Ausführlich dargestellt werden die Verhältnisse der Sprachforschung in der Zeit des Nationalsozialismus, mit einer Dokumentation der Verfolgten und ins Exil Getriebenen (insgesamt 301 verfolgte Personen) und einer ausführlichen Darstellung der Forschungssituation im 'Reich'. Ausgehend von dieser Darstellung wird die Entwicklung der Sprachforschung (nicht nur in Deutschland) seit dem 19. Jahrhundert skizziert"--Back cover.

Kant mostra que uma teoria fundamental da normatividade e da moralidade não pode dar nem uma explanação nem uma prova da normatividade, mas apenas pode articular e explicitar sua origem. Ela pode fazer isso indicando o lugar ou o topos e a virada ou a trope de seu originar. Conforme Kant, o topos da normatividade é a vontade enquanto razão prática e sua trope é o uso geral desta razão que tipicamente é instrumental, no sentido da reflexão. A trope da (...) origem da moralidade é a autonomia, i.e., a virada da razão prática sobre si mesma, tornando-se pura neste ato. Nisso, a razão prática estabelece sua própria forma como lei para si mesma, na forma do imperativo categórico. Em consequência disso, a ética fundamental serve duas funções : formalmente, ela fornece evidência da originalidade e autenticidade da moralidade; materialmente, ela fornece um princípio criteriológico para o conteúdo da moralidade. O artigo argumenta que Kant estava certo em sua visão da fundamentação da ética, mas estava errado com relação à maneira como ele tentou cumprir as exigências estabelecidas. O topos da normatividade e, em consequência disso, da moralidade, não pode ser a razão, mas precisa ser a consciência ou, mais exatamente, o saber de se ; e sua trope fundamental não pode ser reflexão e, depois, autonomia, mas precisa ser o que pode ser descrito como conversão da consciência. Essa conversão pode ser identificada com o philein no sentido de Aristóteles. Este “amar amigável” tem quatro aspectos diferentes: desejo, cognição, benevolência e reconhecimento. Quando este philein for recíproco e estiver continuamente vivido, nasce a philia, a amizade. Essa é descrita, consequentemente, como o topos da origem de normatividade e moralidade. (shrink)

Joining voluntary thematic initiatives can be a means for firms to legitimate their business activities. However, a lack of review mechanisms could create incentives for free-riding. This might lead to a lower commitment to the initiative’s principles, and endanger its credibility and its members’ legitimacy benefits. Whether members of voluntary initiatives take advantage of the opportunity to free-ride has not been analyzed empirically so far. To fill this research gap, we investigate from an institutional theory perspective the actual implementation behavior (...) of publicly listed signatories of the United Nations Principles for Responsible Investment (UN PRI) in a difference-in-differences and an event study setting. Our empirical results show that, after signing, UN PRI signatories integrate environmental, social, and governance (ESG) criteria in their business activities significantly more than matched non-signatories from the financial sector, indicating the commitment of the signatories to the UN PRI in general. However, while the initial members show a high commitment to the initiative’s principles by increasing their ESG integration performance substantially, new members signing at a later stage of the initiative perform considerably less, and thus undermine the UN PRI’s credibility. We derive implications for voluntary thematic initiatives to avoid such a development. (shrink)

Recent years have witnessed tremendous growth in the epidermal growth factor (EGF) family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for these factors. Accompanying this growth has been an increased appreciation for the roles these molecules play in tumorigenesis and in regulating cell proliferation and differentiation during development. Consequently, a significant question has been how diverse biological responses are specified by these hormones and receptors. Here we discuss several characteristics of hormone-receptor interactions and receptor (...) coupling that contribute to specificity: 1) a single EGF family hormone can bind multiple receptors; 2) a single ErbB family receptor can bind multiple hormones; 3) there are three distinct functional groups of EGF family hormones; 4) EGF family hormones can activate receptors in trans, and this heterodimerization diversifies biological responses; 5) ErbB3 requires a receptor partner for signaling; and 6) ErbB family receptors differentially couple to signaling pathways and biological responses. BioEssays 20:41–48, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Publisher: Philosophical Library Publication date: 1953 Subjects: Medicine Medical / Diseases Medical / General Medical / Diseases Medical / Microbiology Science / Life Sciences / Biology / Microbiology Notes: This is an OCR reprint. There may be typos or missing text. There are no illustrations or indexes. When you buy the General Books edition of this book you get free trial access to Million-Books.com where you can select from more than a million books for free. You can also preview the (...) book there. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Ideas and Forms of Tragedy from Aristotle to the Middle AgesRichard J. UtzIdeas and Forms of Tragedy from Aristotle to the Middle Ages, by Henry Ansgar Kelly; xvii & 257 pp. Cambridge: Cambridge University Press, 1993, $59.95.If H. A. Kelly had wanted to sing the tune of Norman Cantor’s recent book on nineteenth- and twentieth-century medievalists, he could have called his study “Inventing Tragedy.” However, besides a certain (...) revisionistic attitude, there are no correspondences between the hasty, essayistic Inventing the Middle Ages (1991) and the scholarly, thoroughly philological Ideas and Forms of Tragedy. Where Cantor attempts to convince his readers that the various critical appropriations of the Middle Ages say more about the cultures of their modern reinventors than about the subject of their researches, Kelly is positive that sound source study and textual criticism can provide secure data for a more accurate application of perhaps the most famous of all genre terms to respective historical authors and individual plays. Thus, Kelly considers his book to be a necessary critical corrective of faulty and preconceived (modern) ideas about classical and medieval notions of tragedy. His methodological insistence on a purely philological investigation is responsible for some of the [End Page 253] outstanding virtues of this investigation such as authority, exactitude, and scholarliness; at the same time it is also the cause for the omission of questions essential to a study which purports to present an account not only of the forms but also the “ideas” of tragedy from classical antiquity through late medieval times.Chapters one and two examine various ideas and practices associated with tragedy in ancient Greece and Rome. This concise survey should become assigned reading for students of literary drama because it debunks the belief that the term tragedy conjures up a uniform idea, one that has been relatively constant throughout the ages and that can be attributed to Aristotle’s discussion of the best kind of tragedy in his Poetics. Kelly demonstrates how Aristotle’s broad definition of the term (any serious story, even with a happy ending) was transformed in late antiquity to mean a story ending in irremediable misfortune.Chapter three studies the semantic shifts the word tragedy underwent in the early Middle Ages. Kelly establishes convincingly that the various early medieval lexicographers and commentators (the most intriguing discussions include Isidore of Seville, Remigius of Auxerre, and Papias) knew much less about tragedy and had a much less unified idea of tragedy than is assumed by many modern-day scholars of drama. A vague knowledge of the genre also characterizes the twelfth century (chapter four), when—with the exception of John of Salisbury—creative mélanges of authentic classical traits and postclassical distortions dominated.The fifth chapter demonstrates that most commentators in the high Middle Ages, despite the reception of Aristotle directly from the Greek or through Arabic intermediaries, vary widely on the meanings they attach to the word “tragedy.” Most of them, such as John Garland, even consider it an empty, obsolete genre, one practiced only by very few poets of classical antiquity. Only Dante Aligheri believed that tragedy was a current genre and that he had made his contribution to it.The study concludes by surveying the developments in fourteenth- and fifteenth-century England, France, Italy, and Spain. Kelly argues that in spite of the greatly increased currency of ideas of tragedy in the later Middle Ages, other genres (vitae of famous men or saints, exempla, complaints) negotiated stories of disaster and death. It seems problematic, however, that Kelly does not further investigate any of the cultural ramifications for and the “ideas” behind the existence and nature of these other genres and the coeval absence of (Aristotelian) tragedy. While he rightly states that medieval vitae, exempla, and planctus all do without discussions of the empathic sorrow for the misfortune of others which characterizes Aristotle’s (and Chaucer’s) ideas of tragedy, his exclusively philological approach—one concerned with sources and textual traditions but not with society or mentalities—makes him circumnavigate essential deliberations about the causes for these conspicuous medieval notions. [End Page 254] Thus, Kelly’s book does not even attempt to answer the... (shrink)

Claude Bernard a réservé à la contre-épreuve un rôle fondamental dans le raisonnement expérimental. Il a soutenu que la seule preuve qu'un phénomène joue le rôle de cause par rapport à un autre, c'est qu'en supprimant le premier on fait cesser le second. Cependant, la contre-épreuve expérimentale n'en reste pas moins une expérimentation; la structure logique des deux, preuve et contre-épreuve, est la même. Or, si la preuve exige la contre-épreuve, la dernière à son tour exige la première comme sa (...) contre-épreuve. On arrive ainsi à une suite infinie d'expérimentations dont chaque membre se rapporte à l'autre comme soit à sa preuve, soit à sa contre-épreuve. Cependant, ce travail expérimental, qui s'arrête dans sa réalité à un moment choisi, il est vrai, plus ou moins arbitrairement, se poursuit dans la pensée de l'expérimentateur passant ainsi des résultats individuels à leur généralisation. Au sein du raisonnement expérimental il y a donc un raisonnement analogique et c'est le „sentiment du déterminisme“ et la pensée causale qu'il implique plutôt que le nombre des preuves et contre-épreuves qui surgissent comme les seuls critères de la vérité expérimentale.Claude Bernard ascribed to the counter-proof a fundamental role in his experimental method and the reasoning on which the method rests. He saw the only proof of the causal nature of a given phenomenon in the fact that the effect fails to appear after elimination of the alleged cause. However, the experimental counter-proof still remains an experiment; the logical structure of both proof and counter-proof, is the same; it is true that the proof calls for a counter-proof; but the latter in its turn calls for the proof as for its counter-proof. One thus arives at an infinite chain of experiments, each link referring to each other as to its proof or counter-proof. This experimental work, nevertheless, comes to its end, though at a moment still chosen more or less arbitrarily; the work continues however in the thought of the experimenter, thus passing from individual results to generalization. There is embodied in the experimental method and in experimental thought a reasoning by analogy. The “sense of determinism” and the causal thought on which this sense rests rather than the number of proofs and counter-proofs emerge as the ultimate criteria of experimental truth.Claude Bernard hat dem experimentellen Gegenbeweis eine hervorragende Stellung in seiner experimentellen Methode und dem ihr zugrundeliegenden Denkvorgang eingeräumt. Seiner Überzeugung nach ist der einzige Beweis der ursächlichen Natur eines Faktors darin zu suchen, dass die Wirkung ausbleibt, wenn man den als Ursache angeschuldigten Faktor ausschaltet. Indessen ist auch der experimentelle Gegenbeweis nichts anderes und nicht mehr als ein Experiment. Beide, Experiment und Gegenexperiment, haben die gleiche logische Struktur. Wenn demnach jedes Experiment den Gegenbeweis verlangt, so bedarf auch der Gegenbeweis seinerseits des Beweises als seines Gegenbeweises. So gelangt man schliesslich zu einer unendlichen Kette von Experimenten, deren jedes Glied sich zu jedem anderen wie zu seinem Beweis oder Gegenbeweis verhält. Diese experimentelle Arbeit wird aber in einem mehr oder weniger willkürlich gewählten Augenblick abgebrochen; sie wird indessen in Gedanken vom Experimentalforscher fortgesetzt, der auf diese Weise schliesslich von den Einzelresultaten zu ihrer Verallgemeinerung schreitet. Innerhalb der experimentellen Methode trifft man also auf ein Denken nach Analogie. DerBernard-sche „Kausal sinn“ und das diesem zurgrundeliegende kausale Denken, nicht aber die Anzahl der experimentellen Beweise und Gegenbeweise sind es, welche die letzten Kriterien der experimentellen Wahrheit enthalten. (shrink)

Signaling by the Epidermal Growth Factor Receptor (EGFR) and related ErbB family receptor tyrosine kinases can be deregulated in human malignancies as the result of mutations in the genes that encode these receptors. The recent identification of EGFR mutations that correlate with sensitivity and resistance to EGFR tyrosine kinase inhibitors in lung and colon tumors has renewed interest in such activating mutations. Here we review current models for ligand stimulation of receptor dimerization and for activation of receptor signaling by receptor (...) dimerization. In the context of these models, we discuss ErbB receptor mutations that affect ligand binding and those that cause constitutive receptor phosphorylation and signaling as a result of constitutive receptor dimerization. We discuss mutations in the cytoplasmic regions that affect enzymatic activity, substrate specificity and coupling to effectors and downstream signaling pathways. Finally, we discuss how emergent mechanisms of ErbB receptor mutational activation could impact the search for clinically relevant ErbB receptor mutations. BioEssays 29:558–565, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

„Ein jedes Ding in der Natur wirkt nach Gesetzen. Nur ein vernünftiges Wesen hat das Vermögen, nach der Vorstellung der Gesetze, i.e. nach Prinzipien zu handeln oder einen Willen.“ So definiert Kant in der Grundlegung zur Metaphysik der Sitten den Willen oder, was für ihn dasselbe ist, die praktische Vernunft. Die Moral ergibt sich sowohl unter dem formalen Gesichtspunkt ihres Geltungsanspruchs wie unter dem materialen ihrer Grundnorm, nämlich des kategorischen Imperativs, aus der Selbstanwendung der apriorischen Grundstruktur der praktischen Vernunft. Damit (...) ist die Frage beantwortet, "von woher ein unbedingtes Sollen verbindet, was der Grund seiner Verbindlichkeit ist", wie sie beispielhaft Dirk Greimann formuliert. (shrink)

A questão “por quê ser moral”, que foi formulada expressamente no contexto do debate filosófico acadêmico por Francis Herbert Bradley, divide os leitores quando buscam sua resposta em Kant. Uns acham, como Gerold Prauss, que Kant negue a possibilidade de tal resposta e diga que a moral precisa ser aceita como um fato simplesmente dado, o “fato da razão”. Contudo, como tal imediatismo ou “decisionismo transcendental” parece insatisfatório, um outro grupo defende a assim chamada “interpretação do agente racional”, onde este (...) último apresenta o valor supremo, absoluto, que fundamenta a moral e, com isso, apresenta a razão em virtude da qual devemos agir moralmente. Mas tal valor absoluto ou já é moral, mas então a resposta dada à questão “por quê ser moral” entra num círculo vicioso. Ou tal valor faz a moral depender de algo fora da moral o que, conforme Kant, destruiria toda moral. A solução do problema é a seguinte: Kant não deriva a moral de um pressuposto extramoral nem pressupõe a própria moral como simplesmente dada, mas explica o originar da moral. Ela origina da razão prática pela volta dessa razão sobre si mesma que constitui sua autonomia. Por este seu originar, a moral não é uma mera derivação de algo pressuposto, mas algo radicalmente novo, original, autónomo. Pelo outro lado, existe, sim, uma fundamentação da moral, i.e., um processo compreensível de sua constituição. Com isso, Kant evita o imediatismo: a moral não precisa ser simplesmente aceita como um fato puro, mas pode ser compreendida pela razão. (shrink)

Some features of Hegel’s Philosophy of History make it hardly acceptable in the 21st century. It proposes a final destination (Endzweck) of history, together with a principle of rational, dialectic necessity to take it there. In fact, these conceptions are not as absurd as they may seem to contemporary eyes. Nevertheless, the article doesn’t pretend to defend them, but aims to show that there is, behind these two, a third principle which is well worth to be defended –and which, in (...) fact, can systematically maintained without support from the other two. This we can call the “Principle of ethical asymmetry in history”. However, we also can name it by the formula Hegel himself coined: the “progress in the consciousness of liberty”. To explain this idea, the article evidences that the fundamental characteristic of all normativity is practical knowledge de se. In morality or ethics, this turns reflexive and self-determining. Liberty in Hegel’s sense effectively realizes this knowledge de se not only in a formal and abstract way, as in Kant, but concretely in history and in specific communities. However, since liberty in this process always remains linked to that normative self-comprehension which constitutes our practical self-consciousness, the processes of historical realization of liberty are normatively irreversible. Precisely for this process has an element of objective and unconditional aspect. The article concludes with some remarks as to how this principle of ethical asymmetry in history can serve as a basis of e new ethical theory which is strongly normative and, at the same time, sensitive to historic context an human finitude. (shrink)

Kant did not explain the method of his foundation of ethics expressly. However, we can comprehend it as the demonstration of the originality of morality. For morality cannot be derived from anything non-moral – such a relation of derivation would destroy it. Therefore, there cannot be a justification or proof of morality in the strong sense, there can only be a “groundwork”, as the term “Grundlegung” is normally translated in English. This groundwork or grounding consists in disclosing the place or (...) topos and the turn or trope of its originating. According to Kant, the first is the will as practical reason; the latter is the turn of the will towards itself as autonomy. The result of such groundwork is, first, the evidence of the authenticity of morality and, hence, its unconditional validity – since such original validity is not conditioned on anything extra-moral. Second, we get a normative criterion for the contents of morality, which in Kant takes the form of the Categorical Imperative. The article seeks to defend the view that there is no alternative to Kant’s method of the foundation of ethics. However, by describing this method in a purely formal way, the author aims to open up thepossibility to implement it in another way and with other results than Kant does. (shrink)

Le traite sur les vertus, a moins d'etre simplement un traite sur des valeurs differentes, n'a sa place que dans une ethique finaliste, c'est-a-dire dans une ethique quie considere l'action morale comme un phenomene interieur, destine a perfectionner l'homme. C'est a partir de la qu'on peut se demander comment l'homme prepare son action, en acquerant des forces "doublant" la nature. Quant a savoir quelles sont les capacites naturelles exigeant une vertu, cela depend principalement de la question de savoir dans quelles (...) puissances la spontaneite naturelle ne forme pas suffisamment la fermete de caractere, necessaire a la recherche du bien. Pour Thomas d'Aquin, comme pour Aristote, la raison pratique, la volonte et les appetits sensibles sont le siege des vertus. Pour ce qui est de la raison pratique et de la volonte. l'experience commune suffirait a verifier cette opinion. en ce qui concerne les appetits sensibles, il faut d'abord resoudre la question de savoir s'ils ont vraiment un caractere moral, ou s'ils sont simplement des phenomenes psychiques. Dans ce dernier cas ils ne font que suivre les directives de la volonte morale comme les forces motrices physiques. Nous avons essaye de montrer que les appetits sensibles (Passions) ont un caracter moral. (shrink)

O artigo tenciona explicar o conceito da subjetividade na Ciência da Lógica (CdL) a partir de sua forma inicial, diferentemente da maioria dos vários estudos sobre a temática, que discute as formas já mais desenvolvidas, que ocorrem dentro da Lógica do Conceito. Porém, como essa última, desde início, é “Lógica Subjetiva”, a subjetividade precisa ser constituída antes ou no ponto do começo dela. Essa subjetividade inicial e mínima explica-se por primeiro pela identificação de subjetividade e liberdade, por segundo, pela compreensão (...) da liberdade como autodeterminação. Essa autodeterminação ocorre, na CdL, pela primeira vez na “necessidade absoluta” e torna-se verdadeiramente autônoma na “relação absoluta” da “ação recíproca”. Essa, quando levada a suas últimas conseqüências, é autodeterminação conceitual ou conceito autodeterminante – e aí inicia-se o reino da liberdade. Mas isso quer dizer que liberdade, inicialmente, não é outra coisa que necessidade internalizada na determinação conceitual, isto é, autodeterminação necessária do conceito. Obviamente, o conhecer, destarte, não faz parte da forma inicial da liberdade e da subjetividade: subjetividade não é, originariamente, auto-consciente. Seu saber-de-si, a subjetividade adquire apenas, através de um desenvolvimento longo e complexo, na “Idéia”, mais especificamente na “Idéia do conhecer”, para plenificar-se na “Idéia absoluta”. O artigo conclui com uma crítica dessa transição à consciência no desenvolvimento imanente da subjetividade, mantendo que a consciência seja algo originário, não reduzível a estruturas conceituais. Palavras chaves: Hegel, Subjetividade, Liberdade, Consciência, Ciência da Lógica. (shrink)

Kant shows that a fundamental theory of normativity and morality can give neither an explanation nor an explication of normativity, but can only articulate and render explicit its origin. It can do so by indicating the place or topos and the turn or trope of its originating. According to Kant, the topos of normativity is the will qua practical reason and its trope is the general, typically instrumental use of this reason, i.e. reflection. The trope of the origin of morality (...) is autonomy, i.e. practical reason turning on itself and thus becoming pure practical reason, thereby establishing its own form as law: the categorical imperative. Consequently, fundamental ethics serves two functions : formally, it provides evidence for the originality or authenticity of morality; materially, it gives a criteriological principle for the content of morality. The article argues that Kant was right in his view of the foundation of ethics, but was wrong in the manner in which he met the requirements thus established. The topos of normativity and, consequently, of morality cannot be reason, but must be consciousness or, more precisely, knowledge de se; and its fundamental trope cannot be reflection, but must be what can be described as a conversion of consciousness. This conversion can be identified with philein in the sense of Aristotle. It has four different aspects: desire, cognition, benevolence, and recognition. When philein is reciprocal and lived, philia ensues. Friendship is then described as the topos of the origin of Normativity and Morality. (shrink)

As normas da moral são as regras sob as quais o indivíduo livre limita livremente sua liberdade em prol da liberdade geral. As normas da lei são regras sob as quais o indivíduo livre é forçado a limitar sua liberdade em prol da liberdade geral. Com isso quase todos os filósofos modernos concordam. A ideia genial e central da filosofia prática de Hegel é que as normas tanto da moral quanto da lei não são limitações da liberdade, mas o cumprimento (...) dela, porque nelas e somente nelas a liberdade se realiza. O conceito dessa realidade geral da liberdade nas normas éticas é a “eticidade”. Essa concepção Hegel desenvolve a partir da reflexão, necessariamente chega à compreensão de que o cumprimento pleno de sua liberdade consiste na eticidade. O presente artigo tenta expor esse nexo lógico-conceitual. Em seguida, oferece algumas indicações concretas para a situação política atual, para, por fim, apontar um defeito que inclusive o conceito hegeliano de liberdade tem. (shrink)