Omniprésent dans les médias, le terme transhumanisme nécessite un éclaircissement académique. En effet, il n'existe pas un, mais des transhumanismes. La parole est ici donnée à des penseurs de diverses disciplines, plus ou moins ouverts à ce courant d'idées parfois taxé d'idéologie, voire de menace pour l'Humanité. Ces craintes sont-elles fondées? Quelles sont les origines de ce mouvement de pensée? Quels en sont les différentes ramifications? Quelles en sont les réalisations, notamment dans le domaine médical? Un encadrement éthique et/ou juridique (...) de ces pratiques est- elle nécessaire? De nouveaux droits fondamentaux méritaient-ils d'être reconnus? La parole est ici donnée tant aux militants transhumanistes qu'aux penseurs critiques afin de croiser leurs regards"--Page 4 of cover. (shrink)

Compared to other animals, humans appear to have a special motivation to share experiences and mental states with others (Clark, 2006; Grice, 1975), which enables them to enter a condition of ‘we’ or shared intentionality (Tomasello & Carpenter, 2005). Shared intentionality has been suggested to be an evolutionary response to unique problems faced in complex joint action coordination (Levinson, 2006; Tomasello, Carpenter, Call, Behne, & Moll, 2005) and to be unique to humans (Tomasello, 2014). The theoretical and empirical bases for (...) this claim, however, present several issues and inconsistencies. Here, we suggest that shared intentionality can be approached as an interactional achievement, and that by studying how our closest relatives, the great apes, coordinate joint action with conspecifics, we might demonstrate some correlate abilities of shared intentionality, such as the appreciation of joint commitment. We provide seven examples from bonobo joint activities to illustrate our framework. (shrink)

This study examines the relationships of servant leadership to organizational commitment, voice behaviors, and antisocial behaviors. Adopting a multifaceted approach to commitment, we hypothesized that servant leadership would be positively related to affective, normative, and perceived sacrifice commitment, but unrelated to few alternatives commitment. We further hypothesized that affective commitment would be positively related to voice behaviors, controlling for the other commitment components, and would mediate a positive relationship between servant leadership and voice behaviors. Similarly, we hypothesized that normative commitment (...) would be negatively related to antisocial behaviors, controlling for the other commitment components, and would mediate a negative relationship between servant leadership and antisocial behaviors. These predictions were tested using matched data from a sample of 181 Canadian customer service employees and their managers. Results largely supported the above predictions. Importantly, affective commitment mediated a positive relationship between servant leadership and voice behaviors. Yet, while servant leadership was positively related to normative commitment and the latter was negatively related to antisocial behaviors, the indirect effect of servant leadership on these behaviors through normative commitment was nonsignificant. Theoretical implications and future research directions are discussed. (shrink)

Patočka has never developed the political and historical concept of dissidence. But trying to sketch its phenomenological foundation in the writings of the Czech philosopher, who experienced human liberty as an act of dissidence, could be an original way in qualifying his alternative idea of the modern subjectivity in phenomenology: between finitude and autonomy. The first part of the article presents the radical criticism aimed by Patočka to the transcendental subjectivism of Husserl, and thinks the requirement of a split between (...) autofoundation and autonomy. Then, it is analysed the articulation between the movement of life and the movement of existence, in which lies the very idea of dissidence. In a third and final part, one shows to what extent the dissident subjectivity fully reveals itself in the political life. (shrink)

Patočka has never developed the political and historical concept of dissidence. But trying to sketch its phenomenological foundation in the writings of the Czech philosopher, who experienced human liberty as an act of dissidence, could be an original way in qualifying his alternative idea of the modern subjectivity in phenomenology: between finitude and autonomy. The first part of the article presents the radical criticism aimed by Patočka to the transcendental subjectivism of Husserl, and thinks the requirement of a split between (...) autofoundation and autonomy. Then, it is analysed the articulation between the movement of life and the movement of existence, in which lies the very idea of dissidence. In a third and final part, one shows to what extent the dissident subjectivity fully reveals itself in the political life. (shrink)

This paper draws on an in-depth phenomenological analysis of some interviews taken from volunteers, inviting them to reflect on their lived experiences of meaningfulness in the context of volunteering and citizenship. It is found that while some testimonies reinforce the standard conceptions of meaningfulness, other testimonies vary from it. The main challenge of this contribution consists in phenomenologically describing this alternative picture of meaningfulness, depicted as the event of wit(h)nessing. In a final part, the authors consider how volunteering is at (...) times especially prone to further experiences of wit(h)nessing. (shrink)

Après avoir présenté l’institution récente de la kafâla, qui fut légalisée en Algérie en 1984 et au Maroc en 1993 en faveur des enfants abandonnés et en substitution au modèle prohibé de l’adoption, l’article propose une analyse des données recueillies lors d’une enquête ethnographique menée de 2005 à 2009. Elle révèle que l’enfant illégitime encourt davantage le risque d’être abandonné à la naissance s’il est de sexe masculin. En revanche, s’il est de sexe féminin, il bénéficie de plus de chances (...) de faire l’objet d’un don provisoire, direct et négocié, et surtout d’être adopté ou recueilli en kafâla suite à son abandon en institution. (shrink)

Background: Autonomy is a central concept in both bioethics and rehabilitation. Bioethics has emphasized autonomy as self-governance and its application in treatment decision-making. In addition to discussing decisional autonomy, rehabilitation also focuses on autonomy as functional independence. In practice, responding to patients with diminished autonomy is an important component of rehabilitation care, but also gives rise to tensions and challenges. Our objective was to better understand the complex and distinctive ways that autonomy is understood and upheld in the context of (...) rehabilitation care by reviewing how autonomy is discussed in the rehabilitation literature. Methods: We conducted a scoping review addressing issues of autonomy in the context of mental and physical rehabilitation. Our process followed three sequential steps. We extracted and analyzed bibliometric information. We then examined how autonomy was defined and conceptualized. Finally, we examined how the articles discussed the roles of rehabilitation health professionals in responding to patient autonomy. Findings: The articles include 16 empirical reports, 17 case studies and 30 theoretical papers. The most common conceptual accounts of autonomy drew upon principlism, rights-based and legal analyses, and relational/social approaches. We identified four broad approaches for responding to patient autonomy: supporting, promoting, respecting and advocating. Conclusion: This review helps clarify some of the ambiguities and conceptual distinctions underlying discussions and practices related to autonomy in rehabilitation. It also draws attention to a wide range of activities that health professionals can undertake with the goal of supporting, promoting, respecting and advocating for patient autonomy in rehabilitation care. (shrink)

Background: Autonomy is a central concept in both bioethics and rehabilitation. Bioethics has emphasized autonomy as self-governance and its application in treatment decision-making. In addition to discussing decisional autonomy, rehabilitation also focuses on autonomy as functional independence. In practice, responding to patients with diminished autonomy is an important component of rehabilitation care, but also gives rise to tensions and challenges. Our objective was to better understand the complex and distinctive ways that autonomy is understood and upheld in the context of (...) rehabilitation care by reviewing how autonomy is discussed in the rehabilitation literature. Methods: We conducted a scoping review addressing issues of autonomy in the context of mental and physical rehabilitation. Our process followed three sequential steps. We extracted and analyzed bibliometric information. We then examined how autonomy was defined and conceptualized. Finally, we examined how the articles discussed the roles of rehabilitation health professionals in responding to patient autonomy. Findings: The articles include 16 empirical reports, 17 case studies and 30 theoretical papers. The most common conceptual accounts of autonomy drew upon principlism, rights-based and legal analyses, and relational/social approaches. We identified four broad approaches for responding to patient autonomy: supporting, promoting, respecting and advocating. Conclusion: This review helps clarify some of the ambiguities and conceptual distinctions underlying discussions and practices related to autonomy in rehabilitation. It also draws attention to a wide range of activities that health professionals can undertake with the goal of supporting, promoting, respecting and advocating for patient autonomy in rehabilitation care. (shrink)

There are an increasing number of cell therapy approaches being studied and employed world‐wide. An emerging area in this field is the use of human pluripotent stem cell (hPSC) products for the treatment of injuries/diseases that cannot be effectively managed through current approaches. However, as with any cell therapy, vast numbers of functional and safe cells are required. Bioreactors provide an attractive avenue to generate clinically relevant cell numbers with decreased labour and decreased batch to batch variation. Yet, current methods (...) of performing quality control are not readily scalable to the cell densities produced during bioreactor scale‐up. One potential solution is the application of inducible/controllable suicide genes that can trigger cell death in unwanted cell types. These types of approaches have been demonstrated to increase the quality and safety of the resultant cell products. In this review, we will provide background on these approaches and how they could be used together with bioreactor technology to create effective bioprocesses for the generation of high quality and safe hPSCs for use in regenerative medicine approaches. (shrink)

Chora – le «cratère à mélanger» maternel, vannant et secouant de Platon – remplit «l’écart explicatif» entre les paradigmes formels «intelligibles et toujours existants» (48E5) et un monde encosmique «généré et visible». Proclus traite la gamme polysémique des termes utilisés par Platon pour chôra : hypodochê (réceptacle), kratêr (cratère à mélanger), etc., comme désignant des forces actives dans un univers où la sympathie cosmique règne, à partir des plus élevées, jusqu’aux plus basses manifestations de l’ «Un» transcendant. L’univers proclusien est (...) un «hénothéisme», dans lequel une «unité» dominante surgit sur la totalité de l’Être et du Devenir. Chôra permet à la fois au monde immatériel et au monde matériel de recevoir, de manière appropriée à chacun, les mêmes dons transcendants que leurs homologues intellectifs‑intelligibles superieurs. Aucun niveau de la réalité n’est dépourvu de cette donation. La réceptivité (hypodochê), indéterminée, mais toujours active, est présente à tous les niveaux. L’âme reçoit l’Intellect, la temporalité reçoit le temps monadique, la matière reçoit la structure géométrique polyédrique, etc. Chôra n’est pas l’equivalent de la matière, mais permet à la matière d’être imprimée par des paradigmes formels. Dans son rôle de «cratère à mélanger», elle protège la matière de sa potentielle itérabilité et dissolution infinie. Dans l’univers proclusien, le Bien atteint la dernière et la plus extrême de ses limites, il est espace et lieu, recevant à la fois l’expansivité et une capacité à donner place à la forme pour qu’elle puisse s’imposer à la matière. Après tout, les dons lui sont accordés depuis la plus haute hypostase, celle de la Limite et de l’Illimité, premier niveau après l’Un lui‑même. Vitale pour la création, la Chôra est alors la «mère» de tout. Il n’est donc pas étonnant que, comme nous le dit Proclus, la chôra soit, en fait, la déesse Rhéa. En hommage à la littérature révélatrice antique, comme les Oracles chaldaïques, Homère et Hésiode, Proclus fournit une élucidation non seulement philosophique, mais aussi théologique, de la chôra. À la différence de Platon, il théologise la Physique. (shrink)

Soul is the self-moving, self-constituting entity linking the transcendent with the immanent. Proclus distinguishes many types of souls. This chapter concentrates on the World Soul and the rational human soul. The World Soul infuses the sensible, temporal, divided, and material cosmos with unity and Forms ultimately deriving from the One and Intelligible Being, in a manner reminiscent of human phantasia. The mathematical psychology of the Timaeus is explained as referring to the Soul’s activity, rather than its essence. Concerning the human (...) soul, with its eternal essence and temporal activity, the authors concentrate on the function and nature of the many ‘vehicles’, assisting the soul’s descent and, in a different manner, its ascent. (shrink)

In this article, I take up Uri McMillan’s work in Embodied Avatars to rethink the subject–object relationship in women’s preaching. In performance art, the subject fashions herself into an object. I stretch the performance art genre to include preachers Rachel Baker, Jarena Lee, and Florence Spearing Randolph, arguing that these women have strategically performed objecthood to navigate gendered and racialized constraints in Christian proclamation. Examining these three women preachers through the lens of performing objecthood opens up theological understandings of how (...) the Spirit works in a world marked by social sin. Contrary to theologians who describe submission to the Spirit as self-effacement, I show how submission to the Spirit can counter worldly authorities, while enabling women preachers to transform perceptions of gender and race in a liberative way. (shrink)

Cet article s’inscrit dans une réflexion sur le tournant que représente la philosophie politique moderne. Il a pour but de déconstruire la manière dont Michel Villey expose ce tournant : dans des cours professés entre 1961 et 1966 à la Faculté de droit de Paris, ce dernier extrapole, à la pensée juridique moderne, le mythe de l’« augustinisme politique », qui avait été forgé par Henri-Xavier Arquillière pour caractériser la source principale des doctrines théocratiques médiévales. Cette déconstruction montre que la (...) philosophie politique moderne provient certes d’un motif central de la Cité de Dieu, mais ce motif subit une double interprétation qui en modifie la signification : Luther accomplit le passage du motif spirituel des deux cités au problème théologico-politique des deux régimes, tandis que Hobbes fait entrer ce problème en philosophie sur la base des principes de la métaphysique classique. (shrink)

Marcella Althaus-Reid puts in print a discussion of sex, gender, and politics. For womanist theologian and ethicist, Townes, black women's experiences have been left out of the theoretical and material constructs of both black and feminist theologies in the United States. Townes argues that Althaus-Reid casts the reader in the role of voyeur as she describes the women lemon vendors in Indecent Theology. The reader observes them from the safety of their own cultural, economic, theo-ethical and sociopolitical mud huts in (...) the same way as the Europeans who queued to view the so-called'Hottentot Venus' in the early 1800s. Nevertheless, Althaus-Reid offers an integrated, interstructured analysis that helps pry open the dynamics of oppressions. (shrink)

Le présent article établit deux résultats distincts mais complémentaires : il montre d’abord que Jan Patočka découvre, dans les années soixante-dix, le primat épistémologique de la donation, à partir duquel la question du monde dans son rapport au problème du donné se pose et se résout – le monde comme donné en totalité, le donné comme avance du monde ; il montre ensuite que cette découverte permet au philosophe tchèque de poser à nouveaux frais la question du sujet et de (...) faire émerger une nouvelle figure du sujet, dont les principales caractéristiques anticipent sur celles de l’adonné – le sujet comme adonné-au-monde. Cet article aboutit ainsi à montrer que les concepts fondamentaux de la phénoménologie de la donation (donné, adonné, contre-expérience, témoin, appel-réponse, etc.), quand ils sont appliqués à la phénoménologie de Patočka, ne fonctionnent pas comme des catégories anachroniques, mais au contraire comme des clés herméneutiques qui révèlent à la fois l’originalité et l’actualité de cette phénoménologie. (shrink)

The anvartha-saṃjñā compound associates two contradictory terms: anvartha, which means “[used] in conformity with his [etymological/first] meaning”, and saṃjñā which implies the idea of a convention; it therefore appears to be quite intriguing. The question is: is it relevant to focus on this contradiction or is it only a false problem? The aim of this paper is to answer the above question and this implies to grasp somewhat better the use of this notion by the Pāṇinian grammarians. To do so, (...) the author has studied the main texts of the Pāṇinian tradition, having in mind the following questions: did the Pāṇinian grammarians deal with this notion and, if so, in what terms? Did they perceive the contradiction raised by the association of the terms anvartha and samjñā? The study will show that this contradiction is only a false problem: according to the Pāṇinian grammarians quoted above, even when a saṃjñā is provided with an etymological/first meaning and its bearer (or one of its properties) is partly described by this meaning, this saṃjñā belongs, above all, to the domain of convention. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

Adaptive phenotypic plasticity allows organisms to cope with environmental variability, and yet, despite its adaptive significance, phenotypic plasticity is neither ubiquitous nor infinite. In this review, we merge developmental and population genetic perspectives to explore costs and limits on the evolution of plasticity. Specifically, we focus on the role of modularity in developmental genetic networks as a mechanism underlying phenotypic plasticity, and apply to it lessons learned from population genetic theory on the interplay between relaxed selection and mutation accumulation. We (...) argue that the environmental specificity of gene expression and the associated reduction in pleiotropic constraints drive a fundamental tradeoff between the range of plasticity that can be accommodated and mutation accumulation in alternative developmental networks. This tradeoff has broad implications for understanding the origin and maintenance of plasticity and may contribute to a better understanding of the role of plasticity in the origin, diversification, and loss of phenotypic diversity. (shrink)

After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have to be (...) assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, self-related knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species. (shrink)

This paper draws on an in-depth phenomenological analysis of some interviews taken from volunteers, inviting them to reflect on their lived experiences of meaningfulness in the context of volunteering and citizenship. It is found that while some testimonies reinforce the standard conceptions of meaningfulness, other testimonies vary from it. The main challenge of this contribution consists in phenomenologically describing this alternative picture of meaningfulness, depicted as the event of witnessing. In a final part, the authors consider how volunteering is at (...) times especially prone to further experiences of witnessing. (shrink)

In this comment on Johan Von Essen’s contribution on the meaning of volunteering we make some remarks about Von Essen’s starting point, which reveals a particular perspective on meaningfulness, namely that people perceive reality as meaningful when their actions and the things they encounter are part of a meaningful whole. By introducing another perspective on meaningfulness, namely that the shattering of a meaningful whole is full of meaning, we question if practices of volunteering which occur in face-to-face situations—and thus outside (...) the public realm—can be fully captured by the five predicates that make up the phenomenological structure of volunteering. (shrink)

In recent years, humans’ ability to selectively modify genes has increased dramatically as a result of the development of new, more efficient, and easier genetic modification technology. In this paper, we argue in favor of using this technology to improve the welfare of agricultural animals. We first argue that using animals genetically modified for improved welfare is preferable to the current status quo. Nevertheless, the strongest argument against pursuing gene editing for welfare is that there are alternative approaches to addressing (...) some of the challenges of modern agriculture that may offer ethical advantages over genetic modification; namely, a dramatic shift towards plant-based diets or the development of in vitro meat. Nevertheless, we provide reasons for thinking that despite these possible comparative disadvantages there are important reasons for continuing the pursuit of welfare improvements via genetic modification. (shrink)

The Darwinian economic theory that Thorstein Veblen proposed and refined while he served as a professor of Political Economy at the University of Chicago from 1891 to 1906 should be assessed in the context of the community of Darwinian scientists and social scientists with whom Veblen worked and lived at Chicago. It is important to identify Veblen as a member of this broad community of Darwinian-inclined philosophers, physiologists, geologists, astronomers, and biologists at Chicago because Veblen’s involvement with this circle suggests (...) that the possible sources of his engagement with Darwinism extend beyond the pragmatists and Continental socialists to whom scholars have typically ascribed Veblen’s Darwinian roots. Additionally, that an extensive community continued to use Darwinian evolutionary theory to construct new models of scientific and social scientific analysis at the turn of the twentieth century, a period during which Darwinism was purportedly in decline, suggests that the “eclipse of Darwinism” narrative has been overstated in literature about Darwinism’s intellectual arc. (shrink)

"Literature and the Right to Marriage," which bears the same title as the special issue that it introduces, takes up the challenge of the claim that marriage is a universal right. Framing the questions that traverse the five essays in the collection with a close reading of the sections on marriage from Hegel's Elements of the Philosophy of Right, the authors argue that if marriage can be considered a right, this right both guarantees access to and is founded upon each (...) partner's vow to abide by his or her vows to the other. Hegel's text is important because it underscores the linguistic dimension of the marriage ceremony; and it thus helps to show that, if the right to marriage were universal, it must be understood as the right to an irreplaceable kind of ritual speech. Moreover, this text is remarkably modern in its emphasis upon love as the condition of rightful marriage. Hegel considered the exchange of marriage vows to be a political event at which love becomes ethical , and ethics becomes political ; and thus also the point at which the model for "ethical love" becomes the verbally solemnized love between a man and a woman rather than the priestly love of the neighbor. Marriage, for Hegel, is always a turning point, both in the lives of the couple and in the history of the state. But this means that the importance of any marriage cannot be measured in terms of a norm; it can only be measured in terms of the amorous situation that precedes the event of marriage. Hegel's analyses are indispensable for grasping the stakes of the essays collected in this special issue and for addressing contemporary questions about which couples have the right to marry and what marriage becomes when those who would marry already have shared long and complex lives together. (shrink)

"Literature and the Right to Marriage," which bears the same title as the special issue that it introduces, takes up the challenge of the claim that marriage is a universal right. Framing the questions that traverse the five essays in the collection with a close reading of the sections on marriage from Hegel's Elements of the Philosophy of Right, the authors argue that if marriage can be considered a right, this right both guarantees access to and is founded upon each (...) partner's vow to abide by his or her vows to the other. Hegel's text is important because it underscores the linguistic dimension of the marriage ceremony; and it thus helps to show that, if the right to marriage were universal, it must be understood as the right to an irreplaceable kind of ritual speech. Moreover, this text is remarkably modern in its emphasis upon love as the condition of rightful marriage. Hegel considered the exchange of marriage vows to be a political event at which love becomes ethical (distinct from seduction), and ethics becomes political (distinct from morality and inseparable from civil society and the state); and thus also the point at which the model for "ethical love" becomes the verbally solemnized love between a man and a woman rather than the priestly love of the neighbor. Marriage, for Hegel, is always a turning point, both in the lives of the couple and in the history of the state. But this means that the importance of any marriage cannot be measured in terms of a norm; it can only be measured in terms of the amorous situation that precedes the event of marriage. Hegel's analyses are indispensable for grasping the stakes of the essays collected in this special issue and for addressing contemporary questions about which couples have the right to marry and what marriage becomes when those who would marry already have shared long and complex lives together. (shrink)

This paper examines Irish campaigns for condom access in the early 1990s. Against the backdrop of the AIDS crisis, activists campaigned against a law which would not allow condoms to be sold from ordinary commercial spaces or vending machines, and restricted sale to young people. Advancing a conception of ‘transformative illegality’, we show that illegal action was fundamental to the eventual legalisation of commercial condom sale. However, rather than foregrounding illegal condom sale as a mode of spectacular direct action, we (...) show that tactics of illegal sale in the 1990s built on 20 years of everyday illegal sale within the Irish family planning movement. Everyday illegal sale was a long-term world-making practice, which gradually transformed condoms’ legal meanings, eventually enabling new forms of provocative and irreverent protest. Condoms ‘became legal’ when the state recognised modes of condom sale, gradually built up over many years and publicised in direct action and in the courts. (shrink)