Peirce's Scientific Metaphysics is the first book devoted to understanding Charles Sanders Peirce's (1839-1914) metaphysics from the perspective of the scientific questions that motivated his thinking. While offering a detailed account of the scientific ideas and theories essential for understanding Peirce's metaphysical system, this book is written in a manner accessible to the non-specialist.

The cell theory—the thesis that all life is made up of one or more cells, the fundamental structural and physiological unit—is one of the most celebrated achievements of modern biological science. And yet from its very inception in the nineteenth century it has faced repeated criticism from some biologists. Why do some continue to criticize the cell theory, and how has it managed nevertheless to keep burying its undertakers? The answers to these questions reveal the complex nature of the cell (...) theory and the cell concept on which it is based. Like other scientific ‘laws’, the assertion that all living things are made of cells purchases its universality at the expense of abstraction. If, however, this law is regarded merely as a widely applicable empirical generalization with notable exceptions, it still remains too important to discard. Debate about whether the cell or the organism standpoint provides the more correct account of anatomical, physiological, and developmental facts illustrates the tension between our attempts to express the truth about reality in conceptual terms conducive to a unified human understanding. (shrink)

Cadherin‐mediated cell‐cell adhesion is perturbed in protein tyrosine kinase (PTK)‐transformed cells. While cadherins themselves appear to be poor PTK substrates, their cytoplasmic binding partners, the Arm catenins, are excellent PTK substrates and therefore good candidates for mediating PTK‐induced changes in cadherin behavior. These proteins, p120ctn, β‐catenin and plakoglobin, bind to the cytoplasmic region of classical cadherins and function to modulate adhesion and/or bridge cadherins to the actin cytoskeleton. In addition, as demonstrated recently for β‐catenin, these proteins also have crucial signaling (...) roles that may or may not be related to their effects on cell‐cell adhesion. Tyrosine phosphorylation of cadherin complexes is well documented and widely believed to modulate cell adhesiveness. The data to date, however, is largely correlative and the mechanism of action remains unresolved. In this review, we discuss the current literature and suggest models whereby tyrosine phosphorylation of Arm catenins contribute to regulation or perturbation of cadherin function. (shrink)

Peirce is often credited with having formulated a pragmatic theory of truth. This can be misleading, if it is assumed that Peirce was chiefly interested in providing a metaphysical analysis of the immediate conditions under which a belief or proposition is true, or the conditions under which a proposition or belief is said to be madetrue. Cheryl Misak has exposed the subtleties in Peirce's discussion of truth, especially showing the difficulties faced by any ascription to him of an analytic definition (...) of truth. In this paper I follow Misak in urging that Peirce's contribution to the philosophical discussion about the nature of truth was not of that kind. What makes his pragmatic approach distinctive is that rather than attempting to state the nature of truth per se, it attempts to uncover the beliefs and expectations we commit ourselves to when we make specific claims that such and such is true or is the case. (shrink)

Alan Reynolds: This paper is divided into three sections. First, I describe the wide plurality of views on issues of animal ethics, showing that our disagreements here are deep and profound. This fact of reasonable pluralism about animal ethics presents a political problem. According to the dominant liberal tradition of political philosophy, it is impermissible for one faction of people to impose its values upon another faction of people who reasonably reject those values. Instead, we are obligated to justify our (...) political actions to each other using reasons that everyone can accept. Thus, in the second section I suggest that our condition of reasonable pluralism inspires us to turn toward some form of contractarianism. The social contract tradition emerged precisely as an attempt to think about how a society characterized by deep moral disagreement could nonetheless agree about the basic principles of justice. I will show, in this section, that although the social contract tradition would seem to contain the best tools for thinking about how to deal with moral disagreement, it fails to help us think through the important issues of animal ethics. In the concluding section, I suggest some ways in which political philosophy might move beyond contractarianism when thinking about this issue, including embracing an agonistic style of politics. -/- Cet article est divisé en trois sections. Tout d’abord, je décris la grande pluralité des opinions existant sur les questions de l’éthique animale, montrant que nos désaccords sur le sujet sont profonds. Cette réalité du pluralisme raisonnable en matière d’éthique animale pose un problème politique. Selon la tradition libérale dominante de la philosophie politique, une faction de personnes ne peut imposer ses valeurs à une autre faction qui rejette raisonnablement ces valeurs. Au lieu de cela, nous sommes obligés de justifier nos actions politiques en utilisant des raisons que tout le monde peut accepter. Ainsi, dans la seconde section, je suggère que notre condition de pluralisme raisonnable nous mène à une forme de contractualisme. La tradition du contrat social est justement apparue comme une tentative de réfléchir à la façon dont une société caractérisée par un profond désaccord moral peut néanmoins s’entendre sur les principes fondamentaux de la justice. Dans cette section, je montre que, bien que la tradition du contrat social semble offrir les meilleurs outils pour définir la manière de traiter le désaccord moral, elle ne parvient pas à nous aider à réfléchir aux questions essentielles de l’éthique animale. Dans la dernière section, je suggère quelques façons susceptibles de permettre à la philosophie politique de dépasser le contractualisme dans sa réflexion sur cette question, ceci comprenant l’adoption d’un style de politique agonistique. (shrink)

This book reconsiders the meaning of modernism across the globe, stretching beyond both the Western modernist canon and the literary-heavy scope of the field to a broader cultural consideration of global modernisms and modernity. Through the use of masks as a thematic focus, the volume challenges popular assumptions about what modernism looks like, what modernity is, and how each of these ideas are produced within a historical moment.

In September of 1869, while studying sponges off the Norwegian island of Gisoe, Ernst Haeckel (1834-1919) discovered a tiny, flagellated ball-shaped organism swimming about in his samples. Appearing first to be the planula larva of an invertebrate marine animal further observation revealed it to be a colony of flagellated cells with a complex life cycle transitioning between multicellular and single-cell stages and several distinct forms of protozoa. Haeckel named it Magosphaera planula (the "magician's ball") and it eventually assumed a central (...) role in his theories of animal evolution, appearing as the modern exemplar of the blastaea stage in his gastraea theory of metazoan evolution. Throughout the latter half of the nineteenth century and into the twentieth it was an object of considerable scientific interest, and yet it was only ever observed by Haeckel himself and then only the once. Eventually it faded altogether from scientific discussion. This paper traces the rise and fall of Magosphaera as an important epistemic object in the theories of Haeckel and other biologists, and an attempt is made to identify what exactly the organism (or organisms!) was that Haeckel observed in the fall of 1869. (shrink)

In Consequences of Pragmatism, Richard Rorty provocatively quipped, “James and Dewey were not only waiting at the end of the dialectical road which analytic philosophy traveled, but are waiting at the end of the road which, for example, Foucault and Deleuze are currently traveling” (1982: xviii). Which is to say, the richness of the pragmatist tradition lies in its ability to offer us countless conceptual tools for problems that continue to emerge and re-emerge, in various times, numerous con...

Debates about "equality" are pervasive in our politics today. The widening gap between the rich and the poor is having major effects on our society and politics, galvanizing social justice movements on the left and nationalist-populist movements on the right. On a different register, America's culture war is heating up on topics such as privilege, oppression, identity, racism, patriarchy, implicit bias, and so forth. These debates are not always as constructive as they might be, in part because the concept of (...) equality is a complicated, contested, and confusing term. Although everyone seems to care about equality, we do not all mean the same thing—just consider the typical contrast between "equality of opportunity"... (shrink)

Factors such as subsistence turnover, warfare, or interaction between different groups can be major sources of cultural change in human populations. Global demographic shifts such as the transition to agriculture during the Neolithic and more recently the urbanization and globalization of the twentieth century have been major catalysts for cultural change. Here, we test whether cultural traits such as patri/matrilocality and postmarital migration persist in the face of social upheaval and gene flow during the past 150 years in postcolonial South (...) Africa. The recent history of South Africa has seen major demographic shifts that resulted in the displacement and forced sedentism of indigenous Khoekhoe and San populations. During the expansion of the colonial frontier, the Khoe-San admixed with European colonists and enslaved individuals from West/Central Africa, Indonesia, and South Asia, introducing novel cultural norms. We conducted demographic interviews among Nama and Cederberg communities representing nearly 3,000 individuals across three generations. Despite the history of colonial expansion, and the subsequent incorporation of Khoe-San and Khoe-San-descendant communities into a colonial society with strong patrilocal norms, patrilocality is the least common postmarital residence pattern in our study populations today. Our results suggest that more recent forces of integration into the market economy are likely the primary drivers of change in the cultural traits examined in our study. Birthplace had a strong effect on an individual’s odds of migration, distance moved, and postmarital residence form. These effects are at least partially explained by the population size of the birthplace. Our results suggest that market factors local to birthplaces are important drivers of residence decisions, although the frequency of matrilocal residence and a geographic and temporal cline in migration and residence patterns also indicate the persistence of some historic Khoe-San cultural traits in contemporary groups. (shrink)

To view a work knowingly gives understanding but not hope Rorty, "The Necessity of Inspired Reading" I cannot count one. I know not the first letter of the alphabet. Thoreau, Walden.

In this paper I examine the role of tragedy in the ancient emergence of philosophical interiority and in the recent return of exteriority that marks the birth of theory. I argue that tragedy names a kind of epistemic threshold between systems of knowledge predicated on exteriority and interiority. I conclude by arguing that Derrida's late effort to articulate a messianic model of the tragic in Specters of Marx and elsewhere, his effort to “think the ghost,” both confirms and complicates tragedy's (...) place in the history of theory. (shrink)

“Historicism” has become a ubiquitous and equivocal term. A classification is given here of five separate uses of the term currently in vogue, each provided with a unique qualifying adjective to help keep them distinct. I then offer a few objections to some of the more radical conclusions which have been drawn by proponents of a specific version of historicism, one associated with “postmodernism “. The positions of Rorty and Putnam are contrasted as examples of strong and weak degrees of (...) historicism, respectively. (shrink)

In the nineteenth century protozoology and early cell biology intersected through the nexus of Darwin's theory of evolution. As single-celled organisms, amoebae offered an attractive focus of study for researchers seeking evolutionary relationships between the cells of humans and other animals, and their primitive appearance made them a favourite model for the ancient ancestor of all living things. Their resemblance to human and other metazoan cells made them popular objects of study among morphologists, physiologists, and even those investigating animal behaviour. (...) The amoeba became the exemplar of the new protoplasmic cell concept of mid-century and because its apparent simplicity made it widely generalizable it became a popular subject in a breadth of experimental investigations and theoretical speculations. It was able to do this because "the amoeba" denotes not a particular organism, but a general type of behaviour common to the cells of a range of protozoa, simple plants and higher animals. Its status as an exemplary cell also rested upon auxiliary philosophical assumptions about what constitutes a primitive characteristic and the thesis that evolution is a progressive development of order from chaos. (shrink)

This is a collection of eight essays plus one short “ afterthought,” all but one of which have been previously published in the 1990s. The theme running throughout is a plea for a less professional, less exclusive, less technical, less abstract approach to philosophy than the commonly labelled “analytic” approach. Solomon’s complaint against analytic philosophy is that when it does not outright ignore the philosophical problems that concern the day-to-day lives of regular people, it turns them into abstract “brain-teasers” void (...) of any real-life context. Philosophy then becomes an opportunity for an elite group to show off how smart they are. Analytic philosophers tend to abstract away all the rich detail of the real life contexts in which most of our impulses to philosophize arise. What is thus gained by eliminating supposedly extraneous details, so as to arrive at the essential—and timeless?—“thin” conceptions of such things as reason, justice, personal identity, and a meaningful life, is offset by the inability of people to apply the results to what is significant in their own lives. Small wonder then if most North Americans think philosophy is useless and irrelevant. Solomon warns, “[I]t is only a matter of time before more parents, taxpayers, readers, and administrators start to ask, Why should we pay for this? Is this what our kids should be learning? Is this philosophy?”. (shrink)