: Protection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, publication standards, and government regulation, but "intrinsic conflicts of interest"—conflicts of interest inherent in all clinical research—have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients (...) and both academic and financial incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest. (shrink)

Uniqueness appears to enhance intrinsic value. A unique stamp sells for millions of dollars; Stradivarius violins are all the more precious because they are unlike any others. This observation has not gone overlooked in the value theory literature: uniqueness plays a starring role recalibrating the dominant Moorean understanding of the nature of intrinsic value. But the thesis that uniqueness enhances intrinsic value is in tension with another deeply plausible and widely held thesis, namely the thesis that there (...) is a pro tanto reason to promote the good. It is argued that there is a second, distinct type of uniqueness that plays a more interesting and important axiological role: uniqueness imparts irreplaceable value. This gives occasion to develop the surprisingly undertheorized notion of irreplaceable value. (shrink)

In this paper I show that the problem of temporary intrinsics and a fundamental philosophical problem concerning the doctrine of the incarnation are isomorphic. To do so, I present the problem of temporary intrinsics, along with five responses to the problem. I then present the fundamental problem for Christology, which I call the problem of natural intrinsics. I present six responses to that problem, all but the last analogous to a response to the problem of temporary intrinsics. My goal is (...) not to argue that any individual response to either problem is correct. Instead, my goal is to present and defend an interesting and unnoticed similarity between two different problems, and to note how work on one problem can help with work on the other. -/- This is a penultimate manuscript, and not a final version, of a forthcoming article in Oxford Studies in Philosophy of Religion. As such, please do not cite this version; cite the official version, due out in OSPR VII in 2015. (shrink)

The wave function in quantum mechanics presents an interesting challenge to our understanding of the physical world. In this paper, I show that the wave function can be understood as four intrinsic relations on physical space. My account has three desirable features that the standard account lacks: it does not refer to any abstract mathematical objects, it is free from the usual arbitrary conventions, and it explains why the wave function has its gauge degrees of freedom, something that are (...) usually put into the theory by hand. Hence, this account has implications for debates in philosophy of mathematics and philosophy of science. First, by removing references to mathematical objects, it provides a framework for nominalizing quantum mechanics. Second, by excising superfluous structure such as overall phase, it reveals the intrinsic structure postulated by quantum mechanics. Moreover, it also removes a major obstacle to ``wave function realism.''. (shrink)

In this paper I have briefly presented the problem of temporary intrinsics, along with five types of responses to the problem. I then presented the fundamental problem for Christology, which I called the problem of natural intrinsics. I presented six types of response to the problem, all but the last analogous to a response to the problem of temporary intrinsics. my goal has not been to argue that any individual response to either problem is correct. Instead, my goal has been (...) to present an interesting and unnoticed similarity between two different problems, and to note how work on one problem can help with work on the other. (shrink)

Strawson’s case in favor of panpsychism is at heart an updated version of a venerable form of argument I’ll call the ‘intrinsic nature’ argument. It is an extremely interesting argument which deploys all sorts of high caliber metaphysical weaponry (despite the ‘down home’ appeals to common sense which Strawson frequently makes). The argument is also subtle and intricate. So let’s spend some time trying to articulate its general form.

Environmental philosophers often conflate the concepts of intrinsic value and moral standing. As a result, individualists needlessly deny intrinsic value to species, while holists falsely attribute moral standing to species. Conceived either as classes or as historical individuals, at least some species possess intrinsic value. Nevertheless, even if a species has interests or a good of its own, it cannot have moral standing because species lack sentience. Although there is a basis for duties toward some species (in (...) terms of their intrinsic value), it is not the one that the holists claim. (shrink)

Here I argue that wild nature has intrinsic value, which gives rise to obligations both to preserve it and to restore it. First, an account of intrinsic value, which permits core environmentalist claims, is outlined and defended. Second, connections between intrinsic value and obligation are discussed. Third, it is argued that wild nature has intrinsic value, in part, in virtue of its naturalness.

In this essay I propose an environmental ethic in the pragmatic vein. I begin by suggesting that the contemporary debate in environmental ethics is forced into a familiar but highly restrictive set of distinctions and problems by the traditional notion of intrinsic value, particularly by its demands that intrinsic values be self-sufficient, abstract, and justified in special ways. I criticize this notion and develop an alternativewhich stresses the interdependent structure of values, a structure which at once roots them (...) deeply in our selves and at the same time opens them to critical challenge and change. Finally, I apply this alternative view back to environmental ethics. It becomes easy to justify respect for other life forms and concern for the natural environment, and indeed many of the standard arguments only become stronger, once the demand to establish intrinsic values is removed. (shrink)

The central and most recalcitrant problem for environmental ethics is the problem of constructing an adequate theory of intrinsic value for nonhuman natural entities and for nature as a whole. In part one, I retrospectively survey the problem, review certain classical approaches to it, and recommend one as an adequate, albeit only partial, solution. In part two, I show that the classical theory of inherent value for nonhuman entities and nature as a whole outlined in part one is inconsistent (...) with a contemporary scientific world view because it assumes the validity of the classical Cartesian partition between subject and object which has been overturned by quantum theory. Based upon the minimalistic Copenhagen Interpretation of quantum theory, I then develop a theory of inherent value which does not repose upon the obsolete subject/object and ancillary fact/value dichotomies. In part three, I suggest that a more speculative metaphysical interpretation of quantum theory--one involving the notion ofreal internal relations anda holistic picture of nature-permits a principle of “axiological complementary,” a theory of “intrinsic”-as opposed to “inherent”-value in nature as a simple extension of ego. (shrink)

In this essay I propose an environmental ethic in the pragmatic vein. I begin by suggesting that the contemporary debate in environmental ethics is forced into a familiar but highly restrictive set of distinctions and problems by the traditional notion of intrinsic value, particularly by its demands that intrinsic values be self-sufficient, abstract, and justified in special ways. I criticize this notion and develop an alternativewhich stresses the interdependent structure of values, a structure which at once roots them (...) deeply in our selves and at the same time opens them to critical challenge and change. Finally, I apply this alternative view back to environmental ethics. It becomes easy to justify respect for other life forms and concern for the natural environment, and indeed many of the standard arguments only become stronger, once the demand to establish intrinsic values is removed. (shrink)

The notion that some things have intrinsic value, independently of whether they are valued or would be valued under certain conditions, is puzzling not only to noncognitivists and skeptics, but to theorists who understand value in terms of what would be accepted by rational preference, in a social contract, or under conditions of vivid imagination. Written in the tradition of Roderick Chisholm’s Brentano and Intrinsic Value, Noah Lemos’s Intrinsic Value: Concept and Warrant is unlikely to diminish the (...) puzzlement, though it will be beneficial to those who accept intrinsic value and our knowledge of it. (shrink)

Conventional wisdom suggests that environmental pragmatists balk at the mere mention of intrinsic value. Indeed, the leading expositor of the pragmatic position in environmental philosophy, Bryan Norton, has delivered withering criticisms of the concept as it has been employed by nonanthropocentrists in the field. Nevertheless, I believe that Norton has left an opening for a recognition of intrinsic value in his arguments, albeit a version that bears little resemblance to most of its traditional incarnations. Drawing from John Dewey’s (...) contextual approach toward moral inquiry, I offer a reconstructed notion of intrinsic value that avoids the metaphysical pitfalls identified by Norton. I argue that this contextual understanding of noninstrumental claims has the advantage of turning our attention toward, and not away from, the critical realm of practice and policy, and that it is especially compatible with the norms of democratic deliberation. By way of example and in defense of my position, I conclude with a rejoinder to Holmes Rolston’s claims about the role of foundational intrinsic value commitments in settling the human-nature dilemma at Royal Chitwan National Park in Nepal. (shrink)

Heirlooms and memorabilia are sometimes thought to be valuable for their own sakes even if they lack intrinsic value. They can have extrinsic final value, meaning that they can be valuable for their own sakes on account of their relation to other things. Yet if heirlooms and memorabilia can have this sort of value, then perhaps so can natural entities. If correct, this idea secures the claim that nature is valuable for its own sake without requiring that it have (...) a normative property just in itself. Additionally, it does not commit one to the contentious view that natural entities have a more foundational value than that of persons or sentient beings. Yet it remains to be shown how, precisely, natural entities can have this sort of value. As argued here, one such way is if the given natural entity is related to something else that people are justified in valuing in a partly passive manner. This account then sheds light on the values present in a world increasingly affected by humans. (shrink)

Conventional wisdom suggests that environmental pragmatists balk at the mere mention of intrinsic value. Indeed, the leading expositor of the pragmatic position in environmental philosophy, Bryan Norton, has delivered withering criticisms of the concept as it has been employed by nonanthropocentrists in the field. Nevertheless, I believe that Norton has left an opening for a recognition of intrinsic value in his arguments, albeit a version that bears little resemblance to most of its traditional incarnations. Drawing from John Dewey’s (...) contextual approach toward moral inquiry, I offer a reconstructed notion of intrinsic value that avoids the metaphysical pitfalls identified by Norton. I argue that this contextual understanding of noninstrumental claims has the advantage of turning our attention toward, and not away from, the critical realm of practice and policy, and that it is especially compatible with the norms of democratic deliberation. By way of example and in defense of my position, I conclude with a rejoinder to Holmes Rolston’s claims about the role of foundational intrinsic value commitments in settling the human-nature dilemma at Royal Chitwan National Park in Nepal. (shrink)

Franz Brentano developed an original theory of intrinsic value which he attempted to base on his philosophical psychology. Roderick Chisholm presents here a critical exposition of this theory and its place in Brentano's general philosophical system. He gives a detailed account of Brentano's ontology, showing how Brentano tried to secure objectivity for ethics not through a theory of practical reason, but through his theory of the intentional objects of emotions and desires. Professor Chisholm goes on to develop certain suggestions (...) about intrinsic value made by Brentano and his students, and discusses their relevance to theodicy and the problem of evil. Brentano, as the teacher of Husserl, Meinong, Twardowski, and others, stands at the origin of the phenomenological tradition and of the Polish school of philosophy that developed after World War I. He has also had considerable influence on Anglo-American philosophy. This book will interest those concerned with the origins of phenomenological value theory and more generally with the connections between ethics and philosophical psychology. (shrink)

Kit Fine famously objected against the idea that essence can be successfully analyzed in terms of de re necessity. In response, I want to explore a novel, interesting, but controversial modal account of essence in terms of intrinsicality and grounding. In the first section, I will single out two theoretical requirements that any essentialist theory should meet—the essentialist desideratum and the essentialist challenge—in order to clarify Fine’s objections. In the second section, I will assess Denby’s improved modal account, which appeals (...) to the notion of intrinsicality, and argue that it is untenable. In the third section, I will explain how, when combined with a modal-existential criterion, a hyperintensional account of intrinsicality—in the same vein as Bader (J Philos 110(10): 525–563, 2013) and Rosen (in: Hale and Hoffman (eds) Modality: Metaphysics, logic, and epistemology, Oxford, OUP, 2010)—can help successfully address Fine’s counterexamples. In the fourth section, I will evaluate how this novel analysis of essence stands with respect to sortal, origin, and natural kinds essentialism and discuss potential objections and difficulties. (shrink)

To hold an environmental ethic is to hold that non-human beings and states of affairs in the natural world have intrinsic value. This seemingly straightforward claim has been the focus of much recent philosophical discussion of environmental issues. Its clarity is, however, illusory. The term ‘intrinsic value’ has a variety of senses and many arguments on environmental ethics suffer from a conflation of these different senses: specimen hunters for the fallacy of equivocation will find rich pickings in the (...) area. This paper is largely the work of the underlabourer. I distinguish different senses of the concept of intrinsic value, and, relatedly, of the claim that non-human beings in the natural world have intrinsic value; I exhibit the logical relations between these claims and examine the distinct motivations for holding them. The paper is not however merely an exercise in conceptual underlabouring. It also defends one substantive thesis: that while it is the case that natural entities have intrinsic value in the strongest sense of the term, i.e., in the sense of value that exists independently of human valuations, such value does not as such entail any obligations on the part of human beings. The defender of nature’s intrinsic value still needs to show that such value contributes to the well-being of human agents. (shrink)

Consider two of my properties: my mass and my weight. There seems to be an interesting distinction between the reasons for my having these two properties. I have my mass solely in virtue of how I am, whereas I have my weight in virtue of both how I am and how my surroundings are. I have my weight as a result of the gravitational pull exerted by the Earth on a thing having my mass, whereas I have my mass independently (...) of other things around me. If you change my surroundings, if you put me on the moon say, my weight will change, but my mass will stay the same. (shrink)

This paper claims that a particular interpretation of Kant`s legal-political philosophy, as it is presented in his Doctrine of Right, provides us with the much needed resolution to the question of the normativity of law, precisely because it brings in a perspective that avoids both positivism and ethicism. This particular interpretation follows a strategy of argumentation that I call the “argument for the intrinsic normativity of law”, i.e., the argument that law is defined and justified on its own grounds, (...) without any need to refer to ethics, or rational/enlightened self-interest. This argument highlights the concept of legal person with the innate right to freedom as the necessary presupposition of legal practices, and sets forth a fundamental sense of justice inherent to the concept of law that consists in the reciprocal recognition of legal personality. In the end, I come up with a distinctive conception of law that I formulate as a last resort of normativity in the face of a conflict wherein an ethical solution does not appeal to all parties. (shrink)

Metaethical questions are typically held to be a priori , and therefore impervious to empirical evidence. Here I examine the metaethical claim that motive-internalism about belief , the position that moral beliefs are intrinsically motivating, is true. I argue that belief-internalists are faced with a dilemma. Either their formulation of internalism is so weak that it fails to be philosophically interesting, or it is a substantive claim but can be shown to be empirically false. I then provide evidence for the (...) falsity of substantive belief-internalism. I describe a group of brain-damaged patients who sustain impairment in their moral sensibility: although they have normal moral beliefs and make moral judgments, they are not inclined to act in accordance with those beliefs and judgments. Thus, I argue that they are walking counterexamples to the substantive internalist claim. In addition to constraining our conception of moral reasoning, this argument stands as an example of how empirical evidence can be relevantly brought to bear on a philosophical question typically viewed to be a priori. (shrink)

Since environmental ethics research started in China in the 1980s, it has been deeply influenced by environmental ethics theory in the United States. Some Chinese environmental philosophers have adopted the key concept of intrinsic value to construct Chinese environmental ethics. However, in recent decades, the concept of intrinsic value has been criticized by scholars in both the United States and China. Many Chinese have found that environmental ethics in the United States that is founded on the concept of (...) intrinsic value is incompatible with Chinese philosophy and culture. They have begun a new effort that is aimed at developing a localized environmental ethics based on traditional Chinese philosophy. However, the Chinese scholars’ theoretical effort neglects the important concept of wilderness that is emerging from preservation and conservation practices in China. In this context, the emotion of wonder and its interrelationship with intrinsic value is the new paradigm for constructing a Chinese environmental ethics. (shrink)

There are many computational problems which are generally “easy” to solve but have certain rare examples which are much more difficult to solve. One approach to studying these problems is to ignore the difficult edge cases. Asymptotic computability is one of the formal tools that uses this approach to study these problems. Asymptotically computable sets can be thought of as almost computable sets, however every set is computationally equivalent to an almost computable set. Intrinsic density was introduced as a (...) way to get around this unsettling fact, and which will be our main focus.Of particular interest for the first half of this dissertation are the intrinsically small sets, the sets of intrinsic density $0$. While the bulk of the existing work concerning intrinsic density was focused on these sets, there were still many questions left unanswered. The first half of this dissertation answers some of these questions. We proved some useful closure properties for the intrinsically small sets and applied them to prove separations for the intrinsic variants of asymptotic computability. We also completely separated hyperimmunity and intrinsic smallness in the Turing degrees and resolved some open questions regarding the relativization of intrinsic density.For the second half of this dissertation, we turned our attention to the study of intermediate intrinsic density. We developed a calculus using noncomputable coding operations to construct examples of sets with intermediate intrinsic density. For almost all $r\in $, this construction yielded the first known example of a set with intrinsic density r which cannot compute a set random with respect to the r-Bernoulli measure. Motivated by the fact that intrinsic density coincides with the notion of injection stochasticity, we applied these techniques to study the structure of the more well-known notion of MWC-stochasticity.prepared by Justin Miller.E-mail: [email protected]: https://curate.nd.edu/show/6t053f4938w. (shrink)

Kittle's recent paper brings into focus two interesting aspects of dispositions and employs them in an attempt to distinguish between cases where dispositions are subject to intrinsic interferers and cases where not. But I will argue below that Kittle doesn’t succeed in this attempt. The upshot is that no such distinction is in sight, and this continues to be a troubling problem for those philosophers who uphold the possibility of intrinsic interferers with dispositions by insisting that, whilst some (...) dispositions aren’t subject to intrinsic interferers, others are. (shrink)

We do not yet have a sound ontology for intrinsic value. Albert Borgmann’s work on information technology and Daniel Dennett’s thoughts on evolutionary theory can provide the basis for an account of intrinsic value in terms of what it is, how it comes into existence, where it is found, and whether it can be quantified or compared. Borgmann’s information and realization relations are cornerstones forunderstanding value. According to Borgmann, things are valuable when they are meaningful and things become (...) meaningful as information and realizations. It is in these relations that intrinsic and extrinsic values find their common roots. Dennett’s musing on the relationship between DNA instructions, DNA readers, and phenotypes invites a commingling of information technology and evolutionary theory. His notion of design space provides a basis for the claim the biotic community has on intrinsic and extrinsic values. (shrink)

We do not yet have a sound ontology for intrinsic value. Albert Borgmann’s work on information technology and Daniel Dennett’s thoughts on evolutionary theory can provide the basis for an account of intrinsic value in terms of what it is, how it comes into existence, where it is found, and whether it can be quantified or compared. Borgmann’s information and realization relations are cornerstones forunderstanding value. According to Borgmann, things are valuable when they are meaningful and things become (...) meaningful as information and realizations. It is in these relations that intrinsic and extrinsic values find their common roots. Dennett’s musing on the relationship between DNA instructions, DNA readers, and phenotypes invites a commingling of information technology and evolutionary theory. His notion of design space provides a basis for the claim the biotic community has on intrinsic and extrinsic values. (shrink)

Professional environmental ethics arose directly out of the interest in the environment created by Earth Day in 1970. At that time many environmentalists, primarily because they had read Aldo Leopold’s essay, “The Land Ethic,” were convinced that the foundations of environmental problems were philosophical. Moreover, these environmentalists were dissatisfied with the instrumental arguments based on human use and benefit—which they felt compelled to invoke in defense of nature—because they thought these arguments were part of the problem. Wanting to counter (...) instrumental arguments in some way with non- or even anti-instrumental arguments, and unable to think of anything else to say, they began wistfully suggesting that perhaps nature had or ought to have rights. When professional environmental ethics came into its own in the early 1980s, rights for nature were one of the first subjects to be debated in detail. Unfortunately, however, no one could come up with a theory to support such rights attributions. Nevertheless, because rights had been invoked by environmentalists to challenge the preeminent role of instrumental value arguments, and because the field of environmental ethics developed in support of environmental concerns and arguments, environmental ethicists turned to an examination of noninstrumental or intrinsic value arguments for the preservation of nature. (shrink)

It is widely held that all hope for a satisfactory environmental ethic rests on the question whether intrinsic value can be discovered in non-human nature, for it is also widely held that intrinsic value is what, if anything, grounds human obligations to non-human nature. The work of J. Baird Callicott on intrinsic value has been central to the contemporary discussion of environmental ethics and the present paper leads off with an overview of some aspects of his work (...) in this area. (shrink)

The Paleolithic paintings and drawings found on cave walls at sites in France and Spain, such as Lascaux, Altamira and Vallon-Pont-D'Arc, have profound effects on those who see them. In addition to their historical interest, they are prized for their aesthetic and spiritual qualities, which have had an important influence on modern art. But the caves are small and the paintings are fragile. Access to them has been sharply limited: some caves have been closed to protect the paintings from (...) the damage caused by human respiration; access to others is limited to those who negotiate a daunting reservation scheme. Despite being the heritage of humanity as a whole, the cave paintings are, and must be, restricted to a very few. Not everyone who wants to see the paintings can do so if they are to survive. (shrink)

Kant’s doctrine of the “categorical imperative” with respect to ratiocentrism needs to be examined for its implications for environmental ethics. Kant’s argument is that moral actions must be categorical or unqualified imperatives that reflect the sovereignty of moral obligations that all rational moral agents could figure out by virtue of their rationality. For Kant, humans have no direct moral obligations to non-rational, nonhuman nature: only rational beings, i.e., humans, are worthy of moral consideration. I argue that this position is excessively (...) anthropocentric and ratiocentric in excluding the nonhuman natural world from moral consideration. While conceding that nonhuman nature is instrumentally valuable owing to some inevitable existential, ontological considerations, moral obligation should be extended to the natural world in order to achieve environmental wholeness. (shrink)

Many people who claim to genuinely care about nature still seem reluctant to ascribe intrinsic value to it. Environmentalists, nature friendly people in general, and even environmental activists, often hesitate at the idea that nature possesses value in its own right—value that is not reducible to its importance to human or other sentient beings. One crucial explanation of this reluctance is probably the thought that such value—at least when attached to nature—would be mysterious in one way or another, or (...) at least very difficult to account for. In addition, Bryan Norton’s influential convergence hypothesis states that, from a practical point of view, it makes no or little difference whether we ascribe intrinsic value to nature, given the depth and variety of instrumental value it possesses. In this paper, I argue that people who genuinely care about nature cannot avoid ascribing intrinsic value (in a certain sense) to it, if they want to be able to consistently defend the kind of claims about protecting nature they arguably want to make, i.e., claims to the effect that we ought to protect for instance nature areas and species. The cost of denying intrinsic value in nature is the cost of giving up a crucial resource to philosophically defend such claims. (shrink)

In [3] I argued for a particular kind of semantics for subjunctive conditionals. The arguments were based upon some linguistic considerations of the general character of what we mean when we say such and such. I urged that a semantics for subjunctive conditionals ought to provide a distinct representation of the subjunctive mood of a sentence, and should take seriously the fact that subjunctive conditionals admit distinctions of tense. The envisaged semantics took the subjunctive conditional to be about occasions, and (...) the central problem discussed was, accordingly, how to represent what must count as the same occasion in spite of whatever changes were required to make the antecedent of the conditional true. (shrink)

Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena—oscillations and bistability—in signaling cascades possessing at least (...) one stage with a double-phosphorylation cycle as in MAPK cascades. (shrink)

We propose a rudimentary formal framework for reasoning about recursion equations over inductively generated data. Our formalism admits all equational programs , and yet singles out none. While being simple, this framework has numerous extensions and applications. Here we lay out the basic concepts and definitions; show that the deductive power of our formalism is similar to that of Peano's Arithmetic; prove a strong normalization theorem; and exhibit a mapping from natural deduction derivations to an applied λ -calculus, à la (...) Curry–Howard, which provides a transparent proof of Gödel's result that the provably recursive functions of PA are definable by primitive recursion in finite types. Also of interest is the extent, uncommon among similar constructions, to which our mapping is oblivious to first order terms, including first order quantification and equality. Additional applications and extensions of the method will be presented in sequel papers. In particular, the methodology introduced here lends itself to systematic links between natural sub-formalisms and computational complexity classes. Since these sub-formalisms are largely transparent, allowing one to reason formally in the full system while leaving to automatic software tools the task of verifying that restrictions are complied with, the framework is particularly attractive for the development of Feasible Mathematics. (shrink)

Central to Holmes Rolston’s Environmental Ethics is the theoretical quest of most enviromnental philosophers for a defensible concept of intrinsic value for nonhuman natural entities and nature as a whole. Rolston’s theory is similar to Paul Taylor’s in rooting intrinsic value in conation, but dissimilar in assigning value bonuses to consciousness and self-consciousness and value dividends to organic wholes andelemental nature. I argue that such a theory of intrinsic value flies in the face of the subject/object and (...) fact/value dichotomies of the metaphysical foundations of modem science—a problem Rolston never directly confronts. The modern scientific world view is obsolete. A post-modem scientific world view provides for a range of potential values in nature actualizable upon interaction with consciousness. The bestthat a modem scientific world view can provide are subject-generated—though not necessarily subject-centered—values in nature. (shrink)

The Mīmāṃsāka doctrine of "svatah prāmānya" has seldom been given the serious philosophical attention it deserves. This doctrine in fact grows out of a sophisticated critique of epistemological foundationalism. This critique, as well as the larger project that it serves, has striking similarities with the philosophical project advanced in William Alston's "Perceiving God". A comparison of the two helps to highlight the strengths and the problems of both projects, and shows, perhaps more importantly, that the Mīmāṃsāka doctrine is in fact (...) still relevant, as it resembles one of the more interesting positions currently in play in contemporary philosophy. (shrink)

Two major philosophical movements have sought to fundamentally rethink the relationship between humans and their environment(s): environmental ethics and enactivism. Surprisingly, they virtually never refer to or seek inspiration from each other. The goal of this analysis is to bridge the gap. Our main purpose, then, is to address, from the enactivist angle, the conceptual backbone of environmental ethics, namely the concept of intrinsic value. We argue that intrinsic value does indeed exist, yet its "intrinsicality" does not boil (...) down to being independent of the interests and needs of humans. Rather, it is brought forth by what we callshared enactionof an axiological domain. The latter is built upon such core posits of enactivism as autonomy, enaction, participatory sense-making as well as the most recent concept of loving as knowing proposed by Hanne De Jaegher. (shrink)

Central to Holmes Rolston’s Environmental Ethics is the theoretical quest of most enviromnental philosophers for a defensible concept of intrinsic value for nonhuman natural entities and nature as a whole. Rolston’s theory is similar to Paul Taylor’s in rooting intrinsic value in conation, but dissimilar in assigning value bonuses to consciousness and self-consciousness and value dividends to organic wholes andelemental nature. I argue that such a theory of intrinsic value flies in the face of the subject/object and (...) fact/value dichotomies of the metaphysical foundations of modem science—a problem Rolston never directly confronts. The modern scientific world view is obsolete. A post-modem scientific world view provides for a range of potential values in nature actualizable upon interaction with consciousness. The bestthat a modem scientific world view can provide are subject-generated—though not necessarily subject-centered—values in nature. (shrink)

Anthony Weston has criticized the place of “inttinsic value” in the development of an environmental ethic, and he has urged a “pragmatic shift” toward a plurality of values based on human desires and experiences. I argue that Weston is mistaken for two reasons: (1) his view of the methodology of environmental ethics is distorted: the intrinsic value of natural entities is not the ground of all moral obligations regarding the environment; and (2) his pragmatic theory of value is too (...) anthropocentric and subjective for the development of a secure and reliable environmental ethic. The obligation to protect the natural environment should not be based on certain “correct” experiences of humans as they interact with wild nature. (shrink)

DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the “functional packaging” (...) of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right‐handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis‐acting DNA elements and activators that trigger transcription. BioEssays 23:708–715, 2001. © 2001 John Wiley & Sons, Inc. (shrink)