Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided (...) novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function. (shrink)

Since each term only has significance in contrast to its negation, the distinction between the noumenal and the phenomenal is a Kantian philosophical postulation that is as arbitrary as any binary (e.g., presence–absence) when submitted to Jacques Derrida’s method of deconstruction. According to Noumenism – a philosophy founded on the non-dualistic reinscription of phenomena and noumena – works of art possess elements which are simultaneously sense-data, and no data to any mind. This paradoxical status is achieved by means of an (...) artist-invented mechanism which allows its generative workings to run amok. The mechanism itself is a ‘compound-image’ formed by the paranoiac-critical activity of abolishing the mutual exclusivity of two or more different systems (i.e., the organization of related elements into complex wholes, methods, procedures, techniques, etc.). To illustrate this, an analysis of ‘No. 6’ from Noumenist poet Jason Johnson’s Hymns from Purgatory is undertaken. As they develop, refine or adopt their own philosophies of art, today’s artists and tomorrow’s are challenged to reckon with the ideas put forward in this article. (shrink)

How did the 3.5-inch Winchester hard disk drive become the fundamental building block of the modern data center? In attempting to answer this question, I theorize the concept of "data peripheries" to attend to the awkward, uneven, and unintended outsides of data infrastructures. I explore the concept of data peripheries by first situating Big Data in one of its many unintended outsides—an unassuming dog kennel in Indiana housed in a former permanent magnet manufacturing plant. From the perspective of this dog (...) kennel, I then build a history of the 3.5-inch Winchester hard disk drive, and weave this hard drive history through the industrial histories of rare earth mining and permanent magnet manufacturing, focusing principally on Magnequench, a former General Motors subsidiary, and its sale and movement of operations from Indiana to China in the mid-1990s and early 2000s. I then discuss how mobilities of rare earths, both as materials and political discourse, shape Big Data futures, and conclude by speculating on how using the situated lenses of data peripheries can open up new methods for studying the material entanglements of Big Data writ large. (shrink)

A compelling combination of photography, cultural history, and philosophical geography, Double Take presents more than seventy photographic pairs - each a distinctive "then" and "now" view of the same location - that document more than a century of change in downtown Madison, Wisconsin. Presented side-by-side, the dramatic transformations comprise one of the most ambitious and exacting urban rephotography surveys ever undertaken. Celebrated Wisconsin photographer Zane Williams has meticulously replicated the original views of an earlier Madison photographer, Angus McVicar, who (...) first shot these locales from the 1920s to the 1950s. The result is a rich archive of historic and contemporary images and a provocative examination into the nature of change in a mid-sized American city. (shrink)

This collection posits three questions. 1. What structures of violence and oppression are experienced and shared by human and nonhuman laborers working and dying in these necropolitical facilities? 2. If there is an intersection between class and species, which, in turn incorporates race, gender, abilities, and other categories of oppression, in which ways is the contemporary animal advocacy nonprofit sector reifying or disrupting these hierarchies in its mission towards animal liberation? 3. If there are classist and racist biases in Animal (...) Activist Nonprofit Sector (AANS), how can the AANS incorporate social class in dialogue with the liberation of nonhuman animals in order to build strategic alliances and coalitions between social movements and political subjects? This book not only envision a world without these hierarchies but offer tangible steps the AANS can take to achieve liberation for human and nonhuman animals. (shrink)

This spectacular collection of photographs takes the viewer on a stroll through the heart of Madison, around the Capitol Square and down renowned State Street, with stops at some of the most recent additions to the city s skyline, including the Monona Terrace Convention Center and the Overture Center for the Arts. Then it s on toward the University of Wisconsin campus, with its historic buildings, walkways, and the Memorial Union Terrace, one of the city s best-known spots for students (...) and locals to meet, eat and listen to live music. The tour continues through Madison s diverse neighborhoods, visiting numerous ethnic restaurants, music festivals and the one Madison s most famous traditions, the Dane County Farmers Market. The visual journey finishes with visits to the breathtaking parks and gardens scattered throughout the city.". (shrink)

In Elements of Legislation, Neil Duxbury examines the history of English law through the lens of legal philosophy in an effort to draw out the differences between judge-made and enacted law and to explain what courts do with the laws that legislatures enact. He presents a series of rigorously researched and carefully rehearsed arguments concerning the law-making functions of legislatures and courts, the concepts of legislative supremacy and judicial review, the nature of legislative intent and the core principles of (...) statutory interpretation. (shrink)

This unique study offers a comprehensive analysis of American jurisprudence from its emergence in the later stages of the nineteenth century through to the present day. The author argues that it is a mistake to view American jurisprudence as a collection of movements and schools which have emerged in opposition to each other. By offering a highly original analysis of legal formalism, legal realism, policy science, process jurisprudence, law and economics, and critical legal studies, he demonstrates that American jurisprudence has (...) evolved as a collection of themes which reflects broader American intellectual and cultural concerns. (shrink)

Chance inevitably plays a role in law but it is not often that we consciously try to import an element of randomness into a legal process. Random Justice: On Lotteries and Legal Decision-Making explores the potential for the use of lotteries in social, and particularly legal, decision-making contexts. Utilizing a variety of disciplines and materials, Neil Duxbury considers in detail the history, advantages, and drawbacks of deciding issues of social significance by lot and argues that the value of the (...) lottery as a legal decision-making device has generally been underestimated. The very fact that there exists widespread resistance to the use of lotteries for legal decision-making purposes betrays a commonly held belief that legal processes are generally more important than are legal outcomes. Where, owing to the existence of indeterminacy, the process of reasoning is likely to be excessively protracted and the reasons provided strongly contestable, the most cost-efficient and impartial decision-making strategy may well be recourse to lot. Aversion to this strategy, while generally understandable, is not necessarily rational. Yet in law, as Professor Duxbury demonstrates, reason is generally valued more highly than is rationality. The lottery is often conceived to be a decision-making device that operates in isolation. Yet lotteries can frequently and profitably be incorporated into other decision-frameworks. The book concludes by controversially considering how lotteries might be so incorporated and also advances the thesis that it may sometimes be sensible to require that adjudication takes place in the shadow of a lottery. (shrink)

This unique study offers a comprehensive analysis of American jurisprudence from its emergence in the later stages of the nineteenth century through to the present day. The author argues that it is a mistake to view American jurisprudence as a collection of movements and schools which have emerged in opposition to each other. By offering a highly original analysis of legal formalism, legal realism, policy science, process jurisprudence, law and economics, and critical legal studies, he demonstrates that American jurisprudence has (...) evolved as a collection of themes which reflect broader American intellectual and cultural concerns. (shrink)

This controversial book explores the potential for the use of lotteries in social, and particularly legal, decision-making contexts. Utilizing a variety of disciplines and materials, the author considers in detail the history, advantages, and drawbacks of deciding issues of social significance by lot and argues that the value of the lottery as a legal decision-making device has generally been underestimated. The final chapter of the book considers how lotteries might be combined with other decision-mechanisms and suggests that it may sometimes (...) be sensible to require that adjudication takes place in the shadow of the lottery. (shrink)

_Fugitive Images: From Photography to Video_ Edited by Patrice Petro Bloomington: Indiana University Press, 1995 ISBN 0-253-20890-4 314 pp.

Confusion prevails in the anthropological literature concerning the nature of spirit possession belief and its effects. In large, this is due to the difficulty in differentiating between culture‐specific categories of altered states of consciousness and reconciling these to analytical categories. Theories of spirit possession tend either toward description of the culture context without reference to outside theories, thus lacking comparability, or toward application of externally derived categories to the possession behavior, which often lack on‐the‐ground relevance. Since comparison is the aim (...) of anthropology, we need categories which enable us to accomplish that and still reflect cultural belief. I propose focusing on "ritual states of consciousness" rather than just altered states, which may or may not be spirit possession according to different criteria. This will enable us to retain the culturally relevant categorization while achieving a useful comparability among cultures. I test this idea by analyzing the Spiritual Baptists of St. Vincent and other Caribbean religions. (shrink)

The Court of Justice of the European Union (CJEU) has some basic structural features similar to that of most judicial bodies. According to the treaties, the members of the Court are chosen from individuals whose independence is beyond doubt and who possess the ability required for appointment to higher judicial offices. The involvement of the Court and its president in the most important reforms of the European Union's judicial architecture in recent years is a striking feature which may be called (...) judicial self‐government. International courts have shifted away from being principally committed to dispute settlement towards pursuing other goals, such as advancing international norms and facilitating cooperative international arrangements. The reinforcement of the cooperation of the Court with national courts on the one hand, and with international courts and tribunals on the other, is one of the great current challenges facing the Court. (shrink)

This paper focuses on Hannah Arendt’s ideas concerning freedom and the political in the Greek polis. By outlining the structure of the notions of labour, work, and action in relation to thinking, responsibility, and necessity, it aims to explore the possibility of thinking about freedom in the context of contemporary society. Arendt’s phenomenological reflections on the nature of human beings and the significance of the political in Western society within the framework of the decline of Europe encompass a broad spectrum (...) of themes. It traces the origins of Western culture and exposes how the evolving dynamics of the private and public, thought and action, and the progress of science and technology have contributed to a way of thinking that has led to the emergence of totalitarianism. Keywords: freedom, work, labour, action, political, human being. (shrink)

Restraint as an intervention in the management of acute mental distress has a long history that predates the existence of psychiatry. However, it remains a source of controversy with an ongoing debate as to its role. This article critically explores what to date has seemingly been only implicit in the debate surrounding the role of restraint: how should the concept of validity be interpreted when applied to restraint as an intervention? The practice of restraint in mental health is critically examined (...) using two post-positivist constructions of validity, the pragmatic and the psychopolitical, by means of a critical examination of the literature. The current literature provides only weak support for the pragmatic validity of restraint as an intervention and no support to date for its psychopolitical validity. Judgements regarding the validity of any intervention that is coercive must include reference to the psychopolitical dimensions of both practice and policy. (shrink)

VIRTUALLY ALL MODAL LOGICIANS after Aristotle have been troubled by his insistence that, given a valid first figure categorical syllogism.

This chapter contains sections titled: Modern Legal Theory and the Impact of Realism Policy Science Legal Process References.

This article offers a critical reassessment of the jurisprudence of Rudolf von Jhering. During the 20th century, Anglo-American legal philosophers who drew inspiration from Jhering's work usually lauded him either as a German forerunner to American legal realism or as an early proponent of a jurisprudence of interests. These representations of his work do not do justice to Jhering's jurisprudential project. This study demonstrates that he sought to explain how legal systems originate and how they maintain authority. It is shown (...) that his explanation of legal authority depends not only upon familiar jurisprudential notions such as reciprocity and positional duty, but also upon the concept of Rechtsgefühl—namely, the idea that authority is conditioned by citizens’ feelings of what is right or just. Jhering, it is demonstrated, believed that the authority of a legal system depends very much on its ability to negotiate and accommodate struggles based upon feelings of right—struggles between citizens, between citizens and State, and between States. It is also argued that the manner in which Jhering relies on the idea of Rechtsgefühl undermines the received wisdom that he was an interest theorist. (shrink)

Frederick Pollock and the English Juristic Tradition provides the first detailed historical account of one of England's great jurists. Drawing upon a vast array of sources, Neil Duxbury examines Pollock's career, jurisprudence, philosophy of the common law, treatise writing, and editorial initiatives, and shows that Pollock's contribution to the development of English law and juristic inquiry is both complex and crucial.Readership: Scholars and students of legal history and legal thought, barristers, and judges.

Common-law judgments tend to be more than merely judgments, for judges often make pronouncements that they need not have made had they kept strictly to the task in hand. Why do they do this? The Intricacies of Dicta and Dissent examines two such types of pronouncement, obiter dicta and dissenting opinions, primarily as aspects of English case law. Neil Duxbury shows that both of these phenomena have complex histories, have been put to a variety of uses, and are not (...) amenable to being straightforwardly categorized as secondary sources of law. This innovative and unusual study casts new light on – and will prompt lawyers to pose fresh questions about – the common law tradition and the nature of judicial decision-making. (shrink)

This article examines the concepts of retrospective and retroactive—both forms of ex post facto—law. It shows that although the distinction between retrospective and prospective law is difficult to draw (given that laws generally alter rights), the classification of particular laws as retrospective is not arbitrary, since the proposition that only some legal rules interfere with “vested” rights is, while vague, not meaningless. Retroactive legislation is recognized to attract a long list of objections. The article seeks to identify and assess those (...) objections, and to provide a comprehensive account of the various possible (if invariably limited) justifications for retroactivity. The conclusion offers some brief reflections on why the complaint that a law operates ex post facto is less likely to be directed at a judicial decision than at a statute. (shrink)