Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

The majority of antimicrobials that are produced are administered to animals, particularly food animals. While the overall impact of antimicrobial use in animals on antimicrobial resistance in humans and the environment is unclear, it undeniably has a role. Yet, some degree of antimicrobial use in animals is necessary for animal health and welfare purposes. Balancing the benefits and risks of antimicrobial use in animals is challenging because of the complexity of the problem and limitations in available data. However, a range (...) of measures can be implemented to reduce, refine and optimize antimicrobial use in animals, with a goal of minimizing the impact on human and environmental health while maintaining necessary therapeutic use in animals. A pandemic instrument can provide the necessary foundation for the whole-of-society and whole-of government One Health approach that is required to strengthen surveillance, communication, collaboration, and action. (shrink)

'The problem of the twentieth-century is the problem of the color-line.' Originally published in 1903, The Souls of Black Folk is a classic study of race, culture, and education at the turn of the twentieth century. With its singular combination of essays, memoir, and fiction, this book vaulted W. E. B. Du Bois to the forefront of American political commentary and civil rights activism. The Souls of Black Folk is an impassioned, at times searing account of the situation of African (...) Americans in the United States. Du Bois makes a forceful case for the access of African Americans to higher education, memorably extols the achievements of black culture (above all the spirituals or 'sorrow songs'), and advances the provocative and influential argument that due to the inequalities and pressures of the 'race problem', African American identity is characterized by 'double consciousness'. This edition includes a valuable appendix of other writing by Du Bois, which sheds light on his attitudes and intentions. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

That holobionts are units of selection squares poorly with the observation that microbes are often recruited from the environment, not passed down vertically from parent to offspring, as required for collective reproduction. The taxonomic makeup of a holobiont’s microbial community may vary over its lifetime and differ from that of conspecifics. In contrast, biochemical functions of the microbiota and contributions to host biology are more conserved, with taxonomically variable but functionally similar microbes recurring across generations and hosts. To save what (...) is of interest in holobiont thinking, we propose casting metabolic and developmental interaction patterns, rather than the taxa responsible for them, as units of selection. Such units need not directly reproduce or form parent-offspring lineages: their prior existence has created the conditions under which taxa with the genes necessary to carry out their steps have evolved in large numbers. These taxa or genes will reconstruct the original interaction patterns when favorable conditions occur. Interaction patterns will vary in ways that affect the likelihood of and circumstances under which such reconstruction occurs. Thus, they vary in fitness, and evolution by natural selection will occur at this level. It is on the persistence, reconstruction, and spread of such interaction patterns that students of holobiosis should concentrate, we suggest. This model also addresses other multi-species collectively beneficial interactions, such as biofilms or biogeochemical cycles maintaining all life. (shrink)

Along with the Chan’s “linguistic turn”, the significance of sutras, which were despised and even regarded as the obstacle to complete enlightenment, became accepted by the Chan. Due to Yanshou’s contributions, the principle that emphasized the diversity of teaching in terms of the relationship between meaning and expression in the Sui and Tang Dynasties has been changed into a system which stressed the importance of the root/branches relationship of the mind and words. According to Yanshou, the conflict between the Chan (...) and doctrinal teachings is resolved by highlighting the significance of words. Yanshou’s work greatly inspired the Chan’s interest in words in the Song Dynasty. (shrink)

Le Songe de Scipion est l’occasion pour Cicéron de revenir sur cette notion généralement dévalorisée politiquement qu’est l’espoir, par le biais de la longue narration d’un rêve, dans lequel Scipion a eu la vision, non seulement de sa destinée future, mais de l’ensemble de l’univers, et a été instruit du destin des âmes humaines après la mort. En réponse aux interrogations du républicanisme antique sur les limites dans lesquelles une République peut aspirer à la gloire et à l’expansion impériale, l’eschatologie (...) développée par Cicéron dans le Songe de Scipion vient relégitimer l’espoir, en le réorientant vers cette gloire céleste, et non plus terrestre, promise après la mort aux hommes politiques attachés à la vertu. Prêter attention au traitement de l’espoir dans le De Republica permet à la fois de ressaisir l’unité que forme le Songe avec le reste de l’œuvre et d’esquisser l’histoire d’une réflexion sur la valeur politique de l’espoir. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Unmasking the Maxim: An Ancient Genre And Why It Matters Now W. ROBERT CONNOR We live surrounded by maxims, often without even noticing them. They are easily dismissed as platitudes, banalities or harmless clichés, but even in an age of big data and number crunching we put them to work almost every day. A Silicon Valley whiz kid says, Move Fast and Break Things. Investors try to Buy (...) Low and Sell High. Investigative reporters Follow the Money. Others Follow their Bliss. The lavish host thinks, The More the Merrier, while the Modernist architect is sure that Less is More. Captains of Industry whisper to themselves, Me First; captains of sinking ships shout, Women and Children First. Be Prepared was the Boy Scouts’ marching song, while the Proud Boys Stand Down and Stand By, awaiting their marching orders. Maxims are perhaps the smallest members in a large family of speech acts, which among the Greeks included proverbs, oracles, riddles, blessings, curses and lamentations. Not all of these continue in use, but maxims have found companions—mottos, mantras, advertising tag lines and jingles, slogans, political rallying cries, hashtags, three- or four-letter acronyms and 280 character tweets from the goddess Twitter. Familiarity, however, can breed contempt, or at least inattentiveness to the full range of their influence. Sometimes what sounds at first like empty verbiage turns into action. Bruce Lee adapted an old Taoist saying when he said, Be Water, and thereby provided what was for a while a surprisingly effective strategy for protesters in Hong Kong. arion 28.3 winter 2021 6 unmasking the maxim Maxims empower, for good or ill. In the hands of bigots or ideologues, they can turn deadly. Sic Semper Tyrannis shouted John Wilkes Booth after shooting Abraham Lincoln. A manufacturer of assault rifles urged potential customers to Earn Your Man Card. How better to earn it than to obey 8chan, a web site favored by white nationalists, with its own maxim, Embrace Infamy. A devotee of the site did just that, perpetrating a mass shooting in El Paso, Texas. Maxims, then, should not be lightly dismissed. Since the ancient Greeks so relished maxims, they should surely be interrogated to help us better understand the power of these often underestimated speech acts. Before turning to the Greeks, however, the English word maxim needs a closer look. english “maxim” english borrowed maxim from a Latin phrase and boiled it down for everyday use. In Latin writings about logic, the expression maxima propositio, biggest proposition, denoted a statement that did not need to be proved, but could provide the basis for proof of other, lesser propositions. This phraseology goes back at least to Boethius in the sixth century of our era. It’s the equivalent of the generalizations that serve as the major premises in syllogistic logic. If this makes maxims sound like the axioms of geometry, that is historically right. The starting points of plane geometry are propositions that deserve to be accepted; even without proof that they are worthy of belief. That’s the meaning of the term axiōma. No one needs to prove that things equal to the same thing are equal to each other. Think about it; after a while it seems self-evident. It is worthy of assent. We might equally well call such an axiom a maxim; indeed, the earliest (1426) attested use of maxim in English is described in the Oxford English Dictionary as “an axiom; a self-evident proposition assumed as a premise in mathematical, or dialectical reasoning.” W. Robert Connor 7 This usage is now obsolete, but Thomas Jefferson understood the idea behind it, since he believed that there were such truths, waiting to be put to work in building a society where all people were equal and possess certain inalienable rights. He did not feel he had to prove these propositions; they were in his view self-evident. In using these ideas in his draft of the Declaration of Independence, he was, in effect, transferring to politics what Euclid had done in geometry. It was a swift, strategic stroke on his part, for, since self-evident truths require no argument or explanation, they focus discussion not on... (shrink)

Dai Zhen’s philosophy of language took the opportunity of a transition in Chinese philosophy to develop a form of humanist positivism, which was different from both the Song and Ming dynasties’ School of Principles and the early Qing dynasty’s philosophical forms. His philosophy of language had four primary manifestations: It differentiated between “names pointing at entities and real events” and “names describing summum bonum and perfection”; In discussing the metaphysical issue of “the Dao,” it was the first to introduce (...) a syntax analysis of linguistics, clearly differentiating between the different roles of predicate verbs “zhi wei” and “wei zhi” in Classical Chinese; In criticizing Confucian thought during the Song and Ming dynasties, it adopted specific philological skills such as the analysis of phraseology, the meaning of sentences and the thread of words in texts; and It re-interpreted the meaning of Confucian classics by studying characters and language, adopting a positivist and philological manner to seek metaphysical sense in philosophy. In this way, his philosophy was different from the scholars of the School of Principles during the Song and Ming dynasties and from the goal of Western linguistic philosophy in the 20th century, which refuted metaphysics. Accordingly, it helped to develop 18th century Chinese philosophy as it turned towards linguistic philology. (shrink)

For many years the evolution of language has been seen as a disreputable topic, mired in fanciful “just so stories” about language origins. However, in the last decade a new synthesis of modern linguistics, cognitive neuroscience and neo-Darwinian evolutionary theory has begun to make important contributions to our understanding of the biology and evolution of language. I review some of this recent progress, focusing on the value of the comparative method, which uses data from animal species to draw inferences about (...) language evolution. Discussing speech first, I show how data concerning a wide variety of species, from monkeys to birds, can increase our understanding of the anatomical and neural mechanisms underlying human spoken language, and how bird and whale song provide insights into the ultimate evolutionary function of language. I discuss the “descended larynx” of humans, a peculiar adaptation for speech that has received much attention in the past, which despite earlier claims is not uniquely human. Then I will turn to the neural mechanisms underlying spoken language, pointing out the difficulties animals apparently experience in perceiving hierarchical structure in sounds, and stressing the importance of vocal imitation in the evolution of a spoken language. Turning to ultimate function, I suggest that communication among kin (especially between parents and offspring) played a crucial but neglected role in driving language evolution. Finally, I briefly discuss phylogeny, discussing hypotheses that offer plausible routes to human language from a non-linguistic chimp-like ancestor. I conclude that comparative data from living animals will be key to developing a richer, more interdisciplinary understanding of our most distinctively human trait: language. (shrink)

Beauty has not figured prominently in contemporary notions of human flourishing. This essay seeks to reclaim a notion of beauty that the Church and the academy can find valuable again. The question is engaged here specifically from the perspective of a biblical scholar using a biblical text-the poem in Song 4:1–7 — to focus and source the discussion.

Robert Grosseteste was a foundational figure for the Franciscan tradition. Although not a Franciscan himself, he was the first lector hired to teach the Franciscans theology in their studium at Oxford, and as bishop of Lincoln, he maintained a positive relationship with the Franciscans. Upon his death, he left his collected works to the Greyfriars at Oxford, where John Duns Scotus appears to have consulted them.1 It is possible that Bonaventure in Paris had some contact with Grosseteste's works as well.2 (...) In addition to the direct influence of his teaching and works, Grosseteste's tenure at Oxford resulted in much indirect influence of Franciscan thinkers. Through his... (shrink)

Although women’s words account for a small portion of biblical scripture, the Bible records two related prayerful songs that were sung by female prophets: the song of Hannah, in the Old Testament, and the Magnificat of Mary, in the New Testament. This essay uses typological methodology to explore the songs’ connections, including their shared literary precedents and nearly identical theological themes. Their fundamental similarities suggest Hannah’s song served as a harbinger of the Magnificat. Hannah and Mary’s shared blessing, (...) divinely ordained motherhood, and their shared inspiration, the Holy Spirit, explain the parallels of their prayerful verses and prophetic utterances, which were of great relevance for both covenants of the Judeo-Christian faith. (shrink)

Schooling fish, swarms of starlings, plodding wildebeest, and musicians all display impressive synchronization. To what extent do they use acoustic cues to achieve these feats? Could the acoustic cues used in movement synchronization be relevant to the treatment of movement disorders such as Parkinson's disease in humans? In this article, we build on the emerging view in evolutionary biology that the ability to synchronize movement evolved long before language, in part due to acoustic advantages. We use this insight to explore (...) potential mechanisms that explain why music therapy has beneficial effects for PD patients. We hypothesize that rhythmic auditory cues, particularly music, can stimulate neuronal and behavioral processes that ease the symptoms and potentially the causes of PD because the neural circuits used in auditory entrainment at individual and group levels are associated with dopamine production. We summarize current treatment of PD and outline how new insights from an evolutionary perspective could improve understanding and eventual treatment of movement disorders in humans. (shrink)

Development in animals is frequently characterized by periods of heightened capacity for both neural and behavioral change. So‐called sensitive periods of development are windows of opportunity in which brain and behavior are most susceptible to modification. Understanding what factors regulate sensitive periods constitutes one of the main goals of developmental neuroscience. Why is the ability to learn complex behavioral patterns often restricted to sensitive periods of development? Songbirds provide a model system for unraveling the mysteries of neural mechanisms of learning (...) during development. Like many songbirds, zebra finches (Taeniopygia guttata) learn a specific vocal pattern during a restricted period early in life. Young birds must hear songs produced by members of their species; this auditory experience is thought to engender specific changes in the brain to guide the process of vocal learning. Many studies of the songbird system have focused on examining relationships between brain development and learning. One goal of this work is to elucidate mechanisms that regulate basic processes of neural development, and in so doing to shed light on factors governing the emergence of a complex learned behavior. (shrink)

Of all the themes treated by the mimes, perhaps the one that gave the most delight to their audiences throughout the centuries was that of adultery. References to it, from various parts of the ancient world, are found from the first century before Christ to the sixth century of the Christian era, and in many cases it is spoken of as a theme typical of the mime as a whole. There does not seem to be satisfactory evidence of its existence (...) in a genuinely dramatic form at an earner date. It is reported that the μαγδoί, among other impersonations, mimicked the behaviour of μoιχoί, but their performance, so far as can be discovered, was purely a piece of imitative buffoonery. When the theme of adultery was treated by Greek mimes of a later date, the approach seems to have been rather a psychological study of the adulteress than an attempt to bring out the dramatic possibilities inherent in the situation. This is certainly the case with Herondas' fifth mime, which portrays a lady jealously in love with a slave. Evidence from sources bearing a close relationship to the mime is equally negative. Thus a well-known Egyptian papyrus contains a song, written perhaps in the third or second century B.C., in which Helen complains of Menelaus' indifference to her after bringing her back from Troy; but this is far from constituting a variant on the adultery theme. The wall-song in Marissa, which was composed in the middle of the second century B.C., does indicate a situation in which a woman is trying to keep her lover's presence outside the house from the knowledge of another man with whom she is consorting inside. (shrink)

How do our embodied experiences of music shape our analysis, theorizing, and interpretation of musical texts, and our engagement with practices including composing, improvising, listening, and performing? 'Music, Analysis, and the Body: Experiments, Explorations, and Embodiments' is a pioneering essay collection uniting major and emerging scholars to consider how theory and analysis address music's literal and figurative bodies. The essayists offer critical overviews of different theoretical approaches to music analysis and embodiment, then test and demonstrate their ideas in specific repertoires. (...) The range of musics analysed is diverse: Western art music sits alongside non-Western repertoires, folk songs, jazz, sound art, audio-visual improvisations, soundtracks, sing-alongs, live events, popular songs, and the musical analysis of non-musical experiences. Topics examined include affect, agency, energetics, feel, gesture, metaphor, mimesis, rehearsal, subjectivity, and the objects of music analysis--as well as acoustic ecology, alterity, class, distraction, excess, political authority, sensoriality, technology, and transcendence. (shrink)

The most distinctive and highly valued poems of the modern era offer an image of a dramatized "I" acting in a concrete setting. The variety and importance of the poems which fall under this description are suggested simply by the mention of such names as "Elegy Written in a Country Courtyard," "Tintern Abbey," "Ode to a Nightingale," "Ulysses," "My Last Duchess," "Dover Beach," "The Windhover," "The Darkling Thrush," "Sailing to Byzantium," "Leda and the Swan," "The Love Song of J. (...) Alfred Prufrock," "Stopping by Woods on a Snowy Evening." The power and beauty of such poems seems intimately connected with the fact of their dramatic integrity and autonomy, and we have all been taught, in analyzing them, to refer to a "speaker" existing independent of the poet and to avoid the "intentional" and "biographical" fallacies which spuriously link the poem to the poet and the world outside the poem. Such an approach tends to undercut any notion that a poem has a single definite meaning, the meaning the poet gave it, and to support the idea that the meaning of a poem is indeterminate and/or multiple. All this is quite in accord with the orthodox critical doctrine that poetic language is differentiated from scientific language and preserved from competition with it by the fact that it is nonreferential, making no claim upon the real world; and complex, indefinite, and alogical, where scientific language is simple, definite, and logical. Ralph W. Rader is chairman of the department of English at the University of California at Berkeley. His previous contributions to Critical Inquiry are "Fact, Theory, and Literary Explanation" , "Explaining Our Literary Understanding: A Response to Jay Schleusener and Stanley Fish" , and "The Literary Theoretical Contribution of Sheldon Sacks" . Professor Rader's influential studies include Tennyson's "Maud": The Biography Genesis, "Literary Form in Factual Narrative: The Example of Boswell's Johnson," and "The Concept of Genre and Eighteenth-century Studies.". (shrink)

The ego-focus of pioneer women on the South African frontier, 1760–1860, reflects distinct traits of mystical spirituality. The pioneer spirituality of women on the borders increasinglycame to expression in ego-texts with experiential inclinations. The leaning towards Jesuscentredmystical spirituality developed parallel to pietistic tendencies in Holland and Germany,and allegorical and tropological applications of the bridal metaphors in the Song of Songsformed a distinct element of female pietism on the frontier. Women believers in the interiorfavoured tropological applications of bridal metaphors in (...) the Song of Songs. The popularity ofsuch tropological applications can firstly be attributed to the physical conditions under whichpioneer women found themselves. Secondly, the availability of German pietistic workscontributed towards the religious culture of mystical and individualistic readings of bridalmetaphors in the Song of Songs. Tropological readings of the Song of Songs’ bridal metaphorsare traced to the theology of Bernard of Clairvaux particularly and other pre-reformationalmystical sources. (shrink)

"College" is a word that means many things to many people: a space for knowledge, a place to gain lifelong friends, and an opportunity to transcend one's socioeconomic station. Today, though, this word also recalls a slew of headlines that have revealed a dark and persistent world of racial politics on campus. Does this association disturb our idealized visions of what happens behind the ivied walls of higher learning? It should - because campus racism on college campuses is as American (...) as college football on Fall Saturdays. From Lawrence Ross, author of The Divine Nine and the leading expert on sororities and fraternities, Blackballed is an explosive and controversial book that rips the veil off America's hidden secret: America's colleges have fostered a racist environment that makes them a hostile space for African American students. Blackballed exposes the white fraternity and sorority system, with traditions of racist parties, songs, and assaults on black students; and the universities themselves, who name campus buildings after racist men and women. It also takes a deep dive into anti-affirmative action policies, and how they effectively segregate predominately white universities, providing ample room for white privilege. A bold mix of history and the current climate, Blackballed is a call to action for universities to make radical changes to their policies and standards to foster a better legacy for all students"--. (shrink)