This volume handles in various perspectives the concept of function and the nature of functional explanations, topics much discussed since two major and conflicting accounts have been raised by Larry Wright and Robert Cummins’s papers in the 1970s. Here, both Wright’s ”etiological theory of functions’ and Cummins’s ”systemic’ conception of functions are refined and elaborated in the light of current scientific practice, with papers showing how the ”etiological’ theory faces several objections and may in reply be revisited, while its (...) counterpart became ever more sophisticated, as researchers discovered fresh applications for it. Relying on a firm knowledge of the original positions and debates, this volume presents cutting-edge research evincing the complexities that today pertain in function theory in various sciences. Alongside original papers from authors central to the controversy, work by emerging researchers taking novel perspectives will add to the potential avenues to be followed in the future. Not only does the book adopt no a priori assumptions about the scope of functional explanations, it also incorporates material from several very different scientific domains, e.g. neurosciences, ecology, or technology. In general, functions are implemented in mechanisms; and functional explanations in biology have often an essential relation with natural selection. These two basic claims set the stage for this book’s coverage of investigations concerning both ”functional’ explanations, and the ”metaphysics’ of functions. It casts new light on these claims, by testing them through their confrontation with scientific developments in biology, psychology, and recent developments concerning the metaphysics of realization. Rather than debating a single theory of functions, this book presents the richness of philosophical issues raised by functional discourse throughout the various sciences.​ Content Level » Research Keywords » Causal role theory of functions - Determination of content - Ecosystem selection - Etiological theory of function - Evolutionary biology - Functional explanations - Historical concepts in biology - Larry Wright - Neurosciences - New mechanism - Selected effects functions - Systemic theory of functions - William Wimsatt Related subjects » Anthropology & Archaeology - Epistemology & Philosophy of Science - Evolutionary & Developmental Biology - Neuroscience - Philosophy TABLE OF CONTENTS Introduction.- Section I. Biological functions and functional explanations: genes, cells, organisms and ecosystems.- Part 1.A. Functions, organization and development in life sciences.- Chapter 1. William C. Wimsatt. Evolution and the Stability of Functional Architectures.- Chapter 2. Denis M. Walsh. Teleological Emergence: The Autonomy of Evo-Devo.- Chapter 3. Jean Gayon. Does oxygen have a function, or: where should the regress of biological functions stop?.- Part 1.B. Functional pluralism for biologists? Chapter 4. Frédéric Bouchard. How ecosystem evolution strengthens the case for functional pluralism.- Chapter 5. Robert N. Brandon. A general case for functional pluralism.- Chapter 6. Philippe Huneman. Weak realism in the etiological theory of functions.- Section 2. Section II. Psychology, philosophy of mind and technology: Functions in a man’s world.- Part 2.A. 2A. Metaphysics, function and philosophy of mind.- Chapter 7. Carl Craver. Functions and Mechanisms in Contemporary Neuroscience.- Chapter 8. Carl Gillett. Understanding the sciences through the fog of ”functionalism.’.- 2.B. Philosophy of technology, design and functions.- Chapter 9. Fran¸ coise Longy. Artifacts and Organisms: A Case for a New Etiological Theory of Functions.- Chapter 10. Pieter Vermaas and Wybo Houkes. Functions as Epistemic Highlighters: An Engineering Account of Technical, Biological and Other Functions.- Epilogue.- Larry Wright. Revising teleological explanations: reflections three decades on. (shrink)

The purpose of this paper is modelling and controlling the spread of COVID-19 disease in Morocco. A nonlinear mathematical model with two subclasses of infectious individuals is proposed. The population is divided into five classes, namely, susceptible, exposed, undiagnosed infectious, diagnosed patients, and removed individuals. To reflect the real dynamic of the COVID-19 transmission in Morocco, the real reported data are used for estimating model parameters. Two controls representing screening effort and limited treatment are considered. Based on viability theory and (...) set-valued analysis, a Lyapunov function is constructed such that both exposed and infected populations are decreased to zero asymptotically. The corresponding controls are derived via a continuous selection of adequately designed feedback map. Numerical simulations are presented with three scenarios. Our results show that when only one control is to be applied, screening is the most effective in decreasing the number of people in the three infected compartments, whereas combining both controls is found to be highly effective and leads to a significant improvement in the epidemiological situation of Morocco. To the best of our knowledge, this work is the first one that applies the set-valued approach to a controlled COVID-19 model which agrees with the observed cases in Morocco. (shrink)

The program of Reverse Mathematics (Simpson 2009) has provided us with the insight that most theorems of ordinary mathematics are either equivalent to one of a select few logical principles, or provable in a weak base theory. In this paper, we study the properties of the Dirac delta function (Dirac 1927; Schwartz 1951) in two settings of Reverse Mathematics. In particular, we consider the Dirac Delta Theorem, which formalizes the well-known property \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} (...) \setlength{\oddsidemargin}{-69pt} \begin{document}$${\int_\mathbb{R}f(x)\delta(x)\,dx=f(0)}$$\end{document} of the Dirac delta function. We show that the Dirac Delta Theorem is equivalent to weak König’s Lemma (see Yu and Simpson in Arch Math Log 30(3):171–180, 1990) in classical Reverse Mathematics. This further validates the status of WWKL0 as one of the ‘Big’ systems of Reverse Mathematics. In the context of ERNA’s Reverse Mathematics (Sanders in J Symb Log 76(2):637–664, 2011), we show that the Dirac Delta Theorem is equivalent to the Universal Transfer Principle. Since the Universal Transfer Principle corresponds to WKL, it seems that, in ERNA’s Reverse Mathematics, the principles corresponding to WKL and WWKL coincide. Hence, ERNA’s Reverse Mathematics is actually coarser than classical Reverse Mathematics, although the base theory has lower first-order strength. (shrink)

Two scenarios illustrate uses of von Neumann–Morgenstern stable sets in the construction of choice functions. A comparison is made to the construction of choice functions by the selection of maximal elements. A characterization is given of choice functions that are von Neumann–Morgenstern stable set rationalizable by acyclic, asymmetric binary relations. Two examples illustrate the use of the characterization.

The neutrosophic cubic hesitant fuzzy set can efficiently handle the complex information in a decision-making problem because it combines the advantages of the neutrosophic cubic set and the hesitant fuzzy set. The algebraic operations based on Dombi norms and co-norms are more flexible than the usual algebraic operations as they involve an operational parameter. First, this paper establishes Dombi algebraic operational laws, score functions, and similarity measures in neutrosophic cubic hesitant fuzzy sets. Then, we proposed Dombi exponential operational laws in (...) which the exponents are neutrosophic cubic hesitant fuzzy values and bases are positive real numbers. To use neutrosophic cubic hesitant fuzzy sets in decision-making, we are developing Dombi exponential aggregation operators in the current study. In the end, we present applications of exponential aggregation operators in multiattribute decision-making problems. (shrink)

We present several selection theorems for Borel relations, involving only Borel sets and functions, all of which can be obtained as consequences of closely related theorems proved in [DSR 96,99,01,01X] involving coanalytic sets. The relevant proofs given there use substantial set theoretic methods, which were also shown to be necessary. We show that none of our Borel consequences can be proved without substantial set theoretic methods. The results are established for Baire space. We give equivalents of some of the (...) main results for the reals. (shrink)

Assembly of minimal genomes revealed many genes encoding unknown functions. Three overlooked functional categories account for some of them. Cells are prone to make errors and age. As a first key function, discrimination between proper and changed entities is indispensable. Discrimination requires management of information, an authentic, yet abstract, cur- rency of reality. For example proteins age, sometimes very fast. The cell must identify, then get rid of old proteins without destroying young ones. Implementing discrimination in cells leads to (...) the second set of functions, usually ignored. Being abstract, information must nevertheless be embodied into material entities, with unavoidable idiosyncratic properties. This brings about novel unmet needs. Hence, the buildup of cells elicits specific but awkward material implementations, ‘kludges’ that become essential under particular settings, while difficult to identify. Finally, a third functional category char- acterizes the need for growth, with metabolic implementations allowing the cell to put together the growth of its cytoplasm, membranes, and genome, spanning different spatial dimensions. Solving this metabolic quandary, critical for engineering novel synthetic biology chassis, uncovered an unexpected role for CTP synthetase as the coordinator of nonhomothetic growth. Because a significant number of SynBio constructs aim at creating cell factories we expect that they will be attacked by viruses (it is not by chance that the function of the CRISPR system was identified in industrial settings). Substantiating the role of CTP, natural selection has dealt with this hurdle via synthesis of the antimetabolite 30-deoxy-30,40-didehydro- CTP, recruited for antiviral immunity in all domains of life. (shrink)

Choice often proceeds in two stages: We construct a shortlist on the basis of limited and uncertain information about the options and then reduce this uncertainty by examining the shortlist in greater detail. The goal is to do well when making a final choice from the option set. I argue that we cannot realise this goal by constructing a ranking over the options at shortlisting stage which determines of each option whether it is more or less worthy of being included (...) in a shortlist. This is relevant to the 2010 UK Equality Act. The Act requires that shortlists be constructed on grounds of candidate rankings and affirmative action is only permissible for equally qualified candidates. This is misguided: Shortlisting candidates with lower expected qualifications but higher variance may raise the chance of finding an exceptionally strong candidate. If it does, then shortlisting such candidates would make eminent business sense and there is nothing unfair about it. This observation opens up room for including more underrepresented candidates with protected characteristics, as they are more likely to display greater variance in the selector’s credence functions at shortlisting stage. (shrink)

Many lament that solidarity is declining, implying there is something good about it; but what is solidarity and why should we want it? Here, we defend an original functionalist re-interpretation of solidarity. Political solidarity plays a key functional role in a polity’s persistence through time. Thus, we should want institutions that foster solidarity. This paper is divided into three parts. In the first, we draw on the philosophy of biology to pinpoint what counts as a proper function, in a (...) way that is naturalistic, objective, and selective. On this aetiological account, a sharp distinction between functional needs (e.g. the pumping of blood) and functional mechanisms (e.g. the valve that pumps blood) is drawn. In the second part of the paper, we propose that solidarity should be understood as an aetiological function of society. This new conception sheds light on the widely acknowledged, yet seldom clarified connection between two common readings of solidarity: solidarity as a set of feelings of mutual kinship (its functional need), and solidarity as a set of redistributive institutions (a key functional mechanism). The third part concludes that this new functional conception of solidarity provides normative reasons to foster solidarity. (shrink)

This essay starts from the observation that the issue of talent, in relation to the problem of distributive justice, can be approached from two different angles. First, it is common to discuss the justificatory function of talent, that is, its role in the justification of educational or social inequalities. In addition, however, this essay proposes to look at practices of talent ascription and their causal role in the distribution of educational prospects. These practices tend to exacerbate educational inequalities due (...) to social background, especially when they are tied to selective educational settings. There is reason to avoid talent-based selection in education, in order to contain the negative effects of practices of talent ascription. (shrink)

I argue for two claims. First I argue against the consensus view that accurate behavioral prediction based on accurate representation of cognitive states, i.e. mind reading , is the sustaining function of propositional attitude ascription. This practice cannot have been selected in evolution and cannot persist, in virtue of its predictive utility, because there are principled reasons why it is inadequate as a tool for behavioral prediction. Second I give reasons that favor an alternative account of the sustaining (...) class='Hi'>function of propositional attitude ascription. I argue that it serves a mind-shaping function. Roughly, propositional attitude ascription enables human beings to set up regulative ideals that function to mold behavior so as to make it easier to coordinate with. (shrink)

Authors frequently refer to gene-based selection in biological evolution, the reaction of the immune system to antigens, and operant learning as exemplifying selection processes in the same sense of this term. However, as obvious as this claim may seem on the surface, setting out an account of “selection” that is general enough to incorporate all three of these processes without becoming so general as to be vacuous is far from easy. In this target article, we set out (...) such a general account of selection to see how well it accommodates these very different sorts of selection. The three fundamental elements of this account are replication, variation, and environmental interaction. For selection to occur, these three processes must be related in a very specific way. In particular, replication must alternate with environmental interaction so that any changes that occur in replication are passed on differentially because of environmental interaction. One of the main differences among the three sorts of selection that we investigate concerns the role of organisms. In traditional biological evolution, organisms play a central role with respect to environmental interaction. Although environmental interaction can occur at other levels of the organizational hierarchy, organisms are the primary focus of environmental interaction. In the functioning of the immune system, organisms function as containers. The interactions that result in selection of antibodies during a lifetime are between entities (antibodies and antigens) contained within the organism. Resulting changes in the immune system of one organism are not passed on to later organisms. Nor are changes in operant behavior resulting from behavioral selection passed on to later organisms. But operant behavior is not contained in the organism because most of the interactions that lead to differential replication include parts of the world outside the organism. Changes in the organism's nervous system are the effects of those interactions. The role of genes also varies in these three systems. Biological evolution is gene-based (i.e., genes are the primary replicators). Genes play very different roles in operant behavior and the immune system. However, in all three systems, iteration is central. All three selection processes are also incredibly wasteful and inefficient. They can generate complexity and novelty primarily because they are so wasteful and inefficient. Key Words: evolution; immunology; interaction; operant behavior; operant learning; replication; selection; variation. (shrink)

We study the preservation of selective covering properties, including classic ones introduced by Menger, Hurewicz, Rothberger, Gerlits and Nagy, and others, under products with some major families of concentrated sets of reals.Our methods include the projection method introduced by the authors in an earlier work, as well as several new methods. Some special consequences of our main results are : Every product of a concentrated space with a Hurewicz S1S1 space satisfies S1S1. On the other hand, assuming the Continuum Hypothesis, (...) for each Sierpiński set S there is a Luzin set L such that L×SL×S can be mapped onto the real line by a Borel function. Assuming Semifilter Trichotomy, every concentrated space is productively Menger and productively Rothberger. Every scale set is productively Hurewicz, productively Menger, productively Scheepers, and productively Gerlits–Nagy. Assuming d=ℵ1d=ℵ1, every productively Lindelöf space is productively Hurewicz, productively Menger, and productively Scheepers.A notorious open problem asks whether the additivity of Rothberger's property may be strictly greater than addadd, the additivity of the ideal of Lebesgue-null sets of reals. We obtain a positive answer, modulo the consistency of Semifilter Trichotomy >ℵ1.Our results improve upon and unify a number of results, established earlier by many authors. (shrink)

A hard choice is a situation in which an agent is unable to make a justifiable choice from a given menu of alternatives. Our objective is to present a systematic treatment of the axiomatic structure of such situations. To do so, we draw on and contribute to the study of choice functions that can be indecisive, i.e., that may fail to select a non-empty set for some menus. In this more general framework, we present new characterizations of two well-known choice (...) rules, the maximally dominant choice rule and the top-cycle choice rule. Together with existing results, this yields an understanding of the circumstances in which hard choices arise. (shrink)

Personal indexicals are often taken to refer to the agent of an expression’s context, but deviant uses (e.g. ‘I’m parked out back’) complicate matters. I argue that personal indexicals refer to the extended self of the agent, where the extended self is a mereological chimera incorporating whatever determines our behavioral capacities. To ascertain the persistence conditions of personal identity, I propose a method for selecting a level of description and a set of functional properties at that level that remain constant (...) over a lifetime. I argue for functional constancy, and against continuity, as the central determinant of diachronic identity. (shrink)

On analyzing the problem that arises whenever the set of maximal elements is large, and a selection is then required (see Peris & Subiza 1998), we realize that logical ways of selecting among maximals violate the classical notion and axioms of rationality. We arrive at the same conclusion if we analyze solutions to the problem of choosing from a tournament (where maximal elements do not necessarily exist). So, in our opinion the notion of rationality must be discussed, not only (...) in the traditional sense of external conditions (Sen 1993), but in terms of the internal information provided by the binary relation. (shrink)

Based on a close study of benchmark examples in default reasoning, such as Nixon Diamond, Penguin Principle, etc., this paper provides an in depth analysis of the basic features of default reasoning. We formalize default inferences based on Modus Ponens for Default Implication, and mark the distinction between "local inferences"(to infer a conclusion from a subset of given premises) and "global inferences"(to infer a conclusion from the entire set of given premises). These conceptual analyses are captured by a formal semantics (...) that is built upon the set-selection function technique. A minimal logic system M of default reasoning that accommodates Modus Ponens for Default Implication and suitable for local inferences is proposed, and its soundness is proved. (shrink)

In this paper I suggest that play is a distinctive behavioural category whose adaptive significance calls for explanation. Play primarily affords juveniles practice toward the exercise of later skills. Its benefits exceed its costs when sufficient practice would otherwise be unlikely or unsafe, as is particularly true with physical skills and socially competitive ones. Manipulative play with objects is a byproduct of increased intelligence, specifically selected for only in a few advanced primates, notably the chimpanzee.The adaptiveness of play in pongid (...) evolution is traced through the probable changes in selective pressures that occurred in hominid evolution. It is argued that fantasy was an emergent property in hominids, made possible by symbolic intelligence and language, and serving to make play complex enough to continue to provide useful practice for increasingly complex later skills.The advent of organised instruction and education has meant that play's unplanned, intrinisic goal-setting could be replaced by extrinsic goal-setting in the systematic development of particular skills. However, the need to ensure adequate motivation has continued to give play educational value. In addition, its capacity to enhance innovative behaviour seems to be a residual function of play which has acquired a new cultural importance. (shrink)

The investigation of computational properties of discontinuous functions is an important concern in computable analysis. One method to deal with this subject is to consider effective variants of Borel measurable functions. We introduce such a notion of Borel computability for single-valued as well as for multi-valued functions by a direct effectivization of the classical definition. On Baire space the finite levels of the resulting hierarchy of functions can be characterized using a notion of reducibility for functions and corresponding complete functions. (...) We use this classification and an effective version of a Selection Theorem of Bhattacharya-Srivastava in order to prove a generalization of the Representation Theorem of Kreitz-Weihrauch for Borel measurable functions on computable metric spaces: such functions are Borel measurable on a certain finite level, if and only if they admit a realizer on Baire space of the same quality. This Representation Theorem enables us to introduce a realizer reducibility for functions on metric spaces and we can extend the completeness result to this reducibility. Besides being very useful by itself, this reducibility leads to a new and effective proof of the Banach-Hausdorff-Lebesgue Theorem which connects Borel measurable functions with the Baire functions. Hence, for certain metric spaces the class of Borel computable functions on a certain level is exactly the class of functions which can be expressed as a limit of a pointwise convergent and computable sequence of functions of the next lower level. (shrink)

This article argues that a theory of media selectivity needs a theory of attention, because attention to a media stimulus is the starting point of each process of reception. Attention sequences towards media stimuli – pages of newspapers and online-newspapers – were analyzed using eye-tracking patterns from three different perspectives. First, attention patterns were compared under varying task conditions. Second, different types of media were tested. Third, attention sequences towards different forms of news with different design patterns were compared. Attention (...) was seen as a prerequisite for reception: Its selective functions for these processes are especially important. Reception itself was examined within an action-theoretical framework and therefore described as a form of interaction between recipient and the media. Eye-tracking data were used as indicators of attention. Starting with a hypothesis on the impact of different media such as printed newspapers and online newspapers on the agenda-setting process of their audience, the study examined how the type of media and the form of news influences attention and selectivity. Our findings showed that visual cues such as salient photos or graphics and information hierarchies signalled by design and layout guide attention processes, not as an automatic process driven from the bottom up, but as stimuli for an active, intention-driven selection process. The results indicate that the form of news affects these patterns of interactive attention more than the medium itself. (shrink)

The aim of this study was to verify whether chimpanzees demonstrate an auditory laterality during the orientation reaction, and which hemisphere is responsible for processing the emotional stimuli and which for the species-specific vocalizations. The study involved nine chimpanzees from the Warsaw Municipal Zoological Garden. They were tested individually in their bedrooms. Chimpanzees approached a tube filled with food, located in the centre of the cage. Randomly selected sounds were played from the speakers when the subject was focused on getting (...) food. Individual reactions were observed and outcomes reported. The four types of sound used: thunderstorm, dog barking, chimpanzee vocalization and a zookeeper’s voice. To test whether chimpanzees demonstrate auditory laterality we used a single sample X2 test. The existence of auditory laterality has been confirmed. The sound of the storm caused the orientation reaction to the left, while chimpanzee vocalization - to the right. On this basis we can conclude that among chimpanzees, arousing stimuli are being processed by the right hemisphere, and species-specific vocalizations by the left. However, the set of stimuli was limited so the study did not unequivocally resolve this issue. (shrink)

For an integer \, Ramsey Choice\ is the weak choice principle “every infinite setxhas an infinite subset y such that\ has a choice function”, and \ is the weak choice principle “every infinite family of n-element sets has an infinite subfamily with a choice function”. In 1995, Montenegro showed that for \, \. However, the question of whether or not \ for \ is still open. In general, for distinct \, not even the status of “\” or “\” (...) is known. In this paper, we provide partial answers to the above open problems and among other results, we establish the following:1.For every integer \, if \ is true for all integers i with \, then \ is true for all integers i with \.2.If \ are any integers such that for some prime p we have \ and \, then in \: \ and \.3.For \, \\\ implies \, and \ implies neither \ nor \ in \.4.For every integer \, \ implies “every infinite linearly orderable family of k-element sets has a partial Kinna–Wagner selection function” and the latter implication is not reversible in \ ). In particular, \ strictly implies “every infinite linearly orderable family of 3-element sets has a partial choice function”.5.The Chain-AntiChain Principle implies neither \ nor \ in \, for every integer \. (shrink)

This collection of twenty-three papers from the period 1934-1960 is concerned with formal number theory and syntax, axiomatic set theory, truth functions, and quantification theory. In the first group appear "Concatenation as a basis for arithmetic" and "Definition of substitution," among others; the second includes "Set-theoretic foundations for logic," "On ω-inconsistency," and "Element and number." Quine's important articles "Completeness of the propositional calculus" and "Cores and prime implicants of truth functions" are in the third section; the last one includes "A (...) proof procedure for quantification theory" and "Church's theorem on the decision problem". These are but a few of many important articles. All the articles have been reset in a new, perspicuous type-face which makes study easier. Several important papers which were omitted should, in the reviewer's opinion, have been included, but this is a minor quibble. Quine's stature in modern logic can be gauged by examining these papers.—P. J. M. (shrink)

This article proposes an Analytic Hierarchy Process Dempster-Shafer and similarity-based network selection algorithm for the scenario of dynamic changes in user requirements and network environment; combines machine learning with network selection and proposes a decision tree-based network selection algorithm; combines multiattribute decision-making and genetic algorithm to propose a weighted Gray Relation Analysis and genetic algorithm-based network access decision algorithm. Firstly, the training data is obtained from the collaborative algorithm, and it is used as the training set, and (...) the network attributes are used as the attribute set, and the continuous attributes are discretized by dichotomization, and the attribute that can make the greatest information gain is selected as the division feature, and a decision tree with strong generalization ability is finally obtained, which is used as the decision basis for network access selection. The simulation results show that the algorithm proposed in this thesis can effectively improve user service quality under three services, and the algorithm is simple and effective with low complexity. It first uses AHP-DS hierarchical analysis to establish a recursive hierarchy for the network selection problem and obtains the subjective weights of network attributes through the judgment matrix. Then, it uses a genetic algorithm to adjust the subjective weight, defines the fitness function in the genetic algorithm-based on gray correlation analysis, adjusts the weights of the selection operator, crossover operator, and variation operator in the genetic algorithm, and gets the network with the largest fitness as the target network, which can effectively improve the user service quality. (shrink)

The purpose of this paper is to present an overview of current studies on the general limitations of using the International Classification of Functioning, Disability and Health (ICF), as well as to review the results of its application in adults with visual impairment. The literature search was performed in ERIC, EBSCO-Host, ScienceDirect, PROKUEST, SCOPUS, and Google Scholar. Articles were selected if they reported on any of the strengths and weaknesses of the ICF, also its application to adults with visual impairment. (...) The literature review was performed using the PRISMA criteria. The search of relevant literature revealed 8 articles that met the eligibility criteria. The overall conclusion is that while the ICF is a valuable tool for describing how a person functions, it is not an evaluation instrument in itself. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Arguing about PsychiatryNatural Selection, Austinian Conservatism, and Finding Our Way to the BestJoseph Gough (bio)Professors Murphy and Lieberman have offered two generous and interesting commentaries on my article, each very insightful and helpful in its own way, and each offering an interesting alternative characterization of the subject matter of psychiatry. I found each extremely thought-provoking, hence this rather bloated response. I strongly disagree with each. In brief, I (...) disagree with the 'preliminaries' of each commentary, struggle to see the tension between Hull's view of science and my view of psychiatry, reject Lieberman's appeal to the history of mind-like and mental-illness-like concepts, and finally, believe my position neither suffers from the instability of psychiatry, nor blocks the route to best practice, nor counsels despair.Metaphysical Precision and Conceptual Evolution: Response to MurphyMurphy begins by offering some helpful context for the debate, and for our disagreement within that debate. Partly it is helpful because it raises a cluster of questions, which I agree with him, are related to the topic at hand. Partly it is helpful because it lays out Murphy's background metaphysics, with which I broadly agree, but where I think it is important to be more pedantic than Murphy himself is. Murphy and I agree that there are animate objects, importantly different from inanimate objects; we also agree that there is no object in nature that is a mind. However, in that [End Page 45] opening paragraph, there are a few things that look to me a little like conflations—and while I am happy to grant this as pedantry, I am not happy to deny its importance.First, not everything animate is intelligent and unpredictable—a presumably accidental implication of Murphy's use of 'these' throughout the paragraph. Second, intelligence and unpredictability do not in my view cluster in the way that Murphy suggests in the passage—a highly intelligent system may be exceptionally predictable at least so long as its goals and knowledge are fixed, and a highly unpredictable system may, of course, be entirely unintelligent. Of course, when some systems behave other than we expect, we count this as a failing of the system; but this is a feature of artifacts as well as animate systems, and perhaps also of objects that are neither artifacts nor animate (think of a farmer whose crops fail to go—might they not think there is something wrong with the soil?). The class of 'predictions' Murphy identifies is what I would describe as a class of normative expectations, that, of course, must be somewhat in line with the way things actually are, but are not 'predictions' in the paradigmatic sense of guesses about what will happen.This pedantry matters because this implied (or perhaps less charitably, enforced) alignment between non-coextensive categories in this picture of Murphy's is leveraged, I think, to gesture towards an objection. First, Murphy claims that this class of systems has required a special vocabulary, 'mental' vocabulary. Second, it is, I think, suggested in Murphy's set-up (and perhaps in Murphy's work; Murphy & Stich, 1999) that at some level this vocabulary anchors what we are talking about when we are talking about 'mental illness.'But here, of course, I disagree—or at least, I might disagree if I were clear what is being claimed. Which class of systems is that gives rise to this 'special vocabulary? Several have been mentioned. It should also come as no surprise that I think it is deeply unclear what counts as 'mental' vocabulary. Is it the vocabulary of animacy? Of normative expectation and function-ascription? Perhaps of intentionality? Or of consciousness? Maybe it is defined 'ostensively' with respect to terms like belief and desire?After these preliminaries, Murphy offers an objection to my position, and a brief defense of his own. I would like to begin with his defense of his own position:the best way to think about the claim that mental illnesses are brain diseases … is to see them as committing us to a form of explanation that treats psychiatry as continuous with other sciences of mind, in... (shrink)

Introduction: Electroconvulsive therapy is a commonly used brain stimulation treatment for treatment-resistant or severe depression. This study was planned to find the effects of ECT on brain connectivity by conducting a systematic review and coordinate-based meta-analysis of the studies performing resting state fMRI in patients with depression receiving ECT.Methods: We systematically searched the databases published up to July 31, 2020, for studies in patients having depression that compared resting-state functional connectivity before and after a course of pulse wave ECT. Meta-analysis (...) was performed using the activation likelihood estimation method after extracting details about coordinates, voxel size, and method for correction of multiple comparisons corresponding to the significant clusters and the respective rsFC analysis measure with its method of extraction.Results: Among 41 articles selected for full-text review, 31 articles were included in the systematic review. Among them, 13 articles were included in the meta-analysis, and a total of 73 foci of 21 experiments were examined using activation likelihood estimation in 10 sets. Using the cluster-level interference method, one voxel-wise analysis with the measure of amplitude of low frequency fluctuations and one seed-voxel analysis with the right hippocampus showed a significant reduction in the left cingulate gyrus and a significant increase in the right hippocampus with the right parahippocampal gyrus, respectively. Another analysis with the studies implementing network-wise resting state functional connectivity showed a significant increase in bilateral posterior cingulate cortex. There was considerable variability as well as a few key deficits in the preprocessing and analysis of the neuroimages and the reporting of results in the included studies. Due to lesser studies, we could not do further analysis to address the neuroimaging variability and subject-related differences.Conclusion: The brain regions noted in this meta-analysis are reasonably specific and distinguished, and they had significant changes in resting state functional connectivity after a course of ECT for depression. More studies with better neuroimaging standards should be conducted in the future to confirm these results in different subgroups of depression and with varied aspects of ECT. (shrink)

In the present meta-analysis, we examined the effect of cognitive training on the Executive Function (EF) of preschool children (age range: 3-6 years). We selected a final set of 32 studies from 27 papers with a total sample of 123 effect sizes. We found an overall effect of cognitive training for improving EF (g =.352; k = 123; p <.001), without significant difference between near and far transfer effects on executive domains. No significant additional outcome effects were found for (...) behavioral- and learning-related outcomes. Cognitive training programs for preschoolers are significantly more effective for developmentally at-risk children (ADHD or low socio-economic status) than for children with typical development and without risks. Other significant moderators were computerized versus non-computerized training, individual versus group sessions, and length of training. The number of sessions was not a significant moderator. This is the first demonstration of cognitive training far transfer effects among different executive processes. We discuss this result in relationship with the lower level of modularization of EFs in younger children. (shrink)

In this article we, given a free ultrafilter p on ω, consider the following classes of ultrafilters:(1) T(p) - the set of ultrafilters Rudin-Keisler equivalent to p,(2) S(p)={q ∈ ω*:∃ f ∈ ω ω , strictly increasing, such that q=f β (p)},(3) I(p) - the set of strong Rudin-Blass predecessors of p,(4) R(p) - the set of ultrafilters equivalent to p in the strong Rudin-Blass order,(5) P RB (p) - the set of Rudin-Blass predecessors of p, and(6) P RK (p) (...) - the set of Rudin-Keisler predecessors of p,and analyze relationships between them. We introduce the semi-P-points as those ultrafilters p ∈ ω* for which P RB (p)=P RK (p), and investigate their relations with P-points, weak-P-points and Q-points. In particular, we prove that for every semi-P-point p its α-th left power α p is a semi-P-point, and we prove that non-semi-P-points exist in ZFC. Further, we define an order ⊴ in T(p) by r⊴q if and only if r ∈ S(q). We prove that (S(p),⊴) is always downwards directed, (R(p),⊴) is always downwards and upwards directed, and (T(p),⊴) is linear if and only if p is selective.We also characterize rapid ultrafilters as those ultrafilters p ∈ ω* for which R(p)∖S(p) is a dense subset of ω*.A space X is M-pseudocompact (for ) if for every sequence (U n ) n < ω of disjoint open subsets of X, there are q ∈ M and x ∈ X such that x=q-lim (U n ); that is, for every neighborhood V of x. The P RK (p)-pseudocompact spaces were studied in [ST].In this article we analyze M-pseudocompactness when M is one of the classes S(p), R(p), T(p), I(p), P RB (p) and P RK (p). We prove that every Frolik space is S(p)-pseudocompact for every p ∈ ω*, and determine when a subspace with is M-pseudocompact. (shrink)

The greatest challenge for Cultural Selection Theory, which holds that Darwinian natural selection contributes to cultural evolution, lies is the paucity of evidence for structural mechanisms in cultural systems that are sufficient for adaptation by natural selection. In part, clarification is required with respect to the interaction between cultural systems and their purported selective environments. Edmonds, Hull, and others have argued that Cultural Selection Theory requires simple, conclusive, unambiguous case studies in order to meet this challenge. (...) To this end, I am employing the songs of the Rufous-collared Sparrow, which seem to exhibit cultural adaptations that minimize signal degradation relative to local environments (Handford, et al.). Specifically, the more forested the habitat, the more the tail end of the song resembles a whistle rather than a trill; yet, variation in song is uncorrelated with genetic variation. I explore the mechanisms responsible for these putative acoustic adaptations through a series of computer simulations. I modify the framework of Alexander and Skyrms’ ‘Bargaining with Neighbours’: this dynamic evolutionary game theoretic framework is well-suited for my investigation because the local interactions between agents provide a basis for modeling song transmission from adults to fledglings. In the simplest version of the model, each bird adopts one of two song types – trill or whistle – and sings that song type for the duration of its life. These song strategies are communicated to other birds in neighboring territories, which are arranged as a grid composed of two acoustic habitats (forest and field). Birds have a set probability of dying in each year, and deceased birds are succeeded by fledglings. The likelihood that a fledgling adopts a particular song type depends on (i) the popularity of a particular song-type among neighboring birds and (ii) the relative ‘audibility’ of each signal, which is a joint function of the habitat and song type of the signaling bird. The main point of this research is not to test this model, but to demonstrate that models of this type have the resources to meet the outstanding challenges in Cultural Selection Theory. The benefits of this research are threefold. First, it will lend much needed empirical support to Cultural Selection Theory by clarifying the nature of the interaction between culture and environment. Second, it will support Alexander and Skyrms’ work by providing a set of empirically testable consequences for their model. Finally, it will contribute to evolutionary theory by clarifying the scope and limits of adaptation by natural selection. (shrink)

A set of constraints forces trade-offs which prevent us from achieving the best possible definitions of the ‘level’ and ‘unit’ of natural selection. This set consists in decisions concerning conflicting pre-analytic intuitions in problematic cases, the relative roles of various conceptual resources in the definitions, which facts need to be accounted for using the definitions, how the relation between selection and evolution orients the definitions, and the relation between the level and unit concepts. Systematic reconstruction and evaluation of (...) leading analyses along these dimensions favors a new functional analysis over Williams’ consequentialist analysis, Sober’s causal analysis, and Dawkins’ teleological analysis. (shrink)

A set of constraints forces trade-offs which prevent us from achieving the best possible definitions of the ‘level’ and ‘unit’ of natural selection. This set consists in decisions concerning conflicting pre-analytic intuitions in problematic cases, the relative roles of various conceptual resources in the definitions, which facts need to be accounted for using the definitions, how the relation between selection and evolution orients the definitions, and the relation between the level and unit concepts. Systematic reconstruction and evaluation of (...) leading analyses along these dimensions favors a new functional analysis over Williams’ consequentialist analysis, Sober’s causal analysis, and Dawkins’ teleological analysis. (shrink)

A set of constraints forces trade-offs which prevent us from achieving the best possible definitions of the ‘level’ and ‘unit’ of natural selection. This set consists in decisions concerning conflicting pre-analytic intuitions in problematic cases, the relative roles of various conceptual resources in the definitions, which facts need to be accounted for using the definitions, how the relation between selection and evolution orients the definitions, and the relation between the level and unit concepts. Systematic reconstruction and evaluation of (...) leading analyses along these dimensions favors a new functional analysis over Williams’ consequentialist analysis, Sober’s causal analysis, and Dawkins’ teleological analysis. (shrink)

Functional information means an encoded network of functions in living organisms from molecular signaling pathways to an organism’s behavior. It is represented by two components: code and an interpretation system, which together form a self-sustaining semantic closure. Semantic closure allows some freedom between components because small variations of the code are still interpretable. The interpretation system consists of inference rules that control the correspondence between the code and the function (phenotype) and determines the shape of the fitness landscape. The (...) utility factor operates at multiple time scales: short-term selection drives evolution towards higher survival and reproduction rate within a given fitness landscape, and long-term selection favors those fitness landscapes that support adaptability and lead to evolutionary expansion of certain lineages. Inference rules make short-term selection possible by shaping the fitness landscape and defining possible directions of evolution, but they are under control of the long-term selection of lineages. Communication normally occurs within a set of agents with compatible interpretation systems, which I call communication system. Functional information cannot be directly transferred between communication systems with incompatible inference rules. Each biological species is a genetic communication system that carries unique functional information together with inference rules that determine evolutionary directions and constraints. This view of the relation between utility and inference can resolve the conflict between realism/positivism and pragmatism. Realism overemphasizes the role of inference in evolution of human knowledge because it assumes that logic is embedded in reality. Pragmatism substitutes usefulness for truth and therefore ignores the advantage of inference. The proposed concept of evolutionary pragmatism rejects the idea that logic is embedded in reality; instead, inference rules are constructed within each communication system to represent reality, and they evolve towards higher adaptability on a long time scale. (shrink)

The importance of developmental agendas -- A capability framework for development goals -- A Republican account of local authority in development -- Third wave development expertise -- Selecting capabilities for a development agenda -- Methods for the selection of capabilities and functionings -- An inclusive framework for setting development agendas.

We consider the logics determined by the set of all natural implicative expansions of Kleene’s strong 3-valued matrix and select the class of all logics functionally equivalent to Łukasiewicz’s 3-valued logic Ł3. The concept of a “natural implicative matrix” is based upon the notion of a “natural conditional” defined in Tomova.

Since Darwin it is widely accepted that natural selection (NS) is the most important mechanism to explain how biological organisms—in their amazing variety—evolve and, therefore, also how the complexity of certain natural systems can increase over time, creating ever new functions or functional structures/relationships. Nevertheless, the way in which NS is conceived within Darwinian Theory already requires an open, wide enough, functional domain where selective forces may act. And, as the present paper will try to show, this becomes even (...) more evident if one looks into the problem of origins. If there was a time when NS was not operating (as it is quite reasonable to assume), where did that initial functional diversity, necessary to trigger off the process, come from? Self-organization processes may be part of the answer, as many authors have claimed in recent years, but surely not the complete one. We will argue here that a special type of self-maintaining organization, arising from the interplay among a set of different endogenously produced constraints (pre-enzymatic catalysts and primitive compartments included), is required for the appearance of functional diversity in the first place. Starting from that point, NS can progressively lead to new (and, at times, also more complex) organizations that, in turn, provide wider functional variety to be selected for, enlarging in this way the range of action and consequences of the mechanism of NS, in a kind of mutually enhancing effect. (shrink)

Many applications of intuitionistic fuzzy sets depend on ranking or comparing intuitionistic fuzzy numbers. This paper presents a novel ranking method for intuitionistic fuzzy numbers based on the preference attitudinal accuracy and score functions. The proposed ranking method considers not only the preference attitude of decision maker, but also all the possible values in feasible domain. Some desirable properties of preference attitudinal accuracy and score functions are verified in detail. A total order on the set of intuitionistic fuzzy numbers is (...) established by using the proposed two functions. The proposed ranking method is also applied to select renewable energy. The advantage and validity of the proposed method are shown by comparing with some representative ranking methods. (shrink)

The Intelligence Quotient (IQ) tests and the corresponding psychometric explanations dominate both the scientific and popular views about human intelligence. Though the IQ tests have been in currency for long, there exists a gap in what they are believed to measure and what they do. While the IQ tests index the quality of cognitive functioning in selected domains of mental repertoire, the applied settings often inflate their predictive value leading to an interpretive gap. The present article contends that studying the (...) influence of motivational and affective processes on cognitive functioning would help to evolve a more psychologically comprehensive account of the IQ tests and bridge the interpretive gap. To conclude, the article suggests possible future research directions that could strengthen the predictive value of the IQ tests. (shrink)

In 1993, biologist Margie Profet captured the attention of the popular press with the publication of her radical thesis: menstruation has a function. Traditional theories, she claims, typically view menstruation as a functionless by-product of cyclic flux. The details of Profet's functional account are similarly radical: she argues that menstruation has been naturally selected to defend the female reproductive tract from sperm-borne pathogens. There are a number of weaknesses in Profet's evolutionary analysis. However, I focus on a set of (...) pragmatic problems that arise prior to any details of her evolutionary account. In arguing for the importance of pragmatic considerations, I draw from the linguistic analyses of Nelson Goodman. I conclude that critical investigation of the evolutionary details of Profet's pathogen defense account will be more feasible if and when biologists more frequently feature the female system of pathogen defense in their inductive generalisations. The system needs to be better entrenched before its functional components, such as menstruation, can be thoroughly investigated. (shrink)

An expanding media universe confronts readers, viewers, and users with an abundance of media content that, for the most part, will not be used by the audience, and will, in many cases, not even be considered for use. Selecting what to use and not to use is functional in avoiding information overload or ‘technostress’, but, at the same time, necessary to make use of the media environment. The selection of media initiates gratifications, serves particular functions, enables certain effects, all (...) depending on the perspective. Media use and selectivity constitute a field of remarkable tradition in communication research. The question how individuals deal with media and why they use certain media content has been in the focus of communication research from the very beginning of empirical media research; since Lazarsfeld and his colleagues conducted their radio research projects, which included Herzog's widely cited study on daytime serial listeners. Thinking about media use reached a first prime with the emergence of Uses and Gratifications approaches; an abundance of studies about ‘what people do with the media’ have been published during the golden years of Uses and Gratifications in the 1970s and 1980s. Bryant and Miron identified Uses and Gratifications – along with Agenda Setting – as the approach most frequently used in three communication journals from 1956 through 2000. (shrink)

Let and T be a set‐valued map from E to. We prove that if T is p‐adic semi‐algebraic, lower semi‐continuous and is closed for every, then T has a p‐adic semi‐algebraic continuous selection. In addition, we include three applications of this result. The first one is related to Fefferman's and Kollár's question on existence of p‐adic semi‐algebraic continuous solution of linear equations with polynomial coefficients. The second one is about the existence of p‐adic semi‐algebraic continuous extensions of continuous functions. (...) The other application is on the characterization of right invertible p‐adic semi‐algebraic continuous functions under the composition. (shrink)

ebec and Queensland, we applied four methods to assess the extent to which environmental surrogates can represent biodiversity components: (1) surrogacy graphs; (2) marginal representation plots; (3) Hamming distance function; and (4) Syrjala statistical test for spatial congruence. For Qu´ebec we used 719 faunal and floral species as biodiversity components, and for Queensland we used 2348 plant species. We used four climatic parameter types (annual mean temperature, minimum temperature during the coldest quarter, maximum temperature during the hottest quarter, and (...) annual precipitation), along with slope, elevation, aspect, and soil types, as environmental surrogates. To study the effect of scale, we analyzed the data at seven spatial scales ranging from 0.01◦ to 0.10◦ longitude and latitude. At targeted representations of 10% for environmental surrogates and biodiversity components, all four methods indicated that using a full set of environmental surrogates systematically provided better results than selecting areas at random, usually ensuring that ≥90% of the biodiversity components achieved the 10%. (shrink)

We establish that, in ZF, the statementRLT: Given a setIand a non-empty setF\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal{F}}$$\end{document}of non-empty elementary closed subsets of 2Isatisfying the fip, ifF\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal{F}}$$\end{document}has a choice function, then⋂F≠∅\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\bigcap\mathcal{F} \ne \emptyset}$$\end{document},which was introduced in Morillon :739–749, 2012), is equivalent to the Boolean Prime Ideal Theorem. The result provides, on one hand, an affirmative answer to Morillon’s (...) corresponding question in Morillon and, on the other hand, a negative answer—in the setting of ZFA —to the question in Morillon of whether RLT is equivalent to Rado’s selection lemma. (shrink)

This volume offers to the English-speaking world a collection of important works by the eminent twentieth century logician, Jan Lukasiewicz, many of which are here translated into English for the first time. This edition differs significantly from the Polish edition which appeared in 1961—containing ten logic papers not appearing there and omitting articles primarily of interest to the Polish reader. In addition to writing in Polish, Lukasiewicz also published works in French, English, and notably in German, and sometimes translated his (...) own works from one language to another. One of the most valuable works on the history of logic is Lukasiewicz’ paper, "On the History of the Logic of Propositions". Lukasiewicz points out the difference between the two basic areas of formal logic, the logic of propositions and the logic of terms, undifferentiated before the development of modern mathematical logic. The understanding of this distinction leads Lukasiewicz to trace the history of propositional logic back to its original development by the Stoics, its further development by the medieval Scholastics, and its axiomatization by Gottlob Frege. The status of mathematical logic is discussed in various works. The most basic system is propositional logic, upon which depend the other logical disciplines and also mathematics. Mathematical logic, also called logistic, is independent of philosophy and espouses no philosophical viewpoint. Early in his career, Lukasiewicz refers to mathematical logic as the logic of algebra and uses mathematical symbolism to represent logical propositions. Later he introduces what we now call "Polish notation," in particular, "Cpq" for "if p, then q" and "Np" for "it is not the case that p" for the primitive functions, eliminating the need for punctuation. He adopts the symbols Π and Σ for quantification from Charles S. Peirce, and also brings to light the almost unknown fact that it was Peirce who invented the matrix method in 1885. The paper, "Investigations into the Sentential Calculus", written by Lukasiewicz and Tarski embodies the results of a decade of research on the sentential calculus initiated by Lukasiewicz at the University of Warsaw systematically compiling the contributions of five logicians: Lindenbaum, Sobocinski, Wajsberg, Tarski, and Lukasiewicz. The approach is metalogical and depends heavily upon set theoretic concepts; it covers both the matrix and axiomatic methods. One of the problems that preoccupied Lukasiewicz was that of determinism, which led to his development of three-valued logic. A proposition such as "I shall be in Warsaw at noon on 21 December of next year" is neither true nor false; a third truth value is needed, one which Lukasiewicz calls "the possible." Another area to which Lukasiewicz contributed is modal logic, proving that modal logic cannot be two-valued. Lukasiewicz’ analysis and axiomatization of Aristotle’s syllogistic is not included in the present volume since an English edition by Lukasiewicz on this topic is available. We have here briefly touched upon a few of Lukasiewicz’ numerous achievements in logic; the best means of appreciating them is to read his works.—T. G. N. (shrink)

The optimization of high-dimensional functions is an important problem in both science and engineering. Wolf pack algorithm is a technique often used for computing the global optimum of a multivariable function. In this paper, we develop a new wolf pack algorithm that can accurately compute the optimal value of a high-dimensional function. First, chaotic opposite initialization is designed to improve the quality of initial solution. Second, the disturbance factor is added in the scouting process to enhance the searching (...) ability of wolves, and an adaptive step length is designed to enhance the global searching ability to prevent wolves from falling into the local optimum effectively. A set of standard test functions are selected to test the performance of the proposed algorithm, and the test results are compared with other algorithms. The high-dimensional and ultrahigh-dimensional functions are tested. The experimental results show that the proposed algorithm features in good global convergence, high accuracy calculation, strong robustness, and excellent performance in high-dimensional functions. (shrink)

It has been claimed that the intentional stance is necessary to individuate behavioral traits. This thesis, while clearly false, points to two interesting sets of problems concerning biological explanations of behavior: The first is a general in the philosophy of science: the theory-ladenness of observation. The second problem concerns the principles of trait individuation, which is a general problem in philosophy of biology. After discussing some alternatives, I show that one way of individuating the behavioral traits of an organism is (...) by a special use of the concept of biological function, as understood in an enriched causal role (not selected effect) sense. On this view, a behavioral trait is essentially a special kind of regularity, namely a regularity that is produced by some regulatory mechanism. Regulatory mechanisms always require goal states, which can only be provided by functional considerations. As an example from actual (as opposed to folk) science, I examine the case of social behavior in nematodes. I show that the attempt to explain this phenomenon actually transformed it. This supports the view that scientific explanation does not explain an explanandum phenomenon that is given prior to the explanation; rather, the explanandum is changed by the explanation. This means that there could be a plurality of stances that have some heuristic value initially, but which will be abandoned in favor of a functional characterization eventually. (shrink)

Top-down causation is often taken to be a metaphysically suspicious type of causation that is found in a few complex systems, such as in human mind-body relations. However, as Ellis and others have shown, top-down causation is ubiquitous in physics as well as in biology. Top-down causation occurs whenever specific dynamic behaviors are realized or selected among a broader set of possible lower-level states. Thus understood, the occurrence of dynamic and structural patterns in physical and biological systems presents a problem (...) for reductionist positions. We illustrate with examples of universality and functional equivalence classes how higher-level behaviors can be multiple realized by distinct lower-level systems or states. Multiple realizability in both contexts entails what Ellis calls “causal slack” between levels, or what others understand as relative explanatory autonomy. To clarify these notions further, we examine procedures for upscaling in multi-scale modeling. We argue that simple averaging strategies for upscaling only work for simplistic homogenous systems, because of the scale-dependency of characteristic behaviors in multi-scale systems. We suggest that this interpretation has implications for what Ellis calls mechanical top-down causation, as it presents a stronger challenge to reductionism than typically assumed. (shrink)

The origin of the genetic code has been attributed in part to an accidental assignment of codons to amino acids. Although several lines of evidence indicate the subsequent expansion and improvement of the genetic code, the hypothesis of Francis Crick concerning a frozen accident occurring at the early stage of genetic code evolution is still widely accepted. Considering Crick’s hypothesis, mathematical descriptions of hypothetical scenarios involving a huge number of possible coexisting random genetic codes could be very important to explain (...) the origin and evolution of a selected genetic code. This work aims to contribute in this regard, that is, it provides a theoretical framework in which statistical parameters of error functions are calculated. Given a genetic code and an amino acid property, the functional code robustness is estimated by means of a known error function. In this work, using analytical calculations, general expressions for the average and standard deviation of the error function distributions of completely random codes with standard stop codons were obtained. As a possible biological application of these results, any set of amino acids and any pure or mixed amino acid properties can be used in the calculations, such that, in case of having to select a set of amino acids to create a genetic code, possible advantages of natural selection of the genetic codes could be discussed. (shrink)

Alcohol use disorder is a burden to society creating social and health problems. Detection of AUD and its effects on the brain are difficult to assess. This problem is enhanced by the comorbid use of other substances such as nicotine that has been present in previous studies. Recent machine learning algorithms have raised the attention of researchers as a useful tool in studying and detecting AUD. This work uses AUD and controls samples free of any other substance use to assess (...) the performance of a set of commonly used machine learning classifiers detecting AUD from resting state functional network connectivity derived from independent component analysis. The cohort used included 51 alcohol dependent subjects and 51 control subjects. Despite alcohol, none of the 102 subjects reported use of nicotine, cannabis or any other dependence or habit formation substance. Classification features consisted of whole brain rsFNC estimates undergoing a feature selection process using a random forest approach. Features were then fed to 10 different machine learning classifiers to be evaluated based on their classification performance. A neural network classifier showed the highest performance with an area under the curve of 0.79. Other good performers with similar AUC scores were logistic regression, nearest neighbor, and support vector machine classifiers. The worst results were obtained with Gaussian process and quadratic discriminant analysis. The feature selection outcome pointed to functional connections between visual, sensorimotor, executive control, reward, and salience networks as the most relevant for classification. We conclude that AUD can be identified using machine learning classifiers in the absence of nicotine comorbidity. (shrink)