Dr Edwards' stimulating and provocative book advances the thesis that the appropriate axiomatic basis for inductive inference is not that of probability, with its addition axiom, but rather likelihood - the concept introduced by Fisher as a measure of relative support amongst different hypotheses. Starting from the simplest considerations and assuming no more than a modest acquaintance with probability theory, the author sets out to reconstruct nothing less than a consistent theory of statistical inference in science.

The contemporary world faces a number of problems that are both deep-seated and interrelated, since they arise from the very nature of technological society. The environment upon which all life depends is seriously threatened by climate change, rising sea levels, pollution, overpopulation, resource depletion and increased risks of droughts, forest fires, floods and other extreme weather events. Environmental degradation is intimately connected to the consumer lifestyle of developed countries. This lifestyle promotes materialism, entertainment and hedonistic superficiality that ultimately lead to (...) moral corruption. Our insensitive and destructive attitude towards nature is not isolated, or unrelated to other problems of social justice. The environmental crisis reflects human structures of domination that include political and economic exploitation, racism, sexism and ageism. These challenges are immense, and solutions to them will require a renewed dedication to moral reflection and a commitment to social justice. This book discusses the challenges in connection with topics such as human rights, economic exploitation and inequality, environmental protection, globalization, global food justice, technology, gender equality and ageism. It provides a plurality of moral and spiritual perspectives including Hinduism, Buddhism, Daoism and Christianity that offer guidance in finding responses that are both possible and reasonable. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)