèdent une „valeur” sociale dans la mesure où elle est partagée par les autres joueurs.Moderne Kenntnissen im Gebiete von Folgegeraeten und Rechenmaschinen ermoeglichen es einen elektrischen Kreis aufzuwerfen, der die Regeln und gewinnbringende Zuege eines Spieles wie Schach induktiv erfassen kann und wird, wenn diese Regeln und Zuege nur ostensiv gegeben sind; d.h. indem mit Gegnern gespielt wird, die das Spiel einstellen sobald regelwidrige oder verlustbringende Zuege gemacht werden. Solche Kreise schaffen demnach einen Wert, der gesellschaftlich in dem Sinn ist, dass er auch von den Mitspielern geteilt wird. (shrink)

A product harm crisis undermines a firm’s reputation as well as its managers’ career outlook. To shake off the stigmatization resulting from the PHC and regain a firm’s legitimacy among stakeholders, managers usually face an ethical dilemma as they choose to be transparent about the crisis’ financial implications or to obfuscate them to neutralize the negative impact of the PHC. We find evidence that managers engage in income-increasing earnings management when their firms experience PHCs. Moreover, while income-increasing earnings management in (...) PHCs reduces the likelihood of customer loss and CEO forced turnover in the short run, such behavior can be deemed opportunistic and unethical as it carries long-run negative consequences in terms of a higher likelihood of accounting restatement and weaker future operating performance. Finally, managers in firms that are subject to stricter external monitoring and managers in firms with proactive ethical policies are less likely to engage in upward earnings management in PHCs. (shrink)

Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming increasingly (...) complete. The postgenomic era has provided encyclopedic information on gene‐function correlations and systems biology is now delivering comprehensive details on the dynamics of biochemical reaction networks in living organisms. The time has come to reassemble these catalogued items and design new biological devices and systems with novel and useful functionality in a rational and systematic manner. This is the premise of synthetic biology, a constructive systems biology discipline likely to become the life science revolution of the 21st century. (shrink)

Like Kant at his time, Jürgen Habermas wants to encourage the reader to use his „reasonable liberty“. There is no doubt, that the philosophical positions of Kant on the one hand and of Hegel on the other hand hold, until today, a key role in the development of the „discourse of modern age“. In order to oppose a short-circuited synthesis of both systems, which are obliged to the idea of liberty quite differently, this essay demonstrates the substantial differences regarding (...) to elementary concepts like peculiarity of the individual will, law and legislation, people and sovereignty of the people. That both philosophers differ in their interest of questioning becomes quite clear regarding to the citizen/state relation. While Hegel tries to describe the reality of the state as a „moral universe“ and therefore as „reality of reason“, Kant is interested in knowing about the potential state togetherness of individuals which have experienced in them the „radical evil“. The differences concerning the estimation of the „subjective“ individual will in its relationship to the „objective“ will of „generality“, concerning also the (Rousseauian) concept of contract and the citizens as „co-legislators“ are culminating in the relationship between „law“ and „morality“. Whereas Kant (wrongly) ignores ethos and history, Hegel is lacking the concept of „intersubjective communication“ (so Habermas states). From both insufficiencies conclusions are resulting which are important for coping with the actual difficulties with „inclusion“ and „integration“. (shrink)

Child trauma plays an important role in the etiology of Bordeline Personality Disorder. Of all traumas, sexual trauma is the most common, severe and most associated with receiving a BPD diagnosis when adult. Etiologic models posit sexual abuse as a prognostic factor in BPD. Here we apply machine learning using Multiple Kernel Regression to the Magnetic Resonance Structural Images of 20 BPD and 13 healthy control to see whether their brain predicts five sources of traumas: sex abuse, emotion neglect, emotional (...) abuse, physical neglect, physical abuse. We also applied the same analysis to predict symptom severity in five domains: affective, cognitive, impulsivity, interpersonal for BPD patients only. Results indicate that CTQ sexual trauma is predicted by a set of areas including the amygdala, the Heschl area, the Caudate, the Putamen, and portions of the Cerebellum in BPD patients only. Importantly, interpersonal problems only in BPD patients were predicted by a set of areas including temporal lobe and cerebellar regions. Notably, sexual trauma and interpersonal problems were not predicted by structural features in matched healthy controls. This finding may help elucidate the brain circuit affected by traumatic experiences and connected with interpersonal problems BPD suffer from. (shrink)

Recent conjectures regarding the nature and mechanism of consciousness are extended to include the contribution of the cerebellum. The role of this brain structure appears to be a rather sophisticated form of prediction, as exemplified by certain dynamical capabilities of the visual system, and by the difficulty of self-administered tickling. The pars intermedia of the cerebellum is perceived as a direct feedback device, functioning in parallel to the primary neuronal circuit involved in consciousness; this leads to the suggestion that it (...) serves as a tutor for the putative master node, the latter governing the collective movements of all the body's muscles. The cerebellar hemispheres are believed to act as an internal feedback device, and to be more directly coupled to the master node; they are seen as serving plenisentient unconsciousness. The possible importance of muscular spindles for the generation of qualia is discussed, as are the significance of the frontal lobes, the basal ganglia and the limbic system for the content of consciousness. Finally, the stages through which infant consciousness gradually acquires its sophistication are tentatively identified. (shrink)

Neural organization: Structure, function, and dynamics shows how theory and experiment can supplement each other in an integrated, evolving account of the brain's structure, function, and dynamics. (1) Structure: Studies of brain function and dynamics build on and contribute to an understanding of many brain regions, the neural circuits that constitute them, and their spatial relations. We emphasize Szentágothai's modular architectonics principle, but also stress the importance of the microcomplexes of cerebellar circuitry and the lamellae of hippocampus. (2) (...) Function: Control of eye movements, reaching and grasping, cognitive maps, and the roles of vision receive a functional decomposition in terms of schemas. Hypotheses as to how each schema is implemented through the interaction of specific brain regions provide the basis for modeling the overall function by neural networks constrained by neural data. Synthetic PET integrates modeling of primate circuitry with data from human brain imaging. (3) Dynamics: Dynamic system theory analyzes spatiotemporal neural phenomena, such as oscillatory and chaotic activity in both single neurons and (often synchronized) neural networks, the self-organizing development and plasticity of ordered neural structures, and learning and memory phenomena associated with synaptic modification. Rhythm generation involves multiple levels of analysis, from intrinsic cellular processes to loops involving multiple brain regions. A variety of rhythms are related to memory functions. The Précis presents a multifaceted case study of the hippocampus. We conclude with the claim that language and other cognitive processes can be fruitfully studied within the framework of neural organization that the authors have charted with John Szentágothai. Key Words: cognitive maps; computational neuroscience; dynamics; hippocampus; memory; modular architectonics; neural modeling; neural organization; neural plasticity; rhythmogenesis; Szentágothai. (shrink)

Neural organization: Structure, function, and dynamics shows how theory and experiment can supplement each other in an integrated, evolving account of the brain's structure, function, and dynamics. Structure: Studies of brain function and dynamics build on and contribute to an understanding of many brain regions, the neural circuits that constitute them, and their spatial relations. We emphasize Szentágothai's modular architectonics principle, but also stress the importance of the microcomplexes of cerebellar circuitry and the lamellae of hippocampus. Function: Control (...) of eye movements, reaching and grasping, cognitive maps, and the roles of vision receive a functional decomposition in terms of schemas. Hypotheses as to how each schema is implemented through the interaction of specific brain regions provide the basis for modeling the overall function by neural networks constrained by neural data. Synthetic PET integrates modeling of primate circuitry with data from human brain imaging. Dynamics: Dynamic system theory analyzes spatiotemporal neural phenomena, such as oscillatory and chaotic activity in both single neurons and neural networks, the self-organizing development and plasticity of ordered neural structures, and learning and memory phenomena associated with synaptic modification. Rhythm generation involves multiple levels of analysis, from intrinsic cellular processes to loops involving multiple brain regions. A variety of rhythms are related to memory functions. The Précis presents a multifaceted case study of the hippocampus. We conclude with the claim that language and other cognitive processes can be fruitfully studied within the framework of neural organization that the authors have charted with John Szentágothai. (shrink)

The explanatory gap . Consciousness is a mystery. No one has ever given an account, even a highly speculative, hypothetical, and incomplete account of how a physical thing could have phenomenal states. Suppose that consciousness is identical to a property of the brain, say activity in the pyramidal cells of layer 5 of the cortex involving reverberatory circuits from cortical layer 6 to the thalamus and back to layers 4 and 6,as Crick and Koch have suggested for visual consciousness. (...) .) Still, that identity itself calls out for explanation! Proponents of an explanatory gap disagree about whether the gap is permanent. Some say that we are like the scientifically naive person who is told that matter = energy, but does not have the concepts required to make sense of the idea. If we can acquire these concepts, the gap is closable. Others say the gap is uncloseable because of our cognitive limitations. Still others say that the gap is a consequence of the fundamental nature of consciousness. (shrink)

Is consciousness based in prefrontal circuits involved in cognitive processes like thought, reasoning, and memory or, alternatively, is it based in sensory areas in the back of the neocortex? The no-report paradigm has been crucial to this debate because it aims to separate the neural basis of the cognitive processes underlying post-perceptual decision and report from the neural basis of conscious perception itself. However, the no-report paradigm is problematic because, even in the absence of report, subjects might engage (...) in post-perceptual cognitive processing. Therefore, to isolate the neural basis of consciousness, a no-cognition paradigm is needed. Here, I describe a no-cognition approach to binocular rivalry and outline how this approach can help resolve debates about the neural basis of consciousness. (shrink)

Freely falling point-like objects converge toward the center of the Earth. Hence the gravitational field of the Earth is inhomogeneous, and possesses a tidal component. The free fall of an extended quantum mechanical object such as a hydrogen atom prepared in a high principal-quantum-number state, i.e. a circular Rydberg atom, is predicted to fall more slowly than a classical point-like object, when both objects are dropped from the same height above the Earth’s surface. This indicates that, apart from (...) transitions between quantum states, the atom exhibits a kind of quantum mechanical incompressibility during free fall in inhomogeneous, tidal gravitational fields like those of the Earth.A superconducting ring-like system with a persistent current circulating around it behaves like the circular Rydberg atom during free fall. Like the electronic wavefunction of the freely falling atom, the Cooper-pair wavefunction is quantum mechanically incompressible. The ions in the lattice of the superconductor, however, are not incompressible, since they do not possess a globally coherent quantum phase. The resulting difference during free fall in the response of the nonlocalizable Cooper pairs of electrons and the localizable ions to inhomogeneous gravitational fields is predicted to lead to a charge separation effect, which in turn leads to a large Coulomb force that opposes the convergence caused by the tidal gravitational force on the superconducting system.A “Cavendish-like” experiment is proposed for observing the charge separation effect induced by inhomogeneous gravitational fields in a superconducting circuit. The charge separation effect is determined to be limited by a pair-breaking process that occurs when low frequency gravitational perturbations are present. (shrink)