Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

Conventionally, technologies are seen as rigid, immutable; social systems as malleable. Constructivist theories of technology, such as actor network theory, have corrected that view. Technologies are flexible, reinterpretable. Often that flexibility is alleged to explain their success in transforming social systems. This article presents the story of PREOP—a flexible technology that met with an immutable social system and failed to become what was expected of it. The article contrasts two interpretations of the story, an actor network version and a labor (...) process version. Drawing on elements of the labor process version, the author suggests that preexisting networks be brought more into focus in actor network analyses, that the role of conflict in networks be acknowledged, and that flexibility be examined in more detail. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

An argument, Based on the continuity of the gestation process, Which purports to show that the fetus is, From the moment of conception, A bearer of rights, Is criticized. The criticism is then located within a strategy for the defense of abortion.

We began by…implying a comparison between Duchamp and the swindlers; we lately find ourselves . . . implying a comparison between Duchamp and the child. I believe that in the end both comparisons are essential to a thorough understanding of Duchamp's significance; it is also, however, essential that each comparison temper and qualify the other. The swindlers begin and end as aliens to the community on which they practice their art. Duchamp is as much inside the artworld as is the (...) child inside his community. On the other hand, Duchamp is not disenfranchised, as is the child, though, like the child, he is innocent of certain illusions typical of full enfranchisement. Like the swindlers, and unlike the child, Duchamp is full of guile. He pointedly produces something ambiguous, something which supports diametrically opposed readings, depending on where one's bets are placed. One of the readings amounts to a critique of the other reading as a hoax. But unlike the swindle, whose effectiveness depends on the degree to which the critique remains hidden and the hoax enjoys full rein, Duchamp's gesture is effective, as is the child's unambiguous announcement, to the degree that the critique embarrasses the hoax. It seems, then, that Duchamp embodies some rare and interesting combination of guile and innocence which the fable keeps apart by dividing them between agents whose activities are at cross-purposes. The limitation of the fable as an analogy is that it provides no model for the combination. The fable contains the figures of the swindler, of the gullible mark, and of the observer so innocent as to be incapable of duplicity. What we are confronted with in Duchamp is the figure of the wise guy.Joel Rudinow, a conceptual artist, created a multimedia satire entitled Higher Learnin'; or, The Song and Dance of Socrates: In Which the Love of Wisdom Leads to the Discovery that the Unlived Life is Not Worth Examining. (shrink)

What rational foundation underlies argument-critical judgements? What are the canons of argument criticism and how are they to be "justified"? This paper explores an analogy between art- and argument-criticism and argues that the analogy promises not only to illuminate the nature of argument criticism and capture the central goals of instruction in informal logic, but also to resolve fundamental problems at the foundations of normative theory of argument concerning the "justification" of standards of reasoning.

This chapter contains sections titled: Notes.

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

Providing an original and systematic treatment of foundational issues in philosophy of religion, J. L. Schellenberg's new book addresses the structure of..

According to realist structuralism, mathematical objects are places in abstract structures. We argue that in spite of its many attractions, realist structuralism must be rejected. For, first, mathematical structures typically contain intra-structurally indiscernible places. Second, any account of place-identity available to the realist structuralist entails that intra-structurally indiscernible places are identical. Since for her mathematical singular terms denote places in structures, she would have to say, for example, that 1 = − 1 in the group (Z, +). We call this (...) the identity problem and conclude that nominalism is presently the safest route for the structuralist. (shrink)

Ned Block argues that the higher-order (HO) approach to explaining consciousness is ‘defunct’ because a prominent objection (the ‘misrepresentation objection’) exposes the view as ‘incoherent’. What’s more, a response to this objection that I’ve offered elsewhere (Weisberg 2010) fails because it ‘amounts to abusing the notion of what-it’s-like-ness’ (xxx).1 In this response, I wish to plead guilty as charged. Indeed, I will continue herein to abuse Block’s notion of what-it’s-like-ness. After doing so, I will argue that the HO approach accounts (...) for the sense of what-it’s-like-ness that matters in a theory of consciousness. I will also argue that the only incoherence present in the HO theory is that generated by embracing Block’s controversial notion of what-it’s-like-ness, something no theorist of any stripe ought to do. Block is famous for (among other things) having introduced the notion of ‘phenomenal consciousness’ into contemporary philosophy of mind (Block 1995). This term is widely employed in the philosophical literature and it even appears in the empirical literature. But wide-speared usage has brought about divergent interpretations of the term. We can distinguish a ‘moderate’ and a ‘zealous’ reading of ‘phenomenal consciousness’. On the moderate reading, ‘phenomenal consciousness’ just means ‘experience’. Many people have embraced this sense of the term and use it to roughly pick out conscious experience involving sensory quality (states like conscious visual experiences or conscious pains, for example).2 On the zealous reading, however, phenomenal consciousness is held to be ‘distinct from any cognitive, intentional, or functional property’ (Block 1995: 234). That is, any explanation of phenomenal consciousness in exclusively cognitive, intentional, or functional terms will fail to capture, without remainder, what is really distinctive about phenomenal consciousness. Block, of course, is fully clear about embracing the zealous reading; indeed, his initial introduction of the notion is in those terms. The same ambiguity occurs with the much-used (and abused) idea of ‘what-it’s-like-ness’.. (shrink)

Scientists and laypeople alike use the sense of understanding that an explanation conveys as a cue to good or correct explanation. Although the occurrence of this sense or feeling of understanding is neither necessary nor sufficient for good explanation, it does drive judgments of the plausibility and, ultimately, the acceptability, of an explanation. This paper presents evidence that the sense of understanding is in part the routine consequence of two well-documented biases in cognitive psychology: overconfidence and hindsight. In light of (...) the prevalence of counterfeit understanding in the history of science, I argue that many forms of cognitive achievement do not involve a sense of understanding, and that only the truth or accuracy of an explanation make the sense of understanding a valid cue to genuine understanding. (shrink)

The purpose of this text is to draw attention to eight forgotten heroes: William C. Bagley, Charles DeGarmo, David Felmley, William Torrey Harris, Isaac L. Kandel, Charles McMurry, William C. Ruediger, and Edward Austin Sheldon. They have been marginalized from our profession, and drawing upon their legacy is the best hope for restoring the profession of teaching today. This work also includes a chapter at the end of the book entitled "John Dewey's Forgotten Essays." The audience for this book includes: (...) 1) classroom teachers, 2) school administrators, 3) teacher educators, 4) deans and other university administrators, 5) college and university presidents, 6) legislators, 7) historians of education, 8) curriculum specialists, 9) specialists in teacher training, and 10) the general public. (shrink)