The Somatic Mutation Theory has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis. However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting differences regarding the philosophical, methodological and experimental approaches on which they respectively rely. We conclude that SMT has not explained carcinogenesis due to severe epistemological and (...) empirical shortcomings, while TOFT is gaining momentum. The main issue is actually to submit SMT to rigorous testing. This concern includes the imperatives to seek evidence for disproving one’s hypothesis, and to consider the whole, and not just selective evidence. (shrink)

This paper analyzes how national institutions impact corporate social responsibility practices for small- and medium-sized enterprises in the food-processing industries of France and Morocco. In this study, CSR practices are defined around two main dimensions: corporate performance and the CSR approach. Qualitative data were collected during semi-structured interviews with SME managers in charge of CSR issues. We then performed a content analysis. Our study shows that there is a distinct difference between the CSR practices adopted by SMEs in France and (...) Morocco. Indeed, the findings suggest that under the rule-based governance system of France, most SMEs view CSR as an economic tool and it is adopted as an opportunity-seeking perspective anchored in the search for global performance. The findings also show that under the relationship-based governance system of Morocco, SMEs mainly see CSR from a constraint-reducing perspective. However, some Moroccan SMEs have begun to see the economic opportunities of CSR, especially in accessing foreign markets. (shrink)

Developments in fields as diverse as biotechnology, animal cognition, and computer science have cast serious doubt on the common belief that human beings are unique and that only they should have dignity and basic rights. A movement referred to as ‘new dignitarianism’ has recently reclaimed human dignity to fend off the threats to human uniqueness that it perceives to arise from these developments. This ‘new’ dignitarianism, however, is not new at all. Drawing on a debate between two Enlightenment philosophers, this (...) article shows that dignitarianism has already surfaced in the eighteenth century as the negative image of another movement: naturalism. Building on this historical account, I propose to understand dignitarianism and naturalism as opposing ideal-types on a normative spectrum. Doing so allows us to see a thus-far neglected problem, which I call the Zero-Sum Problem: any gains a concrete theory makes by approximating one ideal-type, it loses by moving away from the other. I end by showing how accepting this fact is a first step to more practically viable theories that attempt to find a middle ground between the two ideal-types. (shrink)

Developments in fields as diverse as biotechnology, animal cognition, and computer science have cast serious doubt on the common belief that human beings are unique and that only they should have dignity and basic rights. A movement referred to as ‘new dignitarianism’ has recently reclaimed human dignity to fend off the threats to human uniqueness that it perceives to arise from these developments. This ‘new’ dignitarianism, however, is not new at all. Drawing on a debate between two Enlightenment philosophers, this (...) article shows that dignitarianism has already surfaced in the eighteenth century as the negative image of another movement: naturalism. Building on this historical account, I propose to understand dignitarianism and naturalism as opposing ideal-types on a normative spectrum. Doing so allows us to see a thus-far neglected problem, which I call the Zero-Sum Problem: any gains a concrete theory makes by approximating one ideal-type, it loses by moving away from the other. I end by showing how accepting this fact is a first step to more practically viable theories that attempt to find a middle ground between the two ideal-types. (shrink)

The global age is distinguished by disobedience, from the protests in Tiananmen Square to the fall of the Berlin Wall, to the anti-G8 and anti-WTO demonstrations. In this book, Raffaele Laudani offers a systematic review of how disobedience has been conceptualized, supported, and criticized throughout history. Laudani documents the appearance of "disobedience" in the political lexicon from ancient times to the present, and explains the word's manifestations, showing how its semantic wealth transcended its liberal interpretations in the 1960s and (...) 1970s. Disobedience, Laudani finds, is not merely an alternative to revolution and rebellion, but a different way of conceiving radical politics, one based on withdrawal of consent and defection in relation to the established order. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 109 Heft: 1 Seiten: 223-282.

The use of conventional manufacturing methods is mainly limited by the size of the production run and the geometrical complexity of the component, and as a result we are occasionally forced to use processes and tools that increase the final cost of the element being produced. Additive manufacturing techniques provide major competitive advantages due to the fact that they adapt to the geometrical complexity and customised design of the part to be manufactured. The following may also be achieved according to (...) field of application: lighter weight products, multimaterial products, ergonomic products, efficient short production runs, fewer assembly errors and, therefore, lower associated costs, lower tool investment costs, a combination of different manufacturing processes, an optimised use of materials, and a more sustainable manufacturing process. Additive manufacturing is seen as being one of the major revolutionary industrial processes of the next few years. Additive manufacturing has several alternatives ranging from simple RepRap machines to complex fused metal deposition systems. This paper will expand upon the structural design of the machines, their history, classification, the alternatives existing today, materials used and their characteristics, the technology limitations, and also the prospects that are opening up for different technologies both in the professional field of innovation and the academic field of research. It is important to say that the choice of technology is directly dependent on the particular application being planned: first the application and then the technology. (shrink)

In this study, we examine the influence of senior leadership on firms’ corporate social responsibility. We integrate upper echelons research that has investigated either the influence of the CEO or the top management team on CSR. We contend that functional experience complementarity between CEOs and TMTs in formulating and implementing CSR strategy may underlie differentiated strategies in CSR. We find that when CEOs who have predominant experience in output functions are complemented by TMTs with a lower proportion of members who (...) have experience in output functions, there is a pronounced effect on the community, product, and diversity dimensions of CSR. In turn, when output-oriented CEOs are complemented by output-oriented TMTs, we observe an effect on the employee relations dimension of CSR. Interestingly, we find no influence of CEO-TMT complementarity on the environment dimension of CSR. In general, our empirical results support the relevance of the interaction between CEOs and their TMTs in defining their firms’ CSR profile. (shrink)

Die Schlusssatze von Darwins Entstehung der Arten formulieren ein Prinzip, das weit uber die Biologie hinaus einflussreich wurde: "Es ist wahrlich eine grossartige Ansicht, dass der Schopfer den Keim allen Lebens, das uns umgibt, nur wenigen oder nur einer einzigen Form eingehaucht habe, und dass... aus so einfachem Anfang sich eine endlose Reihe immer schonerer und vollkommenerer Wesen entwickelt hat und noch fort entwickelt." Die Autoren dieses Bandes beschaftigen sich mit dem Evolutionsgedanken im Christentum und Islam, gehen dem Zusammenhang von (...) Religion und der Entwicklung des Bewusstseins nach und setzen sich mit dem Prinzip Evolution in Philosophie und Religionstheorie auseinander. (shrink)

El presente libro es un trabajo de investigación conjunto del Departamento de Filosofía de la Universidad de Navarra y el Instituto K. J. Somaiya Bharatiya Sanskriti Peetham. Se trata de un estudio centrado en cinco filósofos que abarcan el período que va del siglo VIII hasta el siglo XVI; los filósofos estudiados pertenecen a la Escuela Vedanta cuyo objetivo principal es analizar la naturaleza del Ser Absoluto y sus relaciones con el universo increado de seres materiales y espirituales. La obra (...) pretende mostrar una parte de esa búsqueda de la verdad, a nivel teórico y práctico, que ha caracterizado la filosofía en el subcontinente indio. (shrink)

Rationalitat hat religiose und andere metaphysisch anspruchsvolle Grossen in ihrer ehemals privilegierten Stellung als Begrundungsinstanzen in der Moralphilosophie abgelost. David Gauthier hat mit Morals by Agreement hier fur den moralischen Kontraktualismus die bisher am besten elaborierte Theorie vorgelegt, die auch die Methoden der modernen Entscheidungs- und Spieltheorie einbezieht. Die zentrale Herausforderung besteht in dem Erbringen des Nachweises, dass es in einer Gesellschaft mit ungleicher Machtverteilung fur alle Personen rational ist, einen Kooperationsvertrag einzugehen, der von Anfangsbedingungen der Gleichheit ausgeht. Iturrizaga stellt (...) in seiner tief greifenden kritischen Analyse diesen Nachweis in Frage und liefert dabei zugleich eine umfassende Darstellung der Theorie Gauthiers.". (shrink)

First published in 1917 and 1918, with a second edition in 1946, this is the first English translation of Santi Romano's classic work, L'ordinamento giuridico. The main focus of The Legal Order is the notion of institution, which Romano considers to be both the core and distinguishing feature of law. After criticising accounts of the nature of law centred on notions of rule, coercion or authority, he offers a compelling conception, not merely of law as an institution, but of the (...) institution as 'the first, original and essential manifestation of law'. Romano advances a definition of a legal institution as any group who share rules within a bounded context: for example, a family, a firm, a factory, a prison, an association, a church, an illegal organisation, a state, the community of states, and so on. Therefore, this understanding of legal institutionalism at the same time provides a ground-breaking theory of legal pluralism whereby 'there are as many legal orders as institutions'. The acme of a jurisprudential current long overlooked in the Anglophone environment, The Legal Order not only proposes what Carl Schmitt described as a 'very significant theory', but, more importantly, it offers precious insights for a thorough rethinking of the relationship between law and society in today's world. (shrink)