We applaud Ray and Cooper (2024) for emphasizing environmental health as a bioethics issue. As a team of interdisciplinary pediatric researchers and providers who are part of an institutional clima...

The optimality approach to modeling natural selection has been criticized by many biologists and philosophers of biology. For instance, Lewontin (1979) argues that the optimality approach is a shortcut that will be replaced by models incorporating genetic information, if and when such models become available. In contrast, I think that optimality models have a permanent role in evolutionary study. I base my argument for this claim on what I think it takes to best explain an event. In certain contexts, optimality (...) and game-theoretic models best explain some central types of evolutionary phenomena. ‡Thanks to Michael Friedman, Helen Longino, Michael Weisberg, and especially Elliott Sober for comments on earlier drafts of this paper. †To contact the author, please write to: Department of Philosophy, Stanford University, Stanford, CA 94305-2155; e-mail: [email protected]. (shrink)

O Transtorno do Espectro Autista (TEA) é caracterizado pela presença de déficits persistentes na comunicação e interação social, além de padrões restritos e repetitivos de comportamentos, interesses e atividades. Como forma de viabilizar a inclusão das crianças autistas no ambiente escolar, a orientação dos professores que atuam com este público é de suma importância. O objetivo do estudo é apresentar a experiência de orientação feita para os professores que lecionam para alunos autistas, acompanhados pelo Núcleo de Atenção ao TEA, da (...) cidade de Monte Alto-SP, no período de junho de 2022 a junho de 2023. Trata-se de um estudo descritivo, do tipo relato de experiência, embasado na ciência ABA (Análise do Comportamento Aplicada) e relacionado às vivências com os professores em orientações, realizadas mensalmente. Como resultado, observou-se a dificuldade dos docentes em acolher estes alunos, direcionar atividades, lidar com comportamentos disruptivos e no manejo das atividades de vida diária. Discute-se a importância de uma ferramenta de apoio para proporcionar aos docentes maior respaldo teórico à prática com alunos autistas, para contribuir na inclusão, aprendizagem e socialização no ambiente escolar. Esta experiência ampliou as vivências sobre a perspectiva do professor na inclusão escolar de crianças com TEA, lançando luz sobre a necessidade de formação teórica e instrumentalização dos docentes, considerando as particularidades de neurodesenvolvimento e comportamento desta população e contribuindo para a maior eficácia da assistência educacional inclusiva. (shrink)

The purpose of this article is to show that animal rights are not necessarily at odds with the use of animals for research. If animals hold basic moral rights similar to those of humans, then we should consequently extend the ethical requirements guiding research with humans to research with animals. The article spells out how this can be done in practice by applying the seven requirements for ethical research with humans proposed by Ezekiel Emanuel, David Wendler and Christine Grady to (...) animal research. These requirements are i) social value, ii) scientific validity, iii) independent review, iv) fair subject selection, v) favorable risk-benefit ratio, vi) informed consent, and vii) respect for research subjects. In practice, this means that we must reform the practice of animal research to make it more similar to research with humans, rather than completely abolish the former. Indeed, if we banned animal research altogether, then we would also deprive animals of its potential benefits – which would be ethically problematic. (shrink)

Several evolutionary biologists have used a parsimony argument to argue that the single gene is the unit of selection. Since all evolution by natural selection can be represented in terms of selection coefficients attaching to single genes, it is, they say, "more parsimonious" to think that all selection is selection for or against single genes. We examine the limitations of this genic point of view, and then relate our criticisms to a broader view of the role of causal concepts and (...) the dangers of reification in science. (shrink)

Making data broadly accessible is essential to creating a medical information commons. Transparency about data-sharing practices can cultivate trust among prospective and existing MIC participants. We present an analysis of 34 initiatives sharing DNA-derived data based on public information. We describe data-sharing practices captured, including practices related to consent, privacy and security, data access, oversight, and participant engagement. Our results reveal that data-sharing initiatives have some distance to go in achieving transparency.

Advances in technologies and biomedical informatics have expanded capacity to generate and share biomedical data. With a lens on genomic data, we present a typology characterizing the data-sharing landscape in biomedical research to advance understanding of the key stakeholders and existing data-sharing practices. The typology highlights the diversity of data-sharing efforts and facilitators and reveals how novel data-sharing efforts are challenging existing norms regarding the role of individuals whom the data describe.

The propensity interpretation of fitness draws on the propensity interpretation of probability, but advocates of the former have not attended sufficiently to problems with the latter. The causal power of C to bring about E is not well-represented by the conditional probability Pr. Since the viability fitness of trait T is the conditional probability Pr, the viability fitness of the trait does not represent the degree to which having the trait causally promotes surviving. The same point holds for fertility fitness. (...) This failure of trait fitness to capture causal role can also be seen in the fact that coextensive traits must have the same fitness values even if one of them promotes survival and the other is neutral or deleterious. Although the fitness of a trait does not represent the trait’s causal power to promote survival and reproduction, variation in fitness in a population causally promotes change in trait frequencies; in this sense, fitness variation is a population-level propensity. (shrink)

To evaluate Hume's thesis that causal claims are always empirical, I consider three kinds of causal statement: ?e1 caused e2 ?, ?e1 promoted e2 ?, and ?e1 would promote e2 ?. Restricting my attention to cases in which ?e1 occurred? and ?e2 occurred? are both empirical, I argue that Hume was right about the first two, but wrong about the third. Standard causal models of natural selection that have this third form are a priori mathematical truths. Some are obvious, others (...) less so. Empirical work on natural selection takes the form of defending causal claims of the first two types. I provide biological examples that illustrate differences among these three kinds of causal claim. (shrink)

I want to explain some of the gaps I see between the concepts of morality and altruism. Indeed, there are three concepts here that need to be disentangled, not just two. Evolutionists use the terms “altruism” and “selfishness” in a way that differs from the usage found in ordinary parlance. So my goal is to separate evolutionary altruism, psychological altruism, and morality. Morality includes a variety of characteristics. There is more to morality than altruism. If we can avoid the mistake (...) of thinking we have explained the whole when we have explained only the part, we may yet be able to advance our understanding of what morality is and where it came from. (shrink)

Realism and empiricism have always been contradictory tendencies in the philosophy of science. The view I will sketch is a synthesis, which I call Contrastive Empiricism. Realism and empiricism are incompatible, so a synthesis that merely conjoined them would be a contradiction. Rather, I propose to isolate important elements in each and show that they combine harmoniously. I will leave behind what I regard as confusions and excesses. The result, I hope, will be neither contradiction nor mishmash.

Is it accurate to label Darwin's theory "the theory of evolution by natural selection," given that the concept of common ancestry is at least as central to Darwin's theory? Did Darwin reject the idea that group selection causes characteristics to evolve that are good for the group though bad for the individual? How does Darwin's discussion of God in The Origin of Species square with the common view that he is the champion of methodological naturalism? These are just some of (...) the intriguing questions raised in this volume of interconnected philosophical essays on Darwin. The author's approach is informed by modern issues in evolutionary biology, but is sensitive to the ways in which Darwin's outlook differed from that of many biologists today. The main topics that are the focus of the book--common ancestry, group selection, sex ratio, and naturalism--have rarely been discussed in their connection with Darwin in such penetrating detail. (shrink)

The properties, theoretical magnitudes, and natural kinds which science seeks to characterize, and not the sense or meanings which parts of speech may possess, are the subject of this paper. Many philosophers (e.g., Putnam [1971] and Achinstein [1974]) have agreed that two predicates of different meaning may pick out the same property, but they usually hold that that logically equivalent predicates must pick out the same properties. I propose to deny this thesis. My argument is by way of an example (...) and by appeal to a principle. The principle connects propertyhood with causal efficacy. The example situation I will describe in what follows is intended to show that the property of being a closed straight-sided figure having three sides is not the same property as that of being a closed straight-sided figure having three angles (a triangle). (shrink)

God and numbers provide two challenges to metaphysical naturalism–the former if God exists and is a supernatural being, the latter if numbers exist and mathematical Platonism is true. Evolutionary theory is often described as having a commitment to naturalism, but this is doubly wrong. The theory is neutral on the question of whether God exists and mathematical evolutionary theory entails that numbers exist. The chapter develops the point about theistic neutrality by considering what evolutionary biologists mean when they say that (...) mutations are “unguided.” Evolutionary theory is logically compatible with deism and also with various interventionist theologies. In connection with mathematical evolutionary theory, the chapter discusses and criticizes the indispensability argument for mathematical Platonism developed by Quine and Putnam. The chapter criticizes their epistemological holism by considering ideas in Bayesian confirmation theory. (shrink)

An empirical procedure is suggested for testing a model that postulates variables that intervene between observed causes and abserved effects against a model that includes no such postulate. The procedure is applied to two experiments in psychology. One involves a conditioning regimen that leads to response generalization; the other concerns the question of whether chimpanzees have a theory of mind.

Richard Boyd and Nicholas Sturgeon develop distinctive naturalistic arguments for scientific realism and moral realism. Each defends a realist position by an inference to the best explanation. In this paper, I suggest that these arguments for realism should be reformulated, with the law of likelihood replacing inference to the best explanation. The resulting arguments for realism do not work.

I consider three theses that are friendly to anthropomorphism. Each makes a claim about what can be inferred about the mental life of chimpanzees from the fact that humans and chimpanzees both have behavioral trait B and humans produce this behavior by having mental trait M. The first thesis asserts that this fact makes it probable that chimpanzees have M. The second says that this fact provides strong evidence that chimpanzees have M. The third claims that the fact is evidence (...) that chimpanzees have M. The third thesis follows from a plausible Reichenbachian model of how a common ancestor is probabilistically related to its descendants. The first two theses do not, and they have no general evolutionary justification. (shrink)

Quine has developed two reasons for thinking that our ontology should not include the ontological category of properties. His first point is that the criterion for individuating properties is unclear, and the second is that postulating the existence of properties would not explain anything. In what follows I critically examine these two themes, which I will call the clarity argument and the parsimony argument. Although I will suggest that these two arguments are defective, I also will try to show that (...) certain related arguments on behalf of the existence of properties are likewise flawed. This will set the stage for the discussion in the fourth section of the perspective provided by evolutionary theory on the question of the ontological status of properties. It will emerge that evolutionary theory provides reason for thinking that properties exist, and, additionally, gives an interesting point of view on the epistemological and metaphysical issues that Quine has addressed. (shrink)

In what follows, I propose to evaluate Giere's analysis by applying it to a causal process considered in evolutionary theory, namely, natural selection. To say that there is selection for a given trait is to say that possessing that trait causes differential reproductive success. If there is selection for a trait and if no other evolutionary forces impinge and there is no "sampling error" due to random drift, individuals with the trait will on average have more offspring than individuals without (...) it. But sampling error can't be discounted for finite populations; so the combined effect of selection and drift will be a probability distribution of numbers of offspring. In this event, selection for a trait will imply that the mean value of the distribution associated with the individuals possessing the trait exceeds the mean value for individuals without the trait. Evolutionary theory assigns a probability distribution of possible reproductive outputs to each organism and, thereby, views organisms as stochastic systems. This implies no commitment to indeterminacy at the microlevel, of course. (shrink)

In this paper I discuss two questions. What does Kant understand by mechanical explanation in the Critique of judgment? And why does he think that mechanical explanation is the only type of the explanation of nature available to us? According to the interpretation proposed, mechanical explanations in the Critique of judgment refer to a particular species of empirical causal laws. Mechanical laws aim to explain nature by reference to the causal interaction between the forces of the parts of matter and (...) the way in which they form into complex material wholes. Just like any other empirical causal law, however, mechanical laws can never be known with full certainty. The conception according to which we can explain all of nature by means of mechanical laws, it turns out, is based on what Kant calls ‘regulative’ or ‘reflective’ considerations about nature. Nothing in Kant’s Critique of judgment suggests that these considerations can ever be justified by reference to how the natural world really is. I suggest that what, upon first consideration, appears to be a thoroughly mechanistic conception of nature in Kant is much more limited than one might have expected. (shrink)

There are two concepts of causes, property causation and token causation. The principle I want to discuss describes an epistemological connection between the two concepts, which I call the Connecting Principle. The rough idea is that if a token event of type Cis followed by a token event of type E, then the support of the hypothesis that the first event token caused the second increases as the strength of the property causal relation of C to E does. I demonstrate (...) the principle, illustrate its application to phylogenies, infections, and rumours, and discuss its consequence for the conceptual distinctness of causal processes from the events they connect. Although I am by no means confident that the Connecting Principle is ultimately correct, it seems to be a useful point of departure into an important aspect of the epistemology of causality. (shrink)

In this paper, I'll explore three contexts in which the heuristic of personification yields the wrong answer. They all come from game theoretic discussion of altruism and the Prisoner's Dilemma. Whether it is applied to evolution or to rational deliberation, game theory models situations that involve frequency dependence. In the evolutionary case, how fit a trait is, and whether it is more or less fit than the alternatives, depends on the composition of the population (Maynard Smith 1982). In the case (...) of rational deliberation, which act is best for the agent depends on what other actors are likely to do. As we now will see, frequency dependence can throw a monkey wrench into the convenient relationship between deliberation and evolution posited by the heuristic of personification. (shrink)

The 1940s and 1950s were marked by intense debates over the origin of drug resistance in microbes. Bacteriologists had traditionally invoked the notions of ‘training’ and ‘adaptation’ to account for the ability of microbes to acquire new traits. As the field of bacterial genetics emerged, however, its participants rejected ‘Lamarckian’ views of microbial heredity, and offered statistical evidence that drug resistance resulted from the selection of random resistant mutants. Antibiotic resistance became a key issue among those disputing physiological vs. genetic (...) explanations of variation in bacteria. Postwar developments connected with the Lysenko affair gave this debate a new political valence.Proponents of the neo-Darwinian synthesis weighed in with support for the genetic theory. However, certain features of drug resistance seemed inexplicable by mutation and selection, particularly the phenomenon of ‘multiple resistance’—the emergence of resistance in a single strain against several unrelated antibiotics. In the late 1950s, Tsutomu Watanabe and his collaborators solved this puzzle by determining that resistance could be conferred by cytoplasmic resistance factors rather than chromosomal mutation. These R factors could carry resistance to many antibiotics and seemed able to promote their own dissemination in bacterial populations. In the end, the vindication of the genetic view of drug resistance was accompanied by a recasting of the ‘gene’ to include extrachromosomal hereditary units carried on viruses and plasmids. (shrink)

Nelson Goodman suggests that a generalization of the form “all A’s are B” is confirmable by an observed instance only if the generalization is law-like. Jackson and Pargetter deny this and give examples of how accidental generalizations can be confirmed. A possible response from Goodman appears to make these accidental generalizations look law-like, but I show it’s defective. And Jackson and Pargetter's substitute nomological condition fares no better than Goodman’s. Because of the multiplicity of possible background assumptions, I doubt that (...) there is a single “nomological condition” that each and every act of confirmation must obey. (shrink)

Moving away from the strong body of critique of pervasive ‘bad data’ practices by both governments and private actors in the globalized digital economy, this book aims to paint an alternative, more optimistic but still pragmatic picture of the datafied future. The authors examine and propose ‘good data’ practices, values and principles from an interdisciplinary, international perspective. From ideas of data sovereignty and justice, to manifestos for change and calls for activism, this collection opens a multifaceted conversation on the kinds (...) of futures we want to see, and presents concrete steps on how we can start realizing good data in practice. (shrink)

When philosophers discuss the topic of explanation, they usually have in mind the following question: given the beliefs one has and some proposition that one wishes to explain, which subset of the beliefs constitutes an explanation of the target proposition? That is, the philosophical ‘problem of explanation’ typically has bracketed the issue of how one obtains the beliefs; they are taken as given. The problem of explanation has been the problem of understanding the relation ‘x explains y’. Since Hempel did (...) so much to canonize this way of thinking about explanation, it deserves to be called ‘Hempel's problem’. (shrink)

Markov models of evolution describe changes in the probability distribution of the trait values a population might exhibit. In consequence, they also describe how entropy and conditional entropy values evolve, and how the mutual information that characterizes the relation between an earlier and a later moment in a lineage’s history depends on how much time separates them. These models therefore provide an interesting perspective on questions that usually are considered in the foundations of physics—when and why does entropy increase and (...) at what rates do changes in entropy take place? They also throw light on an important epistemological question: are there limits on what your observations of the present can tell you about the evolutionary past? (shrink)

My chapter aims to advance the debate on a problem often raised by philosophers who are skeptical of implied narrators in movies. This is the concern that positing such elusive narrators gives rise to absurd imaginings (Gaut 2004: 242; Carroll 2006: 179-180). -/- Friends of the implied cinematic narrator reply that the questions critics raise about the workings of the implied cinematic narrator are "silly ones" to ask. -/- I examine how the "absurd imaginings" problem arises for all the central (...) arguments for the elusive cinematic narrator and discuss why the questions critics pose about this narrator are legitimate ones to ask. (shrink)

This paper examines the US Atomic Energy Commission’s radioisotope distribution program, established in 1946, which employed the uranium piles built for the wartime bomb project to produce specific radioisotopes for use in scientific investigation and medical therapy. As soon as the program was announced, requests from researchers began pouring into the Commission’s office. During the first year of the program alone over 1000 radioisotope shipments were sent out. The numerous requests that came from scientists outside the United States, however, sparked (...) a political debate about whether the Commission should or even could export radioisotopes. This controversy manifested the tension between the aims of the Marshall Plan and growing US national security concerns after World War II. Proponents of international circulation of radioisotopes emphasized the political and scientific value of collaborating with European scientists, especially biomedical researchers. In the end, radioisotopes were shipped from the Commission’s Oak Ridge facility to many laboratories in England and continental Europe, where they were used in biochemical research on animals, plants, and microbes. However, the issue of radioisotope export continued to draw political fire in the United States, even after the establishment of national atomic energy facilities elsewhere. (shrink)

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During (...) the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

In this chapter, it is argued that some animal shelters fulfill the conditions that make triage protocols necessary, namely, the operation with limited financial budgets, space, medical resources, and staff. It is suggested that requirements presented for triage in humans can be fruitfully applied to the context of animal shelters. The focus lies on the criteria of maximizing benefit, justice, medical criteria, life-span considerations, fair decision-making, patient will, re-evaluation of triage decisions and changes in the therapeutic goal, and burden of (...) triage and staff support. The establishment of triage protocols for shelters will make the decision-making process less arbitrary, fairer, and more transparent. Furthermore, it is argued that, in situations where disagreement persist among shelter staff, an external Ethics Board could be called in to help analyze and potentially resolve some of the remaining ethical issues. (shrink)

The likelihood justification of cladistic parsimony suggested in Sober (1984) is here shown to be incomplete. Even so, cladistic parsimony remains a counter-example to the principle of the common cause formulated by Reichenbach (1956) and Salmon (1975, 1979, 1984).

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During (...) the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

Suppose that several observations “coincide,” meaning that they are similar in some interesting respect. Is this coinciding a mere coincidence, or does it derive from a common cause? Those who reason about this kind of question—whether they embrace the first answer or the second—often deploy a mode of inference that I call probabilistic modus tollens. In this chapter I criticize probabilistic modus tollens and consider likelihood and Bayesian frameworks for reasoning about coincidences. I also consider the perspective offered by model (...) selection theory (including the Akaike information criterion), and argue that model selection often provides important insights. (shrink)

Scientists and historians have often presumed that the divide between biochemistry and molecular biology is fundamentally epistemological.100 The historiography of molecular biology as promulgated by Max Delbrück's phage disciples similarly emphasizes inherent differences between the archaic tradition of biochemistry and the approach of phage geneticists, the ur molecular biologists. A historical analysis of the development of both disciplines at Berkeley mitigates against accepting predestined differences, and underscores the similarities between the postwar development of biochemistry and the emergence of molecular biology (...) as a university discipline. Stanley's image of postwar biochemistry, with its focus on viruses as key experimental systems, and its preference for following macromolecular structure over metabolism pathways, traced the outline of molecular biology in 1950.Changes in the postwar political economy of research universities enabled the proliferation of disciplines such as microbiology, biochemistry, biophysics, immunology, and molecular biology in universities rather than in medical schools and agricultural colleges. These disciplines were predominantly concerned with investigating life at the subcellular level-research that during the 1930s had often entailed collaboration with physicists and chemists. The interdisciplinary efforts of the 1930s (many fostered by the Rockefeller Foundation) yielded a host of new tools and reagents that were standardized and mass-produced for laboratories after World War II. This commercial infrastructure enabled “basic” researchers in biochemistry and molecular biology in the 1950s and 1960s to become more independent from physics and chemistry (although they were practicing a physicochemical biology), as well as from the agricultural and medical schools that had previously housed or sponsored such research. In turn, the disciplines increasingly required their practitioners to have specialized graduate training, rather than admitting interlopers from the physical sciences.These general transitions toward greater autonomy for biochemistry and allied disciplines should not mask the important particularities of these developments on each campus. At the University of Caliornia at Berkeley, agriculture had provided, with medicine, significant sponsorship for biochemistry. The proximity of Lawrence and his cyclotrons supported the early development of Berkeley as a center for the biological uses of radioisotopes, particularly in studies of metabolism and photosynthesis. Stanley arrived to establish his department and virus institute before large-scale federal funding of biomedical research was in place, and he courted the state of California for substantial backing by promising both national prominence in the life sciences and virus research pertinent to agriculture and public health. Stanley's venture benefited significantly from the expansion of California's economy after World War II, and his mobilization against viral diseases resonated with the concerns of the Cold War, which fueled the state's rapid growth. The scientific prominence of contemporary developments at Caltech and Stanford invites the historical examination of the significance of postwar biochemistry and molecular biology within the political and cultural economy of the Golden State.In 1950, Stanley presented a persuasive picture of the power of biochemistry to refurbish life science at Berkeley while answering fundamental questions about life and infection. In the words of one Rockefeller Foundation officer,There seems little doubt in [my] mind that as a personality Stanley will be well able to dominate the other personalities on the Berkeley campus and will be able to drive his dream through to completion, which, incidentally, leaves Dr. Hubert [sic] Evans and the whole ineffective Life Sciences building in the somewhat peculiar position of being by-passed by much of the truly modern biochemistry and biophysics research that will be carried out at Berkeley. Furthermore, it seems likely that Dr. S's show will throw Dr. John Lawrence's Biophysics Department strongly in the shade both figuratively and literally, but should make the University of California pre-eminent not only in physics but in biochemistry as well.101Stanley, Sproul, Weaver, and this officer (William Loomis) all testified to a perceptible postwar opportunity to capitalize on public support for biological research that relied on the technologies from physics and chemistry without being captive to them, and that addressed issues of medicine and agriculture without being institutionally subservient. What is striking, given the expectation by many that Stanley would ‘be able to drive his dream through to completion,” was that in fact he did not. Biochemists who had succeeded in making their expertise valued in specialized niches were resistant to giving up their affiliations to joint Stanley's “liberated” organization. Stanley's failure was not simply due to institutional factors: researchers as well as Rockefeller Foundation officers faulted him for his lack of scientific imagination, which made it difficult for him to gain credibility in leading the field. Moreover, many biochemists did not share Stanley's commitment to viruses as the key material for the “new biochemistry.”In the end, Stanley's free-standing department did become a first-rate department of biochemistry, but only after freeing itself from Stanley's leadership and his single-minded devotion to viruses. Nonetheless, the falling-out with the Berkeley biochemists was rapidly followed by the establishment of a Department of Molecular Biology, attesting to the unabating economic and institutional possibilities for an authoritative “general biology” (or two, for that matter) to take hold. In each case, following Stanley's dream sheds light on how the possible and the real shaped the (re)formation of biochemistry and molecular biology as postwar life sciences. (shrink)

This paper proposes a game-theoretic solution of the surprise examination problem. It is argued that the game of “matching pennies” provides a useful model for the interaction of a teacher who wants her exam to be surprising and students who want to avoid being surprised. A distinction is drawn between prudential and evidential versions of the problem. In both, the teacher should not assign a probability of zero to giving the exam on the last day. This representation of the problem (...) provides a diagnosis of where the backwards induction argument, which “proves” that no surprise exam is possible, is mistaken. (shrink)

Philosophers frequently extract two lessons from Moliere's joke about the doctor who tried to explain why opium puts people to sleep by claiming that it has a dormative virtue. First, the principle I will call the equivalence thesis: attributions of dispositional properties are equivalent to certain associated subjunctive conditionals. The second is what I will call the reducibility thesis: for a dispositional concept to be nonproblematic, its “physical basis” must be found. In what follows, I will briefly describe three theoretical (...) positions that have been defended in different areas of psychology. Each claims that a certain disposition does not exist, even though the associated subjunctive conditional is not called into question. Besides showing that the equivalence thesis is mistaken, these examples also illustrate how that doctrine in fact conflicts with the requirement of reducibility. Not that that demand can withstand criticism either; both the equivalence claim and the reducibility claim are mistaken. (shrink)

Although the justification for using cladistic parsimony to infer phylogenetic trees has been extensively discussed, much less attention has been paid to the use of cladistic parsimony to reconstruct the character states of the ancestral species postulated by an inferred phylogenetic tree. These two problems differ in terms of both their inputs and their outputs, as shown in the following table. In the former, one begins with data on the character states of extant species and tries to find the best (...) supported phylogenetic tree. In the latter, one begins with the tree that is most firmly supported by characteristics C1, C2,... Cn-1; one then takes some new characteristic Cn and records the character states of Cn that attach to the tree’s interior nodes, which represent common ancestors. In both cases, cladistic parsimony solves the problem by finding the hypothesis that requires the fewest changes in character state that are needed to explain the observations. (shrink)