The concept of locally specialized functions dominates research on higher brain function and its disorders. Locally specialized functions must be complemented by processes that coordinate those functions, however, and impairment of coordinating processes may be central to some psychotic conditions. Evidence for processes that coordinate activity is provided by neurobiological and psychological studies of contextual disambiguation and dynamic grouping. Mechanisms by which this important class of cognitive functions could be achieved include those long-range connections within and between cortical regions that (...) activate synaptic channels via NMDA-receptors, and which control gain through their voltage-dependent mode of operation. An impairment of these mechanisms is central to PCP-psychosis, and the cognitive capabilities that they could provide are impaired in some forms of schizophrenia. We conclude that impaired cognitive coordination due to reduced ion flow through NMDA-channels is involved in schizophrenia, and we suggest that it may also be involved in other disorders. This perspective suggests several ways in which further research could enhance our understanding of cognitive coordination, its neural basis, and its relevance to psychopathology. Key Words: attention; cerebral cortex; cognitive coordination; cognitive neuropsychiatry; cognitive neuropsychology; context disorganization; Gamma rhythms; Gestalt theory; glutamate; grouping; memory; NMDA-receptors; PCP-psychosis; perceptual organization; schizophrenia. (shrink)

Studies of aging and autism as outlined by Bertone, Mottron, & Faubert (Bertone et al.) and by Faubert & Bertone suggest that disorders of cognitive coordination involving impairments of dynamic gestalt grouping and context-sensitivity may be common to several different disorders. We agree that such studies may shed light on these processes and their neuronal bases. However, we also emphasize that dynamic grouping and context-sensitivity can fail in various ways, and that, although the underlying pathophysiology may often involve NMDA-receptor malfunction, (...) many different malfunctions are possible, and each of these may result from any one of a number of different etiologies. (shrink)

This article addresses key concepts pertaining to Adab on the one hand and Abbasid administrative practices on the other, by focusing on an unpublished work that straddles both themes. It is shown that Arabic works on both Adab and bureaucracy are difficult to isolate and categorise conclusively as both genres were receptive to diverse flavourings, be they of an ornamental nr of a strictly practical nature. Although the article adopts a comparative approach to these issues, detailed attention is paid to (...) the character of the particular work under discussion and its author. (shrink)

This article assesses the importance of the biblical book of Daniel in the first four Islamic centuries, focusing in particular on the legendary materials contained in Daniel 1–6. The article is divided into three sections. In the first section the treatments of Daniel 1–6 in Isrāʾīliyyāt works are examined, and it is shown that summaries of Daniel 1–6 in these works display evidence of oral transmission. Additionally, it is shown that some authors’ familiarity with Daniel legends led them to insert (...) this character into “biblical” narratives that do not otherwise relate to him. In the second section it is argued that Daniel’s exploits were so widely known that they served as a sort of yardstick for judging the relative importance of some other “heroic” figures who are described in classical Islamic sources. In the third section it is postulated that the introductory sections of Ibn Hishām’s Sīra consciously relate stories with Danielic associations in order to bring the Sīra into line with the Christian Gospels. (shrink)

This commentary challenges the argument that the diathesis for hallucinations is equivalent to that for schizophrenia. Evidence against this comes from data on the prevalence of hallucinations in schizophrenia, their nonspecificity, and their relationships with moderating variables. We also highlight, however, the manner in which the Behrendt & Young (B&Y) hypothesis extends recent neuroscientific theories of schizophrenia, and its potential treatment applications.

Reductive metaethical views have ethical implications that are frequently inconsistent with our settled ethical intuitions and favored ethical theories. This makes theory choice in metaethics difficult. When we are assessing reductive views, what sort of weight should we accord to their counterintuitive ethical implications? How should we weigh intensional adequacy and explanatory power against apparent extensional inadequacy? I argue that we currently assign too much weight to extensional worries in our metaethical theorizing: We should be willing to tolerate even a (...) great many counterintuitive ethical implications for the sake of a compelling explanation of our ethical practices. Especially when it comes to theorizing about reasons for action, extensional worries should take a back seat to intensional adequacy and explanatory power. My case for this claim beings with a familiar story about the origins of our moral concepts drawn from the work of G. E. M. Anscombe and Alisdair MacIntyre and proceeds via an observation about the nature of practical reasoning. (shrink)

Over the past decade, Convergence Research has increasingly gained prominence as a research, development, and innovation (RDI) strategy to address grand societal challenges. However, a dearth of research-based evidence is available to aid researchers, research teams, and institutions with navigating the complexities attendant to the specifics of Convergence Research. This paper presents a multilevel research agenda that accounts for an integral understanding of Convergence Research as a complex adaptive system. Furthermore, by developing a framework that accounts for ancillary, yet essential, (...) systems associated with Convergence Research, we enrich the agenda with a literature-steeped discussion that considers how systems-based practices of collaboration, inquiry, and context interact with the processes and products of Convergence Research. Finally, we synthesize and apply insights from the reviewed literature by providing paths for empirical exploration emphasizing systems-based practices. In so doing, we delineate an extended boundary for a research stream that both clarifies and enlarges our understanding of Convergence Research as a ‘system-of-systems’. (shrink)

Health disparities education is an integral and required part of medical professional training, and yet existing curricula often fail to effectively denaturalize injustice or empower learners to advocate for change. We discuss a novel collaborative intervention that weds the health humanities to the field of health equity. We draw from the health humanities an intentional focus retraining provider imaginations by centering patient narratives; from the field of health equity, we draw the linkage between stigmatized social identities and health disparities. We (...) describe a longitudinal health equity curriculum for the Hospice and Palliative Medicine fellowship in Memphis, Tennessee, to give trainees exposure to the concept of structural violence and how it affects clinical care. The curriculum was developed in partnership with humanities and social sciences faculty who staff a Health Equity academic program at a small liberal arts college in Memphis. This curriculum has been implemented for the past four years in support of 22 hospice and palliative medicine fellows. Group debriefs and a mixed methods survey have revealed widespread and lasting impact towards understanding health equity concepts, enhanced communication and treatment of patients, and empowerment to address the broader needs and policies affecting patients and the communities in which they live. Ultimately, we model an educational initiative that integrates equity across the full scope of healthcare practice and equips learners with skills for sustaining compassionate practices, focusing on equity-oriented, person-centered care across the full scope of healthcare practice. (shrink)

Throughout his career, the problems that attracted Louis Pasteur almost invariably involved considerations of specificity of structure and/or of action. Thus, his work on asymmetric crystals showed that chemical form not only specifies crystalline structure, but affects the affinity of ferments as well. In his studies of diseases of silkworms, of beer, and of wine, he could unerringly distinguish with the microscope the specific agents of disease. From this emerged his concept of the specificity of species and against the nonspecificity (...) of spontaneous generation, whence the germ theory of disease. It was in the new field of immunology, however, where the manifestations of an exquisite specificity were most clearly seen. Here, Pasteur's vaccines worked because he chose the specific pathogen in order to induce a specific immunity, and he succeeded each time. But the two most prominent Pastorian successors in immunology, Elie Metchnikoff and Jules Bordet, were not equally successful. Although each contributed significantly to the birth of immunology, each advanced a theory that neglected the principle of specificity and paid a price in consequence. Metchnikoff's phagocytic theory of immunity could not survive the demonstrable specificity of humoral antibodies, while Bordet's physical adsorptive concept of the antibody-cell interaction quickly fell to Paul Ehrlich's demonstration of the stereochemical determination of immunological specificity. (shrink)

Teachers face significant stressors in relation to their work, placing them at increased risk for burnout and attrition. The COVID-19 pandemic has brought about additional challenges, resulting in an even greater burden. Thus, strategies for reducing stress that can be delivered virtually are likely to benefit this population. Mental and Physical Training combines meditation with aerobic exercise and has resulted in positive mental and physical health outcomes in both clinical and subclinical populations. The aim of this pilot study was to (...) evaluate the feasibility and potential effectiveness of virtual MAP Training on reducing stress and improving mood and well-being in teachers. Participants were from recruited online from kindergarten to grade twelve schools in the Northeastern region of the United States and randomly assigned to a 6-week program of virtual MAP Training or no training. Primary outcomes included pre-intervention and post-intervention ratings on self-report measures of social and emotional health. Changes in cognitive functioning and physical health were also examined in secondary analyses. By intervention end, participants in the MAP Training group reported less anxiety and work-related stress compared to those who received no training. Additionally, MAP Training participants reported improvements in depressive symptoms, rumination, work-related quality of life, perceived stress, and self-compassion, whereas no changes were observed in the no training group. Participants also reported increased subjective ratings of executive functioning, working memory, cognitive flexibility, and fewer sleep disturbances. Together, these results suggest that the combination of meditation and aerobic exercise is an effective virtual intervention for improving mental health and well-being among K-12 teachers and may enhance resilience to stressful life events such as occurred during the coronavirus pandemic. (shrink)

This current study is a pilot project designed to clarify changes in the lived world among people with diagnoses within the schizophrenia spectrum. The Examination of Anomalous World Experience was used to interview ten participants with schizophrenia spectrum disorders and a comparison group of three participants with major depressive disorder. Interviews were analyzed using the descriptive phenomenological method. This analysis revealed two complementary forms of experience unique toszparticipants: Destabilization, the experience that reality and the intersubjective world are less comprehensible, less (...) stable, and generally less real; and Subjectivization, the dominance of one’s internal, subjective experiences in the perception or interpretation of the lived world. Persons with depressive disorders, by contrast, did not experience disruptions of the reality or independence of the world or any significant disruptions of appearance or meaning. These results are consistent with contemporary and classic phenomenological views on anomalous world experience in schizophrenia. (shrink)

Many philosophers believe that Robert Nozick's experience machine argument poses an insurmountable obstacle to hedonism as a theory of well-being. After an initial attempt to demonstrate that the persuasiveness of this argument rests on a key ambiguity, I argue that the intuitions to which the thought experiment appeals are not nearly as clear as many philosophers suppose they are. I believe that a careful consideration of the origin of those intuitions -- especially in light of the so-called "paradox of hedonism" (...) -- reveals that they can, in fact, fit quite comfortably into a hedonistic theory of well-being. (shrink)

Reasons are considerations that figure in sound reasoning. This is considered by many philosophers to be little more than a platitude. I argue that it actually has surprising and far-reaching metanormative implications. The view that reasons are linked to sound reasoning seems platitudinous only because we tend to assume that soundness is a normative property, in which case the view merely relates one normative phenomenon (reasons) to another (soundness). I argue that soundness is also a descriptive phenomenon, one we can (...) pick out with purely descriptive terms, and that the connection between normative reasons and sound reasoning therefore provides the basis for a reductive account of reasons. Like all proposed reductions, this one must confront some version of G. E. Moore’s open question argument. I argue that a reductive view rooted in the idea that reasons figure in sound reasoning is well-equipped to meet the open question challenge head on. (shrink)

Constitutivists seek to locate the metaphysical foundations of ethics in nonnormative facts about what is constitutive of agency. For most constitutivists, this involves grounding authoritative norms in the teleological structure of agency. Despite a recent surge in interest, the philosophical move at the heart of this sort of constitutivism remains underdeveloped. Some constitutivists—Foot, Thomson, and Korsgaard (at least in her recent *Self-Constitution*)—adopt a broadly Aristotelian approach. They claim that the functional nature of agency grounds normative judgments about agents in much (...) the same way that the functional natures of artifacts and bodily organs ground normative judgments about those kinds of things. I argue that the neo-Aristotelian conclusions about goodness which follow so straightforwardly from teleological premises are not genuinely normative. Functions are not by their very nature normatively significant. Other constitutivists—notably J. David Velleman and Paul Katsafanas—eschew Aristotelian talk of functions in favor of an approach based on the idea that agency has a constitutive aim. Velleman and Katsafanas both claim that aims are normatively significant. I argue that the fact that agency has a constitutive aim is merely a fact about the motives that produce and regulate actions. And so we are still left with a gap between the teleological and the normative. I conclude by suggesting that constitutivists have failed to find a way to bridge this gap not because none exists, but rather because they have been looking in the wrong place. The constitutivist project can be salvaged, but only if it is supplemented with a reductive metanormative account of reasons for action, an account that links reasons to sound or successful practical reasoning. (shrink)

Phillips & Singer's compelling presentation is weakest in its demonstration of commonalities between sensory plasticity and higher forms of learning and behavior. We propose that available data on schizophrenia can provide such evidence, because of the presence of impairments in a number of functions central to their model, and strong relationships between these dysfunctions and behavior.

A treasured classic on character refinement. This is a newly researched, corrected, annotated and vowelized Hebrew edition with a contemporary English translation. Discusses refining character traits and maintaining a balance in all matters.

When we make ethical claims, we invoke a kind of objective authority. A familiar worry about our ethical practices is that this invocation of authority involves a mistake. This worry was perhaps best captured by John Mackie, who argued that the fabric of the world contains nothing so queer as objective authority and thus that all our ethical claims are false. Kantians such as Christine Korsgaard and David Velleman offer accounts of the objectivity of ethics that do without the controversial (...) realist assumptions which gives rise to Mackie’s skepticism. They contend that our ethical claims correctly invoke objective authority not by corresponding to some normative pocket of the fabric of reality, but rather by expressing commitments that are inescapable. This Kantian strategy is often advertised as an alternative to traditional but “boring” metaethics. Its proponents promise to vindicate our ethical practices without entangling us in familiar metanormative disputes about the metaphysics, epistemology and semantics of ethics. In this paper, I argue that the Kantian strategy cannot make good on this promise. Considered as an attempt to sidestep traditional metaethics, it lacks the resources to produce the desired normative conclusions. The outlook for the Kantian strategy becomes more promising, though, if we pair it with one of two familiar metanormative theories: expressivism or reductionism. The resulting metaethically-loaded versions of the Kantian strategy can deliver the promised conclusions, but only by plunging straight into the quagmire of traditional metaethics. And there all of the familiar objections to expressivism and reductionism await. (shrink)

We are agents: we can deliberate about what to do, and then act on the basis of that deliberation. We are also capable of normative self-governance: we can identify and respond to reasons as reasons. Many theorists believe that these two capacities are intimately connected. On the basis of this connection they conclude that practical reasoning must be carried out under the guise of a justification. This paper explores two strategies for avoiding that conclusion. The first, which just denies the (...) connection between agency and normative self-governance, is rejected as too costly, since it leaves the normative significance of agency unexplained. The second, which suggests that we can respond to a consideration as a reason without representing it as a reason, seems more promising, but it requires a reductive account of reasons for action. The upshot is that metaethics and action theory are entwined in ways that few have recognized. (shrink)

This chapter begins with a discussion of the “Epicurean view” — the view stating that death cannot intelligibly be regarded as an evil for the person who dies because the alleged evil lacks a subject or “recipient.” An argument is then presented in opposition to this view that possesses two key components. The first is an account of the “Values Connect with Feelings” requirement, according to which the connection need not be actual, but merely possible and that the requirement is (...) satisfied provided that the relevant object, state, or event is a possible object, even if it is not a possible cause, of the relevant feelings. The second key component is the employment of a four-dimensional framework that makes it possible to claim that temporally distant events or states, like spatially distant events, exist, and thus are possible objects of relevant feelings. (shrink)

Cleopatra VII, the last of the Ptolemaic rulers of Egypt, reveled in perfume (Plutarch, Life of Marcus Antonius 26.2). She even used it in her seduction of the Roman general Marc Antony. Sailing up the river Cydnus to meet him, she reclined in a canopy spangled with gold, adorned like Venus in a painting. Boys dressed as cupids fanned her and wondrous scents from incense offerings wafted along the riverbanks. Not long after her death in August 30 BCE, a book (...) circulated under her name called Cleopatra’s Cosmetic, full of recipes for fragrant oils and cleansers (Totelin 2017: 114–18). (shrink)

We applaud Shen et al. (2024) for offering a framework to address how to return research results from digital phenotyping within the discipline of psychiatry. However, given the value-laden nature...

The 21st Century has seen a dramatic increase in the number of books published on practical halakha. As a result, Halakhic observance has never been more accessible. But how does increased commitment to halakhic detail accomplish its goal of personal and ethical refinement? Halakhic practices are meant to be spiritual entry points for divine encounters. Commitment to Jewish ritual should mold one's character and help facilitate a life guided by divine ideals. In fact, adherence to Jewish law without a parallel (...) understanding of the meaning behind the law runs the risk of transforming halakha into a formulaic set of rules without any larger spiritual vision. Jewish Law as a Journey is a valuable companion to published works of practical halakha. It explores virtues and ideals foundational to daily halakhic practice. Moreover, it offers a systematic exploration of the mitzvot one encounters in a given day and the transformative religious messages that underlie them"--front flap. (shrink)

…behind the diversity of discoveries [in molecular biology] moved a unity, a constant direction of change, the development of the concept of biological specificity.In his landmark book Evolution by Gene Duplication, geneticist Susumu Ohno pointed out that whereas most evolutionary developments represent adjustments to past challenges and mutations, two unique systems had evolved to deal with future challenges: the immune response and neural memory functions. He named these two evolutionary modes after the Titan brothers of Greek mythology: “standard” evolutionary developments (...) were named for rearward-looking Epimetheus, and “anticipatory” evolutionary mechanisms for foresighted Prometheus (Ohno 1976; Ohno et.. (shrink)

The average person makes hundreds of decisions each day. They range from the ordinary and mundane to life altering events. May decisions we are faced with have little effect of our lives. They deal with simple problems and require simple choices. However, there are those decisions which impact our lives and the lives of those around us in very significant and consequential ways."--Back cover.

Since the advent of the women's movement, women have made unprecedented gains in almost every field, from politics to the professions. Paradoxically, doctors and mental health professionals have also seen a staggering increase in the numbers of young women suffering from an epidemic of depression, eating disorders, and other physical and psychological problems. In The Cost of Competence, authors Brett Silverstein and Deborah Perlick argue that rather than simply labeling individual women as, say, anorexic or depressed, it is time (...) to look harder at the widespread prejudices within our society and child-rearing practices that lead thousands of young women to equate thinness with competence and success, and femininity with failure. They argue that continuing to treat depression, anxiety, anorexia and bulimia as separate disorders in young women can, in many cases, be a misguided approach since they are really part of a single syndrome. Furthermore, their fascinating research into the lives of forty prominent women from Elizabeth I to Eleanor Roosevelt show that these symptoms have been disrupting the lives of bright, ambitious women not for decades, but for centuries. Drawing on all the latest findings, rare historical research, cross-cultural comparisons, and their own study of over 2,000 contemporary women attending high schools and colleges, the authors present powerful new evidence to support the existence of a syndrome they call anxious somatic depression. Their investigation shows that the first symptoms usually surface in adolescence, most often in young women who aspire to excel academically and professionally. Many of the affected women grew up feeling that their parents valued sons over daughters. They identified intellectually with their successful fathers, not with their traditional homemaker mothers. Disordered eating is one way of rejecting the feminine bodies they perceive as barriers to achievement and recognition. Silverstein and Perlick uncover medical descriptions matching their diagnosis in Hippocratic texts from the fourth century B.C., in anthropological studies of Africa, Asia, and Latin America, and in case studies of many noted psychologists and psychiatrists, including the "hysteric" patients Freud used to develop his theories on psychoanalysis. They have also discovered that statistics on disordered eating, depression, and a host of other symptoms soared in eras in which women's opportunities grew--particularly the 1920s, when record numbers of women entered college and the workforce, the boyish silhouette of the flapper became the feminine ideal, and anorexia became epidemic, and again from the 1970s to the present day. The authors show that identifying this devastating syndrome is a first step toward its prevention and cure. The Cost of Competence presents an urgent message to parents, educators, policymakers, and the medical community on the crucial importance of providing young women with equal opportunity, and equal respect. (shrink)

In order to create a truly meaningful life, we must first accept that the problem is never other people. "The real problem," Sam Silverstein maintains, "is what we believe about other people." Silverstein's new book shows why everything we have been taught about accountability is wrong. Contrary to popular belief, accountability is not a way of doing. Accountability is a way of thinking. It is how we think about ourselves and others. And it is the highest form of (...) leadership. The secret to creating accountable relationships, and elevating the personal benchmark that Silverstein calls the The Accountability Index, lies in making ten critical choices that support an accountable mindset. I Am Accountable offers a comprehensive plan to help you establish and leverage that mindset, deepen commitments, create lasting meaning in your life and relationships, transform the culture within your organization, and foster positive change in the larger community. (shrink)

My dissertation explores the foundations of ethics—the question of whether and where practical justification comes to an end. What reason do we have to be moral? Is the fact that something is pleasurable at least a defeasible reason to pursue it, and if so, why? I argue that the only way to answer such questions is to look at what is constitutive of action. Nonnormative facts about the nature of agency can ground the normative authority of reasons for action. Recently, (...) an influential group of externalists about reasons for action have argued that normativity is sui generis and cannot be further explained. Recently, too, many of the most prominent internalists to offer an explanation of normative force have merely assimilated the problem to one about motivational force. I argue that neither position is satisfactory. We need answers to our practical questions, and externalism has none to offer beyond brute intuitions. A purely motivational internalism, on the other hand, seems to fall well short of a normative theory. Appeals to facts about motivation do not answer the question of what we have reason to do; they bypass it in favor of the question of what we are going to do. Fortunately, there is a middle way that combines the best of both views: constitutivism. An account of practical normativity based on action’s constitutive aim can explain both how we are governed or moved by reasons and how those reasons have genuine, objective authority. The constitutive aim of action sets the agenda for practical reasoning, and considerations that engage this aim are the ones that bring such reasoning to a close. They settle the practical question of what to do. But if, as I maintain, the normative question of what I ought to do (or what I have reason to do) seeks considerations that bear on the practical question of what to do, then answers to the latter are ipso facto answers to the former. In this way, nonnormative facts about what closes practical deliberation can ground fully normative facts about what we have reason to do. (shrink)

A number of philosophers have accepted the thesis that reasons for action are 'universalizable' in the sense that every such reason commits one to a universal prescription or practical judgment. The purpose of the present paper is to refute this thesis. The author presents and defends counterexamples to both strong and weak versions of the thesis, And shows that the thesis can be given up without denying the general contention that 'reason'-Statements imply universals.

This is a review article of Gog and Magog in Early Christian and Islamic Sources: Sallam’s Quest for Alexander’s Wall. By Emeri van Donzel and Andrea Schmidt. Brill’s Inner Asian Library, vol. 22. Leiden: Brill, 2010. Pp. xx + 271. $147; and Mapping Frontiers across Medieval Islam: Geography, Translation and the ‘Abbāsid Empire. By Travis Zadeh. Library of Middle East History, vol. 27. London: i. B. tauris, 2011. Pp. xiv + 316. £59.50, $99.

Reviews the book, Behavior and mind: The roots of modern psychology by Howard Rachlin . There is an important story about causality in psychology that needs to be told. It is a story which was once well told and widely understood during the Hellenic era, but a number of influential forces in our culture have conspired since then to sweep this story into a dark corner of our intellectual warehouse. In recent centuries, this story has been retrieved from its corner (...) only rarely, and then it has been interpreted in a manner both unnatural to its originators and uncongenial to modern scientists. Authentic reconstructions of this story regarding causes and their effects began to re-emerge in the second half of the twentieth century among biologists and physicists, but it is still rarely heard in psychology. Rachlin's new book, however, tells this story as one of the central themes of the narrative. For this, if for no other reason, this is a book that should be read and carefully considered by all psychologists. The story alluded to is generally called "teleology," and it received its first full treatment by Aristotle in the fourth century before the Christian era. Rachlin delineates these origins, traces them carefully to the present day and develops a persuasive argument for the value and significance of this story for any complete psychological science. 2012 APA, all rights reserved). (shrink)

“Best interests of the child” is a key concept in international law, developed by and through institutions which maintain a stake in international solidarity. This article explores the quality of that solidarity, working to understand the modes of interrelationship between peoples and institutions which it instantiates, and which it could possibly be imagined to instantiate. Focusing on one context—the way that “best interests of the child” has developed within international politics and domestic Australian politics, through an examination of the discourses (...) produced by policy-makers working within child refugee and asylum-seeker realms—this article examines the ways that this concept has relied on, and produced, racialized hierarchical ideas of what “best interests” entails. Looking through a history of Australian settler-colonial governmentality, this article explores the tensions between discourses of security and discourses of “best interests of the child,” historicizing the figure of the refugee child and reimagining the relationships of dependency and solidarity which could be produced. (shrink)