During immune responses against invading pathogenic bacteria, the cytoskeleton network enables macrophages to implement multiple essential functions. To protect the host from infection, macrophages initially polarize to adopt different phenotypes in response to distinct signals from the microenvironment. The extracellular stimulus regulates the rearrangement of the cytoskeleton, thereby altering the morphology and migratory properties of macrophages. Subsequently, macrophages degrade the extracellular matrix (ECM) and migrate toward the sites of infection to directly contact invading pathogens, during which the involvement of cytoskeleton‐based (...) structures such as podosomes and lamellipodia is indispensable. Ultimately, macrophages execute the function of phagocytosis to engulf and eliminate the invading pathogens. Phagocytosis is a complex process that requires the cooperation of cytoskeleton‐enriched super‐structures, such as filopodia, lamellipodia, and phagocytic cup. This review presents an overview of cytoskeletal regulations in macrophage polarization, ECM degradation, migration, and phagocytosis, highlighting the pivotal role of the cytoskeleton in host defense against infection. (shrink)

We consider a uniform r-bundle E on a complex rational homogeneous space X and show that if E is poly-uniform with respect to all the special families of lines and the rank r is less than or equal to some number that depends only on X, then E is either a direct sum of line bundles or unstable with respect to some numerical class of a line. So we partially answer a problem posted by Muñoz et al.. In particular, if (...) X is a generalized Grassmannian \ and the rank r is less than or equal to some number that depends only on X, then E splits as a direct sum of line bundles. So we improve the main theorem of Muñoz et al. 664:141–162, 2012, Theorem 3.1) when X is a generalized Grassmannian. Moreover, by calculating the relative tangent bundles between two rational homogeneous spaces, we give explicit bounds for the generalized Grauert–Mülich–Barth theorem on rational homogeneous spaces. (shrink)

Background: In 2019, an outbreak of COVID-19 broke out in Hubei, China. Medical workers from all over the country rushed to Hubei and participated in the treatment and care of COVID-19 patients. These nurses, dedicated to their professional practice, volunteered to provide compassion and expert clinical care during the pandemic. As with other acts of heroism, the ethical dilemmas associated with working on the front line must be considered for future practice. Purpose: To explore the ethical dilemmas of frontline nurses (...) of Jiangsu Province in China during deployment to Wuhan to fight the novel coronavirus pneumonia, and to provide a basis for developing strategies to help nursing staff address personal and practice concerns in order to work more effectively during this pandemic and other disasters in the future. Research design and method: Using the phenomenological research method and the purpose sampling method, semi-structured interviews were conducted with 10 nurses, post-deployment to Wuhan, who had worked on the front line to fight the novel coronavirus. Ethical considerations: The research proposal was approved by the Research Ethic Committee of Yangzhou University, China. Findings: From the analysis of the interviews of the 10 participants, three main themes were identified: ethical dilemmas in clinical nursing, ethical dilemmas in interpersonal relationships, and ethical dilemmas in nursing management. Conclusion: During a quick response to public health emergencies, where nurses are deployed immediately as a call to action, the issues surrounding ethical dilemmas from several perspectives must be considered. This research suggests that a team approach to proactive planning and open communication during the emergency is an efficient and productive strategy to improve the nurses’ experience and sense of well-being. (shrink)

As disenchantment began to be recognized as a recurring, never-ending process in recent scholarship, “When Jupiter Meets Saturn” argues that Aby Warburg and Karl Sudhoff’s debate on Reformation astrological medicine provided a new theory of the emergence of modern science and rationality. Drawing on their encounter and divergence in interwar Germany, especially their curatorial collaboration for the 1911 Internationale Hygiene-Ausstellung, the article shows that Warburg and Sudhoff generated completely opposite historical evaluations of astrological medicine using the very same materials. Approaching (...) history as healers, they developed different ways of seeing from medical epistemologies and brought out entangled temporalities from images. (shrink)

Patterns of object naming often differ between languages, but bilingual speakers develop convergent naming patterns in their two languages that are distinct from those of monolingual speakers of each language. This convergence appears to reflect interactions between lexical representations for the two languages. In this study, we developed a self-organizing connectionist model to simulate semantic convergence in the bilingual lexicon and investigate the mechanisms underlying this semantic convergence. We examined the similarity of patterns in the simulated data to empirical data (...) from past research, and we identified how semantic convergence was manifested in the simulated bilingual lexical knowledge. Furthermore, we created impaired models in which components of the network were removed so as to examine the importance of the relevant components on bilingual object naming. Our results demonstrate that connections between two languages’ lexicons can be established through the simultaneous activations of related words in the two languages. These connections between languages allow the outputs of their lexicons to become more similar, that is, to converge. Our model provides a basis for future computational studies of how various input variables may affect bilingual naming patterns. (shrink)

White LEDs, which have been widely used in the urban street lighting, are increasingly applied to replace traditional HPS lamps with a lower CCT. Generally, studies on the CCT of street lighting focus on providing safe functional lighting for vehicle drivers. However, it is still unknown how the street light color can affect pedestrians’ perception and preferences with respect to lighting levels and ambient temperature.In this study, a wide range of CCTs was measured for urban street lighting in Beijing, China, (...) for example. And the transition from traditional HPS lamps to LEDs lacks a reference street lighting standard for CCT. The study aims to conduct a cross-sensory test to evaluate urban street lighting with multiple combinations of CCT values and illuminance levels according to pedestrians’ visual perception and psychological preferences.A total of 18 night street lighting scenes with six CCT values and three illuminance levels were first selected in Beijing city, and then HDR videos of these scenes were taken from the view of pedestrians to conduct psychological experiments in an indoor environment with three ambient temperatures. A total of 77 university students were invited to assess videos of the 18 lighting scenes in terms of seven factors, such as lighting brightness, color temperature sensation, light color preference, sense of safety, recognition, comfort, and overall preference. Several key findings were achieved as follows. The CCT of urban street lighting can have significant effects on the visual psychological perceptions of participants. There was a significant interaction between CCT, illuminance, and ambient temperature on the visual psychological performances of participants. The higher ambient temperature will deliver the higher level of overall preference for the street lighting with medium and high CCT, and the perception of warmer light color. There was a strong correlation found between participants’ light color preference, comfort, and overall preferences. (shrink)

In this essay I suggest that we view design principles in systems biology as minimal models, for a design principle usually exhibits universal behaviors that are common to a whole range of heterogeneous (living and nonliving) systems with different underlying mechanisms. A well-known design principle in systems biology, integral feedback control, is discussed, showing that it satisfies all the conditions for a model to be a minimal model. This approach has significant philosophical implications: it not only accounts for how design (...) principles explain, but also helps clarify one dispute over design principles, e.g., whether design principles provide mechanistic explanations or a distinct kind of explanations called design explanations. (shrink)

Stephen Yablo’s notion of proportionality, despite controversies surrounding it, has played a significant role in philosophical discussions of mental causation and of high-level causation more generally. In particular, it is invoked in James Woodward’s interventionist account of high-level causation and explanation, and is implicit in a novel approach to constructing variables for causal modeling in the machine learning literature, known as causal feature learning (CFL). In this article, we articulate an account of proportionality inspired by both Yablo’s account of proportionality (...) and the CFL account of variable construction. The resulting account has at least three merits. First, it illuminates an important feature of the notion of proportionality, when it is adapted to a probabilistic and interventionist framework. The feature is that at the center of the notion of proportionality lies the concept of “determinate intervention effects.” Second, it makes manifest a virtue of (common types of) high-level causal/explanatory statements over low-level ones, when relevant intervention effects are determinate. Third, it overcomes a limitation of the CFL framework and thereby also addresses a challenge to interventionist accounts of high-level causation. (shrink)

Weak judgmentalism of emotions posits that emotions necessarily involve judgments. However, a standard critique of weak judgmentalism is that it cannot adequately account for the rationality of recalcitrant emotions, which persist despite the agent holding beliefs that conflict with them. This leads to the seemingly counter-intuitive conclusion that recalcitrant emotions are as irrational as logical mistakes. In response to this critique, I make two arguments. First, I distinguish between low-level and high-level beliefs, and argue that having two beliefs with contrary (...) contents at different levels can be rational to some extent. Therefore, weak judgmentalism can explain why recalcitrant emotions are not as irrational as logical mistakes. Second, I argue that recalcitrant emotions involve mental conflicts, while normal emotions do not. By framing the issue in this way, weak judgmentalism can also explain why recalcitrant emotions are not as rational as normal emotions. (shrink)

Anti-criterialists argue that there are no criteria that ensure personal persistence. However, this perspective is criticized for resulting in an unacceptable consequence that undermines our intuitions, daily beliefs, and direct introspective awareness of personal persistence. I defend anti-criterialism by responding to this objection and arguing that none of these aspects are undermined by anti-criterialism. The flawed objection against anti-criterialism reveals the excessive ambition of criterialism in seeking criteria for personal persistence with metaphysical necessity, which goes beyond our abilities and needs. (...) As beings living in the actual world, we are not able to consider what happens to personal persistence in remote possible worlds. Moreover, to judge whether a person persists or not in daily life, we do not need a criterion that ensures personal persistence in all situations. Anti-criterialism acknowledges the complexity and variability of personal persistence and offers a more realistic and practical approach to understanding personal identity. (shrink)

Rising negative emotions are like “time bombs” that impede productivity in the workplace. The present investigation provides an insight into the effects of defensive silence and defensive voice on counterproductive work behavior through knowledge hiding in the context of knowledge workers in Chinese academic institutions. Partial least square structural equation modeling was applied to the current samples. The study obtained conjecture the proposed mediating role of knowledge hiding between the negative working attitude and counterproductive work behavior, which is against the (...) organizational norms and performance. The result indicates that the positive relationships exist from defensive silence and defensive voice to counterproductive work behavior, mediated by knowledge hiding. This study links knowledge hiding literature and stimulus-organism-response to better explore the academic behavior in a knowledge setting. (shrink)

This study examines the associations of constructivist beliefs and classroom climate on teachers' self-efficacy in instruction, classroom management, and student engagement among Australian secondary mathematics teachers. To do this, it uses the integrated model of teachers' self-efficacy with the concept of analysis of teaching tasks. The study uses structural equation modeling to analyze data from 495 mathematics teachers in the Teaching and Learning International Survey 2013. The results reveal the integrated model is a valid theoretical framework to explain Australian secondary (...) mathematics teachers' self-efficacy. Teachers' constructivist beliefs and classroom climate are positively and statistically significantly related to teachers' self-efficacy in instruction, classroom management and student engagement. In contrast, constructivist beliefs have no significant correlation with classroom climate. (shrink)

In this essay I propose that what design principles in systems biology and systems neuroscience do is to present abstract characterizations of mechanisms, and thereby facilitate mechanistic explanation. To show this, one design principle in systems neuroscience, i.e., the multilayer perceptron, is examined. However, Braillard (2010) contends that design principles provide a sort of non-mechanistic explanation due to two related reasons: they are very general and describe non-causal dependence relationships. In response to this, I argue that, on the one hand, (...) all mechanisms are more or less general (or abstract), and on the other, many (if not all) design principles are causal systems. (shrink)

Since the beginning of the twentieth century, Chinese scholars have tended to traditional Chinese learning split apart and rearrange it according to the systematics of modern Western academic disciplines. By examining the meaning of Western "philosophy" and "ethics," it is demonstrated that Western and Chinese learning should not be lumped together according to the same systematics. Moreover, classical Chinese learning has always had its own complex systematics and its own long tradition, and it has undergone constant development over time. Thus, (...) it is well beyond any criticism that may be leveled at it from the standpoint of Western systematics. Even so, modern Chinese intellectuals have become accustomed to understanding classical Chinese learning through a Western prism. (shrink)

Di 1 ce. Cang shan ji, zi cang ji shi, "Xin zi xue" gou xiang -- di 2 ce. Zhi yan lu -- di 3 ce. Shang lin ji -- di 4 ce. Cun ya tang yi gao jiao bu -- di 5 ce. Nan Song yi min shi ren qun ti yan jiu, Zhuangzi shi ri tan -- di 6 ce. Zhuangzi shu mu ti yao -- di 7 ce. Zhuangzi xue shi (yi) -- di 8 ce. Zhuangzi xue (...) shi (er) -- di 9 ce. Zhuangzi xue shi (san) -- di 10 ce. Zhuangzi xue shi (si) -- di 11 ce. Zhuangzi xue shi (wu) -- di 12 ce. Zhuangzi xue shi (lu) -- di 13 ce. Zhuang xue shi lüe -- di 14 ce. Zhuangzi quan ping (shang) -- di 15 ce. Zhuangzi quan ping (xia) -- di 16 ce. Zhuangzi zuan yao (yi) -- di 17 ce. Zhuangzi zuan yao (er) -- di 18 ce. Zhuangzi zuan yao (san) -- di 19 ce. Zhuangzi zuan yao (si) -- di 20 ce. Zhuangzi zuan yao (wu) -- di 21 ce. Zhuangzi zuan yao (lu) -- di 22 ce. Zhuangzi zuan yao (qi) -- di 23 ce. Zhuangzi zuan yao (ba) -- di 24 ce. Zhuangzi zuan yao (jiu) -- di 25 ce. Zhuangzi jin gu (shang) -- di 26 ce. Zhuangzi jin gu (xia) -- di 27 ce. Mengzi jin gu -- di 28 ce. Mozi jin gu -- di 29 ce. -- Xunzi jin gu -- di 30 ce. Zhou Han wen chao -- di 31 ce. Shu jing lüe ying. (shrink)

Human resource management (HRM) is underpinned by, and contributes to, the business ethics of the organization. Opportunities available to men and women as managers, and the role of managers more broadly, are critical in shaping business ethics in contemporary organizations. Research on women in management therefore provides an important lens through which to understand the institutional and cultural context of HR ethics as part of the business ethics of a country. To date, women in management in China remains an under-charted (...) topic of research in the HRM field. Extant research and recommendations on the improvement of the position of women in management in China focus primarily on women themselves from a traditional, gender norm angle, instead of challenging the political and patriarchal system or any institutionalized discriminatory practice. This is, in part, due to the absence in China of a critical feminism approach or feminist movement, as found in Western societies, and the continuing strong influence of the state and media in portraying women’s (stereotypical) image. There is significant room for research capacity building in scholarship on women in management research, for example, and through cross-fertilization of different disciplines and more rigorous research design and execution. This paper provides a critical analysis of extant literature on women in management and the ideologies underpinning it, and offers some suggestions for future research and conceptualization. (shrink)

Cyber-physical systems are characterized by integrating computation and physical processes. To cope with the challenges of the application of the CPSs in all kinds of environments, especially the cellular vehicle-to-everything which needs high quality end-to-end communication, the robustness and reliability for CPSs are very crucial. Aiming at the technical challenges of information transmission caused by the fading effect and the fast time-varying characteristics of the channel for C-V2X communication, an improved Tomlinson–Harashima precoding algorithm for multiple input multiple output systems is (...) proposed. Channel state information and correlation are exploited to compensate instantaneous CSI, which could reflect current real-time channel status exactly. Further, the iterative water filling power allocation algorithm and the multiuser scheduling algorithm based on the greedy algorithm are jointly optimized and applied to the THP, which could improve the system performance. Simulation results show that the proposed algorithm can be efficiently applied to high-speed mobility scenarios and improve bit error ratio performance as well as spectrum utilization. (shrink)

本册内容为:“砍爷”的始祖、纵横家的教科书、鬼谷子纵横八术、鬼谷子门徒游说故事等。.

This article examines the early modern household's importance for producing experimental knowledge through an examination of the Halifax household of Margery and Henry Power. While Henry Power has been studied as a natural philosopher within the male-dominated intellectual circles of Cambridge and London, the epistemic labour of his wife, Margery Power, has hitherto been overlooked. From the 1650s, this couple worked in tandem to enhance their understanding of the vegetable world through various paper technologies, from books, paper slips and recipe (...) notebooks to Margery's drawing album and Henry's published Experimental Philosophy. Focusing on Margery's practice of hand-colouring flower books, her copied and original drawings of flowers and her experimental production of ink, we argue that Margery's sensibility towards colour was crucial to Henry's microscopic observations of plants. Even if Margery's sophisticated knowledge of plants never left the household, we argue that her contribution was nevertheless crucial to the observation and representation of plants within the community of experimental philosophy. In this way, our article highlights the importance of female artists within the history of scientific observation, the use of books and paperwork in the botanical disciplines, and the relationship between household science and experimental philosophy. (shrink)

The Iowa Gambling Task (IGT) simulates uncertain gains and losses in real life situations and thus is a good measure of uncertain decision making. The role of working memory (WM) in IGT performance still remains unclear. The present study aimed to examine the effect of WM on IGT performance. Three groups of participants matched on gender ratio were randomly assigned to no WM load, low WM load, and high WM load conditions. Initially the three groups did not show significant difference (...) in WM capacity. They finished a modified version of IGT and then their implicit learning effect and explicit cognition on IGT were assessed. Results indicated a linear increasing trend of IGT performance among high WM load, low WM load and no WM load groups; participants in the no WM load and low WM load groups revealed implicit learning effect, while participants in the high WM load group did not; all participants showed explicit cognition on IGT to the same level. These results suggested that participants in the high WM load group showed good explicit cognition to IGT but showed poor performance. This pattern is similar to frontal patients. Further studies should be conducted to explore this issue. (shrink)