According to popular belief, Charles II of England once heard a prophecy that if ravens left the Tower of London it would "fall," so he ordered that the wings of seven ravens in the Tower be trimmed. Until recently, this claim was not challenged even in scholarly literature. There are, however, no allusions to the Tower Ravens before the end of the nineteenth century. The ravens, today meticulously cared for by Yeoman Warders, are (...) largely an invented tradition, designed to give an impression of continuity with the past. This article examines the few known references, both graphic and textual, to the Tower Ravens through 1906. It concludes that the ravens were originally brought in to dramatize the alleged site of executions at the Tower. Although not accorded great significance at first, legends that would eventually make the ravens mascots of Britain began outside of the Tower. (shrink)

This paper reports a study of the roles of visuo-spatial and verbal working memory capacities in solving a planning task - the five-disc Tower of London (TOL) task. An individual differences approach was taken. Sixty adult participants were tested on 20 TOL tasks of varying difficulty. Total moves over the 20 TOL tasks was taken as a measure of performance. Participants were also assessed on measures of fluid intelligence (Raven's matrices), verbal short-term storage (Digit span), verbal working memory span (...) (Silly Sentence span), visuo-spatial short-term storage (Visual Pattern span and Corsi Block span), visuo-spatial working memory (Corsi Distance Estimation), visuo-spatial processing speed (Manikin test), and verbal speed (Rehearsal speed). Exploratory factor analysis using an oblique rotation method revealed three factors which were interpreted as (1) a visuo-spatial working memory factor, (2) an age-speed factor, and (3) a verbal working memory factor. The visuo-spatial and verbal factors were only moderately correlated. Performance on the TOL task loaded on the visuo-spatial factor but did not load on the other factors. It is concluded that the predominant goal-selection strategy adopted in solving the TOL relies on visuo-spatial working memory capacity and particularly involves the active ''inner scribe'' spatial rehearsal mechanism. These correlational analyses confirm and extend results previously obtained by use of dual task methods, (Phillips, Wynn, Gilhooly, Della Sala, & Logie, 1999). (shrink)

Some believe reality is dynamic: time passes, not just in our experience of reality, but objectively, in reality itself. There are many objections to this view. I focus on the rate objection: that time passes only if it passes at the rate of 1 second per second, but that it cannot coherently pass at that rate. Existing replies to this objection do not fully engage with its motivation. My aim is to refute the rate objection. Time can coherently pass at (...) the rate of 1 second per second. This does not conclusively show that time passes, but it removes one of the main obstacles to believing that it does. (shrink)

The physicalist credo is that the world is physical. But some phenomena, such as minds, morals, and mathematics, appear to be nonphysical. While an uncompromising physicalism would reject these, a conciliatory physicalism needn’t if it can account for them in terms of an underlying physical basis. But if the account must refer to the nonphysical, won’t it conflict with the physicalist credo? This essay aims to clarify this problem and introduce a novel solution that relies on a distinction between “circumstantial” (...) facts that are based in the circumstances and “acircumstantial” facts that are not. This is used in two ways. First, physicalism is restricted to circumstantial facts: only they must have a physical basis that does not refer to the nonphysical. Second, facts accounting for the nonphysical are not restricted to the circumstantial: they may refer to the nonphysical if they are acircumstantial. Facts about how the physical accounts for the nonphysical therefore do not conflict with the physicalist’s credo. This provides a credible answer to what physicalism could be. (shrink)

The unity of science movement was itself far from unified. There may have been unity on the rallying call for a unity of science but that is as far as it went. Not only was there disagreement among the main protagonists on what was meant by the unity of science, but also on how to achieve it. In this paper I shall deal with Edgar Zilsel’s (1891-1944) conception. It represents an interesting break with the more programmatic approaches of Carnap, Neurath; (...) Zilsel emphasizes the need for an empirical demonstration of the unity of science, which has interesting meta-philosophical implications. The unity of science is not just central to his research programme; it is what constitutes the latter’s unifying principle, although this is far from evident if one takes a look at the historical essays he published in exile in the USA during the 1940s. (These important essays on the emergence of science, well known among historians of early modern science, have given rise to the so-called Zilsel Thesis, which holds that modern science came into being when, between 1300 and 1600, the social barriers between those who ‘labored with there minds and tongues’, i.e. the university scholars and the humanists, and those who ‘worked with their hands’, i.e the superior artisans, eroded because of the rise of free-enterprise capitalism.) But simultaneously, he also published a couple of smaller and far less known essays, directed against Southwest-German Neo-Kantianism (Rickert, Windelband), Dilthey’s philosophy of life, and interpretative sociology (Max Weber, W. Sombart, G. Simmel, R. Stammler, Alfred Weber, etc.). His main argumentwas that philosophers of cultural science and the humanities had a falseunderstanding of natural science. Because of this false understanding, they erroneously postulated a fundamental methodological difference between the natural sciences and the human sciences. According to Zilsel, this difference does not exist. In his view the historian is basically confronted with the same problems as the natural scientist. If the science of history is not compared with classical mechanics but with, for example, geophysics – that is, “the physics of earthquakes, sea-currents, volcanology, and meteorology” – one will arrive at the conclusion “that historical phenomena are hardly more difficult to predict than the weather, and certainly no more difficult than earthquakes and volcanic eruptions. What would scientists think of a geophysicist who abandoned the search for geophysical laws because of their inexactness? ” (SOMS: 202). (shrink)

Background: The COVID-19 crisis has had a considerable mental health impact on healthcare workers. High levels of psychological distress are expected to have a significant impact on healthcare systems, warranting the need for evidence-based psychological interventions targeting stress and fostering resilience in this population. Online cognitive behavioral therapy has proved to be effective in targeting stress and promoting resilience. However, online CBT programs targeting stress in healthcare workers are lacking.Objective: The aim of our study is to evaluate the feasibility and (...) acceptability of an internet-based CBT intervention, the My Health Too program we developed during the first COVID-19 epidemic peak in France.Methods: We recruited 10 participants among Alsace region hospital staff during the first peak of the pandemic in France. They were given 1 week to test the website and were then asked to answer an internet survey and a semi-structured phone interview.Results: We conducted a thematic analysis of the content from the phone interviews. Major themes were identified, discussed and coded: the technical aspects, the content of the website and its impact on participants’ emotions and everyday life. Overall, the participants reported finding the website easy to use and interactive. They described the resources as easy to understand, readily usable, and useful in inducing calm and in helping them practice self-compassion.Conclusion: Our results suggest that the My Health Too online CBT program is highly feasible and acceptable to healthcare workers during the highly stressful times of the pandemic peak. The feedback provided helped to improve the program whose efficacy is to be tested. (shrink)

This essay focuses on a recently prominent notion of ground which is distinctive for how it links metaphysics to explanation. Ground is supposed to serve both as the common factor in diverse in virtue of questions as well as the structuring relation in the project of explaining how some phenomena are “built” from more fundamental phenomena. My aim is to provide an opinionated synopsis of this notion of ground without engaging with others. Ground, so understood, generally resists illumination by appeal (...) to more familiar models of explanation. Nevertheless, its distinctive explanatory and metaphysical aspects guide us on characterizing its explanatory logic and its metaphysical features. Some issues concerning the meta-question of what grounds ground are explored, as well as some recent skeptical challenges to ground. (shrink)

By modifying the body in meaningful ways, human beings establish their identity and social status. Lip plugs, ear plugs, penis sheaths, cosmetics, ornaments, scarification, body piercings, and genital modifications encode and transmit messages about age, sex, social status, health, and attractiveness from one individual to another. Through sociocultural sexual selection, male genital modification plays an important role as a sociosexual signal in both male competition and female mate choice. The reliability of the signal correlates with the cost of acquiring the (...) trait. Women use a variety of cues to assess male quality. Male genital modification is one way that some women assess their mates. Extreme male genital modifications not only honestly advertise status, sexual potency, and ability to provide sexual satisfaction, they may provide a reliable index of male-female cooperation through the male’s commitment to endure pain and risk. (shrink)

I defend (metaphysical) ground against recent, unanswered objections aiming to dismiss it from serious philosophical inquiry. Interest in ground stems from its role in the venerable metaphysical project of identifying which facts hold in virtue of others. Recent work on ground focuses on regimenting it. But many reject ground itself, seeing regimentation as yet another misguided attempt to regiment a bad idea (like phlogiston or astrology). I defend ground directly against objections that it is confused, incoherent, or fruitless. This vindicates (...) the very attempt to regiment ground. It also refocuses our attention on the genuine open questions about ground and away from the distracting, unpersuasive reasons for dismissing them. (shrink)

Ayahuasca, an ancient Amazonian psychedelic tea traditionally used ceremonially among indigenous peoples, has recently become known as a possible treatment for a wide range of disorders. The awareness of this sacred medicine has grown exponentially over the past decade, attracting westerners from a wide variety of backgrounds, hoping to find treatment for a myriad of emotional and physical illnesses, as well as spiritual needs. In the wake of the commercialization and westernization of the use of ayahuasca, and the subsequent proliferation (...) of ayahuasca treatment centers, this paper examines the benefits and possible risks of this form of therapy in an effort to create a safety protocol for Westerners in this context. The most practical approach to increasing safety for Westerners attending these Amazonian treatment centers is to educate the seeker prior to treatment and to provide access to specialized therapeutic aftercare services. (shrink)

A commonly held view is that a central aim of metaphysics is to give a fundamental account of reality which refers only to the fundamental entities. But a puzzle arises. It is at least a working hypothesis for those pursuing the aim that, first, there must be fundamental entities. But, second, it also seems possible that the world has no foundation, with each entity depending on others. These two claims are inconsistent with the widely held third claim that the fundamental (...) just is the foundational. It is tempting to resolve the puzzle by rejecting the first or second claim, perhaps because it is obscure how the third claim might plausibly be challenged. But I develop a new analysis of fundamentality which challenges the third claim by allowing for an entity to be fundamental without being foundational. The analysis, roughly, is that an entity is fundamental just in case not all facts about it are grounded in facts about other entities. The possibility of fundamentality without foundations not only provides for a novel resolution to the puzzle, but has applications to some live debates: for example, it undermines Jonathan Schaffer's modal argument for priority monism. (shrink)

Interest surges in a distinctively metaphysical notion of ground. But a Schism has emerged between Orthodoxy’s view of ground as inducing a strict partial order structure on reality and Heresy’s rejection of this view. What’s at stake is the structure of reality (for proponents of ground), or even ground itself (for those who think this Schism casts doubt upon its coherence). I defend Orthodoxy against Heresy.

In the Critique of the Power of Judgment, Kant develops a rigorous formulation of aesthetic judgments, in which he makes a sharp distinction between judgments of taste and judgments of the agreeable if only to dismiss judgments of the agreeable as worthy objects of study. Kant is primarily concerned with judgments of taste, the main example of which is judging something to be beautiful. He asserts that such judgments are subjective, universal, necessary, disinterested, and do not presuppose a purpose. The (...) other type of aesthetic judgment are judgments of the agreeable, “which are the kind of judgment expressed by saying simply that one likes something or finds it pleasing.” These are judgments of what, in Kant’s words, please “the senses in sensation” as opposed to pleasing ourcognition in reflection. (shrink)

There has been much recent interest in a distinctively metaphysical kind of determinative explanation: ground. This paper concerns various skeptical challenges to ground’s relevance to metaphysics, such as that it is an empty posit, that the work it is supposed to do is appropriated by other notions, and that it is inapt for specific issues it should serve. I argue against these challenges. My strategy is both critical and constructive. Critical because I argue that versions of these challenges raised by (...) Elizabeth Barnes, Kathrin Koslicki, Mari Mikkola, and Jessica Wilson are not persuasive. Constructive because we may nevertheless learn from them new work for ground. (shrink)

There are many debates about what constitutes a utopia. Are utopias benign or dangerous? Is the idea of utopianism essential to Christianity or heretical?

A collection of 37 essays surveying the state of the art on metaphysical ground. -/- Essay authors are: Fatema Amijee, Ricki Bliss, Amanda Bryant, Margaret Cameron, Phil Corkum, Fabrice Correia, Louis deRosset, Scott Dixon, Tom Donaldson, Nina Emery, Kit Fine, Martin Glazier, Kathrin Koslicki, David Mark Kovacs, Stephan Krämer, Stephanie Leary, Stephan Leuenberger, Jon Litland, Marko Malink, Michaela McSweeney, Kevin Mulligan, Alyssa Ney, Asya Passinsky, Francesca Poggiolesi, Kevin Richardson, Stefan Roski, Noel Saenz, Benjamin Schnieder, Erica Shumener, Alexander Skiles, Olla Solomyak, (...) Tuomas Tahko, Naomi Thompson, Kelly Trogdon, Jennifer Wang, Tobias Wilsch, and Justin Zylstra. (shrink)

This paper explores the prospects of combining two views. The first view is metaphysical rationalism : all things have an explanation. The second view is metaphysical essentialism: there are real essences. The exploration is motivated by a conflict between the views. Metaphysical essentialism posits facts about essences. Metaphysical rationalism demands explanations for all facts. But facts about essences appear to resist explanation. I consider two solutions to the conflict. Exemption solutions attempt to exempt facts about essences from the demand for (...) explanation. Explanation solutions attempt to explain facts about essences. I argue that exemption solutions are less promising than explanation solutions. I then consider how explanation solutions might be developed. I suggest that a “generative” approach is most promising. I tentatively conclude that the prospects for combining metaphysical rationalism and metaphysical essentialism turn on the viability of a generative approach. This sets the agenda for defending the combination as well as the more general project of explaining essences. (shrink)

This paper raises a problem for the pair of views that universals are immanent in their instantiations and that these instantiations, or states of affairs, are somehow constructed from the instantiated universals. It is argued that the pair is inconsistent. The first view implies that universals are prior to states of affairs, whereas the second view implies that states of affairs are prior to universals. This paper does not attempt to solve this problem, but rather to formulate it precisely. That (...) promises to illuminate how to solve the problem if it can be solved, or why it cannot be solved if it is unsolvable. (shrink)

This paper concerns a distinction between circumstantial truths that hold because of the circumstances and acircumstantial truths that hold regardless of, or transcend, the circumstances. Previous discussions of the distinction tended to focus on its applications, such as to modality, logical truth, and essence. This paper focuses on developing the distinction largely, but not entirely, in abstraction from its potential applications. As such, the paper’s main contribution is to further clarify the distinction itself. An indirect contribution is to help guide (...) its future applications. (shrink)

The social world contains institutions, groups, objects, and more. This essay explores a puzzle about the essences of social items. There is widespread consensus against social essences because of problematic presuppositions often made about them. But it is argued that essence can be freed from these presuppositions and their problems. Even so, a puzzle still arises. In a Platonic spirit, essences in general seem detached from the world. In an Aristotelian spirit, social essences in particular seem embedded in the world. (...) The puzzle is that these inclinations are individually plausible but jointly incompatible. The essay has four aims: to clarify and refine the puzzle; to explore the puzzle's implications for essence in general and for social essences in particular; to illustrate the fruitfulness of the general distinction between detached and embedded; and to develop this distinction to sketch a novel solution to the puzzle. (shrink)

Is logic out of this world? This elusive question reveals a tension in our thinking about the basis of logic: both worldly and unworldly answers get something right and yet they conflict. My aim is to clarify the question and explore a conciliatory answer. I focus on a characterization of unworldliness in terms of ground. This allows for a distinction between proximal and distal unworldliness. That in turn reconfigures our approach to the question. It may now be taken as asking (...) for the proximal or the distal basis of logic. This helps alleviate the tension because the answer for the one needn’t conflict with a different answer for the other. I explore a case study culminating in an illustration of how a logical truth may indeed be proximally worldly but distally unworldly. I conclude by considering some potential extensions. (shrink)

Originally published in 1910, this book attempts to describe knowledge from the point of view of a philosophical psychology. Wodehouse treats the text as a 'psychological preface to metaphysics', and splits her examination into three sections: knowledge as resulting from judgements in the actual world; the philosophical problem of fallible knowledge; and the question of imagination and 'the variousness of reality'. This book will be of value to anyone with an interest in Wodehouse's work or in the overlap of psychology (...) and philosophy. (shrink)

This book traces the intellectual revolution initiated by Thales in the sixth century BC to its culmination in the metaphysics of Parmenides.

This book traces the intellectual revolution initiated by Thales in the sixth century BC to its culmination in the metaphysics of Parmenides.

Simon Evnine’s Making Objects and Events: A Hylomorphic Theory of Artifacts develops amorphic hylomorphism. I critically discuss three of its main themes. One theme is its attempt to do the work of form without forms. A second theme is the requirement that hylomorphs have ‘metabolisms at work’. A third theme is the use of artifacts as the paradigms for hylomorphs. I will raise some criticisms of each of these themes. Although the themes might at first appear disconnected, I believe the (...) third underwrites the first two. So the criticisms of the third theme also bear on the rest. (shrink)

It may seem strange, in view of the spate of recent literature on the subject, that yet another article should be forthcoming on what is certainly the most familiar, as well as the most vexed, of all Platonic passages. But it is precisely this spate of literature that has impelled me to write. The time seems to have come for an article which, rather than seeking desperately for something new, sets out instead to reaffirm those facts and conclusions that even (...) the most resolutely original of scholars could hardly venture to dispute. This article will therefore be based, not on any of the numerous modern interpretations, but on what Plato himself actually wrote. It will contain a number of tentative suggestions which, to the best of my knowledge, have not been made before. They can, and probably will, be rejected. But its primary purpose remains to restate, whenever possible in Plato's own words, a number of important facts that are at once so simple and so obvious that they seem repeatedly, and especially in recent years, to have been quite forgotten. (shrink)

In this paper we explore the nature of the emerging purpose ecosystem and its role in transforming and supporting business to help address the UN Sustainable Development Goals. We argue that interactions among its ‘private actors’, who share efforts and belief in changing and redefining the purpose and nature of business by advocating broader non-financial performance outcomes, have the potential to contribute to a wider sustainability-oriented transformation of the business sector. Through interview data collected in the UK and Australia, we (...) identify six main roles that characterise the activities and interactions among its actors and their stakeholders. Our research contributes to expanding knowledge on the emerging phenomenon of the purpose ecosystem and how its actors support the achievement of the UN SDGs by seeking to change the purpose of business and integrating the goals into their operations and engagements with stakeholders. (shrink)

Impostors are pseudo-problems masquerading as genuine problems. Impostors should be exposed. The problem of change appears genuine. But some, such as Hofweber ( 2009 ) and Rychter ( 2009 ), have recently denounced it as an impostor. They allege that it is mysterious how to answer the meta - problem of saying what problem it is: for even if any problem is genuinely about change per se, they argue, it is either empirical or trivially dissolved by conceptual analysis. There is (...) indeed an impostor in our midst. But it is the meta-problem of change. I defend the appearance that the problem of change is a genuine metaphysical problem about change. This vindicates philosophers’ lasting interest in it. It also illuminates what makes a problem metaphysical, how metaphysics relates to other inquiries, and how best to respond to attempts to undermine metaphysical problems. (shrink)

ObjectivesIn 2015, the Province of Quebec, Canada passed a law that allowed voluntary active euthanasia. Palliative care stakeholders in Canada have been largely opposed to euthanasia, yet there is little research about their views. The research question guiding this study was the following: How do palliative care physicians in Quebec position themselves regarding the practice of VAE in the context of the new provincial legislation?MethodsWe used interpretive description, an inductive methodology to answer research questions about clinical practice. A total of (...) 18 palliative care physicians participated in semistructured interviews at two university-affiliated hospitals in Quebec.ResultsParticipants positioned themselves in opposition to euthanasia. Their justifications were framed within their professional commitment to not hasten death, which sat in tension with the value of patients’ autonomy to choose how to die. Participants described VAE as unacceptable if it impeded opportunities to evaluate and alleviate suffering. Further, they contested government rhetoric that positioned VAE as a way to improve end-of-life care. Participants felt that VAE would diminish the potential of palliative care to relieve suffering. Dilemmas were apparent in their narratives, about reconciling respect for patient autonomy with broader palliative care values, and the value of accompanying and not abandoning patients who make requests for VAE while being committed to neither prolonging nor hastening death.ConclusionsThis study provides insight into nuanced positions of experienced palliative care physicians in Quebec and confirms expected tensions between an important stakeholder and the practice of VAE as guided by the new legislation. (shrink)

This book is an anthology of Plato's writings, connected with sections of commentary.

The conception of “prospective potency” was defined by its author H.Driesch as “the sum of the possible modes of development of a given part of the embryo”. However, in the language of science the word “potency” usually means “power”, not “possibility”. Therefore this conception from the beginning possessed a certain ambiguity, that it retained up to the present. The distinction of “active” and “passive” potency, introduced by Roux, has found no general acceptance. It appeared necessary to submit the conception of (...) “potency” to a profound analysis. In the first place it is shown, that the ambiguity of this conception vanishes, if we understand by the word “potency” those fundamental properties of the embryonic material, that are responsible for its various developmental possibilities. We can distinguish among these properties the “reactive powers”, by which the embryonic material reacts to inductive stimulations, and its own “developmental tendencies”. These faculties only differ by their strength; a “reactive power” may change into a “tendency”, when its intensity increases during development; conversely, a “tendency” may change into a mere “reactive power” by a decrease of its strength. The determination of the material results from the conflict of its tendencies. The inductive actions interfere by strengthening or weakening different tendencies, and by activating new tendencies by reinforcement of the “reactive powers” of the embryonic material. (shrink)

The conception of “prospective potency” was defined by its author H.Driesch as “the sum of the possible modes of development of a given part of the embryo”. However, in the language of science the word “potency” usually means “power”, not “possibility”. Therefore this conception from the beginning possessed a certain ambiguity, that it retained up to the present. The distinction of “active” and “passive” potency, introduced by Roux, has found no general acceptance. It appeared necessary to submit the conception of (...) “potency” to a profound analysis. In the first place it is shown, that the ambiguity of this conception vanishes, if we understand by the word “potency” those fundamental properties of the embryonic material, that are responsible for its various developmental possibilities. We can distinguish among these properties the “reactive powers”, by which the embryonic material reacts to inductive stimulations, and its own “developmental tendencies”. These faculties only differ by their strength; a “reactive power” may change into a “tendency”, when its intensity increases during development; conversely, a “tendency” may change into a mere “reactive power” by a decrease of its strength. The determination of the material results from the conflict of its tendencies. The inductive actions interfere by strengthening or weakening different tendencies, and by activating new tendencies by reinforcement of the “reactive powers” of the embryonic material.La conception de „prospektive Potenz” fut définie par son auteur H.Driesch comme „l'ensemble des modes de développement possibles d'une certaine partie de l'embryon”. Cependant, le, mot „Potenz” dans le langage de la science répond plutôt à la „puissance” qu'à la „possibilité”. De là résulte, que cette conception dès son origine avait une certaine ambiguïté, qui se fait sentir jusqu'à présent. La distinction entre „potentialité active” et „potentialité passive”, proposée par Roux, n'est pas acceptée généralement. Il se trouvait nécessaire, que la conception de „Potenz” fût soumise à une. analyse profonde. D'abord il est démontré, que l'ambiguïté de cette conception disparaît, si on entend par le mot „Potenz” les propriétés fondamentales du matériel embryonnaire, qui sont à la base de ses diverses possibilités de développement. On peut distinguer parmi ces propriétés les „pouvoirs réactifs”, en vertu desquels le matériel embryonnaire répond à des inductions morphogénétiques, et les „tendances propres” du matériel. Ils ne diffèrent que par leur intensité; un „pouvoir réactif” peut se changer en „tendance” par suite d'un renforcement au cours du développement, une „tendance” peut se changer en „pouvoir réactif” par une diminution d'intensité. La détermination du matériel se réalise par une „lutte” entre les tendances. Les actions inductives influent sur cette lutte en renforçant ou en diminuant l'intensité des diverses tendances, et en activant de nouvelles tendances par le renforcement de „pouvoirs réactifs”. (shrink)

A state's foreign policy is constrained by parameters that inhere in the structure of the international system and in the nation's own political‐constitutional, social, and economic systems. The latter, domestic parameters, include “public opinion.” Because the public is largely ignorant of foreign affairs, policy‐making elites have wide scope for acting more rationally than would otherwise be possible, although public opinion operates on the second‐order effects of foreign policy (e.g., taxes, casualties)—inviting mismatches of objectives and means. The prevalent nonrational theories of (...) foreign‐policy derivation are themselves largely ignorant of the dominantly rational processes of the state, particularly in its foreign and military functions. (shrink)

In a well-known quotation from Speusippus in the Theologumena Arithmeticae , said to have been derived from Pythagorean sources, especially Philolaus, occur the following sentences: And again a little later: Similarly Sextus Empiricus , drawing evidently on a relatively early Pythagorean source, writes as follows: And Aristotle himself writes of the Pythagoreans : There were, in fact, certain Pythagoreans who equated the number 2 with the line because they regarded the line as ‘length without breadth extended between two points’; and (...) likewise the number 3 was equated with the plane and 4 with the solid. (shrink)

The complete sequencing of the genome of the fruit fly Drosophila melanogaster offers the prospect of detailed functional analysis of the extensive gene families in this genetic model organism. Comprehensive functional analysis of family members is facilitated by access to a robust, stable and inducible expression system in a fly cell line. Here we show how the Schneider S2 cell line, derived from the Drosophila embryo, provides such an expression system, with the bonus that radioligand binding studies, second messenger assays, (...) ion imaging, patch‐clamp electrophysiology and gene silencing can readily be applied. Drosophila is also ideal for the study of new control strategies for insect pests since the receptors and ion channels that many new animal health drugs and crop protection chemicals target can be expressed in this cell line. In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines. BioEssays 24:1066–1073, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)