This chapter contains section titled: No Abstract.

The vav proto‐oncogene encodes a 95 kDa protein which is expressed exclusively in hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the presence of a src‐homology 2 (SH2) domain, 2 SH3 domains, a cysteine‐rich region with similarity to protein kinase C, and a region highly similar to proteins with guanine nucleotide exchange activity on ras‐like GTPases. Recent work has shown that vav is tyrosine phosphorylated in response to stimulation of surface membrane receptors in a variety of hematopoietic (...) cell lines. Vav may play a role in hematopoietic cell signaling by coupling tyrosine kinase pathways to ras‐like GTPases through the regulation of guanine nucleotide exchange. (shrink)

In this paper, we support a continuistic reading of Joseph Margolis' philosophy, defending the claim that in the 1970s, Margolis tackled the issues suggested by the analytic philosophy of art from an original theoretical perspective and through conceptual tools exceeding the analytical framework. Later that perspective turned out to be a radically pragmatist one, in which explicitly tolerant realistic claims and non-reductive naturalism converged with radical historicism and contextualism. We will endorse this thesis by focusing on two important concepts (...) appearing in Margolis' aesthetics essays from the late 1950s to the 1970s: the type-token pair and the notion of cultural emergence. On the one hand, we will emphasise Margolis' indebtedness to Peirce's first formulation of the type-token distinction, involving a strong interdependence between the two elements of the pair, as well as an anti-essentialistic, historicised, and contextualised notion of type. On the other hand, we will delve into Margolis' exploration of the concept of emergence and cultural emergence, involving a genuinely pluralistic view of ontology, as well as a non-reductive, continuistic form of naturalism. Finally, we will connect the criticism of the so-called closure of the physical world with Margolis' anti-autonomistic stance in defining artworks. (shrink)

In the academic world, Joseph Margolis is best known as the proponent of a particular combination of radical historicism and robust relativism. In his publications, he argues that “humankind is the measure of all things” with regard to aesthetics, history, natural and social sciences, and philosophy. In doing so, he effortlessly interacts with authors from the continental, pragmatist, and analytic traditions. His book Three Paradoxes of Personhood is a collection of the three Venetian lecture...

This book is the outcome of a series of lectures on art-related topics which Margolis gave in various places, including Finland, Russia, Japan and the USA, from 1995 through 1997. Mainly these lectures vividly distill views which Margolis has developed more fully elsewhere. Also, as his readers know, Margolis has an unusually allencompassing and closely integrated series of views on almost all of the main issues concerning both art and philosophy generally. Thus the task of a reviewer of this book (...) is the difficult one of somehow coming to terms and finding something useful to say (in a brief compass) on the full sweep of Margolis's philosophy as encapsulated by these lectures. (shrink)

Joseph Margolis has died on Monday, 2021 June 8th. He has been a member of the scientific board of the European Journal of Pragmatism and American Philosophy since the very beginning. The board as a whole joins his family and friends in mourning his death. Joe gave a unique contribution to the Pragmatist community: his intellectual lucidity, his capacity to overcome traditions and disciplinary divisions, his independence of judgment, and his brave anti-dogmatism will last as a model for us (...) a... (shrink)

This paper begins with a memoir of the author’s interactions with Joseph Margolis that delineates both Margolis’s importance as a teacher and their disagreements on aspects of American philosophy. It then turns to Margolis’s discussions of pragmatism as a philosophical movement, with an emphasis on his understanding of John Dewey. The paper considers, third, Margolis’s account of the decline and rebirth of pragmatism, the latter process attributed largely to the work of Richard Rorty. The paper concludes with an examination (...) of what it sees as Margolis’s most valuable work: his explorations of the nature of the self and of human society. (shrink)

In his long and productive life Joseph Margolis approached many subjects that had been the concern of philosophy all through history. However, when his texts are read carefully it is clear that his main interest was to understand humanity and its cultural values. In my text I will first introduce Margolis philosophy in general and the underlying premises that he defended throughout his work, moving on to specific claims and arguments. I will pursue my analysis through several of Margolis’ (...) texts concerning his main philosophical arguments, such as the definition of the human, relativity, ethics and aesthetics. Margolis was a prolific writer who developed his philosophy in consecutive phases, arriving in his later years to arguments that became more pointed as well as far reaching in scope. Margolis’ reasoning and argumentation proceeds in three steps: defining the problem at hand, understanding the reasonings applicable to his claim and to opposing views, reaching a solution suitable and appropriate according to the context. (shrink)

Hybride et émergent, artéfactuel et culturel sans cesser d’être naturel, le monde humain tel que l’entend Joseph Margolis est aussi, en cela même, dans ses différentes dimensions, un monde fragile, instable et en perpétuelle reconstruction. Les enquêtes scientifiques et philosophiques ne peuvent en effet s’affranchir d’une condition d’impermanence où le flux l’emporte sur la fixité, ni s’émanciper d’un horizon de discours symbiotique ancré dans le langage ordinaire. Métisses et solidaires d’un monde médian conversationnel, les langues humaines répondent également, dans (...) leur indétermination même, aux exigences de formes de vie partagées et changeantes. Les personnes humaines enfin, enculturées et enlangagées, restent inscrites dans un monde Intentionnel et historique, qu’elles s’incorporent et transforment. (shrink)

It is common knowledge that pragmatism acquired a new and quite relevant space within European philosophical debate during the second half of Nineteen Century, and the leading actors of such a renewed interest for the classics of American thought have been Karl Otto Apel and Jürgen Habermas. Especially in Italy, the so called revival of pragmatism took place via their neo-kantianianism, and actually one could say that the pragmatist thought has been, so to speak, cleared from previous discred...

As the sixteenth Century drew to a close, the human race teetered at the brink of an unprecedented intellectual revolution. The Aristotelean conception of a small, spherical, Earth-centered cosmos ceased to confine the imagination of an increasing number of thinkers; the recently proposed Copernican system, problematic though it was, sketched a provocative alternative with some real explanatory advantages ; and distinct intellectual currents converged in the growing search for a new dynamics that would encompass at once all motion, superlunary and (...) sublunary. In the event, the cosmology, the planetary astronomy, and the dynamics finally came together in Newton's uniquely coherent synthesis, and by the dawn of the eighteenth century we had exchanged the dubious comfort of Aristotle's enveloping egg for the more chilling contemplation of a spatially infinite universe. (shrink)

Joseph Margolis’ philosophical work is both sanguine and fair. It is sanguine because much of it captures the inherent worth and dignity of the human condition. This includes aesthetics, anthropological diversity and history, the diversity of cognitive orientations and objectivity without foundations. Margolis embraces science and naturalism without reductionism. His pragmatism, though, is rooted more in James’ perspectivism, his local nice adaptation, and his relativism than that of Peirce and Dewey and their sense of science and the community of (...) inquirers. Margolis’ strength is his attempt to reconcile positions and his fairness towards others as he tries to wedge his pragmatist position amid others. But he celebrates the subjective stance of James, and downplayed the communal sense of Peirce and Dewey so vital to epistemic advances. (shrink)

The distinctive trait of this newest addition to Joseph Margolis’ magnificent oeuvre of thirty books is its broad-ranging and highly partisan approach to evaluating contemporary trends in Western philosophy. The book is divided into three parts. Part 1 addresses the trifecta of competing philosophical traditions: pragmatism, continental philosophy and analytic philosophy. Based on the book’s title, the reader can easily forecast the winner: pragmatism. Margolis directs Part 2 to the goal of reclaiming naturalism as an antidote to the ailments (...) of all three philosophical traditions. Part 3 concerns the enduring challenge that Immanuel Kant’s model of transcendental reason and G. W. F. Hegel’s subsequent critique pose to contemporary philosophy. The book’s thesis is that pragmatism has lost its distinctly American quality. In its more recent incarnations, pragmatism (or neopragmatism) has been continually cross-pollinated with elements in the continental and analytic traditions. Moreover, this open-ended capacity for hybridization is what constitutes pragmatism’s advantage. (shrink)

In this article I focus on some of Joseph Margolis's contributions to medical ethics. I first discuss some of Margolis's normative and metaphysical views on death and abortion, particularly in his early work Negativities, as well as some of his metaphysical assumptions. Then these views and assumptions are related to his theory of persons and, by implication, his theory of culture, set forth in a number of later works. In the course of the discussion, I call attention to some (...) controversial issues of today, such as embryonic stem cell research and the creation of embryos for the sole purpose of research, and ask for Margolis's views on them, given his earlier contributions and assumptions. Finally, I comment on his relativism and his program for research in aesthetics and ethics. (shrink)

In this article I focus on some of Joseph Margolis's contributions to medical ethics. I first discuss some of Margolis's normative and metaphysical views on death and abortion, particularly in his early work Negativities, as well as some of his metaphysical assumptions. Then these views and assumptions are related to his theory of persons and, by implication, his theory of culture, set forth in a number of later works. In the course of the discussion, I call attention to some (...) controversial issues of today, such as embryonic stem cell research and the creation of embryos for the sole purpose of research, and ask for Margolis's views on them, given his earlier contributions and assumptions. Finally, I comment on his relativism and his program for research in aesthetics and ethics. (shrink)