Sexual Justice defends a robust a robust conception of lesbian and gay rights, emphasizing protection against discrimination and recognition of queer relationships and families. Synthesizing materials from law, philosophy, psychoanalysis and literature, Kaplan argues that sexual desire is central to the pursuit of happiness: equal citizenship requires individual freedom to shape oneself through a variety of intimate associations.

We describe here recent work on the molecular genetics of mitosis in the filamentous fungus Aspergillus nidulans. Aspergillus is one of three simple eukaryotes with powerful genetic systems that have been used to analyze mitosis. The modern molecular biological techniques available with this organism have made it possible to use mutations to identify genes and proteins that play an important role in mitosis. Three Aspergillus genes that affect mitosis are described. One gene, nimA, is specifically expressed late in the cell (...) cycle and codes for a putative protein kinase that induces mitosis, even in cells blocked in S‐phase. The second gene, bimG, codes for a putative phosphatase that interacts functionally with the nimA kinase. The third gene, bimE, codes for a protein that suppresses mitosis during interphase, apparently by keeping nimA turned off. None of these genes appear to be similar to any of the genes affecting mitosis that have been characterized in other eukaryotes, but rather appear to be elements of a system that prevents mitosis from occurring during interphase. (shrink)

Part Two, Area A. Resuming the investigation set afoot in Part 1,1 we there proposed that subliminally people do commonly sense moral obligation as a kind of debt (chreos) of shared responsibility ? every person's share in the cost of a good community which is the common cause of all. Testing this ?common understanding? by the facts of human nature and community, this article examines the substratum of my good, good of others, idea of good community, of common cause in (...) it, of shared responsibility for it, of consequent debt of all to whole, and of human freedom and capacity to estimate and pay on a basis to be examined in Area B projected. ?Elementary freedom? depends on capacity for truthful purpose and for independent judgment, ?ultimate freedom? on a determined truthful purpose coupled with adequacy of ideas for interpretation of entire experience. Every human is free in the elementary sense, and accordingly responsible. Ultimate freedom has to be won, and actively affirmed. (shrink)

This paper applies an approach that the author calls Subjective Personal Introspection to the self-reflective examination, inward-looking understanding, and impressionistic evocation of his own consumption experiences as the keeper of a kitten named Rocky Raccoon. Three-dimensional photographs in the form of stereo pairs provide corroborative evidence for the interpretations suggested. In this reflexive, anecdotal, narrative account, Rocky the Cat emerges as a focal point in the author's experiential consumption.

Light is strangely absent from most accounts of the environment. From photosynthesis to vitamin D, however, light is central to human well-being. Human circadian rhythms are keyed the alternation of dark and light. Erosion of the ozone layer makes skin cancer a growing threat from excess ultraviolet radiation. Light plays a significant role in health and illness. In changing historical circumstances, light continues to evoke and to express significant issues of value.

_Sexual Justice_ defends a robust a robust conception of lesbian and gay rights, emphasizing protection against discrimination and recognition of queer relationships and families. Synthesizing materials from law, philosophy, psychoanalysis and literature, Kaplan argues that sexual desire is central to the pursuit of happiness: equal citizenship requires individual freedom to shape oneself through a variety of intimate associations.

We become ill in ways our parents and grandparents did not, with diseases unheard of and treatments undreamed of generations ago. This text tells the story of the modern experience of illness, linking ideas of illness, health, and postmodernism.

Scaffolds are fundamental to many cellular signaling pathways. In this essay, a novel class of scaffolds are proposed, whose action bears striking resemblance to kinetic proofreading. Commonly, scaffold proteins are thought to work as tethers, bringing different components of a pathway together to improve the likelihood of their interaction. However, recent studies show that the cytoskeletal scaffold, anillin, supports contractile signaling by a novel, non‐tethering mechanism that controls the membrane dissociation kinetics of RhoA. More generally, such proof‐reading‐like scaffolds are distinguished (...) from tethers by a rare type of cooperativity, manifest as a super‐linear relationship between scaffold concentration and signaling efficiency. The evidence for this hypothesis is reviewed, its conceptual ramifications are considered, and research questions for the future are discussed. (shrink)

The modernist “biomedical model” offers an inadequate understanding of illness. At the same time, some of the conceptual constructs that are offered to supplement the biomedical model are carelessly employed. Much that is said and written about empathy and healing, in particular, fails to reflect the historical and critical self‐awareness of postmodern thinking at its best.

Summary Recent concern with the academic performance of schools has led a number of local education authorities to develop systems for measuring the ?added value? that can be attributed to particular institutions in their control. An analysis of data published by one Midlands shire county on the performance of A level candidates in 1992 raised questions about the relative levels of academic achievement of pupils who remained within the Catholic school system compared to those who transferred to local authority institutions (...) for their full?time education after the age of 16. A small representative sample of students from a Catholic school who had transferred to a non?Catholic sixth form college to take A level courses was interviewed. The students? comments suggested they found significant differences in the college ethos compared to that of their previous Catholic school. Those findings together with the analysis or the available data from the local authority, raise issues that merit further detailed research. (shrink)

One of the largely untapped potentials of Sausserian semiotics is the ability it provides to examine shifts in the cultural meanings attached to objects and ideasacross time. To explore this potentiality, we trace the intertextual evolution of one of the most enduring mythic figures, the vampire. Our analysis begins with ancient texts and moves forward in time to contemporary cinematic and televised depictions of the vampire. We document the deployment of the vampire as a vehicle carrying oppositional meanings as it (...) moves through various eras. For example, vampires may connote both racism and racial resistance, homophobia and gay acceptance, women’s subjugation and women’s empowerment. By using the vampire to mediate contested, liminal regions of cultural discourse, storytellers have constructed increasingly complex and multivocal portraits of this figure. At present, vampire narratives have come to resemble an alternative universe of human morality and behavior, complete with family structures, emotional depth, and interpersonal conflicts. (shrink)

Eros and Illness explores the place of desire in illness. We urgently need such an exploration because illness is no longer simply a natural feature of the human condition. Most people fall ill, but illness now falls under the supervision of biomedicine, a science-based, state-regulated system dominated by the new molecular gaze. The use of a person's distinctive genetic data to guide treatment and to forestall disease--called "personalized medicine"-- reflects how the molecular gaze can produce valuable advances in biomedical healthcare. (...) What does this indispensable super-vision, however, tend to overlook? Eros and Illness proposes that biomedicine ignores, in clinical practice and in bench science, the powerful role of desire in illness. Desire, always double-edged, requires attention because it can do both great harm and great good. Patients, caregivers, family members, and physicians, as they recognize the role of desire, gain access to a power that can make the passage through illness much less onerous and far more healing: truly "personalized. (shrink)

In his presidential address (American Philosophical Association, Western Division), William Frankena sets himself against the relativist and irrationalist drift of our time in asserting that ?It is of the essence of a normative judgment to claim that it is justified, rational or valid?, and that fully informed men of reason will ultimately agree about value questions. Applauding the return to reason, this note finds a need for further clarification on the definition of normative terms, the justification of normative judgments, the (...) basis of obligation to be rational, and on the promise of agreement among men of reason in axiology. (shrink)

These three papers present a quite diverse and complementary set of answers to the question, “Why Sexuality Matters to Philosophy.” They show the ways in which sexuality as an issue may be of interest to philosophers working on a wide range of questions. The theme of sexuality appears as both subject matter and context for the development of scientific theories of human behavior, as a pervasive dimension of the representation of everyday life, and as a social phenomenon raising important questions (...) bearing on the implications of equal citizenship for persons of different genders and sexualities. Sexuality reveals itself as implicated in epistemology and philosophy of science, aesthetics and ethics, political philosophy and jurisprudence. Sexuality as a subject matter provides rich examples for extending the treatment of quite traditional problems. At the same time, by identifying sexuality as a fundamental human phenomenon, fraught with normative implications and closely linked to emotional and bodily life, these papers show how thinking about sexuality may also act to unsettle and redefine certain important areas of philosophical inquiry. (shrink)

Summary Recent evidence from Diocesan and Office for Standards in Education inspections under the Education Act 1992 seems to suggest that while pupils in Catholic schools in England and Wales obtain high levels of academic success at Key Stage Two and Key Stage Four compared with those attending other schools in the maintained sector, their achievements in Advanced level examinations are lower than one would expect. The article points to evidence of a similar long?standing pattern of performance of pupils in (...) Catholic schools and speculates on some possible causes of the phenomenon. (shrink)

Part One. In our strife to express the meanings of moral terms, we have neglected the one transparently built?in meaning: ?A man ought to keep his promises? could mean ?A man owes it to other men to keep his promises. Such is his debt and duty ? just what is due or owed?. This proposal is supported by the evidence of major languages of the world, ancient and modern, in all of which identical or closely related words serve to express (...) both the idea of material debt and that of moral obligation. But on study the revealing model and analogue of ?moral debt? is found, not in debts of exchange, the simplest and most obvious class of debts, but in debts of shared responsibility. Working from such models we conclude that ?A ought to do X? means X is part of A's share in the cost of the good community, the common cause and stake of all mankind? (shrink)

Judges are typically tasked to consider sentencing benefits but not costs. Previous research finds that both laypeople and prosecutors discount the costs of incarceration when forming sentencing attitudes, raising important questions about whether professional judges show the same bias during sentencing. To test this, we used a vignette-based experiment in which Minnesota state judges reviewed a case summary about an aggravated robbery and imposed a hypothetical sentence. Using random assignment, half the participants received additional information about plausible negative consequences of (...) incarceration. As predicted, our results revealed a mitigating effect of cost exposure on prison sentence term lengths. Critically, these findings support the conclusion that policies that increase transparency in sentencing costs could reduce sentence lengths, which has important economic and social ramifications. (shrink)