Despite of its formal precision and its great many applications, Shannon’s theory still offers an active terrain of debate when the interpretation of its main concepts is the task at issue. In this article we try to analyze certain points that still remain obscure or matter of discussion, and whose elucidation contribute to the assessment of the different interpretative proposals about the concept of information. In particular, we argue for a pluralist position, according to which the different views about information (...) are no longer rival, but different interpretations of a single formal concept. (shrink)

Focusing on Shannon information, this article shows that, even on the basis of the same formalism, there may be different interpretations of the concept of information, and that disagreements may be deep enough to lead to very different conclusions about the informational characterization of certain physical situations. On this basis, a pluralist view is argued for, according to which the concept of information is primarily a formal concept that can adopt different interpretations that are not mutually exclusive, but each useful (...) in a different specific context. (shrink)

IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the (...) efficacy of TBS in geriatric depression.Clinical trial registration[https://clinicaltrials.gov/ct2/], identifier [NCT04842929]. (shrink)

In the present paper we develop different arguments to show that there are no reasons to consider that there exists quantum information as qualitatively different than Shannon information. There is only one kind of information, which can be coded by means of orthogonal or non-orthogonal states. The analogy between Shannon’s theory and Schumacher’s theory is confined to coding theorems. The attempt to extend the analogy beyond this original scope leads to a concept of quantum information that becomes indistinguishable from that (...) of quantum state. But information is essentially linked with communication, as it is clear in both Shannon’s and Schumacher’s proposals. If we detach information from this link, we are not talking about information but about quantum mechanics. We also stress the neutrality of information with respect to the physical theories that describe the systems used for its implementation. This view opens the way towards a non-reductive unification of physics: if different physical theories can be reconstructed on the same neutral informational basis, they could be meaningfully compared with no need of searching for reductive links among them. (shrink)

Integrated Information Theory (IIT) is one of the most influential theories of consciousness, mainly due to its claim of mathematically formalizing consciousness in a measurable way. However, the theory, as it is formulated, does not account for contextual observations that are crucial for understanding consciousness. Here we put forth three possible difficulties for its current version, which could be interpreted as a trilemma. Either consciousness is contextual or not. If contextual, either IIT needs revisions to its axioms to include contextuality, (...) or it is inconsistent. If consciousness is not contextual, then IIT faces an empirical challenge. Therefore, we argue that IIT in its current version is inadequate. (shrink)

RESUMEN El diálogo propuesto entre Heidegger y Adorno, especificamente en lo que concierne a las ideas de crítica y de resistencia, no desconoce la importancia que adquiere para el último la crítica extensa que él mismo dirige a la ontología de Heidegger, ni para este su cuestionamiento de la filosofia dialéctica. El artículo busca mostrar que, en ambos autores, la idea de crítica y de resistencia se resuelve como indagación del sentido negativo de la experiencia. Se concluye que, destacando semejanzas (...) y diferencias en sus planteamientos, la reivindicación del carácter negativo de la experiencia equivale reivindicar el poder crítico de la filosofia y del arte. ABSTRACT The dialogue between these two authors, concerning specifically the ideas of critique and resistance, does not ignore the importance attributed by Adorno to the extensive critique that himself addresses to Heidegger's ontology, nor the one attributed by the latter to his questioning of the dialectical philosophy. The paper shows that in both authors the ideas of critique and resistance can be settled as an inquiry into the negative sense of experience. It is concluded that, highlighting similarities and differences in their approaches, the recognition of the negative trait of experience equals to claiming the critical power of philosophy and art. (shrink)

The present study aimed to translate and identify the psychometric properties of the Behavioral Emotion Regulation Questionnaire in 315 university students from Lima, Peru, aged 16 to 44 years. The BERQ and the Multicultural Inventory of Trait State Depression were administered for the assessment. Evidence of internal structure validity was obtained through confirmatory factor analysis and exploratory structural equation modeling, while evidence of validity in relation to other variables was obtained through linear regression analysis. The results indicate that the pentafactorial (...) structure is replicated in the Peruvian sample; that adaptive strategies significantly predict eutres, and that maladaptive strategies predict distress; in addition, reliability values were acceptable. At the end, theoretical and practical aspects of the findings and the importance of continuing to provide evidence for its use in different populations and contexts are discussed, taking into account that this is the first time that a Spanish version of the BERQ has been analyzed. (shrink)

IntroductionPreoperative neurocognitive disorder is a common condition affecting 14–51. 7% of the elderly population. General anesthesia has already been associated with the one-year post-operative neurocognitive disorder, specifically, a deficit in executive function, measured by the Trail Making Test B, but its long-term effects on cognitive function have not been investigated. We aimed to detect preO-NCD prevalence in patients scheduled for cardiac surgery and further investigate the possible role of previous general anesthesia in general preoperative cognitive status [measured via the Montreal (...) Cognitive Assessment ] and/or in executive functioning.MethodsIn this observational, prospective study, 151 adult patients scheduled for elective cardiac surgery underwent MoCA and TMT-B. Data on age, education, pGA, comorbidities, and laboratory results were collected.ResultsWe discovered a general cognitive function impairment of 79.5% and an executive function impairment of 22%. Aging is associated with an increased likelihood and education with a decreased likelihood of general cognitive impairment, but only education was significantly associated with a decreased likelihood of executive function impairment. While pGA did not significantly affect preO-NCD, a noteworthy interaction between aging and pGA was found, resulting in a synergistic effect, increasing the likelihood of executive function impairment.ConclusionWe found a high prevalence of preO-NCD in patients scheduled for cardiac surgery. General cognitive function impairment is highly associated with advancing age. However, older patients with at least one pGA appeared to be at an increased risk of preO-NCD, especially executive function impairment, suggesting that TMT-B should be associated with MoCA in the preoperative cognitive evaluation in this population. (shrink)

Palabras de agradecimiento al promotor del Congreso Internacional y a los participantes en él. Asimismo, a la persona que ha trabajado en la labor de transcripción de mis escritos y a otros colaboradores míos. También a quienes han tomado en cuenta mis ideas para elaborar sus tesis doctorales, y a otros colegas cuyos planteamientos filosóficos distan de los míos. Como la filosofía es una actividad interminable, queda abierta la sucesiva investigación en mis propuestas.

Theoretical accounts of development exhibit several internal tensions and face multiple challenges. They span from the problem of the identification of the temporal boundaries of development (beginning and end) to the characterization of the distinctive type of change involved compared to other biological processes. They include questions such as the role to ascribe to the environment or what types of biological systems can undergo development and whether they should include colonies or even ecosystems. In this chapter we discuss these conceptual (...) issues, and we argue that adopting an organizational approach may help solve or clarify them. -/- While development is usually identified with the achievement of an adult form with the capability to reproduce and therefore maintain a lineage, adopting the organizational approach may provide a different strategy, which focuses also on the maintenance of the current organization of the organism. By doing so an organizational approach favors a switch in perspective which consists in analyzing how organisms maintain their viability at each moment of development rather than considering them as going through intermediate stages of a process directed toward a specific goal state. This developmental dimension of biological organization has yet to be given a general and detailed analysis within the organizational theoretical perspective, apart from some preliminary attempts. How a biological organization is maintained through a series of radical organizational changes and what these changes are issues that still require clarification. In this chapter we offer the beginnings of such an analysis of developmental transitions, understood as changes in functionality brought forth by regulatory mechanisms in the context of the continued maintenance of organizational viability at every step. (shrink)

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible (...) contributions of definitions of life in scientific domains where such definitions are used most (e.g., Synthetic Biology, Origins of Life, Alife, and Astrobiology). Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research. (shrink)

Biological regulation is what allows an organism to handle the effects of a perturbation, modulating its own constitutive dynamics in response to particular changes in internal and external conditions. With the central focus of analysis on the case of minimal living systems, we argue that regulation consists in a specific form of second-order control, exerted over the core regime of production and maintenance of the components that actually put together the organism. The main argument is that regulation requires a distinctive (...) architecture of functional relationships, and specifically the action of a dedicated subsystem whose activity is dynamically decoupled from that of the constitutive regime. We distinguish between two major ways in which control mechanisms contribute to the maintenance of a biological organisation in response to internal and external perturbations: dynamic stability and regulation. Based on this distinction an explicit definition and a set of organisational requirements for regulation are provided, and thoroughly illustrated through the examples of bacterial chemotaxis and the lac-operon. The analysis enables us to mark out the differences between regulation and closely related concepts such as feedback, robustness and homeostasis. (shrink)

In this pathbreaking study, Micaela di Leonardo reveals the face of power within the mask of cultural difference. From the 1893 World's Fair to Body Shop advertisements, di Leonardo focuses on the intimate and shifting relations between popular portrayals of exotic Others and the practice of anthropology. In so doing, she casts new light on gender, race, and the public sphere in America's past and present. "An impressive work of scholarship that is mordantly witty, passionately argued, and takes (...) no prisoners."--Lesley Gill, News Politics "[Micaela] di Leonardo eloquently argues for the importance of empirical, interdisciplinary social science in addressing the tragedy that is urban America at the end of the century."--Jonathan Spencer, Times Literary Supplement "In her quirky new contribution to the American culture brawl, feminist anthropologist Micaela di Leonardo explains how anthropologists, 'technicians of the sacred,' have distorted American popular debate and social life."--Rachel Mattson, Voice Literary Supplement "At the end of di Leonardo's analyses one is struck by her rare combination of rigor and passion. Simply, [she] is a marvelous iconoclast."--Matthew T. McGuire, Boston Book Review. (shrink)

Organization figures centrally in the understanding of biological systems advanced by both new mechanists and proponents of the autonomy framework. The new mechanists focus on how components of mechanisms are organized to produce a phenomenon and emphasize productive continuity between these components. The autonomy framework focuses on how the components of a biological system are organized in such a way that they contribute to the maintenance of the organisms that produce them. In this paper we analyze and compare these two (...) accounts of organization and argue that understanding biological organisms as cohesively integrated systems benefits from insights from both. To bring together the two accounts, we focus on the notions of control and regulation as bridge concepts. We start from a characterization of biological mechanisms in terms of constraints and focus on a specific type of mechanism, control mechanisms, that operate on other mechanisms on the basis of measurements of variables in the system and its environment. Control mechanisms are characterized by their own set of constraints that enable them to sense conditions, convey signals, and effect changes on constraints in the controlled mechanism. They thereby allow living organisms to adapt to internal and external variations and to coordinate their parts in such a manner as to maintain viability. Because living organisms contain a vast number of control mechanisms, a central challenge is to understand how they are themselves organized. With the support of examples from both unicellular and multicellular systems we argue that control mechanisms are organized heterarchically, and we discuss how this type of control architecture can, without invoking top-down and centralized forms of organizations, succeed in coordinating internal activities of organisms. (shrink)

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range. Here, we put forward a different, organicist perspective on the endocrine regulation of glycaemia, by relying on the pivotal concept of closure of constraints. From this perspective, biological systems are understood as organized ones, which means that they are constituted of a set of (...) mutually dependent functional structures acting as constraints, whose maintenance depends on their reciprocal interactions. Closure refers specifically to the mutual dependence among functional constraints in an organism. We show that, when compared to feedback loops, organizational closure can generate much richer descriptions of the processes and constraints at play in the metabolism and regulation of glycaemia, by making explicit the different hierarchical orders involved. We expect that the proposed theoretical framework will open the way to the construction of original mathematical models, which would provide a better understanding of endocrine regulation from an organicist perspective. (shrink)

In this article an epistemological framework is proposed in order to integrate the emergentist thought with systemic studies on biological autonomy, which are focused on the role of organization. Particular attention will be paid to the role of the observer’s activity, especially: (a) the different operations he performs in order to identify the pertinent elements at each descriptive level, and (b) the relationships between the different models he builds from them. According to the approach sustained here, organization will be considered (...) as the result of a specific operation of identification of the relational properties of the functional components of a system, which do not necessarily coincide with the intrinsic properties of its structural constituents. Also, an epistemological notion of emergence—that of “complex emergence”—will be introduced, which can be defined as the insufficiency, even in principle, of a single descriptive modality to provide a complete description of certain classes of systems. This integrative framework will allow us to deal with two issues in biological and emergentist studies: (1) distinguishing the autonomy proper of living systems from some physical processes like those of structural stability and pattern generation, and (2) reconsidering the notion of downward causation not as a direct or indirect influence of the whole on its parts, but instead as an epistemological problem of interaction between descriptive domains in which the concept of organization proposed and the observational operations related to it play a crucial role. (shrink)

The new mechanists and the autonomy approach both aim to account for how biological phenomena are explained. One identifies appeals to how components of a mechanism are organized so that their activities produce a phenomenon. The other directs attention towards the whole organism and focuses on how it achieves self-maintenance. This paper discusses challenges each confronts and how each could benefit from collaboration with the other: the new mechanistic framework can gain by taking into account what happens outside individual mechanisms, (...) while the autonomy approach can ground itself in biological research into how the actual components constituting an autonomous system interact and contribute in different ways to realize and maintain the system. To press the case that these two traditions should be constructively integrated we describe how three recent developments in the autonomy tradition together provide a bridge between the two traditions: (1) a framework of work and constraints, (2) a conception of function grounded in the organization of an autonomous system, and (3) a focus on control. (shrink)

In this paper we address the question of minimal cognition by investigating the origin of some crucial cognitive properties from the very basic organisation of biological systems. More specifically, we propose a theoretical model of how a system can distinguish between specific features of its interaction with the environment, which is a fundamental requirement for the emergence of minimal forms of cognition. We argue that the appearance of this capacity is grounded in the molecular domain, and originates from basic mechanisms (...) of biological regulation. In doing so, our aim is to provide a theoretical account that can also work as a possible conceptual bridge between Synthetic Biology and Artificial Intelligence. In fact, we argue, Synthetic Biology can contribute to the study of minimal cognition, by providing a privileged approach to the study of these mechanisms by means of artificial systems. (shrink)

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible (...) contributions of definitions of life in scientific domains where such definitions are used most. Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research. (shrink)

This article analyses the Fair Trade sector as a “mixed-form market,” i.e., a market in which different types of players (in this case, nonprofit, co-operative and for-profit organizations) coexist and compete. The purposes of this article are (1) to understand the factors that have led Fair Trade to become a mixed-form market and (2) to propose some trails to understand the market dynamics that result from the interactions between the different types of players. We start by defining briefly Fair Trade, (...) its different dimensions (including the “fair” quality of the products) and its organizational landscape, focusing on the distinction between the pioneer “Alternative Trading Organizations” and the second-mover companies. Then, we recall the theoretical emergence factors for each type of organization (nonprofit, co-operative and for-profit) and apply these emergence factors to the context of Fair Trade. This analysis allows us to capture the specificities of each type of operator with regard to Fair Trade and, thus, to have a better understanding of the dynamics in the sector. Such dynamics includes competition, but also conflict and partnership. Our analysis includes elements on ethical imitation, consumers’ behaviors, effects on welfare and the role of the government. (shrink)

The main models of scientific explanation assume the need for some kind of stable knowledge for assembling a good explanatory argument. While these approaches are useful in the natural sciences, it is doubtful that they are similarly applicable in the socioeconomic realm. In this paper it is expected to show that the logic of socioeconomic processes of being "possibility trees" or "open-ended results" makes regularities the exception rather than the rule. Alternatively, a mode of explanation that focuses on contextual factors (...) and people actions is proposed. Los principales modelos de explicación científica asumen la necesidad de utilizar algún tipo de conocimiento estable para el armado de un buen argumento explicativo. Si bien estos enfoques son muy útiles en las ciencias naturales, es dudoso que sean similarmente aplicables en el reino de lo socioeconómico. En el presente trabajo se prevé mostrar que la lógica de los “árboles de posibilidades” o “resultados de final abierto” propias de los procesos socioeconómicos hace que las regularidades sean más la excepción que la regla. Como alternativa, se propone un modo de explicación que focalice en los factores contextuales y en las acciones de las personas en el momento en que aconteció el fenómeno a explicar. (shrink)

Horacio Fazio EUDEBA 2013, 179 pp. ISBN: 978-950-23-2107-3.

Com recuerdo y fiel homenaje a nuestro genial compatrinta, el ingeniero e inventar santanderino Leonardo Torres Quevedo, THEORIA quiere reeoger hoy en sus páginas dos breves, claros y luminosostextos -el primero sobre máquinas algébricas (1901) y el segundo sobre el alcance de una nueva ciencia: la Automática (1915)- de aquel español itinerante e infatigable que, como muy contadascompatriotas, supo aliar claridad y rlgor lógico en las definiciones de los conceptos básicos y desbordante inventiva creadora en la estricta y audaz (...) aplicación técnica de los mismos.Acompaña a estos textos la inolvidable imagen del primer ajedrecista automático (electromagnetico) concebido y construido por Torres Quevedo, anticipador también en la era electromecanica de los que habían de seguirle en la electrónica e informática y triunfador póstumo, en 1951, en el primer Congreso Cibernético de París, donde fué examinado por el hijo del inventor español y el padre de la Cibernética, Norbert Wiener, tres años después de la aparición en el M.I.T. de la primera edición inglesa de la obra de éste último Cybemetics, or control and communication in the animal and the machine (1948) que iba a inaugurar la era de la Cibernética, anticipada en tantas ideas, muchos decenios antes, por la Automática de nuestro Torres Quevedo. (shrink)

In this article we analyse the problem of emergence in its diachronic dimension. In other words, we intend to deal with the generation of novelties in natural processes. Our approach aims at integrating some insights coming from Whitehead’s Philosophy of the Process with the epistemological framework developed by the “autopoietic” tradition. Our thesis is that the emergence of new entities and rules of interaction (new “fields of relatedness”) requires the development of discontinuous models of change. From this standpoint natural evolution (...) can be conceived as a succession of emergences — each one realizing a novel “extended” present, described by distinct models — rather than as a single and continuous dynamics. This theoretical and epistemological framework is particularly suitable to the investigation of the origin of life, an emblematic example of this kind of processes. (shrink)

O presente artigo apresenta como intuito primordial uma exposição acerca da temática da desumanização presente na literatura de testemunho de Primo Levi (1919-1987) e nas reflexões de Hannah Arendt (1906-1975), sobretudo em sua obra Eichmann em Jerusalém. A investigação acerca do fenômeno da desumanização no universo concentracionário nazista será realizada, primordialmente, a partir de sua relação com a tese da banalidade do mal, que aborda a impessoalização e a perda da consciência moral como integrantes do projeto totalitário de supressão da (...) individualidade e da banalização da barbárie. Numa primeira análise, foi estabelecida uma breve ponderação sobre os principais aspectos do “mal banal” na perspectiva da narrativa histórica de Arendt e de que forma tais elementos dialogam com a despersonalização. Em seguida, a temática da desumanização foi analisada propriamente na literatura primoleviana. Por fim, foi traçado um paralelo entre os dois autores, atestando, de forma categórica, um vínculo direto entre o totalitarismo, a proliferação da banalidade do mal e a desumanização. Fundamentado sob a metodologia de abordagem dedutiva, o presente trabalho foi construído com a utilização de fontes bibliográficas. (shrink)

Resumo Este artigo procura apresentar e discutir tentativas recentes em filosofia social de analisar e interpretar o capitalismo, a partir de uma perspectiva praxeológica. O practice turn em teoria social procurou superar o dualismo entre agência e estrutura, ou entre ação e sistema, por meio da noção de prática social. Seria possível então interpretar o capitalismo como um tipo especifico de prática social? Para tentar encaminhar essa questão, explicita-se brevemente, em um primeiro momento, em que consiste o practice turn em (...) teoria social. Num segundo momento, analisa-se e se discute a proposta de Rahel Jaeggi de conceber a economia como uma rede de práticas sociais. Em seguida, expõe-se e se avalia a tentativa de Christian Lotz em ver, no dinheiro, a chave para compreender aquilo que ele chama de esquema capitalista. Por fim, conclui-se, chamando a atenção para os potenciais e desafios ligados ao empreendimento de interpretar o capitalismo em função de uma teoria da prática, sugerindo que um aprofundamento na análise da imaginação especificamente capitalista, vinculando-a com a típica plasticidade e diversidade do capitalismo, possa ajudar a avançar nesse campo.This paper aims to present and discuss recent attempts in social philosophy to analyze and interpret capitalism from a praxeological perspective. The practice turn in social theory sought to overcome the dualism between agency and structure, or between action and system, through the notion of social practice. Is it then possible to interpret capitalism as a specific type of social practice? To try to address this question, I briefly introduce, in a first moment, the practice turn in social theory. In a second moment, I analyze and discuss Rahel Jaeggi’s proposal to conceive the economy as a network of social practices. I then explain and evaluate Christian Lotz’s attempt to see money as the key to understanding what he names as “the capitalist schema”. Finally, I conclude by drawing attention to the potentials and challenges of interpreting capitalism as a social practice, suggesting that a deeper analysis of specifically capitalist imagination, linking it with the typical plasticity and diversity of capitalism, may help to move forward in this field. (shrink)

En tiempos de olvido, el texto evoca la memoria de sufrimiento de las víctimas. En tiempos de derrota, el texto invoca la utopía de un futuro digno de nuestra humana condición. En tiempos de indolencia, el texto convoca el compromiso con la construcción plural de la democracia.

In this paper a critique to philosophical approaches that presuppose invariant knowledge for policy purposes is carried out. It is shown that socioeconomic processes do not fit to the logic of stable causal factors, but they are more suited to the logic of "open-ended results". On the basis of this ontological variation it is argued that ex-ante interventions are not appropriate in the socioeconomic realm. On the contrary, they must be understood in a “dynamic” sense. Finally, derivational robustness analysis is (...) proposed as a useful tool for overcoming the problem of “overconstraint”, a typical problem of economic models. (shrink)

The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One (...) of the virtues of the organismic approach focused on organization is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes. Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviors are constrained and controlled by the system they realize. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organization, we argue that these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system. In this paper, we provide a new theoretical framework to understand multicellularity, capable to overcome these issues. Our thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organization of the intercellular space. In our view, the capability to be organized in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialized functions such as immunity. We argue that the extracellular matrix plays a crucial active role in this respect, as an evolutionary ancient and specific (non-cellular) control subsystem that contributes as a key actor to the functional specification of the multicellular space and to modulate cell fate and behavior. We also analyze how multicellular systems exert control upon internal movement and communication. Finally, we show how the organization of space is involved in some of the failures of multicellular organization, such as aging and cancer. (shrink)